Keywords
Last Name

David M. Center, MD

TitleAssociate Provost of Translational Research
InstitutionBoston University Medical Campus
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
ORCID ORCID Icon0000-0002-5879-7978
Other Positions
TitleGordon and Ruth Snider Chair
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

TitleGordon and Ruth Snider Professor of Pulmonary Medicine
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleSection Chief
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Awards and Honors

Start-EndDescription
1987-1988A.F.C.R.: Elected National Secretary/Treasurer
1989American Society for Clinical Investigation: Elected Member
1990Boston University: AOA
1996Association of American Physicians: Elected Member
2002Boston University School of Medicine: Distinguished Alumnus Award
2002-2012Best Physicians in America
2002-2006NHLBI Board of Extramural Advisors
2003-2007Best of Boston, Pulmonary Physicians
2008Massachusetts Thoracic Society: Chadwick Medal
2009-2012Best of Boston, Pulmonary Physicians
2011-2011Society for Clinical and Translational Science: Elected Treasurer
2012-2012American Thoracic Society: Edward Livingston Trudeau Medal
 Research Expertise & Professional Interests
Dr. Center is Boston University’s Associate Provost for Translational Research and the Director of the Clinical and Translational Research Institute funded by the NIH. He directs Boston University’s efforts to facilitate translational research and advance team science, with a focus on the use of innovative methods for drug and device discovery and delivery and developing creative tools to expedite and retool traditional research processes.

His own laboratory is interested in two major themes which revolve around roles for Interleukin-16, co-discovered with Bill Cruikshank in 1982. The first theme relates to the functions of IL-16 as a immunomodulatory cytokine. Over the past several years, in collaboration with Bill Cruikshank, he has studied the role of IL-16 in recruitment and development of Regulatory T cells and demonstrated that it plays a key role in tolerance to airborne allergens. Utilizing transgenic knockout and overexpressing mice his laboratory is involved in demonstrating the patterns of CD4+ T cell trafficking through lymph nodes and lung parenchymal in normal and immunologically challenged lungs and identifying potential therapeutic implications of altering recruitment patterns of Regulatory T cells.

The second major emphasis of his laboratory relates to the functional properties of the precursor protein for IL-16, Pro-IL-16 as a tumor suppressor gene. In these studies, along with Yujun Zhang he has shown that Interleukin-16 is synthesized as a precursor which is present in cytoplasm and nucleus of resting T cells. It contains a phosphorylation regulated nuclear localization motif and binds a nuclear chaperone hsc70 which is essential for transport to the nucleus where its presence induces arrest of the cell cycle at G0/G1. It inhibits the cell cycle by acting as a scaffolding protein that assembles a histone deacetylase complex targeted via binding to GA-BP to the Skp2 promoter using intermolecular PDZ binding motifs. Skp2 is an essential member of the ubiquitin ligase protein degradation pathway responsive for degrading the cell cycle cyclin dependent kinase inhibitor p27. In the presence of pro-IL-16, the complex inhibits Skp2 transcription, which in turn decreases p27 degradation resulting in rises in p27 levels and arrest of the cell cycle in G1. Current studies are directed at identifying mutations in Pro-IL-16 that predispose to T cell malignancies and determining its role is permissive exit from G1 in normal T cell activation and proliferation following antigen stimulation.

 Self-Described Keywords
  • Chemotaxis
  • Interleukin 16
  • T Cell Immunology
  • Translational Research
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2014 Nov; 124(11):5085. PMID: 25365075.
    View in: PubMed
  2. Richmond J, Tuzova M, Cruikshank W, Center D. Regulation of cellular processes by interleukin-16 in homeostasis and cancer. J Cell Physiol. 2014 Feb; 229(2):139-47. PMID: 23893766.
    View in: PubMed
  3. Center DM, Schwartz DA, Solway J, Gail D, Laposky AD, Lin QS, Gan W. Genomic medicine and lung diseases. Am J Respir Crit Care Med. 2012 Aug 1; 186(3):280-5. PMID: 22652029.
    View in: PubMed
  4. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9. PMID: 22507116.
    View in: PubMed
  5. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49. PMID: 22080865.
    View in: PubMed
  6. Granada M, Wilk JB, Tuzova M, Strachan DP, Weidinger S, Albrecht E, Gieger C, Heinrich J, Himes BE, Hunninghake GM, Celedón JC, Weiss ST, Cruikshank WW, Farrer LA, Center DM, O'Connor GT. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012 Mar; 129(3):840-845.e21. PMID: 22075330.
    View in: PubMed
  7. Bauchner H, Felson D, Center D. Creating a K-community of investigators. Acad Med. 2010 Dec; 85(12):1814. PMID: 21107029.
    View in: PubMed
  8. Green DS, Center DM, Cruikshank WW. Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. J Virol. 2009 Jun; 83(11):5765-72. PMID: 19297493.
    View in: PubMed
  9. Zhang Y, Tuzova M, Xiao ZX, Cruikshank WW, Center DM. Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. J Immunol. 2008 Jan 1; 180(1):402-8. PMID: 18097041.
    View in: PubMed
  10. McFadden C, Morgan R, Rahangdale S, Green D, Yamasaki H, Center D, Cruikshank W. Preferential migration of T regulatory cells induced by IL-16. J Immunol. 2007 Nov 15; 179(10):6439-45. PMID: 17982032.
    View in: PubMed
  11. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9. PMID: 17548646.
    View in: PubMed
  12. Center DM. Taking the "idio" out of idiopathic pulmonary fibrosis: a call to arms. Am J Respir Crit Care Med. 2007 Jun 1; 175(11):1101-2. PMID: 17519345.
    View in: PubMed
  13. Rahangdale S, Morgan R, Heijens C, Ryan TC, Yamasaki H, Bentley E, Sullivan E, Center DM, Cruikshank WW. Chemokine receptor CXCR3 desensitization by IL-16/CD4 signaling is dependent on CCR5 and intact membrane cholesterol. J Immunol. 2006 Feb 15; 176(4):2337-45. PMID: 16455991.
    View in: PubMed
  14. Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006 Jan; 117(1):86-91. PMID: 16387589.
    View in: PubMed
  15. Little FF, Wilson K, Berman JS, Center DM. T Lymphocyte and Macrophage Mediated Inflammation in the Lung. In Pulmonary Diseases and Disorders. A. Fishman, ed. McGraw-Hill. New York City, NY. 2006.
  16. Wilson KC, Cattel DJ, Wan Z, Rahangdale S, Ren F, Kornfeld H, Sullivan BA, Cruikshank WW, Center DM. Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. Cell Immunol. 2005 Sep; 237(1):17-27. PMID: 16289056.
    View in: PubMed
  17. Ren F, Zhan X, Martens G, Lee J, Center D, Hanson SK, Kornfeld H. Pro-IL-16 regulation in activated murine CD4+ lymphocytes. J Immunol. 2005 Mar 1; 174(5):2738-45. PMID: 15728482.
    View in: PubMed
  18. Wilson KC, Center DM, Cruikshank WW. The effect of interleukin-16 and its precursor on T lymphocyte activation and growth. Growth Factors. 2004 Jun; 22(2):97-104. PMID: 15253385.
    View in: PubMed
  19. Center DM, Cruikshank WW, Zhang Y. Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription. J Immunol. 2004 Feb 1; 172(3):1654-60. PMID: 14734747.
    View in: PubMed
  20. Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 Dec; 14(6):489-502. PMID: 14563351.
    View in: PubMed
  21. Lynch EA, Heijens CA, Horst NF, Center DM, Cruikshank WW. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol. 2003 Nov 15; 171(10):4965-8. PMID: 14607889.
    View in: PubMed
  22. Little FF, Center DM. Induced sputum analysis for T helper type 2 cell regulation: closing the loop. Chest. 2003 Jun; 123(6):1786-8. PMID: 12796149.
    View in: PubMed
  23. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S. PMID: 12629022.
    View in: PubMed
  24. Little FF, Lynch E, Fine G, Center DM, Cruikshank WW. Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):354-62. PMID: 12594062.
    View in: PubMed
  25. Wilson KC, Center DM, Cruikshank WW, Zhang Y. Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein. Virology. 2003 Feb 1; 306(1):60-7. PMID: 12620798.
    View in: PubMed
  26. Wilson KC, Cruikshank WW, Center DM. Interleukin-16. Growth Characteristics of Interleukin-16. In: An Encyclopedia of Hormones (Eds., Henry HL and Norman AW). Academic Press. San Diego, CA. 2003.
  27. Wilson KC, Center DM, Cruikshank WW. Interleukin-16. In: The Cytokine Handbook, 4th Edition (Eds., Thomson A. and Lotze M). Academic Press. San Diego, CA. 2003.
  28. Wilson KC, Cruikshank WW, Center DM, Zhang Y. Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization. Biochemistry. 2002 Dec 3; 41(48):14306-12. PMID: 12450396.
    View in: PubMed
  29. Dent G, Hosking LA, Lordan JL, Steel MD, Cruikshank WW, Center DM, Ellis JH, Holgate ST, Davies DE, Djukanovic R. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals. J Allergy Clin Immunol. 2002 Dec; 110(6):906-14. PMID: 12464958.
    View in: PubMed
  30. Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB. Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther. 2002 Oct; 303(1):300-7. PMID: 12235264.
    View in: PubMed
  31. Bandeira-Melo C, Sugiyama K, Woods LJ, Phoofolo M, Center DM, Cruikshank WW, Weller PF. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. J Immunol. 2002 May 1; 168(9):4756-63. PMID: 11971026.
    View in: PubMed
  32. Wilson K, Cruikshank WW, Center DM. The Role of Chemokines in Lymphocyte Trafficking to Lymph Nodes of the Lung. T. Standiford, R. Strieter, eds. Marcel Dekker, Inc. New York, NY. 2002.
  33. Little F, Cruikshank WW, Center DM . The Role of Interleukin-16 in Asthma. Marcel Dekker, Inc. New York, NY. 2002.
  34. Little FF, Cruikshank WW, Center DM. Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001 Sep; 25(3):347-52. PMID: 11588013.
    View in: PubMed
  35. Center DM, Cruikshank WW, Parada NA, Ryan T, Theodore AC, Viglianti G, Lim KG, Weller PF. Measurement of interleukin 16. Curr Protoc Immunol. 2001 May; Chapter 6:Unit 6.23. PMID: 18432814.
    View in: PubMed
  36. Strohmeier GR, Walsh JH, Klings ES, Farber HW, Cruikshank WW, Center DM, Fenton MJ. Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma. J Immunol. 2001 Feb 1; 166(3):2063-70. PMID: 11160257.
    View in: PubMed
  37. Zhang Y, Kornfeld H, Cruikshank WW, Kim S, Reardon CC, Center DM. Nuclear translocation of the N-terminal prodomain of interleukin-16. J Biol Chem. 2001 Jan 12; 276(2):1299-303. PMID: 11032842.
    View in: PubMed
  38. Van Drenth C, Jenkins A, Ledwich L, Ryan TC, Mashikian MV, Brazer W, Center DM, Cruikshank WW. Desensitization of CXC chemokine receptor 4, mediated by IL-16/CD4, is independent of p56lck enzymatic activity. J Immunol. 2000 Dec 1; 165(11):6356-63. PMID: 11086073.
    View in: PubMed
  39. Center DM. A role for the alveolar epithelium in recruitment of mononuclear cells into the lung. J Clin Invest. 2000 Sep; 106(6):741-3. PMID: 10995783.
    View in: PubMed
  40. Laberge S, Pinsonneault S, Varga EM, Till SJ, Nouri-Aria K, Jacobson M, Cruikshank WW, Center DM, Hamid Q, Durham SR. Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma. J Allergy Clin Immunol. 2000 Aug; 106(2):293-301. PMID: 10932073.
    View in: PubMed
  41. Krug N, Cruikshank WW, Tschernig T, Erpenbeck VJ, Balke K, Hohlfeld JM, Center DM, Fabel H. Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):105-11. PMID: 10903228.
    View in: PubMed
  42. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol. 2000 Jun; 67(6):757-66. PMID: 10857846.
    View in: PubMed
  43. Center DM, Kornfeld H, Ryan TC, Cruikshank WW. Interleukin 16: implications for CD4 functions and HIV-1 progression. Immunol Today. 2000 Jun; 21(6):273-80. PMID: 10825739.
    View in: PubMed
  44. Sciaky D, Brazer W, Center DM, Cruikshank WW, Smith TJ. Cultured human fibroblasts express constitutive IL-16 mRNA: cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism. J Immunol. 2000 Apr 1; 164(7):3806-14. PMID: 10725741.
    View in: PubMed
  45. Hidi R, Riches V, Al-Ali M, Cruikshank WW, Center DM, Holgate ST, Djukanovic R. Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES. J Immunol. 2000 Jan 1; 164(1):412-8. PMID: 10605037.
    View in: PubMed
  46. O’Regan A, Center DM. Cytokines in Cell Mediated Immunity. IN: Cytokines in Lung Diseases, S. Nelson and T. Martin, eds. Marcel Dekkee. New York, NY. 2000.
  47. Yamasaki H, Ando M, Brazer W, Center DM, Cruikshank WW. Polarized type 1 cytokine profile in bronchoalveolar lavage T cells of patients with hypersensitivity pneumonitis. J Immunol. 1999 Sep 15; 163(6):3516-23. PMID: 10477626.
    View in: PubMed
  48. Mashikian MV, Ryan TC, Seman A, Brazer W, Center DM, Cruikshank WW. Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively. J Immunol. 1999 Sep 15; 163(6):3123-30. PMID: 10477578.
    View in: PubMed
  49. Nicoll J, Cruikshank WW, Brazer W, Liu Y, Center DM, Kornfeld H. Identification of domains in IL-16 critical for biological activity. J Immunol. 1999 Aug 15; 163(4):1827-32. PMID: 10438915.
    View in: PubMed
  50. Liu Y, Cruikshank WW, O'Loughlin T, O'Reilly P, Center DM, Kornfeld H. Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation. J Biol Chem. 1999 Aug 13; 274(33):23387-95. PMID: 10438516.
    View in: PubMed
  51. Laberge S, Pinsonneault S, Ernst P, Olivenstein R, Ghaffar O, Center DM, Hamid Q. Phenotype of IL-16-producing cells in bronchial mucosa: evidence for the human eosinophil and mast cell as cellular sources of IL-16 in asthma. Int Arch Allergy Immunol. 1999 Jun; 119(2):120-5. PMID: 10394103.
    View in: PubMed
  52. Wu DM, Zhang Y, Parada NA, Kornfeld H, Nicoll J, Center DM, Cruikshank WW. Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent. J Immunol. 1999 Feb 1; 162(3):1287-93. PMID: 9973381.
    View in: PubMed
  53. Center DM, Kornfeld H, Cruikshank WW. Interleukin-16. Cytokine Database, Oppenheim, M. Feldman, eds. Academic Press. London. 1999.
  54. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. New cytokines as potential drugs (PIR). Eds. S.K. Narula and R. Coffman. Birkhauser Pub. 1999.
  55. Laberge S, Ghaffar O, Boguniewicz M, Center DM, Leung DY, Hamid Q. Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis. J Allergy Clin Immunol. 1998 Oct; 102(4 Pt 1):645-50. PMID: 9802374.
    View in: PubMed
  56. Chupp GL, Wright EA, Wu D, Vallen-Mashikian M, Cruikshank WW, Center DM, Kornfeld H, Berman JS. Tissue and T cell distribution of precursor and mature IL-16. J Immunol. 1998 Sep 15; 161(6):3114-9. PMID: 9743378.
    View in: PubMed
  57. Keane J, Nicoll J, Kim S, Wu DM, Cruikshank WW, Brazer W, Natke B, Zhang Y, Center DM, Kornfeld H. Conservation of structure and function between human and murine IL-16. J Immunol. 1998 Jun 15; 160(12):5945-54. PMID: 9637508.
    View in: PubMed
  58. Mashikian MV, Tarpy RE, Saukkonen JJ, Lim KG, Fine GD, Cruikshank WW, Center DM. Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients. J Allergy Clin Immunol. 1998 Jun; 101(6 Pt 1):786-92. PMID: 9648706.
    View in: PubMed
  59. Hessel EM, Cruikshank WW, Van Ark I, De Bie JJ, Van Esch B, Hofman G, Nijkamp FP, Center DM, Van Oosterhout AJ. Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma. J Immunol. 1998 Mar 15; 160(6):2998-3005. PMID: 9510204.
    View in: PubMed
  60. Parada NA, Center DM, Kornfeld H, Rodriguez WL, Cook J, Vallen M, Cruikshank WW. Synergistic activation of CD4+ T cells by IL-16 and IL-2. J Immunol. 1998 Mar 1; 160(5):2115-20. PMID: 9498748.
    View in: PubMed
  61. Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW, Kornfeld H. Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem. 1998 Jan 9; 273(2):1144-9. PMID: 9422780.
    View in: PubMed
  62. Cruikshank WW, Kornfeld H, Center DM. Signaling and functional properties of interleukin-16. Int Rev Immunol. 1998; 16(5-6):523-40. PMID: 9646175.
    View in: PubMed
  63. Biddison WE, Cruikshank WW, Center DM, Pelfrey CM, Taub DD, Turner RV. CD8+ myelin peptide-specific T cells can chemoattract CD4+ myelin peptide-specific T cells: importance of IFN-inducible protein 10. J Immunol. 1998 Jan 1; 160(1):444-8. PMID: 9552002.
    View in: PubMed
  64. Center DM, Kornfeld H, Cruikshank WW. Interleukin-16. Int J Biochem Cell Biol. 1997 Nov; 29(11):1231-4. PMID: 9451819.
    View in: PubMed
  65. Laberge S, Durham SR, Ghaffar O, Rak S, Center DM, Jacobson M, Hamid Q. Expression of IL-16 in allergen-induced late-phase nasal responses and relation to topical glucocorticosteroid treatment. J Allergy Clin Immunol. 1997 Oct; 100(4):569-74. PMID: 9338554.
    View in: PubMed
  66. Rumsaeng V, Cruikshank WW, Foster B, Prussin C, Kirshenbaum AS, Davis TA, Kornfeld H, Center DM, Metcalfe DD. Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16. J Immunol. 1997 Sep 15; 159(6):2904-10. PMID: 9300714.
    View in: PubMed
  67. Viglianti GA, Parada NA, Maciaszek JW, Kornfeld H, Center DM, Cruikshank WW. IL-16 anti-HIV-1 therapy. Nat Med. 1997 Sep; 3(9):938. PMID: 9288705.
    View in: PubMed
  68. Biddison WE, Kubota R, Kawanishi T, Taub DD, Cruikshank WW, Center DM, Connor EW, Utz U, Jacobson S. Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J Immunol. 1997 Aug 15; 159(4):2018-25. PMID: 9257869.
    View in: PubMed
  69. Laberge S, Ernst P, Ghaffar O, Cruikshank WW, Kornfeld H, Center DM, Hamid Q. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma. Am J Respir Cell Mol Biol. 1997 Aug; 17(2):193-202. PMID: 9271307.
    View in: PubMed
  70. Biddison WE, Taub DD, Cruikshank WW, Center DM, Connor EW, Honma K. Chemokine and matrix metalloproteinase secretion by myelin proteolipid protein-specific CD8+ T cells: potential roles in inflammation. J Immunol. 1997 Apr 1; 158(7):3046-53. PMID: 9120256.
    View in: PubMed
  71. Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol. 1997 Jan 1; 158(1):5-8. PMID: 8977168.
    View in: PubMed
  72. Berman JS, Center DM. T Lymphocyte and Macrophage Mediated Inflammation in the Lung. Pulmonary Diseases and Disorders. A. Fishman, ed. McGraw-Hill. New York City, NY. 1997.
  73. Cruikshank WW, Lim K, Theodore AC, Cook J, Fine G, Weller PF, Center DM. IL-16 inhibition of CD3-dependent lymphocyte activation and proliferation. J Immunol. 1996 Dec 15; 157(12):5240-8. PMID: 8955168.
    View in: PubMed
  74. Mackewicz CE, Levy JA, Cruikshank WW, Kornfeld H, Center DM. Role of IL-16 in HIV replication. Nature. 1996 Oct 10; 383(6600):488-9. PMID: 8849720.
    View in: PubMed
  75. Center DM, Kornfeld H, Cruikshank WW. Interleukin 16 and its function as a CD4 ligand. Immunol Today. 1996 Oct; 17(10):476-81. PMID: 8908813.
    View in: PubMed
  76. Theodore AC, Center DM, Nicoll J, Fine G, Kornfeld H, Cruikshank WW. CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 1996 Sep 1; 157(5):1958-64. PMID: 8757315.
    View in: PubMed
  77. Cruikshank W, Kornfeld H, Berman J, Chupp G, Keane J, Center D. Biological activity of interleukin-16. Nature. 1996 Aug 8; 382(6591):501-2. PMID: 8700223.
    View in: PubMed
  78. Weller PF, Lim K, Wan HC, Dvorak AM, Wong DT, Cruikshank WW, Kornfeld H, Center DM. Role of the eosinophil in allergic reactions. Eur Respir J Suppl. 1996 Aug; 22:109s-115s. PMID: 8871054.
    View in: PubMed
  79. Lim KG, Wan HC, Bozza PT, Resnick MB, Wong DT, Cruikshank WW, Kornfeld H, Center DM, Weller PF. Human eosinophils elaborate the lymphocyte chemoattractants. IL-16 (lymphocyte chemoattractant factor) and RANTES. J Immunol. 1996 Apr 1; 156(7):2566-70. PMID: 8786320.
    View in: PubMed
  80. Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM. IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. Cell Immunol. 1996 Feb 25; 168(1):100-6. PMID: 8599832.
    View in: PubMed
  81. Parada N, Center DM, Berman JS. "Sarcoidosis" in Clinical Immunology. Principles and Practice. Robert R. Rich, ed. Mosby Year Book, Inc. New York, NY. 1996.
  82. Saukkonen JJ, Center DM. Contributions of T cells to Pulmonary Fibrosis. Pulmonary and Critical Care Pharmacology and Therapeutics, Leff, ed. Mosby. New York, NY. 1996.
  83. Laberge S, Cruikshank WW, Beer DJ, Center DM. Secretion of IL-16 (lymphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro. J Immunol. 1996 Jan 1; 156(1):310-5. PMID: 8598478.
    View in: PubMed
  84. Laberge S, Center DM. The Role of T cells in Asthma. Pulmonary and Critical Care Pharmacology and Therapeutics, Leff, ed. Mosby. New York, NY. 1996.
  85. Center DM. How to Respond to a Grant Review in Grant Writing:. Successful Techniques for Securing Pulmonary Funding, Martin, W.J. ed. Kendall/Hunt Publishing Co. Dubuque, Iowa. 1996; 77-80.
  86. Saukkonen J, Center DM. "Immunological Lung Diseases". In: Clinical Immunology: Principles and Practice. RR Rich, ed. Mosby Year Book, Inc. New York, NY. 1996.
  87. Cruikshank WW, Long A, Tarpy RE, Kornfeld H, Carroll MP, Teran L, Holgate ST, Center DM. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):738-47. PMID: 7576712.
    View in: PubMed
  88. Lazarus HM, Cruikshank WW, Narasimhan N, Kagan HM, Center DM. Induction of human monocyte motility by lysyl oxidase. Matrix Biol. 1995 Dec; 14(9):727-31. PMID: 8785587.
    View in: PubMed
  89. Tarpy R, Center DM. When should inhaled corticosteroids be started for asthma? Chest. 1995 Nov; 108(5):1188-90. PMID: 7587410.
    View in: PubMed
  90. Laberge S, Cruikshank WW, Kornfeld H, Center DM. Histamine-induced secretion of lymphocyte chemoattractant factor from CD8+ T cells is independent of transcription and translation. Evidence for constitutive protein synthesis and storage. J Immunol. 1995 Sep 15; 155(6):2902-10. PMID: 7673707.
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  91. Ryan TC, Cruikshank WW, Kornfeld H, Collins TL, Center DM. The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration. J Biol Chem. 1995 Jul 21; 270(29):17081-6. PMID: 7615501.
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  92. Wan HC, Lazarovits AI, Cruikshank WW, Kornfeld H, Center DM, Weller PF. Expression of alpha 4 beta 7 integrin on eosinophils and modulation of alpha 4-integrin-mediated eosinophil adhesion via CD4. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):343-4. PMID: 7613166.
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  93. Lim KG, Wan HC, Resnick M, Wong DT, Cruikshank WW, Kornfeld H, Center DM, Weller PF. Human eosinophils release the lymphocyte and eosinophil active cytokines, RANTES and lymphocyte chemoattractant factor. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):342. PMID: 7542086.
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  94. Center DM, Berman JS, Kornfeld H, Theodore AC, Cruikshank WW. The lymphocyte chemoattractant factor. J Lab Clin Med. 1995 Feb; 125(2):167-72. PMID: 7844466.
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  95. Center DM, Kornfeld H, Wu MJ, Falvo M, Theodore AC, Bernardo J, Berman JS, Cruikshank WW, Djukanovic R, Teran L, et al. Cytokine binding to CD4+ inflammatory cells: implications for asthma. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 2):S59-62. PMID: 7952594.
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  96. Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H. Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5109-13. PMID: 7910967.
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  97. Center DM, Berman JS, Kornfeld H, Theodore AC, Cruikshank WW. Mechanisms of lymphocyte accumulation in pulmonary disease. Chest. 1993 Feb; 103(2 Suppl):88S-91S. PMID: 8094048.
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  98. Brody JS, Center DM, Tkachuk V, eds. Signal Transduction in Lung Cells. Marcel Dekker, Inc. New York, NY. 1993.
  99. Masuyama J, Berman JS, Cruikshank WW, Morimoto C, Center DM. Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol. 1992 Mar 1; 148(5):1367-74. PMID: 1371526.
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  100. Rand TH, Cruikshank WW, Center DM, Weller PF. CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. J Exp Med. 1991 Jun 1; 173(6):1521-8. PMID: 1851800.
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  101. Cruikshank WW, Greenstein JL, Theodore AC, Center DM. Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes. J Immunol. 1991 May 1; 146(9):2928-34. PMID: 1673145.
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  102. Weller PF, Rand T, Cruikshank WW, Center DM . Eosinophil lymphocyte interactions and the pathogenesis of asthma. The Genetics of Asthma, Marsh, D., Lockhart, A., Holgate S.T., eds. Blackwell Scientific. Oxford. 1991.
  103. Berman JS, Beer DJ, Theodore AC, Kornfeld H, Bernardo J, Center DM. Lymphocyte recruitment to the lung. Am Rev Respir Dis. 1990 Jul; 142(1):238-57. PMID: 2195933.
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  104. Farber HW, Center DM, Rounds S, Danilov SM. Components of the angiotensin system cause release of a neutrophil chemoattractant from cultured bovine and human endothelial cells. Eur Heart J. 1990 Apr; 11 Suppl B:100-7. PMID: 2194806.
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  105. Cruikshank WW, Center DM, Pyle SW, Kornfeld H. Biologic activities of HIV-1 envelope glycoprotein: the effects of crosslinking. Biomed Pharmacother. 1990; 44(1):5-11. PMID: 1369693.
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  106. Pinkerton CA, Slack JD, Nasser WK, Center D, Pinto RP, Wilson K. Percutaneous coronary atherectomy: a preliminary report. Indiana Med. 1989 May; 82(5):358-61. PMID: 2754237.
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  107. Berman JS, Cruikshank WW, Beer DJ, Kornfeld H, Bernardo J, Theodore AC, Center DM. Lymphocyte motility and lymphocyte chemoattractant factors. Immunol Invest. 1988 Nov-Dec; 17(8-9):625-77. PMID: 3068125.
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  108. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. 1988 Sep 29; 335(6189):445-8. PMID: 2843775.
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  109. Tapson VF, Boni-Schnetzler M, Pilch PF, Center DM, Berman JS. Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro. J Clin Invest. 1988 Sep; 82(3):950-7. PMID: 3262126.
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  110. Farber HW, Center DM, Rounds S. Effect of ambient oxygen on cultured endothelial cells from different vascular beds. Am J Physiol. 1987 Oct; 253(4 Pt 2):H878-83. PMID: 3661737.
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  111. Cruikshank WW, Berman JS, Theodore AC, Bernardo J, Center DM. Lymphokine activation of T4+ T lymphocytes and monocytes. J Immunol. 1987 Jun 1; 138(11):3817-23. PMID: 3108375.
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  112. Berman JS, Center DM. Chemotactic activity of porcine insulin for human T lymphocytes in vitro. J Immunol. 1987 Apr 1; 138(7):2100-3. PMID: 3549897.
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  113. Farber HW, Weller PF, Rounds S, Beer DJ, Center DM. Generation of, lipid neutrophil chemoattractant activity by histamine-stimulated cultured endothelial cells. J Immunol. 1986 Nov 1; 137(9):2918-24. PMID: 3760577.
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  114. Theodore AC, Center DM, Cruikshank WW, Beer DJ. A human T-T-cell hybridoma-derived lymphocyte chemoattractant factor. Cell Immunol. 1986 Apr 1; 98(2):411-21. PMID: 3093096.
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  115. Kaelin RM, Center DM, Grant MM, Bernardo J. Production of lymphocyte chemokinetic activity by stimulated alveolar macrophages. Exp Lung Res. 1986; 10(2):171-86. PMID: 3082619.
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  116. Berman JS, Beer DJ, Bernardo J, Kornfeld H, Center DM. A proposed model for the accumulation of helper/inducer lymphocytes in sarcoidosis. The role of lymphocyte subset-specific chemoattractant lymphokines. Ann N Y Acad Sci. 1986; 465:98-109. PMID: 2942081.
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  117. Farber HW, Center DM, Rounds S. Bovine and human endothelial cell production of neutrophil chemoattractant activity in response to components of the angiotensin system. Circ Res. 1985 Dec; 57(6):898-902. PMID: 3905045.
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  118. Center D. Assessing the need for immunotherapy. Hosp Pract (Off Ed). 1985 Nov 30; 20(11A):40, 43, 46. PMID: 3934189.
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  119. Berman JS, Cruikshank WW, Center DM, Theodore AC, Beer DJ. Chemoattractant lymphokines specific for the helper/inducer T-lymphocyte subset. Cell Immunol. 1985 Oct 1; 95(1):105-12. PMID: 3161625.
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  120. Kornfeld H, Berman JS, Beer DJ, Center DM. Induction of human T lymphocyte motility by interleukin 2. J Immunol. 1985 Jun; 134(6):3887-90. PMID: 3157752.
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  121. McFadden R, Center DM. Protective Mechanisms of the Lung and Pleura. Pathologic Physiology, Seventh Edition, Sodeman (ed.). WB Saunders. Philadelphia. 1985.
  122. Berman JS, Beer DJ, Cruikshank WW, Center DM. Selective Production of Lymphocyte Chemoattractant Lymphokines with Histamine used as a Ligand: A strategy for the Purification of Lymphokines. In: Molecular and Cellular Biology of Lymphokines. C. Sorg and J.J. Oppenheim, eds. Academic Press. New York, NY. 1985.
  123. Kornfeld H, Berman JS, Beer DJ, Center DM. Interleukin 2 Stimulated Lymphocyte Migration. In: Molecular and Cellular Biology of Lymphokines. C. Sorg and J.J. Oppenheim, eds. Academic Press. New York, NY. 1985.
  124. Beer DJ, Cruikshank WW, Berman JS, Center DM. Histamine- induced Lymphokines Affecting T lymphocyte Motility. In: Frontiers in Histamine Research. Advances in the Biosciences, C.R. Gannelin and J.C. Schwartz, eds. Pergamon Press. Paris, France. 1985; 51.
  125. Hollingsworth H, Center DM. Neutrophil Chemotactic Factor in Aspirin Sensitive Asthma. Chest. 1985; 87:167- 168S.
  126. Kaelin RM, Semerjian A, Center DM, Bernardo J. Influence of ethanol on human T-lymphocyte migration. J Lab Clin Med. 1984 Nov; 104(5):752-60. PMID: 6092500.
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  127. Berman JS, McFadden RG, Cruikshank WW, Center DM, Beer DJ. Functional characteristics of histamine receptor-bearing mononuclear cells. II. Identification and characterization of two histamine-induced human lymphokines that inhibit lymphocyte migration. J Immunol. 1984 Sep; 133(3):1495-504. PMID: 6379050.
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  128. Hollingsworth HM, Downing ET, Braman SS, Glassroth J, Binder R, Center DM. Identification and characterization of neutrophil chemotactic activity in aspirin-induced asthma. Am Rev Respir Dis. 1984 Sep; 130(3):373-9. PMID: 6433757.
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  129. Glassroth JL, Bernardo J, Lucey EC, Center DM, Jung-Legg YJ, Snider GL. Interstitial pulmonary fibrosis induced in hamsters by intratracheally administered chrysotile asbestos. Histology, lung mechanics, and inflammatory events. Am Rev Respir Dis. 1984 Aug; 130(2):242-8. PMID: 6087700.
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  130. O'Brien RF, Seton MP, Makarski JS, Center DM, Rounds S. Thiourea causes endothelial cells in tissue culture to produce neutrophil chemoattractant activity. Am Rev Respir Dis. 1984 Jul; 130(1):103-9. PMID: 6430136.
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  131. McFadden RG, Cruikshank WW, Center DM. Modulation of lymphocyte migration by human lymphokines. III. Characterization of a lymphocyte migration inhibitory factor (LyMIF35K). Cell Immunol. 1984 Apr 15; 85(1):154-67. PMID: 6370461.
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  132. Hollingsworth H, Glassroth J, Binder RG, Downing ET, Braman SS, Center DM. Dissociation of Release of Mast Cell Derived Neutrophil Chemotactic Factor and Bronchospasm in Aspirin Sensitive Asthmatics. Am. Rev. Respir. Dis. 1984; 130:373-379.
  133. Center DM, Cruikshank WW, Berman JS, Beer DJ. Functional characteristics of histamine receptor-bearing mononuclear cells. I. Selective production of lymphocyte chemoattractant lymphokines with histamine used as a ligand. J Immunol. 1983 Oct; 131(4):1854-9. PMID: 6352807.
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  134. Center DM, Wintroub BU, Austen KF. Identification of chemoattractant activity for lymphocytes in blister fluid of patients with bullous pemphigoid: evidence for the presence of a lymphokine. J Invest Dermatol. 1983 Sep; 81(3):204-8. PMID: 6350481.
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  135. Kaelin RM, Center DM, Bernardo J, Grant M, Snider GL. The role of macrophage-derived chemoattractant activities in the early inflammatory events of bleomycin-induced pulmonary injury. Am Rev Respir Dis. 1983 Jul; 128(1):132-7. PMID: 6191602.
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  136. Weller PF, Center DM. Pneumonic Infections Due to Metazoan and Protozoan Parasites, B. Fields and L. Weinstein (eds.). Seminars in Infectious Disease. Thieme Stratton, Inc. New York, NY. 1983.
  137. Center DM. Asthma. Medicine: Essentials of Clinical Practice, Third Edition, R.W. Wilkins and N.G. Levinsky (eds.). Little, Brown and Co. Boston, MA. 1983.
  138. Center DM. Identification of rat mast cell--derived chemoattractant factors for lymphocytes. J Allergy Clin Immunol. 1983 Jan; 71(1 Pt 1):29-35. PMID: 6600464.
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  139. Center DM. Allergic Diseases. Medicine: Essentials of Clinical Practice, Third Edition, R.W. Wilkins and N.G. Levinsky (eds.). Little, Brown and Co. Boston, MA. 1983.
  140. Cruikshank W, Center DM. Modulation of lymphocyte migration by human lymphokines. II. Purification of a lymphotactic factor (LCF). J Immunol. 1982 Jun; 128(6):2569-74. PMID: 7042841.
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  141. Center DM, Cruikshank W. Modulation of lymphocyte migration by human lymphokines. I. Identification and characterization of chemoattractant activity for lymphocytes from mitogen-stimulated mononuclear cells. J Immunol. 1982 Jun; 128(6):2563-8. PMID: 7042840.
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  142. Czop JK, McGowan SE, Center DM. Opsonin-independent phagocytosis by human alveolar macrophages: augmentation by human plasma fibronectin. Am Rev Respir Dis. 1982 May; 125(5):607-9. PMID: 7081821.
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  143. Bernardo J, Center DM. Hypersensitivity pneumonia. Dis Mon. 1981 May; 27(8):1-64. PMID: 6909070.
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  144. Beer DJ, Center DM. The Control of Bronchomotor Tone. Current Topics in the Management of Respiratory Disease, G.L. Snider and J.S. Brody (eds). Churchill Livingstone, Inc. New York, NY. 1981.
  145. Beer DJ, Center DM. In vitro corticosteroid modulation of lymphocyte migration. Cell Immunol. 1980 Oct; 55(2):381-93. PMID: 6968631.
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  146. Wasserman SI, Center DM. The relevance of neutrophil chemotactic factors to allergic disease. J Allergy Clin Immunol. 1979 Oct; 64(4):231-4. PMID: 479473.
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  147. Center DM, Soter NA, Wasserman SI, Austen KF. Inhibition of neutrophil chemotaxis in association with experimental angioedema in patients with cold urticaria: a model of chemotactic deactivation in vivo. Clin Exp Immunol. 1979 Jan; 35(1):112-8. PMID: 428142.
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  148. Center DM, Wasserman SI, Austen KF. Alteration of rat splenic lymphocyte migration in vitro by the state of microtubule integrity. Cell Immunol. 1978 Sep; 39(2):325-35. PMID: 568036.
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  149. Center DM, Austen KF, Wintroub BU. Identification of chemoattractant activity for lymphocytes in bullous pemphigoid bullous fluid. Trans Assoc Am Physicians. 1978; 91:242-52. PMID: 382589.
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  150. Wasserman SI, Soter NA, Center DM, Austen KF. Cold urticaria. Recognition and characterization of a neutrophil chemotactic factor which appears in serum during experimental cold challenge. J Clin Invest. 1977 Jul; 60(1):189-96. PMID: 874083.
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