Nicholas Chavkin | Profiles RNS

Nicholas Chavkin, PhD

Postdoctoral Fellow (previously held)

Boston University Chobanian & Avedisian School of Medicine

Whitaker Cardiovascular Institute

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	Loop Frontiers
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	ResearchGate
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Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Thel MC, Cochran JD, Teruya S, Hayashi O, Xie CR, Srinivasan AR, Chavkin NW, Arai Y, Sano S, Mirabal Santos A, De Los Santos J, Fine D, Sabogal N, Ullah I, Helmke S, Rodriguez C, Prokaeva T, Foster RH, Spencer BH, Izumiya Y, Maurer MS, Walsh K, Ruberg FL. Mosaic Loss of the Y Chromosome Is Enriched in Patients With Wild-Type Transthyretin Cardiac Amyloidosis and Associated With Increased Mortality. Circ Heart Fail. 2024 Aug; 17(8):e011681.View Related Profiles.

Ruberg, Frederick
Chavkin, Nicholas
Prokaeva, Tatiana

PMID: 38853760; PMCID: PMC11335443; DOI: 10.1161/CIRCHEARTFAILURE.124.011681;

Horitani K, Chavkin NW, Arai Y, Wang Y, Ogawa H, Yura Y, Evans MA, Cochran JD, Thel MC, Polizio AH, Sano M, Miura-Yura E, Arai Y, Doviak H, Arnold AP, Gelfand BD, Hirschi KK, Sano S, Walsh K. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. Nat Cardiovasc Res. 2024 Mar; 3(3):343-355. PMID: 39183958; PMCID: PMC11343478; DOI: 10.1038/s44161-024-00441-z;

Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. 2024 Mar 19; 149(12):944-962. PMID: 38126211; PMCID: PMC10954087; DOI: 10.1161/CIRCULATIONAHA.122.062952;

Dunaway LS, Luse MA, Nyshadham S, Bulut G, Alencar GF, Chavkin NW, Cortese-Krott M, Hirschi KK, Isakson BE. Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium. Physiol Genomics. 2024 Feb 01; 56(2):113-127. PMID: 37982169; PMCID: PMC11281809; DOI: 10.1152/physiolgenomics.00109.2023;

Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K. Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans. Front Cardiovasc Med. 2023; 10:1264479.View Related Profiles.

Chavkin, Nicholas
Gokce, Noyan

PMID: 37795485; PMCID: PMC10546194; DOI: 10.3389/fcvm.2023.1264479;

Cochran JD, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, Arai Y, Horitani K, Park E, Chavkin NW, Kour A, Sano S, Mahajan N, Evans M, Huba M, Naya NM, Sun H, Ban YH, Hirschi KK, Toldo S, Abbate A, Druley TE, Ruberg FL, Maurer MS, Ezekowitz JA, Dyck JRB, Walsh K. Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Oct 10; 148(15):1165-1178.View Related Profiles.

Ruberg, Frederick
Chavkin, Nicholas

PMID: 37681311; PMCID: PMC10575571; DOI: 10.1161/CIRCULATIONAHA.123.064170;

Chavkin NW, Evans MA, Walsh K. How clonal hematopoiesis promotes inflammation at a single-cell level. Nat Cardiovasc Res. 2023 Sep; 2(9):801-802. PMID: 39196066

Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK. Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. Life Sci Alliance. 2023 Aug; 6(8). PMID: 37197981; PMCID: PMC10192821; DOI: 10.26508/lsa.202201685;

Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada HH, Goldberg JS, Acharya BR, Bhatt NS, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZM, Eichmann A, Thomas JL, Ffrench-Constant C, Hirschi KK. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Rep. 2023 Apr 25; 42(4):112371. PMID: 37043357; PMCID: PMC10564973; DOI: 10.1016/j.celrep.2023.112371;

Correia-Branco A, Mei A, Pillai S, Jayaraman N, Sharma R, Paquette AG, Neradugomma NK, Benson C, Chavkin NW, Mao Q, Wallingford MC. SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis. Vasc Biol. 2023 Apr 01; 5(1). PMID: 36795703; PMCID: PMC10160536; DOI: 10.1530/VB-22-0018;

Showing 10 of 27 results. Show More

Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba M, Sheynkman GM, Walsh K, Hirschi KK. Endothelial cell cycle state determines propensity for arterial-venous fate. Nat Commun. 2022 Oct 06; 13(1):5891. PMID: 36202789; PMCID: PMC9537338; DOI: 10.1038/s41467-022-33324-7;

Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundström J, Yura Y, Kour A, Arai Y, Thel MC, Arai Y, Mychaleckyj JC, Hirschi KK, Forsberg LA, Walsh K. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science. 2022 07 15; 377(6603):292-297. PMID: 35857592; PMCID: PMC9437978; DOI: 10.1126/science.abn3100;

Chavkin NW, Cain S, Walsh K, Hirschi KK. Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing. J Vis Exp. 2021 10 11; (176). PMID: 34694293; PMCID: PMC8641104; DOI: 10.3791/63133;

Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Circ Res. 2021 09 03; 129(6):684-698. PMID: 34315245; PMCID: PMC8409899; DOI: 10.1161/CIRCRESAHA.121.319314;

Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K. The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. J Am Heart Assoc. 2021 07 06; 10(13):e019904.View Related Profiles.

Chavkin, Nicholas
Gokce, Noyan
Maclauchlan, Susan

PMID: 34155901; PMCID: PMC8403294; DOI: 10.1161/JAHA.120.019904;

Chavkin NW, Leaf EM, Brooks KE, Wallingford MC, Lund SM, Giachelli CM. Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells. J Vasc Res. 2021; 58(5):277-285. PMID: 33951626; PMCID: PMC8478708; DOI: 10.1159/000516044;

Chavkin NW, Min KD, Walsh K. Importance of clonal hematopoiesis in heart failure. Trends Cardiovasc Med. 2022 May; 32(4):198-203.View Related Profiles.

Walsh, Kenneth
Chavkin, Nicholas

PMID: 33892102; PMCID: PMC8526615; DOI: 10.1016/j.tcm.2021.04.005;

Nelson EA, Qiu J, Chavkin NW, Hirschi KK. Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells. J Vis Exp. 2021 03 31; (169). PMID: 33871448; PMCID: PMC8675434; DOI: 10.3791/62391;

Chavkin NW, Walsh K, Hirschi KK. Isolation of Highly Purified and Viable Retinal Endothelial Cells. J Vasc Res. 2021; 58(1):49-57.View Related Profiles.

Walsh, Kenneth
Chavkin, Nicholas

PMID: 33022674; PMCID: PMC7850292; DOI: 10.1159/000510533;

Chavkin NW, Hirschi KK. Single Cell Analysis in Vascular Biology. Front Cardiovasc Med. 2020; 7:42. PMID: 32296715; PMCID: PMC7137757; DOI: 10.3389/fcvm.2020.00042;

Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Sci Rep. 2020 02 20; 10(1):3069. PMID: 32080237; PMCID: PMC7033257; DOI: 10.1038/s41598-020-59430-4;

Wallingford MC, Benson C, Chavkin NW, Chin MT, Frasch MG. Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone. Front Physiol. 2018; 9:1044. PMID: 30131710; PMCID: PMC6090024; DOI: 10.3389/fphys.2018.01044;

Wallingford MC, Chia JJ, Leaf EM, Borgeia S, Chavkin NW, Sawangmake C, Marro K, Cox TC, Speer MY, Giachelli CM. SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification. Brain Pathol. 2017 01; 27(1):64-76. PMID: 26822507; PMCID: PMC4967033; DOI: 10.1111/bpa.12362;

Chavkin NW, Chia JJ, Crouthamel MH, Giachelli CM. Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells. Exp Cell Res. 2015 Apr 10; 333(1):39-48. PMID: 25684711; PMCID: PMC4387109; DOI: 10.1016/j.yexcr.2015.02.002;

Crouthamel MH, Lau WL, Leaf EM, Chavkin NW, Wallingford MC, Peterson DF, Li X, Liu Y, Chin MT, Levi M, Giachelli CM. Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2625-32. PMID: 23968976; PMCID: PMC4009978; DOI: 10.1161/ATVBAHA.113.302249;

Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, Chavkin NW, Rahman M, Wahl P, Amaral AP, Hamano T, Master SR, Nessel L, Chai B, Xie D, Kallem RR, Chen J, Lash JP, Kusek JW, Budoff MJ, Giachelli CM, Wolf M. Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int. 2013 Jun; 83(6):1159-68. PMID: 23389416; PMCID: PMC3672330; DOI: 10.1038/ki.2013.3;

Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, Lemos JC, Chavkin NW, Hagan CE, Neumaier JF, Chavkin C. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. J Neurosci. 2012 Dec 05; 32(49):17582-96. PMID: 23223282; PMCID: PMC3523715; DOI: 10.1523/JNEUROSCI.3220-12.2012;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 10 distinct years, with a maximum of 8 publications in 2023

Bar chart showing 27 publications over 10 distinct years, with a maximum of 8 publications in 2023

Year	Publications
2012	1
2013	2
2015	1
2016	1
2018	1
2020	3
2021	6
2022	2
2023	8
2024	2

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