David Coleman, MD
Wade Professor
Boston University School of Medicine
Dept of Medicine
Infectious Diseases

MD, University of California, San Francisco
MA, Yale University



The initial focus of Dr. Coleman’s original scholarship was in the regulation of macrophage activation and proliferation. He identified novel factors that induce macrophage phagocytic function and oxidative metabolism. He went on to characterize the mechanisms by which macrophages are activated, recruited, retained, and induced to proliferate in local tissues. His research team discovered production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by non-immunological cell and tissue types such as keratinocytes (skin), glomerular mesangial cells (kidney), and respiratory epithelium (trachea). His team also identified production of other soluble cytokines (Macrophage CSF and Interleukin 6) by local tissues that regulate cell traffic and inflammation, particularly in the skin and kidney – two common sites of inflammation and infection. His later studies focused on the subcellular mechanisms of macrophage activation and proliferation induced by GM-CSF. His further delineated the effect of GM-CSF on intracellular second messenger pathways (e.g., cyclic nucleotides, protein kinase C) and early response genes (e.g., Egr-1) in macrophages. He defined the role of cis-acting 3’ regulatory elements in mediating the transcriptional activation of Egr-1 in macrophages. These studies were designed to characterize paracrine and autocrine signals that regulate cells in local tissues in states of inflammation and infection, and to better understand how therapies might be targeted at the extracellular and intracellular signals that underlie the inflammatory process. His work over the past 15 years has focused on medical and civic professionalism in medical education and clinical practice. He has developed incentive plans that promote physician productivity in an academically affiliated VA Medical Center and at Yale School of Medicine. In addition, he has led efforts at Yale and Boston University Schools of Medicine to develop more effective and rigorous policies for the interactions of clinicians with the pharmaceutical and medical device industries. Dr. Coleman’s clinical responsibilities include serving as an inpatient medical attending and infectious disease consult attending at Boston Medical Center.

Chair of Medicine
Boston University School of Medicine
Medicine


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Siegel J, Coleman DL, James T. Integrating Social Determinants of Health Into Graduate Medical Education: A Call for Action. Acad Med. 2017 Nov 14.View Related Profiles. PMID: 29140918.
  2. Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405.View Related Profiles. PMID: 28445220.
  3. Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721.View Related Profiles. PMID: 28720207.
  4. Coleman DL, Wardrop RM, Levinson WS, Zeidel ML, Parsons PE. Strategies for Developing and Recognizing Faculty Working in Quality Improvement and Patient Safety. Acad Med. 2017 01; 92(1):52-57. PMID: 27191838; DOI: 10.1097/ACM.0000000000001230;.
  5. Coleman DL, Johnson DH. The Department of Medicine in 2030: A Look Ahead. Am J Med. 2016 Nov; 129(11):1226-1233. PMID: 27480389; DOI: 10.1016/j.amjmed.2016.07.008;.
  6. Ravid K, Faux R, Corkey B, Coleman D. Building interdisciplinary biomedical research using novel collaboratives. Acad Med. 2013 Feb; 88(2):179-84.View Related Profiles. PMID: 23269301; DOI: 10.1097/ACM.0b013e31827c0f79;.
  7. Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Trans Am Clin Climatol Assoc. 2013; 124:275-82.View Related Profiles. PMID: 23874035; PMCID: PMC3715902.
  8. Joiner KA, Coleman DL. Perspective: key indicators in academic medicine: a suggested framework for analysis. Acad Med. 2012 Feb; 87(2):230-5. PMID: 22273616; DOI: 10.1097/ACM.0b013e31823faafb;.
  9. Coleman DL. A historical perspective on leptin. Nat Med. 2010 Oct; 16(10):1097-9. PMID: 20930752; DOI: 10.1038/nm1010-1097;.
  10. Coleman DL. Establishing policies for the relationship between industry and clinicians: lessons learned from two academic health centers. Acad Med. 2008 Sep; 83(9):882-7. PMID: 18728449; DOI: 10.1097/ACM.0b013e318181da0e;.
Showing 10 of 79 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 78 publications over 28 distinct years, with a maximum of 7 publications in 1988 and 1990

YearPublications
19802
19811
19823
19833
19843
19854
19864
19874
19887
19896
19907
19915
19925
19931
19943
19951
19962
19971
19991
20001
20031
20063
20081
20101
20121
20132
20161
20174
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75 E. Newton St Evans Building
Boston MA 02118
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