Tatiana B. Prokaeva, MD, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

MD, Medical Semashko Institute
PhD, Russian Academy of Medical Sciences

Expertise in genetics of primary and familial types of amyloidosis.

Boston University
Amyloidosis Center

SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations)
05/01/2019 - 02/29/2024 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI

Preclinical evaluation of amyloid binding on tissues and opsonization using CAEL-101
10/02/2022 - 10/01/2023 (PI)
Alexion Pharmaceuticals, Inc.

ALA Study - Janssen Pharmaceuticals
06/09/2020 - 06/09/2023 (PI)
Janssen Research & Development, LLC


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Prokaeva T, Klimtchuk ES, Feschenko P, Spencer B, Cui H, Burks EJ, Aslebagh R, Muneeruddin K, Shaffer SA, Varghese E, Berk JL, Connors LH. An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis. Amyloid. 2022 Oct 26; 1-12.View Related Profiles. PMID: 36286264
  2. Prokaeva T, Joshi T, Klimtchuk ES, Gibson VM, Spencer B, Siddiqi O, Nedelkov D, Hu Y, Berk JL, Cuddy SAM, Dasari S, Chiu A, Choate LA, McPhail ED, Cui H, Chen H, Burks EJ, Sanchorawala V, Connors LH. A novel substitution of proline (P32L) destabilises ß2-microglobulin inducing hereditary systemic amyloidosis. Amyloid. 2022 Dec; 29(4):255-262.View Related Profiles. PMID: 35575118; DOI: 10.1080/13506129.2022.2072199;
  3. Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6428-E6436.View Related Profiles. PMID: 29941560; PMCID: PMC6048550; DOI: 10.1073/pnas.1802977115;
  4. Hanson JLS, Arvanitis M, Koch CM, Berk JL, Ruberg FL, Prokaeva T, Connors LH. Use of Serum Transthyretin as a Prognostic Indicator and Predictor of Outcome in Cardiac Amyloid Disease Associated With Wild-Type Transthyretin. Circ Heart Fail. 2018 02; 11(2):e004000.View Related Profiles. PMID: 29449366; PMCID: PMC5819619; DOI: 10.1161/CIRCHEARTFAILURE.117.004000;
  5. Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, O'Hara CJ, Gursky O, Leszyk J, Steffen M, Browning S, Rosenberg A, Connors LH. Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant. Kidney Int Rep. 2017 Nov; 2(6):1223-1232.View Related Profiles. PMID: 29270531; PMCID: PMC5733886; DOI: 10.1016/j.ekir.2017.07.009;
  6. Klimtchuk ES, Prokaeva TB, Spencer BH, Gursky O, Connors LH. In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid. 2017 Jun; 24(2):115-122.View Related Profiles. PMID: 28632419; PMCID: PMC5580339; DOI: 10.1080/13506129.2017.1336996;
  7. Lu Y, Jiang Y, Prokaeva T, Connors LH, Costello CE. Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein. Int J Mass Spectrom. 2017 05; 416:71-79.View Related Profiles. PMID: 29358899; PMCID: PMC5774984; DOI: 10.1016/j.ijms.2016.11.006;
  8. Prokaeva T, Spencer B, Sun F, O'Hara RM, Seldin DC, Connors LH, Sanchorawala V. Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio. Amyloid. 2016 Dec; 23(4):214-220.View Related Profiles. PMID: 27677679
  9. Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Hum Genet. 2015 Jan; 134(1):111-21.View Related Profiles. PMID: 25367359; PMCID: PMC4282974; DOI: 10.1007/s00439-014-1499-0;
  10. Girnius S, Skinner M, Spencer B, Prokaeva T, Bartholomew C, O'Hara C, Seldin DC, Connors LH. A new lysozyme tyr54asn mutation causing amyloidosis in a family of Swedish ancestry with gastrointestinal symptoms. Amyloid. 2012 Dec; 19(4):182-5.View Related Profiles. PMID: 22978355; DOI: 10.3109/13506129.2012.723074;
Showing 10 of 26 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 26 publications over 16 distinct years, with a maximum of 3 publications in 2007


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

familial amyloidosis
primary amyloidosis
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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