Konstantinos Alysandratos, MD, PHD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Athens
PhD, University of Athens



Dr. Konstantinos D. Alysandratos, MD, PhD is an Assistant Professor in the Department of Medicine at Chobanian and Avedisian School of Medicine and is part of the team at the Center for Regenerative Medicine at Boston University as part of Dr. Darrell N. Kotton’s lab. He received his Doctorate of Medicine from the University of Athens and embarked on his research journey after winning a competitive 3-year scholarship from the Hellenic State Scholarships Foundation. As part of his doctoral work under the mentorship of Dr. Theoharides at Tufts University, he studied the interplay between neuropeptides and cytokines in the pathogenesis of atopic dermatitis and their role on mast cell activation. He has also contributed to translational discoveries relating to mast cell activation in neurodevelopmental disorders such as autism spectrum disorders that may inform novel therapeutic approaches. Dr. Alysandratos completed his internal medicine training at UT Southwestern Medical Center, during which time he developed his passion for intensive and pulmonary care.

Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis
01/01/2023 - 12/31/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
1K08HL163494-01A1

Utilizing a pluripotent stem cell model system to unravel the pathogenesis of pulmonary fibrosis
07/01/2018 - 06/30/2020 (PI)
Pulmonary Fibrosis Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595.View Related Profiles. PMID: 29657097; PMCID: PMC5995784; DOI: 10.1016/j.stemcr.2018.03.013;
     
  2. Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893.View Related Profiles. PMID: 28947536; PMCID: PMC5702071; DOI: 10.1242/dev.150193;
     
  3. Alysandratos KD, Serra M, Mulugeta S, Beers MF, Kotton DN. Am J Respi Crit Care Med. Deriving alveolar type 2 cells from pluripotent stem cells to model surfactant protein C (SP-C) mutations in vitro. 2017; 195:A4317.
  4. Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. PMID: 26525562; PMCID: PMC5121080; DOI: 10.1007/s00394-015-1066-z;
     
  5. Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 2013 Sep; 169(3):695-9. PMID: 24033157; DOI: 10.1111/bjd.12413;
     
  6. Asadi S, Zhang B, Alysandratos KD, Angelidou A, Vasiadi M, Theoharides TC. J Allergy Clin Immunol. Substance P (SP) induces expression of functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in human mast cells. 2011; 127(2 suppl):AB162.
  7. Theoharides TC, Angelidou A, Alysandratos KD, Asadi S, Francis K, Lykouras L, Kalogeromitros D. Autism- A Neurodevelopmental Journey from Genes to Behaviour (Eapen V, Ed.). Perinatal immune activation and risk of autism. Intech Open Access Publisher. Rijeka, Croatia. 2011; 267-88.
  8. Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2012 Jan; 1822(1):34-41.View Related Profiles. PMID: 21193035; DOI: 10.1016/j.bbadis.2010.12.017;
     
  9. Zhang BD, Angelidou A, Alysandratos KD, Tagen M, Kempuraj D, Asadi S, Theoharides TC. FASEB J. Human mast cell degranulation is distinguished from selective secretion of TNF through intracellular calcium, energy and mitochondrial morphology dynamics. 2010; 24:996.3.
  10. Zhang BD, Alysandratos KD, Angelidou A, Vasiadi M, Kempuraj D, Tagen M, Asadi S, Theoharides TC. J Immunol. TNF secretion from human mast cells is regulated by mitochondrial dynamics and mitochondrial uncoupling protein 2 (UCP 2). 2010; 184:135.11.
Showing 10 of 11 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 11 publications over 6 distinct years, with a maximum of 4 publications in 2010

YearPublications
20104
20112
20131
20151
20172
20181


Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases

Genetic Engineering and Biotechnology News 9/1/2021

2018 American Lung Association (ALA): Basic Science Award – 1st Place, Massachusetts Pulmonary Section
2017 6th Annual CTSI Translational Science Symposium: Exceptional poster presentation – 3rd prize award
2017 Annual Meeting of the Massachusetts Pulmonary Section American Lung Association (ALA): Best Case Presentation Award
2017 American Thoracic Society National Meeting: ATS Fellows Track Symposium Award
2013 Alpha Omega Alpha
2009 Hellenic State Scholarships Foundation: Graduate Scholarship for Studies Abroad
2007 Hellenic State Scholarships Foundation: Academic Performance Award
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Pathogenesis of familial interstitial lung diseases
IPF
Idiopathic Pulmonary Fibrosis
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