Andrew A. Wilson, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, University of Texas Southwestern Medical School



My laboratory research to date has focused on the design, cloning, production, and use of lentiviruses in vitro and in vivo to overexpress or knock down gene expression, particularly in alveolar macrophages and stem cell populations, and using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB.

A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium.

Research interests include:
-Alpha-1 antitrypsin deficiency
-gene therapy
-alveolar macrophage biology
-embryonic stem cells

Clinical interests include:
-Critical Care Medicine
-Tuberculosis

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Boston Medical Center
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section



A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2017 (Co-PI)
PI: Darrell Nelson Kotton, MD
NIH/National Center for Advancing Translational Sciences
1U01TR001810-01

CRISPR-DIRECTED Editing Of Patient-iPSCs To Determine Genetic Contributors
07/01/2016 - 06/30/2017 (PI)
Alpha 1 Foundation

Medical University of South Carolina
07/01/2016 - 06/30/2017 (PI)
Medical University of South Carolina Alpha 1 Foundation

Personalized therapy for AATD-associated liver disease via IPS modeling
07/01/2015 - 06/30/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK101501-02

Open Source CRISPR Gene Correction of PiZZ iPSCs
07/01/2015 - 06/30/2017 (PI)
Alpha 1 Foundation

Elucidation of Thyroid Hormone Signaling Mechanisms in Human Tissue
10/01/2016 - 03/31/2017 (PI)
Boston Medical Center Corporation NIH NIDDK
4P30DK046200-24

Effect of gene knockdown on susceptibility to drug toxicity
02/04/2016 - 02/03/2017 (PI)
Alnylam Pharmaceuticals, Inc.

Alpha-1 Clinical Resource Center (CRC) Research Registry
02/01/2016 - 06/30/2016 (PI)
Medical University of South Carolina Alpha 1 Foundation

Emphysema Attenuation Via Modulation of Macrophage NFKB and Antiprotease Activity
09/01/2010 - 09/30/2015 (PI)
NIH/National Heart, Lung, and Blood Institute
5K08HL103771-05

A next-generation in vitro AATD clinical trial
07/01/2014 - 06/30/2015 (PI)
Alpha 1 Foundation

Showing 10 of 13 results. Show All Results

ALPHA-1 Antitrypsin Deficiency Adult Clinical
01/01/2015 - 08/31/2017 (PI)
Alpha-1 Foundation

Alpha-1 Antitrypsin Deficiency Adult Clinical and Genetic Linkage Study
01/01/2015 - 08/31/2017 (PI)
St. Louis University Alpha-1 Foundation


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Payne JG, Takahashi A, Higgins MI, Porter EL, Suki B, Balazs A, Wilson AA. Multilineage transduction of resident lung cells in vivo by AAV2/8 for a1-antitrypsin gene therapy. Mol Ther Methods Clin Dev. 2016; 3:16042. PMID: 27408904; DOI: 10.1038/mtm.2016.42;.
  2. Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ. Induced pluripotent stem cells model personalized variations in liver disease resulting from a1-antitrypsin deficiency. Hepatology. 2015 Jul; 62(1):147-57.View Related Profiles. PMID: 25690322; PMCID: PMC4482790; DOI: 10.1002/hep.27753;.
  3. Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles. PMID: 25843048; PMCID: PMC4437473; DOI: 10.1016/j.stemcr.2015.02.021;.
  4. Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP. Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):253-62.View Related Profiles. PMID: 24010952; PMCID: PMC3930948; DOI: 10.1165/rcmb.2013-0114OC;.
  5. Repasy T, Lee J, Marino S, Martinez N, Kirschner DE, Hendricks G, Baker S, Wilson AA, Kotton DN, Kornfeld H. Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo. PLoS Pathog. 2013 Feb; 9(2):e1003190.View Related Profiles. PMID: 23436998; PMCID: PMC3578792; DOI: 10.1371/journal.ppat.1003190;.
  6. Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN. Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther. 2013 Apr; 21(4):825-33.View Related Profiles. PMID: 23403494; PMCID: PMC3616534; DOI: 10.1038/mt.2013.19;.
  7. Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012 Aug; 11(4):617-27.View Related Profiles. PMID: 22510478; PMCID: PMC3433748; DOI: 10.1111/j.1474-9726.2012.00827.x;.
  8. Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest. 2010 Jan; 120(1):379-89.View Related Profiles. PMID: 20038801; PMCID: PMC2798672; DOI: 10.1172/JCI36666;.
  9. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):133-41.View Related Profiles. PMID: 18323534; PMCID: PMC2542452; DOI: 10.1165/rcmb.2007-0133OC;.
  10. Wilson AA, Kotton DN. Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates. Bioessays. 2008 Feb; 30(2):107-9.View Related Profiles. PMID: 18200564; DOI: 10.1002/bies.20710;.
Showing 10 of 12 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2008

YearPublications
19931
20083
20091
20121
20132
20141
20152
20161
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

alpha-1 antitrypsin
gene therapy
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72 E. Concord St Housman (R)
Boston MA 02118
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