Tatiana B. Prokaeva, MD, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

MD, Medical Semashko Institute
PhD, Russian Academy of Medical Sciences



Expertise in genetics of primary and familial types of amyloidosis.

Member
Boston University
Amyloidosis Center




Preclinical evaluation of Molecular Gates Compounds to inhibit lambda light chain secretion and induce cell death in primary bone marrow AL plasma cells.
11/14/2024 - 11/14/2025 (PI)
Gate Bioscience


Request for paired plasma and serum samples from patients with variant transthyretin (ATTRv) amyloidosis to assess the pan-variant potency of new high-affinity TTR stabilizer Acoramidis
10/30/2024 - 02/28/2025 (PI)
BridgeBio Pharma, Inc.


SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations)
05/01/2019 - 02/28/2025 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI
5R01HL139671-05

Preclinical evaluation of amyloid binding on tissues and opsonization using CAEL-101
10/02/2022 - 10/01/2023 (PI)
Alexion Pharmaceuticals, Inc.


ALA Study - Janssen Pharmaceuticals
06/09/2020 - 06/09/2023 (PI)
Janssen Research & Development, LLC




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Hicks CW, Prokaeva T, Spencer B, Jayaraman S, Huda N, Wong S, Chen H, Sanchorawala V, Lavatelli F, Gursky O. Cryo-EM of Cardiac AL-224L Amyloid Reveals Shared Structural Motifs and Mutation-induced Differences in ?6 Light Chain Fibrils. J Mol Biol. 2026 Feb 01; 438(3):169591.View Related Profiles. PMID: 41389958; PMCID: PMC12811844; DOI: 10.1016/j.jmb.2025.169591;
     
  2. Zhou Y, Lu W, Burks E, Henderson JM, Andry C, Sanchorawala V, Sheikh Z, Prokaeva TB, Chen HA. Optimized methods for efficient application of immunogold electron microscopy to amyloid fibrils typing. Amyloid. 2026 Mar; 33(1):47-58.View Related Profiles. PMID: 41275507
     
  3. Ruberg FL, Teruya S, Helmke S, Smiley DA, Fine D, Kurian D, Raiszadeh F, Prokaeva T, Spencer B, Wong S, Pandey S, Blaner WS, DeLuca A, Johnson LL, Kinkhabwala MP, Leb J, Mintz A, LaValley MP, Einstein AJ, Cohn E, Gallegos C, Murtagh G, Kelly JW, Miller EJ, Maurer MS. Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. JAMA Cardiol. 2025 Oct 01; 10(10):1034-1043.View Related Profiles. PMID: 40928765; PMCID: PMC12423950; DOI: 10.1001/jamacardio.2025.2948;
     
  4. Joshi T, Prokaeva T, Gopal DM, Verma A, Sanchorawala V, Chen H, Burks E, Dasari S, McPhail ED, Staron A. Wild-Type Transthyretin Amyloidosis in the Kidneys. JACC Case Rep. 2025 Sep 24; 30(29):105132.View Related Profiles. PMID: 40833310; PMCID: PMC12539439; DOI: 10.1016/j.jaccas.2025.105132;
     
  5. Morgan GJ, Prokaeva T. Clone-specific residue changes at multiple positions are associated with amyloid formation by antibody light chains. Front Immunol. 2025; 16:1622207.View Related Profiles. PMID: 40861476; PMCID: PMC12375997; DOI: 10.3389/fimmu.2025.1622207;
     
  6. Hicks CW, Prokaeva T, Spencer B, Jayaraman S, Huda N, Wong S, Chen H, Sanchorawala V, Lavatelli F, Gursky O. Cryo-EM of cardiac AL-224L amyloid reveals shared features in ?6 light chain fibril folds. bioRxiv. 2025 Jul 01.View Related Profiles. PMID: 40631131; PMCID: PMC12236830; DOI: 10.1101/2025.06.25.661559;
     
  7. Ramireddy S, Prokaeva T, Chen H, Spencer B, Wong S, Dasari S, Dao L, McPhail ED, Sanchorawala V, Mendelson L. The Amyloidosis Intersection: Dual Amyloid Types in a Single Host. Eur J Haematol. 2025 Sep; 115(3):287-298.View Related Profiles. PMID: 40526008; DOI: 10.1111/ejh.14429;
     
  8. Prokaeva T, Jayaraman S, Klimtchuk E, Burke N, Spencer B, Nedelkov D, Chen H, Dasari S, McPhail ED, Pereira L, Payne MC, Wong S, Burks EJ, Sanchorawala V, Gursky O. An unusual phenotype of hereditary AApoAI amyloidosis caused by a novel Asp20Tyr substitution is linked to pH-dependent aggregation of apolipoprotein A-I. Biochim Biophys Acta Mol Basis Dis. 2025 Jun; 1871(5):167820.View Related Profiles. PMID: 40164396; PMCID: PMC11998993; DOI: 10.1016/j.bbadis.2025.167820;
     
  9. Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Singh Bawa P, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. Amyloid. 2025 Jun; 32(2):179-192.View Related Profiles. PMID: 40134188; DOI: 10.1080/13506129.2025.2478397;
     
  10. Dodge MC, Prokaeva T, Mendelson L, Joshi T, Sanchorawala V, Kataria Y. High-Sensitivity and Conventional Cardiac Troponin-I Assays in AL Amyloidosis. J Appl Lab Med. 2025 Mar 03; 10(2):315-324.View Related Profiles. PMID: 39495058
     
Showing 10 of 66 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 27 distinct years, with a maximum of 10 publications in 2025

YearPublications
19851
19861
19904
19912
19921
19933
19941
19953
19961
19982
20002
20022
20034
20061
20073
20081
20092
20111
20122
20141
20162
20172
20182
20222
20233
20247
202510

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

familial amyloidosis
primary amyloidosis
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