Anthony Hollenberg | Profiles RNS

Anthony Hollenberg, MD

John Wade Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

MD, University of Calgary
AB, Harvard College

Websites

	MED and BMC Fill Critical Roles with Cornell’s Anthony Hollenberg
	Twitter

ORCID : 0000-0001-5760-1868

The focus of my research program is the thyroid with a focus on the role of gland development and the actions of its hormones. To accomplish these goals we have built a unique program in thyroid gland development from endoderm in order to derive new therapies for hypothyroidism. Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. Furthermore, we have used our understanding of thyroid hormone signaling to identify new biomarkers of its action.

My laboratory has a long-standing interest in how thyroid hormone mediates its effects in context of genomic regulation. Specifically we were amongst the first to begin to differentiate how thyroid hormone is able to stimulate both positive and negative gene regulation. Studies in this area allowed us to be able to characterize the interaction of the thyroid hormone receptor with its cofactors which are necessary for genomic regulation.

We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. This has important ramifications for thyroid/steroid action in general. Furthermore these studies have allowed us to better understand the specificity of coregulator interactions with the thyroid hormone receptor and their role in disease.

In addition to our work on thyroid hormone action we have also had a long standing interest in the intersection of the regulation of biomarkers of thyroid hormone action including the regulation of the hypothalamic pituitary thyroid axis by thyroid hormone and other metabolic pathways. Our work has demonstrated that these pathways and others are linked at the molecular and physiological level. Furthermore, they must be considered when trying to understand the effects of thyroid hormone signaling.

Most recently, because of our interest in defining the etiology of the set point of the HPT axis, we became interested in creating a durable thyroid follicular cell model. To accomplish this we began a complete collaboration with the Kotton laboratory at Boston University and have successfully developed the molecular paradigm to develop thyroid follicular cells from ESCs or IPSCs across multiple species. Additionally we have established that these derived cells function in vivo.

Chair
Boston University Chobanian & Avedisian School of Medicine
Medicine

Physician-in-Chief
Boston Medical Center

BU Research
NIH RePORTER Research

Kidney Diseases Hypothalamic Regulation by Thyroid Hormone
04/01/2024 - 05/31/2027 (Subcontract PI)
University of Arizona NIH NIDDK
7R01DK136661-02

Thyroid Follicular Cell Signaling and Development in Humans
05/01/2023 - 04/30/2025 (Multi-PI)
PI: Anthony Hollenberg, MD
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK105029-09

Thyroid Hormone Signaling in Human Hepatocytes
06/30/2023 - 01/31/2025 (Multi-PI)
PI: Anthony Hollenberg, MD
NIH/National Diabetes & Digestive & Kidney Diseases
7R01DK117940-05

Corepressor regulation of nuclear receptor action
01/01/2023 - 12/31/2024 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7R01DK056123-22

Master Faculty and Staff Support Contract-VA Center for Healthcare Organization and Implementation Research
04/14/2022 - 05/29/2024 (PI)
Department of Veterans Affairs

Title

Yr	Title	Project-Sub Proj
2024	Hypothalamic regulation by thyroid hormone receptor phosphorylation	5R01DK136661-03
2024	Thyroid Follicular Cell Signaling and Development in Humans	5R01DK105029-09
2023	Hypothalamic regulation by thyroid hormone receptor phosphorylation	7R01DK136661-02
2023	Hypothalamic regulation by thyroid hormone receptor phosphorylation	1R01DK136661-01
2023	Thyroid Follicular Cell Signaling and Development in Humans	7R01DK105029-08
2023	Corepressor regulation of nuclear receptor action	7R01DK056123-22
2022	Thyroid Hormone Signaling in Human Hepatocytes	7R01DK117940-05
2022	Thyroid Hormone Signaling in Human Hepatocytes	5R01DK117940-04
2022	Thyroid Follicular Cell Signaling and Development in Humans	5R01DK105029-07
2022	Corepressor regulation of nuclear receptor action	5R01DK056123-21

Showing 10 of 59 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Soares De Oliveira L, Kaserman JE, Van Der Spek AH, Lee NJ, Undeutsch HJ, Werder RB, Wilson AA, Hollenberg AN. Thyroid hormone receptor beta (THRß1) is the major regulator of T3 action in human iPSC-derived hepatocytes. Mol Metab. 2024 Oct 29; 102057.View Related Profiles.

Wilson, Andrew
Hollenberg, Anthony
Undeutsch, Hendrik Julian
Kaserman, Joseph
Soares De Oliveira, Lorraine
Werder, Rhiannon Bree

PMID: 39481850

Hu Y, Soares De Oliveira L, Falize K, Paul van Trotsenburg AS, Fliers E, Kaserman JE, Wilson AA, Hollenberg AN, Bruinstroop E, Boelen A. Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. Eur Thyroid J. 2024 Oct 01; 13(5).View Related Profiles.

Wilson, Andrew
Hollenberg, Anthony
Kaserman, Joseph
Soares De Oliveira, Lorraine

PMID: 39316725

Ritter MJ, Amano I, van der Spek AH, Gower AC, Undeutsch HJ, Rodrigues VAP, Daniel HE, Hollenberg AN. Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport. Endocrinology. 2024 Jul 26; 165(9).View Related Profiles.

Gower, Adam
Hollenberg, Anthony
Undeutsch, Hendrik Julian

PMID: 39106294; PMCID: PMC11337007; DOI: 10.1210/endocr/bqae100;

Maddox SA, Ponomareva OY, Zaleski CE, Chen MX, Vella KR, Hollenberg AN, Klengel C, Ressler KJ. Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity. Mol Psychiatry. 2024 Jul 22. PMID: 39039155

Cho YW, Fu Y, Huang CJ, Wu X, Ng L, Kelley KA, Vella KR, Berg AH, Hollenberg AN, Liu H, Forrest D. Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland. Commun Biol. 2023 Dec 11; 6(1):1253. PMID: 38081939; PMCID: PMC10713718; DOI: 10.1038/s42003-023-05546-y;

Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA, Korach KS, Cain DW, Hollenberg AN, Webb P, Forrest D, Jetten AM, Edwards DP, Grimm SL, Hartig S, Lange CA, Richer JK, Sartorius CA, Tetel M, Billon C, Elgendy B, Hegazy L, Griffett K, Peinetti N, Burnstein KL, Hughes TS, Sitaula S, Stayrook KR, Culver A, Murray MH, Finck BN, Cidlowski JA. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. Pharmacol Rev. 2023 Nov; 75(6):1233-1318. PMID: 37586884; PMCID: PMC10595025; DOI: 10.1124/pharmrev.121.000436;

Hu Y, Bruinstroop E, Hollenberg AN, Fliers E, Boelen A. The role of WD40 repeat-containing proteins in endocrine (dys)function. J Mol Endocrinol. 2023 Jul 01; 71(1). PMID: 37256579

Costa-E-Sousa RH, Rorato R, Hollenberg AN, Vella KR. Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. Thyroid. 2023 Jul; 33(7):867-876.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 37166378; PMCID: PMC10354708; DOI: 10.1089/thy.2023.0173;

Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775.View Related Profiles.

Wilson, Andrew
Hollenberg, Anthony
Kotton, Darrell
Bullitt, Esther
Kaserman, Joseph
Werder, Rhiannon Bree
Matte, Taylor

PMID: 36476855; PMCID: PMC9780780; DOI: 10.1016/j.celrep.2022.111775;

Shimizu H, Horibata Y, Amano I, Ritter MJ, Domae M, Ando H, Sugimoto H, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT acts as a strong regulator of both ß-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. PLoS One. 2022; 17(12):e0277830.View Related Profiles.

Hollenberg, Anthony
Ritter, Megan

PMID: 36454860; PMCID: PMC9714868; DOI: 10.1371/journal.pone.0277830;

Showing 10 of 135 results. Show More

Bredella MA, McGroarty KM, Kolessin L, Bard LF, Hollenberg AN, Rutkove SB. Impact of the KL2/Catalyst Medical Research Investigator Training (CMeRIT) Program on the careers of early-stage clinical and translational investigators. J Clin Transl Sci. 2022; 6(1):e16. PMID: 35291214; PMCID: PMC8889229; DOI: 10.1017/cts.2022.7;

Mendoza A, Tang C, Choi J, Acuña M, Logan M, Martin AG, Al-Sowaimel L, Desai BN, Tenen DE, Jacobs C, Lyubetskaya A, Fu Y, Liu H, Tsai L, Cohen DE, Forrest D, Wilson AA, Hollenberg AN. Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. Sci Signal. 2021 11 16; 14(709):eabh3839.View Related Profiles.

Wilson, Andrew
Hollenberg, Anthony
Mendoza Cisneros, Arturo

PMID: 34784250; PMCID: PMC8853622; DOI: 10.1126/scisignal.abh3839;

Vella KR, Hollenberg AN. Early Life Stress Affects the HPT Axis Response in a Sexually Dimorphic Manner. Endocrinology. 2021 09 01; 162(9). PMID: 34214171; PMCID: PMC8315292; DOI: 10.1210/endocr/bqab137;

Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg AN. Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Mol Metab. 2021 11; 53:101315.View Related Profiles.

Hollenberg, Anthony
Soares De Oliveira, Lorraine
Ritter, Megan

PMID: 34390859; PMCID: PMC8429965; DOI: 10.1016/j.molmet.2021.101315;

Posabella A, Alber AB, Undeutsch HJ, Droeser RA, Hollenberg AN, Ikonomou L, Kotton DN. Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Front Endocrinol (Lausanne). 2021; 12:666565.View Related Profiles.

Posabella, Alberto
Alber, Andrea
Hollenberg, Anthony
Kotton, Darrell
Undeutsch, Hendrik Julian

PMID: 33959101; PMCID: PMC8095374; DOI: 10.3389/fendo.2021.666565;

Finn PW, Abel D, Amin A, Anderson ME, Carethers JM, Coleman DL, Curtis AB, Geraci MW, Gladwin MT, Hollenberg A, Parmacek MS, Robbins RJ. Voices for Social Justice and Against Racism: An AAIM Perspective. Am J Med. 2021 07; 134(7):930-934.View Related Profiles.

Hollenberg, Anthony
Coleman, David

PMID: 33848502

Major-Pedersen A, McCullen MK, Sabol ME, Adetunji O, Massaro J, Neugut AI, Sosa JA, Hollenberg AN. A joint industry-sponsored data monitoring committee model for observational, retrospective drug safety studies in the real-world setting. Pharmacoepidemiol Drug Saf. 2021 01; 30(1):9-16.View Related Profiles.

Hollenberg, Anthony
Massaro, Joseph

PMID: 33179845; PMCID: PMC8247341; DOI: 10.1002/pds.5172;

Kahn JH, Goddi A, Sharma A, Heiman J, Carmona A, Li Y, Hoffman A, Schoenfelt K, Ye H, Bobe AM, Becker L, Hollenberg AN, Cohen RN. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10). PMID: 32770234; PMCID: PMC7478322; DOI: 10.1210/endocr/bqaa132;

Gulick RM, Sobieszczyk ME, Landry DW, Hollenberg AN. Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City. J Clin Invest. 2020 09 01; 130(9):4522-4524. PMID: 32692726; PMCID: PMC7456231; DOI: 10.1172/JCI142151;

Ritter MJ, Amano I, Hollenberg AN. Thyroid Hormone Signaling and the Liver. Hepatology. 2020 08; 72(2):742-752.View Related Profiles.

Hollenberg, Anthony
Ritter, Megan

PMID: 32343421; DOI: 10.1002/hep.31296;

Præstholm SM, Siersbæk MS, Nielsen R, Zhu X, Hollenberg AN, Cheng SY, Grøntved L. Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone. PLoS Genet. 2020 05; 16(5):e1008770. PMID: 32453730; PMCID: PMC7274477; DOI: 10.1371/journal.pgen.1008770;

Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717.View Related Profiles.

Hollenberg, Anthony
Ritter, Megan

PMID: 31404087; PMCID: PMC6690520; DOI: 10.1371/journal.pone.0220717;

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW. Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment. Thyroid. 2019 06; 29(6):760-777. PMID: 31081722; PMCID: PMC6913785; DOI: 10.1089/thy.2018.0416;

Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW. Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment. Circulation. 2019 Jun 18; 139(25):2892-2909. PMID: 31081673; PMCID: PMC6851449; DOI: 10.1161/CIRCULATIONAHA.118.036859;

Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARa. Nat Commun. 2019 04 11; 10(1):1684.View Related Profiles.

Hollenberg, Anthony
Mendoza Cisneros, Arturo

PMID: 30975991; PMCID: PMC6459876; DOI: 10.1038/s41467-019-09524-z;

Freudenthal B, Shetty S, Butterfield NC, Logan JG, Han CR, Zhu X, Astapova I, Hollenberg AN, Cheng SY, Bassett JHD, Williams GR. Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha. Thyroid. 2019 05; 29(5):726-734. PMID: 30760120; PMCID: PMC6533791; DOI: 10.1089/thy.2018.0399;

Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM. Thyroid hormone receptor and ERRa coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Sci Signal. 2018 06 26; 11(536).View Related Profiles.

Hollenberg, Anthony
Mendoza Cisneros, Arturo

PMID: 29945885; DOI: 10.1126/scisignal.aam5855;

Hine C, Zhu Y, Hollenberg AN, Mitchell JR. Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity. Antioxid Redox Signal. 2018 06 01; 28(16):1483-1502. PMID: 29634343; PMCID: PMC5930795; DOI: 10.1089/ars.2017.7434;

Aguayo-Mazzucato C, Lee TB, Matzko M, DiIenno A, Rezanejad H, Ramadoss P, Scanlan T, Zavacki AM, Larsen PR, Hollenberg A, Colton C, Sharma A, Bonner-Weir S. T3 Induces Both Markers of Maturation and Aging in Pancreatic ß-Cells. Diabetes. 2018 07; 67(7):1322-1331. PMID: 29625991; PMCID: PMC6014556; DOI: 10.2337/db18-0030;

Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB. Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. J Biol Chem. 2018 02 09; 293(6):2006-2014. PMID: 29222328; PMCID: PMC5808762; DOI: 10.1074/jbc.M117.782557;

Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec; 174 Suppl 1:S1-S16. PMID: 29055037; PMCID: PMC5650665; DOI: 10.1111/bph.13882;

Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893.View Related Profiles.

Jacob, Anjali
Hollenberg, Anthony
Kotton, Darrell
Hawkins, Finn
Alysandratos, Kostas
Ikonomou, Laertis

PMID: 28947536; PMCID: PMC5702071; DOI: 10.1242/dev.150193;

Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8458-E8467.View Related Profiles.

Hollenberg, Anthony
Mendoza Cisneros, Arturo

PMID: 28923959; PMCID: PMC5635887; DOI: 10.1073/pnas.1706917114;

Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S. Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. Endocrinology. 2017 07 01; 158(7):2052-2057. PMID: 28472304; PMCID: PMC6283428; DOI: 10.1210/en.2017-00250;

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. PMID: 28591635; PMCID: PMC5722247; DOI: 10.1016/j.cmet.2017.05.003;

Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294.View Related Profiles.

Khalil, Ahmad
Jacob, Anjali
Hollenberg, Anthony
Kotton, Darrell
Hawkins, Finn
Rock, Jason

PMID: 28463226; PMCID: PMC5451263; DOI: 10.1172/JCI89950;

Vella KR, Hollenberg AN. The actions of thyroid hormone signaling in the nucleus. Mol Cell Endocrinol. 2017 Dec 15; 458:127-135. PMID: 28286327; PMCID: PMC5592130; DOI: 10.1016/j.mce.2017.03.001;

Mendoza A, Hollenberg AN. New insights into thyroid hormone action. Pharmacol Ther. 2017 May; 173:135-145.View Related Profiles.

Hollenberg, Anthony
Mendoza Cisneros, Arturo

PMID: 28174093; PMCID: PMC5407910; DOI: 10.1016/j.pharmthera.2017.02.012;

Dame K, Cincotta S, Lang AH, Sanghrajka RM, Zhang L, Choi J, Kwok L, Wilson T, Kandula MM, Monti S, Hollenberg AN, Mehta P, Kotton DN, Ikonomou L. Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. Stem Cell Reports. 2017 Feb 14; 8(2):216-225.View Related Profiles.

Hollenberg, Anthony
Kotton, Darrell
Dame, Keri
Ikonomou, Laertis
Zhang, Liye
Monti, Stefano

PMID: 28162994; PMCID: PMC5312259; DOI: 10.1016/j.stemcr.2016.12.024;

Hollenberg AN, Choi J, Serra M, Kotton DN. Regenerative therapy for hypothyroidism: Mechanisms and possibilities. Mol Cell Endocrinol. 2017 Apr 15; 445:35-41.View Related Profiles.

Hollenberg, Anthony
Kotton, Darrell

PMID: 27876515; PMCID: PMC5373653; DOI: 10.1016/j.mce.2016.11.012;

Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017 Jan 02; 13(1):169-186. PMID: 27846372; PMCID: PMC5240836; DOI: 10.1080/15548627.2016.1235123;

Kyono Y, Subramani A, Ramadoss P, Hollenberg AN, Bonett RM, Denver RJ. Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells. Endocrinology. 2016 09; 157(9):3647-57. PMID: 27387481; PMCID: PMC5007891; DOI: 10.1210/en.2015-1529;

Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen RN, Hollenberg AN, Abramson J. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016 Apr 19; 15(3):651-665. PMID: 27068467; PMCID: PMC5849426; DOI: 10.1016/j.celrep.2016.03.048;

Hollenberg AN. The Endocrine Society Centennial: The Thyroid Leads the Way. Endocrinology. 2016 Jan; 157(1):1-3. PMID: 26717469; PMCID: PMC4701885; DOI: 10.1210/en.2015-1982;

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA. The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 2015 Dec; 172(24):5729-43. PMID: 26650438; PMCID: PMC4718217; DOI: 10.1111/bph.13347;

Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 5; 17(5):527-42.View Related Profiles.

Hollenberg, Anthony
Kotton, Darrell
Hawkins, Finn
Ikonomou, Laertis

PMID: 26593959; PMCID: PMC4666682; DOI: 10.1016/j.stem.2015.09.004;

Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 01; 291(1):198-214. PMID: 26453307; PMCID: PMC4697156; DOI: 10.1074/jbc.M115.668673;

Castinetti F, Brinkmeier ML, Mortensen AH, Vella KR, Gergics P, Brue T, Hollenberg AN, Gan L, Camper SA. ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism. Mol Endocrinol. 2015 Oct; 29(10):1510-21. PMID: 26296153; PMCID: PMC4588728; DOI: 10.1210/me.2015-1192;

Ng L, Cordas E, Wu X, Vella KR, Hollenberg AN, Forrest D. Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor ß1. Endocrinology. 2015 Oct; 156(10):3853-65. PMID: 26241124; PMCID: PMC4588828; DOI: 10.1210/en.2015-1468;

Petryk A, Kanakatti Shankar R, Giri N, Hollenberg AN, Rutter MM, Nathan B, Lodish M, Alter BP, Stratakis CA, Rose SR. Endocrine disorders in Fanconi anemia: recommendations for screening and treatment. J Clin Endocrinol Metab. 2015 Mar; 100(3):803-11. PMID: 25575015; PMCID: PMC4333044; DOI: 10.1210/jc.2014-4357;

Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. PMID: 25421714; PMCID: PMC4285426; DOI: 10.1128/MCB.01208-14;

Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24713658; PMCID: PMC4001554; DOI: 10.1172/JCI73419;

Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology. 2014 May; 155(5):2031-40. PMID: 24564398; PMCID: PMC3990851; DOI: 10.1210/en.2013-1902;

Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24550004; PMCID: PMC3993596; DOI: 10.1128/MCB.00129-14;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Horm Behav. 2014 Feb; 65(2):190-3. PMID: 24289987; DOI: 10.1016/j.yhbeh.2013.09.001;

Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN. Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24288132; PMCID: PMC3894317; DOI: 10.1074/jbc.M113.521450;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Front Neuroendocrinol. 2014 Jan; 35(1):2-5. PMID: 24268499; DOI: 10.1016/j.yfrne.2013.09.003;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Andrology. 2013 Nov; 1(6):802-5. PMID: 24166945; DOI: 10.1111/j.2047-2927.2013.00151.x;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Eur J Endocrinol. 2013 Dec; 169(6):E1-4. PMID: 24057478; DOI: 10.1530/EJE-13-0763;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Horm Res Paediatr. 2013; 80(5):305-8. PMID: 24107550; DOI: 10.1159/000355668;

Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology. 2013 Nov; 154(11):3957-60. PMID: 24048095; PMCID: PMC5398595; DOI: 10.1210/en.2013-1854;

Fozzatti L, Kim DW, Park JW, Willingham MC, Hollenberg AN, Cheng SY. Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor a. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7850-5. PMID: 23610395; PMCID: PMC3651436; DOI: 10.1073/pnas.1222334110;

Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN. Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus. Mol Cell Endocrinol. 2013 Jan 05; 365(1):84-94. PMID: 23000398; PMCID: PMC3572472; DOI: 10.1016/j.mce.2012.09.006;

Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 22878400; PMCID: PMC3512014; DOI: 10.1210/en.2012-1504;

Astapova I, Hollenberg AN. The in vivo role of nuclear receptor corepressors in thyroid hormone action. Biochim Biophys Acta. 2013 Jul; 1830(7):3876-81. PMID: 22801336; PMCID: PMC3529203; DOI: 10.1016/j.bbagen.2012.07.001;

Costa-e-Sousa RH, Hollenberg AN. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012 Sep; 153(9):4128-35.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 22759379; PMCID: PMC3423621; DOI: 10.1210/en.2012-1467;

Hollenberg AN. Metabolic health and nuclear-receptor sensitivity. N Engl J Med. 2012 Apr 05; 366(14):1345-7. PMID: 22475600; DOI: 10.1056/NEJMcibr1114529;

Li J, Paulson JM, Ye FD, Sung M, Hollenberg AN, Rutkove SB. Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse. Amyotroph Lateral Scler. 2012 Jun; 13(4):372-7. PMID: 22424124; DOI: 10.3109/17482968.2012.662988;

Vella KR, Ramadoss P, Lam FS, Harris JC, Ye FD, Same PD, O'Neill NF, Maratos-Flier E, Hollenberg AN. NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab. 2011 Dec 07; 14(6):780-90. PMID: 22100407; PMCID: PMC3261758; DOI: 10.1016/j.cmet.2011.10.009;

Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY. Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1). Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17462-7. PMID: 21987803; PMCID: PMC3198316; DOI: 10.1073/pnas.1107474108;

Castinetti F, Brinkmeier ML, Gordon DF, Vella KR, Kerr JM, Mortensen AH, Hollenberg A, Brue T, Ridgway EC, Camper SA. PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism. Mol Endocrinol. 2011 Nov; 25(11):1950-60. PMID: 21964592

Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb; 25(2):212-24. PMID: 21239618; PMCID: PMC3386544; DOI: 10.1210/me.2010-0462;

Chiappini F, Cunha LL, Harris JC, Hollenberg AN. Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem. 2011 Mar 11; 286(10):8094-8105. PMID: 21209091; PMCID: PMC3048696; DOI: 10.1074/jbc.M110.178186;

Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol Endocrinol. 2010 Dec; 24(12):2366-81. PMID: 20943814; PMCID: PMC2999480; DOI: 10.1210/me.2010-0203;

Perello M, Cakir I, Cyr NE, Romero A, Stuart RC, Chiappini F, Hollenberg AN, Nillni EA. Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E976-89. PMID: 20858755; PMCID: PMC3006258; DOI: 10.1152/ajpendo.00448.2010;

Ramadoss P, Chiappini F, Bilban M, Hollenberg AN. Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha. J Biol Chem. 2010 May 28; 285(22):16453-66. PMID: 20304921; PMCID: PMC2878015; DOI: 10.1074/jbc.M109.066936;

Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 07; 285(19):14078-82. PMID: 20236931; PMCID: PMC2863226; DOI: 10.1074/jbc.C110.107375;

Sugrue ML, Vella KR, Morales C, Lopez ME, Hollenberg AN. The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo. Endocrinology. 2010 Feb; 151(2):793-801.View Related Profiles.

Hollenberg, Anthony
Lopez, Marisol

PMID: 20032051; PMCID: PMC2817611; DOI: 10.1210/en.2009-0976;

Levine RJ, Vatten LJ, Horowitz GL, Qian C, Romundstad PR, Yu KF, Hollenberg AN, Hellevik AI, Asvold BO, Karumanchi SA. Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ. 2009 Nov 17; 339:b4336. PMID: 19920004; PMCID: PMC2778749; DOI: 10.1136/bmj.b4336;

Vella KR, Hollenberg AN. The ups and downs of thyrotropin-releasing hormone. Endocrinology. 2009 May; 150(5):2021-3. PMID: 19383877; PMCID: PMC2671896; DOI: 10.1210/en.2009-0261;

Astapova I, Dordek MF, Hollenberg AN. The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):83-8. PMID: 19524130; DOI: 10.1016/j.mce.2009.02.028;

Ramadoss P, Unger-Smith NE, Lam FS, Hollenberg AN. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. Mol Endocrinol. 2009 Jun; 23(6):827-37. PMID: 19264844; PMCID: PMC5419286; DOI: 10.1210/me.2008-0264;

Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19544-9. PMID: 19052228; PMCID: PMC2614797; DOI: 10.1073/pnas.0804604105;

Hodgson MC, Shen HC, Hollenberg AN, Balk SP. Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor. Mol Cancer Ther. 2008 Oct; 7(10):3187-94. PMID: 18852122; PMCID: PMC2587007; DOI: 10.1158/1535-7163.MCT-08-0461;

Hollenberg AN, Forrest D. The thyroid and metabolism: the action continues. Cell Metab. 2008 Jul; 8(1):10-2. PMID: 18590688; DOI: 10.1016/j.cmet.2008.06.008;

Hollenberg AN. The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor. Thyroid. 2008 Feb; 18(2):131-9. PMID: 18279013; DOI: 10.1089/thy.2007.0251;

Hodgson MC, Astapova I, Hollenberg AN, Balk SP. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer Res. 2007 Sep 01; 67(17):8388-95. PMID: 17804755; DOI: 10.1158/0008-5472.CAN-07-0617;

Blumberg JM, Tzameli I, Astapova I, Lam FS, Flier JS, Hollenberg AN. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem. 2006 Apr 21; 281(16):11205-13. PMID: 16467308; DOI: 10.1074/jbc.M510343200;

Kishi T, Aschkenasi CJ, Choi BJ, Lopez ME, Lee CE, Liu H, Hollenberg AN, Friedman JM, Elmquist JK. Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol. 2005 Feb 14; 482(3):217-43.View Related Profiles.

Hollenberg, Anthony
Lopez, Marisol

PMID: 15690487; DOI: 10.1002/cne.20432;

Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN. The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists. J Biol Chem. 2005 Feb 25; 280(8):6511-9. PMID: 15598662; DOI: 10.1074/jbc.M408972200;

Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP. Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells. Mol Endocrinol. 2004 Oct; 18(10):2388-401. PMID: 15256534; DOI: 10.1210/me.2003-0436;

Tzameli I, Fang H, Ollero M, Shi H, Hamm JK, Kievit P, Hollenberg AN, Flier JS. Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem. 2004 Aug 20; 279(34):36093-102. PMID: 15190061; DOI: 10.1074/jbc.M405346200;

Bachman ES, Hampton TG, Dhillon H, Amende I, Wang J, Morgan JP, Hollenberg AN. The metabolic and cardiovascular effects of hyperthyroidism are largely independent of beta-adrenergic stimulation. Endocrinology. 2004 Jun; 145(6):2767-74. PMID: 15016719; DOI: 10.1210/en.2003-1670;

Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004 May; 145(5):2221-7. PMID: 14764630; DOI: 10.1210/en.2003-1312;

Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjørbaek C, Schalin-Jäntti C. Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. J Clin Endocrinol Metab. 2004 Feb; 89(2):940-5. PMID: 14764818; DOI: 10.1210/jc.2003-031182;

Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug; 59(2):180-9. PMID: 12864795

Monden T, Yamada M, Ishii S, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Mori M. Leucine at codon 428 in the ninth heptad of thyroid hormone receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of dimer formations. Thyroid. 2003 May; 13(5):427-35. PMID: 12855009; DOI: 10.1089/105072503322021089;

Yohrling GJ, Farrell LA, Hollenberg AN, Cha JH. Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation. Mol Cell Neurosci. 2003 May; 23(1):28-38. PMID: 12799135; DOI: 10.1016/s1044-7431(03)00032-0;

Münzberg H, Huo L, Nillni EA, Hollenberg AN, Bjørbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology. 2003 May; 144(5):2121-31. PMID: 12697721; DOI: 10.1210/en.2002-221037;

Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci. 2003 Apr 01; 23(7):2939-46. PMID: 12684481; PMCID: PMC6742071

Meng X, Yang YF, Cao X, Govindan MV, Shuen M, Hollenberg AN, Mymryk JS, Walfish PG. Cellular context of coregulator and adaptor proteins regulates human adenovirus 5 early region 1A-dependent gene activation by the thyroid hormone receptor. Mol Endocrinol. 2003 Jun; 17(6):1095-105. PMID: 12637585; DOI: 10.1210/me.2002-0294;

Makowski A, Brzostek S, Cohen RN, Hollenberg AN. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol. 2003 Feb; 17(2):273-86. PMID: 12554754; DOI: 10.1210/me.2002-0310;

Shibusawa N, Hollenberg AN, Wondisford FE. Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J Biol Chem. 2003 Jan 10; 278(2):732-8. PMID: 12419821; DOI: 10.1074/jbc.M207264200;

Cheng S, Brzostek S, Lee SR, Hollenberg AN, Balk SP. Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol Endocrinol. 2002 Jul; 16(7):1492-501. PMID: 12089345; DOI: 10.1210/mend.16.7.0870;

Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest. 2002 Jul; 110(1):43-52.View Related Profiles.

Hollenberg, Anthony
Lopez, Marisol

PMID: 12093887; PMCID: PMC151031; DOI: 10.1172/JCI15595;

Bjørbaek C, Hollenberg AN. Leptin and melanocortin signaling in the hypothalamus. Vitam Horm. 2002; 65:281-311. PMID: 12481551; DOI: 10.1016/s0083-6729(02)65068-x;

Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61. PMID: 11435607; DOI: 10.1210/mend.15.7.0669;

Li AW, Morash B, Hollenberg AN, Ur E, Wilkinson M, Murphy PR. Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells. Mol Cell Endocrinol. 2001 May 15; 176(1-2):57-65. PMID: 11369443; DOI: 10.1016/s0303-7207(01)00476-2;

Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest. 2001 Jan; 107(1):111-20. PMID: 11134186; PMCID: PMC198547; DOI: 10.1172/JCI10741;

Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS. Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem. 2000 Nov 17; 275(46):36124-33. PMID: 10967095

Hashimoto K, Zanger K, Hollenberg AN, Cohen LE, Radovick S, Wondisford FE. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J Biol Chem. 2000 Oct 27; 275(43):33365-72. PMID: 10931853; DOI: 10.1074/jbc.M006819200;

Cohen RN, Putney A, Wondisford FE, Hollenberg AN. The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol. 2000 Jun; 14(6):900-14. PMID: 10847591; DOI: 10.1210/mend.14.6.0474;

Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest. 2000 Apr; 105(7):859-61. PMID: 10749565; PMCID: PMC377492; DOI: 10.1172/JCI9725;

Oberste-Berghaus C, Zanger K, Hashimoto K, Cohen RN, Hollenberg AN, Wondisford FE. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. J Biol Chem. 2000 Jan 21; 275(3):1787-92. PMID: 10636876; DOI: 10.1074/jbc.275.3.1787;

Flier JS, Hollenberg AN. ADD-1 provides major new insight into the mechanism of insulin action. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14191-2. PMID: 10588675; PMCID: PMC33942; DOI: 10.1073/pnas.96.25.14191;

Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M. p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. Mol Endocrinol. 1999 Oct; 13(10):1695-703. PMID: 10517671; DOI: 10.1210/mend.13.10.0353;

Safer JD, Cohen RN, Hollenberg AN, Wondisford FE. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 9804773

Cohen RN, Wondisford FE, Hollenberg AN. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol. 1998 Oct; 12(10):1567-81. PMID: 9773980; DOI: 10.1210/mend.12.10.0188;

Monden T, Wondisford FE, Hollenberg AN. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. J Biol Chem. 1997 Nov 21; 272(47):29834-41. PMID: 9368056; DOI: 10.1074/jbc.272.47.29834;

Langlois MF, Zanger K, Monden T, Safer JD, Hollenberg AN, Wondisford FE. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation. J Biol Chem. 1997 Oct 3; 272(40):24927-33.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 9312095

Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J Biol Chem. 1997 Aug 08; 272(32):20230-5. PMID: 9242701

Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem. 1997 Feb 21; 272(8):5283-90. PMID: 9030601; DOI: 10.1074/jbc.272.8.5283;

Safer JD, Langlois MF, Cohen R, Monden T, John-Hope D, Madura J, Hollenberg AN, Wondisford FE. Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone. Mol Endocrinol. 1997 Jan; 11(1):16-26.View Related Profiles.

Hollenberg, Anthony
Safer, Joshua

PMID: 8994184

Hollenberg AN, Monden T, Madura JP, Lee K, Wondisford FE. Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain. J Biol Chem. 1996 Nov 08; 271(45):28516-20. PMID: 8910480; DOI: 10.1074/jbc.271.45.28516;

Medeiros-Neto G, Herodotou DT, Rajan S, Kommareddi S, de Lacerda L, Sandrini R, Boguszewski MC, Hollenberg AN, Radovick S, Wondisford FE. A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene. J Clin Invest. 1996 Mar 01; 97(5):1250-6. PMID: 8636437; PMCID: PMC507178; DOI: 10.1172/JCI118540;

Hollenberg AN, Monden T, Wondisford FE. Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini. J Biol Chem. 1995 Jun 16; 270(24):14274-80. PMID: 7782283; DOI: 10.1074/jbc.270.24.14274;

Hollenberg AN, Monden T, Flynn TR, Boers ME, Cohen O, Wondisford FE. The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements. Mol Endocrinol. 1995 May; 9(5):540-50. PMID: 7565802; DOI: 10.1210/mend.9.5.7565802;

Flynn TR, Hollenberg AN, Cohen O, Menke JB, Usala SJ, Tollin S, Hegarty MK, Wondisford FE. A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition. J Biol Chem. 1994 Dec 30; 269(52):32713-6. PMID: 7528740

Pestell RG, Hollenberg AN, Albanese C, Jameson JL. c-Jun represses transcription of the human chorionic gonadotropin alpha and beta genes through distinct types of CREs. J Biol Chem. 1994 Dec 09; 269(49):31090-6. PMID: 7983049

Hollenberg AN, Pestell RG, Albanese C, Boers ME, Jameson JL. Multiple promoter elements in the human chorionic gonadotropin beta subunit genes distinguish their expression from the luteinizing hormone beta gene. Mol Cell Endocrinol. 1994 Dec; 106(1-2):111-9. PMID: 7534731; DOI: 10.1016/0303-7207(94)90192-9;

Bauer-Dantoin AC, Hollenberg AN, Jameson JL. Dynamic regulation of gonadotropin-releasing hormone receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endocrinology. 1993 Oct; 133(4):1911-4. PMID: 8404635; DOI: 10.1210/endo.133.4.8404635;

Jameson JL, Hollenberg AN. Regulation of chorionic gonadotropin gene expression. Endocr Rev. 1993 Apr; 14(2):203-21. PMID: 8325253; DOI: 10.1210/edrv-14-2-203;

Jameson JL, Hollenberg AN. Recent advances in studies of the molecular basis of endocrine disease. Horm Metab Res. 1992 May; 24(5):201-9. PMID: 1398458; DOI: 10.1055/s-2007-1003294;

Hollenberg AN, Arnold A. Hypercalcemia with low-normal serum intact PTH: a novel presentation of primary hyperparathyroidism. Am J Med. 1991 Nov; 91(5):547-8. PMID: 1951417; DOI: 10.1016/0002-9343(91)90193-2;

Jameson L, Chin WW, Hollenberg AN, Chang AS, Habener JF. The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. J Biol Chem. 1984 Dec 25; 259(24):15474-80. PMID: 6096374

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 135 publications over 35 distinct years, with a maximum of 10 publications in 2017

Bar chart showing 135 publications over 35 distinct years, with a maximum of 10 publications in 2017

Year	Publications
1984	1
1991	1
1992	1
1993	2
1994	3
1995	2
1996	2
1997	5
1998	2
1999	2
2000	5
2001	3
2002	4
2003	7
2004	6
2005	1
2006	1
2007	1
2008	4
2009	5
2010	4
2011	5
2012	6
2013	8
2014	4
2015	6
2016	5
2017	10
2018	3
2019	5
2020	5
2021	5
2022	3
2023	4
2024	4

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Recent (within 3 months)

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2018 Weill Cornell Medical College: Sanford I. Weill Chair of Medicine

2018 New York-Presbyterian Hospital-Weill Cornell Medical Center: Physician-in-Chief

2018 American Thyroid Association: Sidney Ingbar Award

2011-2018 Beth Israel Deaconess Medical Center: Chief, Division of Endocrinology, Diabetes and Metabolism

2008 Harvard University: Honorary Phi Beta Kappa member

2000-2018 Beth Israel Deaconess Medical Center: Chief, Thyroid Unit

2000 American Thyroid Association: Van Meter Award

1998 Harvard University: Milton Award

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