Keywords
Last Name

David Coleman, MD

TitleWade Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Diseases
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 638-7254
ORCID ORCID Icon0000-0003-4803-5387
Other Positions
TitleChair of Medicine
InstitutionBoston University School of Medicine
DepartmentMedicine

 Research Expertise & Professional Interests
The initial focus of Dr. Coleman’s original scholarship was in the regulation of macrophage activation and proliferation. He identified novel factors that induce macrophage phagocytic function and oxidative metabolism. He went on to characterize the mechanisms by which macrophages are activated, recruited, retained, and induced to proliferate in local tissues. His research team discovered production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by non-immunological cell and tissue types such as keratinocytes (skin), glomerular mesangial cells (kidney), and respiratory epithelium (trachea). His team also identified production of other soluble cytokines (Macrophage CSF and Interleukin 6) by local tissues that regulate cell traffic and inflammation, particularly in the skin and kidney – two common sites of inflammation and infection. His later studies focused on the subcellular mechanisms of macrophage activation and proliferation induced by GM-CSF. His further delineated the effect of GM-CSF on intracellular second messenger pathways (e.g., cyclic nucleotides, protein kinase C) and early response genes (e.g., Egr-1) in macrophages. He defined the role of cis-acting 3’ regulatory elements in mediating the transcriptional activation of Egr-1 in macrophages. These studies were designed to characterize paracrine and autocrine signals that regulate cells in local tissues in states of inflammation and infection, and to better understand how therapies might be targeted at the extracellular and intracellular signals that underlie the inflammatory process. His work over the past 15 years has focused on medical and civic professionalism in medical education and clinical practice. He has developed incentive plans that promote physician productivity in an academically affiliated VA Medical Center and at Yale School of Medicine. In addition, he has led efforts at Yale and Boston University Schools of Medicine to develop more effective and rigorous policies for the interactions of clinicians with the pharmaceutical and medical device industries. Dr. Coleman’s clinical responsibilities include serving as an inpatient medical attending and infectious disease consult attending at Boston Medical Center.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Coleman DL, Wardrop RM, Levinson WS, Zeidel ML, Parsons PE. Strategies for Developing and Recognizing Faculty Working in Quality Improvement and Patient Safety. Acad Med. 2017 01; 92(1):52-57. PMID: 27191838.
    View in: PubMed
  2. Coleman DL, Johnson DH. The Department of Medicine in 2030: A Look Ahead. Am J Med. 2016 Nov; 129(11):1226-1233. PMID: 27480389.
    View in: PubMed
  3. Ravid K, Faux R, Corkey B, Coleman D. Building interdisciplinary biomedical research using novel collaboratives. Acad Med. 2013 Feb; 88(2):179-84. PMID: 23269301.
    View in: PubMed
  4. Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Trans Am Clin Climatol Assoc. 2013; 124:275-82. PMID: 23874035.
    View in: PubMed
  5. Joiner KA, Coleman DL. Perspective: key indicators in academic medicine: a suggested framework for analysis. Acad Med. 2012 Feb; 87(2):230-5. PMID: 22273616.
    View in: PubMed
  6. Coleman DL. A historical perspective on leptin. Nat Med. 2010 Oct; 16(10):1097-9. PMID: 20930752.
    View in: PubMed
  7. Coleman DL. Establishing policies for the relationship between industry and clinicians: lessons learned from two academic health centers. Acad Med. 2008 Sep; 83(9):882-7. PMID: 18728449.
    View in: PubMed
  8. Coleman DL. The impact of the lack of health insurance: how should academic medical centers and medical schools respond? Acad Med. 2006 Aug; 81(8):728-31. PMID: 16868427.
    View in: PubMed
  9. Wilson MS, Joiner KA, Inzucchi SE, Mulligan GJ, Mechem MF, Gross CP, Coleman DL. Improving clinical productivity in the academic setting: a novel incentive plan based on utility theory. Acad Med. 2006 Apr; 81(4):306-13. PMID: 16565178.
    View in: PubMed
  10. Coleman DL, Kazdin AE, Miller LA, Morrow JS, Udelsman R. Guidelines for interactions between clinical faculty and the pharmaceutical industry: one medical school's approach. Acad Med. 2006 Feb; 81(2):154-60. PMID: 16436576.
    View in: PubMed
  11. Coleman DL, Moran E, Serfilippi D, Mulinski P, Rosenthal R, Gordon B, Mogielnicki RP. Measuring physicians' productivity in a Veterans' Affairs Medical Center. Acad Med. 2003 Jul; 78(7):682-9. PMID: 12857686.
    View in: PubMed
  12. Shapiro ED, Coleman DL. The scholarship of application. Acad Med. 2000 Sep; 75(9):895-8. PMID: 10995610.
    View in: PubMed
  13. Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson PI, Striepen B, Roos DS, Joiner KA. Constitutive calcium-independent release of Toxoplasma gondii dense granules occurs through the NSF/SNAP/SNARE/Rab machinery. J Biol Chem. 1999 Jan 22; 274(4):2424-31. PMID: 9891012.
    View in: PubMed
  14. Budde K, Neumayer HH, Salant DJ, Cybulsky AV, Coleman DL, Sterzel RB. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney Int. 1997 Sep; 52(3):733-41. PMID: 9291194.
    View in: PubMed
  15. Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology. 1996 Feb 15; 216(2):357-66. PMID: 8607265.
    View in: PubMed
  16. Li C, Mitchell D, Coleman DL. Lipopolysaccharide induces expression of Egr-1 in macrophages through upstream CArG box (serum response) elements. J. Endotoxin Research. 1995; (2):239-246.
  17. Li C, Mitchell DH, Coleman DL. Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. Yale J Biol Med. 1994 Sep-Dec; 67(5-6):269-76. PMID: 8579643.
    View in: PubMed
  18. Rupprecht HD, Sukhatme VP, Rupprecht AP, Sterzel RB, Coleman DL. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene-1 by arginine vasopressin in rat mesangial cells. J Cell Physiol. 1994 May; 159(2):311-23. PMID: 8163570.
    View in: PubMed
  19. Takayama K, Mitchell DH, Din ZZ, Mukerjee P, Li C, Coleman DL. Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages. J Biol Chem. 1994 Jan 21; 269(3):2241-4. PMID: 8294481.
    View in: PubMed
  20. Rupprecht HD, Sukhatme VP, Lacy J, Sterzel RB, Coleman DL. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol. 1993 Sep; 265(3 Pt 2):F351-60. PMID: 8214093.
    View in: PubMed
  21. Coleman DL, Bartiss AH, Sukhatme VP, Liu J, Rupprecht HD. Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol. 1992 Nov 1; 149(9):3045-51. PMID: 1401930.
    View in: PubMed
  22. Coleman DL. The influence of genetic background on the expression of mutations at the diabetes (db) locus in the mouse. VI: Hepatic malic enzyme activity is associated with diabetes severity. Metabolism. 1992 Oct; 41(10):1134-6. PMID: 1406300.
    View in: PubMed
  23. Rupprecht HD, Dann P, Sukhatme VP, Sterzel RB, Coleman DL. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. Am J Physiol. 1992 Oct; 263(4 Pt 2):F623-36. PMID: 1415734.
    View in: PubMed
  24. Ruef C, Kashgarian M, Coleman DL. Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion. Am J Pathol. 1992 Aug; 141(2):429-39. PMID: 1323220.
    View in: PubMed
  25. Coleman DL, Ruef C. Interleukin-6: an autocrine regulator of mesangial cell growth. Kidney Int. 1992 Mar; 41(3):604-6. PMID: 1573836.
    View in: PubMed
  26. Rupprecht AP, Coleman DL. Transfection of adherent murine peritoneal macrophages with a reporter gene using DEAE-dextran. J Immunol Methods. 1991 Nov 22; 144(2):157-63. PMID: 1960412.
    View in: PubMed
  27. Coleman DL, Kuzava JE. Genetic regulation of malic enzyme activity in the mouse. J Biol Chem. 1991 Nov 15; 266(32):21997-2002. PMID: 1939220.
    View in: PubMed
  28. Lacy J, Bartiss A, Coleman DL. Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein. Virus Res. 1991 Jun; 20(1):85-96. PMID: 1656626.
    View in: PubMed
  29. Liu JW, Lacy J, Sukhatme VP, Coleman DL. Granulocyte-macrophage colony-stimulating factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages. J Biol Chem. 1991 Mar 25; 266(9):5929-33. PMID: 2005129.
    View in: PubMed
  30. Ruef C, Coleman DL. [GM-CSF and G-CSF: cytokines in clinical application]. Schweiz Med Wochenschr. 1991 Mar 23; 121(12):397-412. PMID: 1709294.
    View in: PubMed
  31. Coleman DL, Eicher EM. Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 1990 Nov-Dec; 81(6):424-7. PMID: 2250094.
    View in: PubMed
  32. Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel RB, Coleman DL. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int. 1990 Aug; 38(2):249-57. PMID: 2402117.
    View in: PubMed
  33. Coleman DL, Kuzava JE, Leiter EH. Effect of diet on incidence of diabetes in nonobese diabetic mice. Diabetes. 1990 Apr; 39(4):432-6. PMID: 2318346.
    View in: PubMed
  34. Chodakewitz JA, Lacy J, Edwards SE, Birchall N, Coleman DL. Macrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide. J Immunol. 1990 Mar 15; 144(6):2190-6. PMID: 2179407.
    View in: PubMed
  35. Ruef C, Coleman DL. Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness. Rev Infect Dis. 1990 Jan-Feb; 12(1):41-62. PMID: 2405468.
    View in: PubMed
  36. Smith SM, Lee DK, Lacy J, Coleman DL. Rat tracheal epithelial cells produce granulocyte/macrophage colony-stimulating factor. Am J Respir Cell Mol Biol. 1990 Jan; 2(1):59-68. PMID: 2407273.
    View in: PubMed
  37. Horowitz M, Brown M, Insogna K, Coleman D, Centrella M, Phillips J, Weir E. PTHrP and PTH induce the secretion of IL-6 by a clonal osteosarcoma cell line. In Molecular and Cellular Biology of Cytokines. Powanda, Oppenheim, Kluger, Dinarello (eds). Alan Liss Inc. NY, NY. 1990; 471-476.
  38. Coleman DL, Liu J, Bartiss AH. Recombinant granulocyte-macrophage colony-stimulating factor increases adenylate cyclase activity in murine peritoneal macrophages. J Immunol. 1989 Dec 15; 143(12):4134-40. PMID: 2687376.
    View in: PubMed
  39. Horowitz MC, Coleman DL, Ryaby JT, Einhorn TA. Osteotropic agents induce the differential secretion of granulocyte-macrophage colony-stimulating factor by the osteoblast cell line MC3T3-E1. J Bone Miner Res. 1989 Dec; 4(6):911-21. PMID: 2692406.
    View in: PubMed
  40. Budde K, Coleman DL, Lacy J, Sterzel RB. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. Am J Physiol. 1989 Dec; 257(6 Pt 2):F1065-78. PMID: 2690641.
    View in: PubMed
  41. Evans R, Duffy TM, Coleman DL, Tai HH. Partial characterization of a low-molecular-weight, macrophage-derived inhibitor of DNA synthesis: a possible immunoregulatory molecule. Cell Immunol. 1989 Mar; 119(1):53-66. PMID: 2920397.
    View in: PubMed
  42. Leiter EH, Chapman HD, Coleman DL. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology. 1989 Feb; 124(2):912-22. PMID: 2912706.
    View in: PubMed
  43. Horowitz MC, Coleman DL, Flood PM, Kupper TS, Jilka RL. Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1989 Jan; 83(1):149-57. PMID: 2642917.
    View in: PubMed
  44. Prochazka M, Leiter EH, Serreze DV, Coleman DL, Jackson RA. Diabetic mouse incorrectly typed. Science. 1988 Nov 11; 242(4880):945. PMID: 3187535.
    View in: PubMed
  45. Bégin-Heick N, Coleman DL. Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes. Mol Cell Endocrinol. 1988 Oct; 59(3):171-8. PMID: 3181620.
    View in: PubMed
  46. Kupper TS, Lee F, Coleman D, Chodakewitz J, Flood P, Horowitz M. Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF). J Invest Dermatol. 1988 Aug; 91(2):185-8. PMID: 3294304.
    View in: PubMed
  47. Coleman DL, Chodakewitz JA, Bartiss AH, Mellors JW. Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages. Blood. 1988 Aug; 72(2):573-8. PMID: 3042043.
    View in: PubMed
  48. Chodakewitz JA, Kupper TS, Coleman DL. Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. J Immunol. 1988 Feb 1; 140(3):832-6. PMID: 3257506.
    View in: PubMed
  49. Kupper TS, Horowitz M, Birchall N, Mizutani H, Coleman D, McGuire J, Flood P, Dower S, Lee F. Hematopoietic, lymphopoietic, and proinflammatory cytokines produced by human and murine keratinocytes. Ann N Y Acad Sci. 1988; 548:262-70. PMID: 2470299.
    View in: PubMed
  50. Coleman DL. Therapeutic effects of dehydroepiandrosterone (DHEA) and its metabolites in obese-hyperglycemic mutant mice. Prog Clin Biol Res. 1988; 265:161-75. PMID: 2970093.
    View in: PubMed
  51. Mellors JW, Bartiss AH, Coleman DL. Stimulation of macrophage H2O2 release by resident thymocytes: effect of a soluble factor distinct from interferon-gamma. Cell Immunol. 1987 Dec; 110(2):391-9. PMID: 3121188.
    View in: PubMed
  52. Kupper T, Flood P, Coleman D, Horowitz M. Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). J Immunol. 1987 Jun 15; 138(12):4288-92. PMID: 2953804.
    View in: PubMed
  53. Coleman DL, Kupper TS, Flood PM, Fultz CC, Horowitz MC. Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1. J Immunol. 1987 May 15; 138(10):3314-8. PMID: 3494765.
    View in: PubMed
  54. Widdicombe JH, Coleman DL, Finkbeiner WE, Friend DS. Primary cultures of the dog's tracheal epithelium: fine structure, fluid, and electrolyte transport. Cell Tissue Res. 1987 Jan; 247(1):95-103. PMID: 3829121.
    View in: PubMed
  55. Kupper TS, Coleman DL, McGuire J, Goldminz D, Horowitz MC. Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4451-5. PMID: 3520573.
    View in: PubMed
  56. Coleman DL, Morrison DC, Ryan JL. Gangliosides block the inhibition of macrophage Fc-dependent phagocytosis by lipopolysaccharide. Cell Immunol. 1986 Jun; 100(1):288-99. PMID: 3742602.
    View in: PubMed
  57. Mellors JW, Coleman DL, Andriole VT. Value of the serum bactericidal test in management of patients with bacterial endocarditis. Eur J Clin Microbiol. 1986 Feb; 5(1):67-70. PMID: 3516687.
    View in: PubMed
  58. Coleman DL. Regulation of macrophage phagocytosis. Eur J Clin Microbiol. 1986 Feb; 5(1):1-5. PMID: 3084238.
    View in: PubMed
  59. Yohe HC, Coleman DL, Ryan JL. Ganglioside alterations in stimulated murine macrophages. Biochim Biophys Acta. 1985 Aug 8; 818(1):81-6. PMID: 4016115.
    View in: PubMed
  60. Coleman DL, Culver KE, Ryan JL. Effect of lipopolysaccharide on the stimulation of macrophage Fc-dependent phagocytosis by splenic B lymphocytes. Cell Immunol. 1985 Apr 1; 91(2):520-7. PMID: 3873284.
    View in: PubMed
  61. Miller SA, Bia FJ, Coleman DL, Lucia HL, Young KR, Root RK. Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia. Infect Immun. 1985 Jan; 47(1):211-6. PMID: 2981196.
    View in: PubMed
  62. Garris DR, Coleman DL, Morgan CR. Age- and diabetes-related changes in tissue glucose uptake and estradiol accumulation in the C57BL/KsJ mouse. Diabetes. 1985 Jan; 34(1):47-52. PMID: 4038372.
    View in: PubMed
  63. Coleman DL, Culver KE, Ryan JL. Enhancement of macrophage immune and nonimmune receptor-mediated phagocytosis by a low molecular weight soluble factor from resident thymocytes. J Immunol. 1984 Dec; 133(6):3121-7. PMID: 6386982.
    View in: PubMed
  64. Coleman DL, Tuet IK, Widdicombe JH. Electrical properties of dog tracheal epithelial cells grown in monolayer culture. Am J Physiol. 1984 Mar; 246(3 Pt 1):C355-9. PMID: 6367482.
    View in: PubMed
  65. Coleman DL, Ernstoff MS, Kirkwood JM, Ryan JL. Effect of intravenous recombinant alpha-2 interferon on monocyte Fc-dependent phagocytosis in patients with malignant melanoma. J Interferon Res. 1984; 4(2):215-21. PMID: 6747348.
    View in: PubMed
  66. Craft J, Coleman D, Coulter HO, Horwitz R, Barry M. Hematologic abnormalities in Southeast Asian refugees. JAMA. 1983 Jun 17; 249(23):3204-6. PMID: 6854850.
    View in: PubMed
  67. Barry M, Craft J, Coleman D, Coulter HO, Horwitz R. Clinical findings in Southeast Asian refugees. JAMA. 1983 Jun 17; 249(23):3200-3. PMID: 6854849.
    View in: PubMed
  68. Coleman DL, Root RK, Ryan JL. Enhancement of macrophage Fc-dependent phagocytosis by resident thymocytes: effect of a unique heat-stable lymphokine. J Immunol. 1983 May; 130(5):2195-9. PMID: 6339624.
    View in: PubMed
  69. Coleman DL, Horwitz RI, Andriole VT. Association between serum inhibitory and bactericidal concentrations and therapeutic outcome in bacterial endocarditis. Am J Med. 1982 Aug; 73(2):260-7. PMID: 7051827.
    View in: PubMed
  70. Coleman DL, Andriole VT. An unusual pontine mass lesion. Yale J Biol Med. 1982 Jan-Feb; 55(1):51-8. PMID: 7051583.
    View in: PubMed
  71. Coleman DL, Barry M. Relapse of Paragonimus westermani lung infection after bithionol therapy. Am J Trop Med Hyg. 1982 Jan; 31(1):71-4. PMID: 7058981.
    View in: PubMed
  72. Coleman DL, Root RK. Pulmonary infections, in Southeast Asian refugees. Clin Chest Med. 1981 Jan; 2(1):133-43. PMID: 6914222.
    View in: PubMed
  73. Coleman DL, Horwitz RI. Lithium carbonate during chemotherapy. N Engl J Med. 1980 Jun 12; 302(24):1365. PMID: 6769041.
    View in: PubMed
  74. Coleman DL, Ryan JL. Gentamicin: clinical role. Conn Med. 1980 Feb; 44(2):67-70. PMID: 7363609.
    View in: PubMed
  75. Leiter EH, Coleman DL, Waymouth C. Cell culture of the endocrine pancreas of the mouse in chemically defined media. In Vitro. 1974 May-Jun; 9(6):421-33. PMID: 4367004.
    View in: PubMed
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