Haiyan Gong, MD, PhD
Professor
Boston University School of Medicine
Dept of Ophthalmology

MD, Jiangxi University of Traditional Chinese Medicine
PhD, Boston University School of Medicine
MS, Peking Union Medical College



Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

Professor
Boston University School of Medicine
Department of Anatomy & Neurobiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2016 Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO


Cell-cell interactions in giant vacuole/pore formation
07/01/2016 - 06/30/2018 (PI)
Bright Focus Foundation

Cellular Physiology of the Aqueous Outflow Pathway
09/01/2016 - 08/31/2017 (PI)
NIH/National Eye Institute
4R01EY022634-05

The Mechanical Basis of Primary Open Angle Glaucoma
07/01/2015 - 06/30/2017 (PI)
Northwestern University NIH NEI
R01EY019696

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2017 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Cellular Physiology of the Aqueous Outflow Pathway
09/30/2012 - 08/31/2016 (PI)
NIH/National Eye Institute
5R01EY022634-04

A Mouse Giaucoma Model and Stem Cell-Based Therapy for Glaucoma
07/01/2014 - 06/30/2016 (PI)
University of Pittsburgh Bright Focus Fdn

Evaluation of the effect of an Aerie drug (AR-13324) on aqueous flow pattern and morphology in enucleated human eyes
10/15/2014 - 12/30/2015 (PI)
Aerie Pharmaceuticals, Inc.

The Mechanical Basis of Primary Open Angle Glaucoma
09/30/2009 - 09/29/2015 (PI)
Northwestern University NIH NEI
R01EY019696

Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
09/01/2013 - 08/31/2014 (PI)
Case Western Reserve University NIH NEI
7R01EY019654-05

Matricellular Proteins in Trabecular Meshwork
09/30/2009 - 08/31/2013 (PI)
Mass Eye and Ear Infirmary NIH NEI
5 R01 EY019654-04

Showing 10 of 18 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209.View Related Profiles. PMID: 27842161; DOI: 10.1167/iovs.16-20189;.
  2. Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60.View Related Profiles. PMID: 26775054; PMCID: PMC4893924; DOI: 10.1016/j.exer.2016.01.008;.
  3. Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
  4. Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760; PMCID: PMC4787989; DOI: 10.1016/j.cvsm.2015.06.005;.
  5. Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48.View Related Profiles. PMID: 25670488; PMCID: PMC4351652; DOI: 10.1167/iovs.14-15593;.
  6. Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm''s canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410; PMCID: PMC4470892; DOI: 10.1007/s10237-014-0640-2;.
  7. Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864; PMCID: PMC4254369; DOI: 10.1016/j.exer.2014.08.015;.
  8. Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021; PMCID: PMC3991982; DOI: 10.1089/jop.2013.0192;.
  9. Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.
  10. Yang CY, Liu Y, Lu Z, Ren R, Gong H. Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013; 54(8):5859-70.View Related Profiles. PMID: 23920374; PMCID: PMC3757907; DOI: 10.1167/iovs.12-10930;.
Showing 10 of 62 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 62 publications over 26 distinct years, with a maximum of 6 publications in 2013

YearPublications
19851
19861
19892
19921
19931
19941
19951
19962
19975
19981
19991
20002
20011
20025
20031
20062
20073
20083
20094
20102
20113
20124
20136
20144
20152
20163
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aqueous outflow resistance
Confocal microscopy
Electron microscopy
Glaucoma
Ocular perfusion
Trabecular meshwork

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
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