Keywords
Last Name

Haiyan Gong, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentOphthalmology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4434
ORCID ORCID Icon0000-0002-7204-5019
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Awards and Honors

Start-EndDescription
2016Association For Research in Vision and Ophthalmology: Silver Fellow of ARVO
 Research Expertise & Professional Interests
Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.

 Self-Described Keywords
  • Aqueous outflow resistance
  • Glaucoma
  • Trabecular meshwork
  • Electron microscopy
  • Ocular perfusion
  • Confocal microscopy
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):6197-6209. PMID: 27842161.
    View in: PubMed
  2. Cha ED, Xu J, Gong L, Gong H. Variations in active outflow along the trabecular outflow pathway. Exp Eye Res. 2016 May; 146:354-60. PMID: 26775054.
    View in: PubMed
  3. Gong H and Swain DL. The histopathological changes in the trabecular outflow pathway and their possible effects on aqueous outflow in eyes with primary open-angle glaucoma. Glaucoma Research and Clinical Advances 2016-2018. Kugler. Amsterdam. 2016; 17-40.
  4. Pizzirani S, Gong H. Functional Anatomy of the Outflow Facilities. Vet Clin North Am Small Anim Pract. 2015 Nov; 45(6):1101-26, v. PMID: 26337760.
    View in: PubMed
  5. Swain DL, Ho J, Lai J, Gong H. Shorter scleral spur in eyes with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015 Mar; 56(3):1638-48. PMID: 25670488.
    View in: PubMed
  6. Vargas-Pinto R, Lai J, Gong H, Ethier CR, Johnson M. Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells. Biomech Model Mechanobiol. 2015 Aug; 14(4):851-63. PMID: 25516410.
    View in: PubMed
  7. Yang CY, Huynh T, Johnson M, Gong H. Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes. Exp Eye Res. 2014 Nov; 128:27-33. PMID: 25217864.
    View in: PubMed
  8. Gong H, Yang CY. Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632. J Ocul Pharmacol Ther. 2014 Mar-Apr; 30(2-3):143-53. PMID: 24460021.
    View in: PubMed
  9. Gong H and Francis A. Surgical Innovations in Glaucoma. Schlemm’s Canal and Collector Channels as Therapeutic Targets. Springer. New York. 2014; 3-25.
  10. Yang CY, Liu Y, Lu Z, Ren R, Gong H. Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013; 54(8):5859-70. PMID: 23920374.
    View in: PubMed
  11. Vargas-Pinto R, Gong H, Vahabikashi A, Johnson M. The effect of the endothelial cell cortex on atomic force microscopy measurements. Biophys J. 2013 Jul 16; 105(2):300-9. PMID: 23870251.
    View in: PubMed
  12. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6. PMID: 25206015.
    View in: PubMed
  13. Swaminathan SS, Oh DJ, Kang MH, Ren R, Jin R, Gong H, Rhee DJ. Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow. Invest Ophthalmol Vis Sci. 2013 Mar; 54(3):2035-47. PMID: 23422826.
    View in: PubMed
  14. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308.
    View in: PubMed
  15. Zhu JY, Ye W, Wang T, Gong HY. Reversible changes in aqueous outflow facility, hydrodynamics, and morphology following acute intraocular pressure variation in bovine eyes. Chin Med J (Engl). 2013; 126(8):1451-7. PMID: 23595376.
    View in: PubMed
  16. Freddo TF, Neville N, Gong H. Pilocarpine-induced flare is physiological rather than pathological. Exp Eye Res. 2013 Feb; 107:37-43. PMID: 23187102.
    View in: PubMed
  17. Haddadin RI, Oh DJ, Kang MH, Villarreal G, Kang JH, Jin R, Gong H, Rhee DJ. Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci. 2012; 53(10):6708-17. PMID: 22930728.
    View in: PubMed
  18. Diskin S, Chen WS, Cao Z, Gyawali S, Gong H, Soza A, González A, Panjwani N. Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling. PLoS One. 2012; 7(9):e44400. PMID: 22973445.
    View in: PubMed
  19. Francis AW, Gyasi ME, Deng L, Gong H. Comparison of moderate and advanced glaucoma patients in Ghana. Clin Ophthalmol. 2012; 6:297-304. PMID: 22393281.
    View in: PubMed
  20. Lu Z, Zhang Y, Freddo TF, Gong H. Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. Exp Eye Res. 2011 Oct; 93(4):397-404. PMID: 21669200.
    View in: PubMed
  21. Kagemann L, Wollstein G, Ishikawa H, Sigal IA, Folio LS, Xu J, Gong H, Schuman JS. 3D visualization of aqueous humor outflow structures in-situ in humans. Exp Eye Res. 2011 Sep; 93(3):308-15. PMID: 21514296.
    View in: PubMed
  22. Freddo TF, Gong H and Civan M. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2011.
  23. Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82. PMID: 20870723.
    View in: PubMed
  24. Zhu JY, Ye W, Gong HY. Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes. Chin Med J (Engl). 2010 Mar 5; 123(5):599-605. PMID: 20367989.
    View in: PubMed
  25. Scott PA, Lu Z, Liu Y, Gong H. Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways. Exp Eye Res. 2009 Dec; 89(6):942-9. PMID: 19679123.
    View in: PubMed
  26. Zhang Y, Toris CB, Liu Y, Ye W, Gong H. Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma. Exp Eye Res. 2009 Nov; 89(5):748-56. PMID: 19591828.
    View in: PubMed
  27. Freddo TF, Gong H. ETIOLOGY OF IOP ELEVATION IN PRIMARY OPEN ANGLE GLAUCOMA. Optom Glaucoma Soc E J. 2009 Jul; 4(1). PMID: 22957318.
    View in: PubMed
  28. Gong H, Freddo TF. The washout phenomenon in aqueous outflow--why does it matter? Exp Eye Res. 2009 Apr; 88(4):729-37. PMID: 19385044.
    View in: PubMed
  29. Sieminski AL, Semino CE, Gong H, Kamm RD. Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. J Biomed Mater Res A. 2008 Nov; 87(2):494-504. PMID: 18186067.
    View in: PubMed
  30. Battista SA, Lu Z, Hofmann S, Freddo T, Overby DR, Gong H. Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5346-52. PMID: 18515571.
    View in: PubMed
  31. Freddo TF, Civan M and Gong H. Principles and Practice of Ophthalmology. Aqueous humor and the dynamics of its flow: mechanisms and routes of aqueous humor drainage. Saunders. 2008.
  32. Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 2008 Feb; 86(2):271-81. PMID: 18155193.
    View in: PubMed
  33. Dimicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes. Osteoarthritis Cartilage. 2007 Oct; 15(10):1207-16. PMID: 17524677.
    View in: PubMed
  34. Sieminski AL, Was AS, Kim G, Gong H, Kamm RD. The stiffness of three-dimensional ionic self-assembling peptide gels affects the extent of capillary-like network formation. Cell Biochem Biophys. 2007; 49(2):73-83. PMID: 17906362.
    View in: PubMed
  35. Scott PA, Overby DR, Freddo TF, Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res. 2007 Mar; 84(3):435-43. PMID: 17173894.
    View in: PubMed
  36. Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10889-94. PMID: 16832052.
    View in: PubMed
  37. Song QH, Gong H, Trinkaus-Randall V. Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4. Cell Tissue Res. 2003 May; 312(2):203-20. PMID: 12715147.
    View in: PubMed
  38. Overby D, Gong H, Qiu G, Freddo TF, Johnson M. The mechanism of increasing outflow facility during washout in the bovine eye. Invest Ophthalmol Vis Sci. 2002 Nov; 43(11):3455-64. PMID: 12407156.
    View in: PubMed
  39. Gong H, Ruberti J, Overby D, Johnson M, Freddo TF. A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy. Exp Eye Res. 2002 Sep; 75(3):347-58. PMID: 12384097.
    View in: PubMed
  40. Vauthey S, Santoso S, Gong H, Watson N, Zhang S. Molecular self-assembly of surfactant-like peptides to form nanotubes and nanovesicles. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5355-60. PMID: 11929973.
    View in: PubMed
  41. Sonsino J, Gong H, Wu P, Freddo TF. Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actin. Exp Eye Res. 2002 Jan; 74(1):123-9. PMID: 11878825.
    View in: PubMed
  42. Freddo TF and Gong H. Duane’s Clinical Ophthalmology. Anatomy of the Ciliary Body and Outflow Pathways. Lippincott, Williams & Wilkins. Philadelphia. 2002.
  43. Overby D, Ruberti J, Gong H, Freddo TF, Johnson M. Specific hydraulic conductivity of corneal stroma as seen by quick-freeze/deep-etch. J Biomech Eng. 2001 Apr; 123(2):154-61. PMID: 11340876.
    View in: PubMed
  44. Wu P, Gong H, Richman R, Freddo TF. Localization of occludin, ZO-1, and pan-cadherin in rabbit ciliary epithelium and iris vascular endothelium. Histochem Cell Biol. 2000 Oct; 114(4):303-10. PMID: 11131095.
    View in: PubMed
  45. Payne J, Gong H, Trinkaus-Randall V. Tyrosine phosphorylation: a critical component in the formation of hemidesmosomes. Cell Tissue Res. 2000 Jun; 300(3):401-11. PMID: 10928271.
    View in: PubMed
  46. Al-Aswad LA, Gong H, Lee D, O'Donnell ME, Brandt JD, Ryan WJ, Schroeder A, Erickson KA. Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1695-701. PMID: 10393038.
    View in: PubMed
  47. Svoboda KKH, Gong H, Rrinkaus-Randall V. Collagen expression and orientation in ocular tissue. Prog Polym Sci. 1998; 23:329-374.
  48. Gong H, Johnson M, Ye W, Kamm RD, Freddo TF. The non-uniform distribution of albumin in human and bovine cornea. Exp Eye Res. 1997 Dec; 65(6):747-56. PMID: 9441698.
    View in: PubMed
  49. Ye W, Gong H, Sit A, Johnson M, Freddo TF. Interendothelial junctions in normal human Schlemm's canal respond to changes in pressure. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2460-8. PMID: 9375563.
    View in: PubMed
  50. Hubbard WC, Johnson M, Gong H, Gabelt BT, Peterson JA, Sawhney R, Freddo T, Kaufman PL. Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys. Exp Eye Res. 1997 Aug; 65(2):177-90. PMID: 9268586.
    View in: PubMed
  51. Sit AJ, Gong H, Ritter N, Freddo TF, Kamm R, Johnson M. The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye. Exp Eye Res. 1997 May; 64(5):813-21. PMID: 9245912.
    View in: PubMed
  52. Gong H, Ye W, Freddo TF, Hernandez MR. Hyaluronic acid in the normal and glaucomatous optic nerve. Exp Eye Res. 1997 Apr; 64(4):587-95. PMID: 9227277.
    View in: PubMed
  53. Gong H, Tripathi RC, Tripathi BJ. Morphology of the aqueous outflow pathway. Microsc Res Tech. 1996 Mar 1; 33(4):336-67. PMID: 8652890.
    View in: PubMed
  54. Hernandez MR and Gong H. The Glaucomas. Extracellular matrix of the trabecular meshwork and optic nerve head. Mosby. 1996.
  55. Bhatt K, Gong H, Freddo TF. Freeze-fracture studies of interendothelial junctions in the angle of the human eye. Invest Ophthalmol Vis Sci. 1995 Jun; 36(7):1379-89. PMID: 7775116.
    View in: PubMed
  56. Gong H, Underhill CB, Freddo TF. Hyaluronan in the bovine ocular anterior segment, with emphasis on the outflow pathways. Invest Ophthalmol Vis Sci. 1994 Dec; 35(13):4328-32. PMID: 7528182.
    View in: PubMed
  57. Johnson M, Gong H, Freddo TF, Ritter N, Kamm R. Serum proteins and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3549-57. PMID: 8258512.
    View in: PubMed
  58. Gong H, Freddo TF, Johnson M. Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork. Exp Eye Res. 1992 Nov; 55(5):691-709. PMID: 1478279.
    View in: PubMed
  59. Gong HY, Trinkaus-Randall V, Freddo TF. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr Eye Res. 1989 Oct; 8(10):1071-82. PMID: 2612196.
    View in: PubMed
  60. Jabbour NM, McCormick SA, Gong HY. Transscleral and transconjunctival diathermy. Retina. 1989; 9(2):127-30. PMID: 2772420.
    View in: PubMed
  61. Gong HY. [Serous detachment of the retinal pigment epithelium. Long-term follow-up studies]. Zhonghua Yan Ke Za Zhi. 1986 Nov; 22(6):339-42. PMID: 3100250.
    View in: PubMed
  62. Zhang CF. [Acute multiple ischemic choroidopathy]. Zhonghua Yan Ke Za Zhi. 1985 Nov; 21(6):331-4. PMID: 3939203.
    View in: PubMed
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