Ricardo da Costa e Sousa

Ricardo Sousa, DVM, MS, DSc

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Endocrinology, Diabetes, Nutrition & Weight Management

PhD, Federal University of Rio De Janeiro
DVM, Federal University of Rio De Janeiro
MSc, Federal University of Rio De Janeiro

Websites

Weill Cornell Medicine

ORCID : 0000-0002-0443-6392

Dr. Ricardo da Costa e Sousa has a broad background in Physiology and Basic Medical Research, with special expertise in Neuroendocrinology. During his Doctorate he has studied how the hypothalamus controls TSH secretion and thyroid activity, focusing on the role of NPY receptors. He further deepened his research on the hypothalamic-pituitary-axis during his postdoc, studying thyroid hormones action in the pituitary and the regulation of TRH neurons. His research has contributed to our current understanding of how the brain controls the thyroid as well as how thyroid hormones acts in different tissues.

In 2019, he joined the Division of Endocrinology, Diabetes and Metabolism at Weill Cornell Medicine to study how specific subpopulations of hypothalamic neurons control the HPT axis, as well as how thyroid hormones act in the hypothalamus. Recent data his team generated is promising and has the potential to change paradigms in the field. He became an Assistant Professor at Boston University in 2022. Currently, his research interest is focused on the neuroendocrine control of thyroid hormones and metabolism.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Costa-E-Sousa RH, Rorato R, Hollenberg AN, Vella KR. Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. Thyroid. 2023 Jul; 33(7):867-876.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 37166378; PMCID: PMC10354708; DOI: 10.1089/thy.2023.0173;

Calvino C, Império GE, Wilieman M, Costa-E-Sousa RH, Souza LL, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Thyroid. 2016 Jan; 26(1):134-43. PMID: 26538454; DOI: 10.1089/thy.2015.0384;

Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24713658; PMCID: PMC4001554; DOI: 10.1172/JCI73419;

Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24550004; PMCID: PMC3993596; DOI: 10.1128/MCB.00129-14;

Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN. Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 24288132; PMCID: PMC3894317; DOI: 10.1074/jbc.M113.521450;

Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 22878400; PMCID: PMC3512014; DOI: 10.1210/en.2012-1504;

Calvino C, Souza LL, Costa-e-Sousa RH, Almeida NA, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action. J Endocrinol. 2012 Oct; 215(1):129-35. PMID: 22875962; DOI: 10.1530/JOE-11-0476;

Costa-e-Sousa RH, Hollenberg AN. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012 Sep; 153(9):4128-35.View Related Profiles.

Hollenberg, Anthony
da Costa e Sousa, Ricardo

PMID: 22759379; PMCID: PMC3423621; DOI: 10.1210/en.2012-1467;

Fidelis-de-Oliveira P, Werneck-de-Castro JP, Pinho-Ribeiro V, Shalom BC, Nascimento-Silva JH, Costa e Souza RH, Cruz IS, Rangel RR, Goldenberg RC, Campos-de-Carvalho AC. Soluble factors from multipotent mesenchymal stromal cells have antinecrotic effect on cardiomyocytes in vitro and improve cardiac function in infarcted rat hearts. Cell Transplant. 2012; 21(5):1011-21. PMID: 22305373; DOI: 10.3727/096368911X623916;

Costa-e-Sousa RH, Souza LL, Calviño C, Cabanelas A, Almeida NA, Oliveira KJ, Pazos-Moura CC. Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul Pept. 2011 Nov 10; 171(1-3):43-7. PMID: 21771616; DOI: 10.1016/j.regpep.2011.07.001;

Showing 10 of 31 results. Show More

Araujo IG, Trindade DC, Mecawi AS, Sonoda-Côrtes R, Werneck-de-Castro JP, Costa-E-Sousa RH, Reis LC, Olivares EL. Inhibition of brain renin-angiotensin system improves diastolic cardiac function following myocardial infarction in rats. Clin Exp Pharmacol Physiol. 2009 Aug; 36(8):803-9. PMID: 19215232; DOI: 10.1111/j.1440-1681.2009.05159.x;

da Veiga MA, Fonseca Bloise F, Costa-E-Sousa RH, Souza LL, Almeida NA, Oliveira KJ, Pazos-Moura CC. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. J Endocrinol. 2008 Nov; 199(2):235-42. PMID: 18755884; DOI: 10.1677/JOE-08-0380;

Miranda A, Costa-e-Sousa RH, Werneck-de-Castro JP, Mattos EC, Olivares EL, Ribeiro VP, Silva MG, Goldenberg RC, Campos-de-Carvalho AC. Time course of echocardiographic and electrocardiographic parameters in myocardial infarct in rats. An Acad Bras Cienc. 2007 Dec; 79(4):639-48. PMID: 18066433; DOI: 10.1590/s0001-37652007000400006;

Cedraz-Mercez PL, Almeida AC, Thomaz CM, Costa-e-Sousa RH, Olivares EL, Côrtes WS, Medeiros MA, Reis LC. Effect of L-5-Hydroxytryptophan on drinking behavior in Coturnix japonica (Temminck and Schlegel, 1849) (Galliformes: Aves): involvement of renin-angiotensin system. Braz J Biol. 2007 Nov; 67(4):771-6. PMID: 18278334; DOI: 10.1590/s1519-69842007000400027;

Olivares EL, Marassi MP, Fortunato RS, da Silva AC, Costa-e-Sousa RH, Araújo IG, Mattos EC, Masuda MO, Mulcahey MA, Huang SA, Bianco AC, Carvalho DP. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology. 2007 Oct; 148(10):4786-92. PMID: 17628010

Cedraz-Mercez PL, Mecawi AS, Lepletier A, Araújo IG, Costa-e-Sousa RH, Rocha FF, Olivares EL, Medeiros MA, Reis LC. Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats. Exp Physiol. 2007 Sep; 92(5):923-31. PMID: 17591682; DOI: 10.1113/expphysiol.2007.037317;

de Magalhães-Nunes AP, Badauê-Passos D, Ventura RR, Guedes Dda S, Araújo JP, Granadeiro PC, Milanez-Barbosa HK, da Costa-e-Sousa RH, de Medeiros MA, Antunes-Rodrigues J, Reis LC. Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats. Exp Physiol. 2007 Sep; 92(5):913-22. PMID: 17573416; DOI: 10.1113/expphysiol.2007.037358;

Trindade DC, Trindade RC, Marassi MP, Martins OP, Costa-e-Sousa RH, Mattos EC, Marinho A, Reis LC, Olivares EL. Role of renin-angiotensin system in development of heart failure induced by myocardial infarction in rats. An Acad Bras Cienc. 2007 06; 79(2):251-9. PMID: 17625680; DOI: 10.1590/s0001-37652007000200008;

Olivares EL, Costa-E-Sousa RH, Werneck-de-Castro JP, Pinho-Ribeiro V, Silva MG, Ribeiro KC, Mattos EC, Goldenberg RC, Campos de Carvalho AC, Masuda MO. Cellular cardiomyoplasty in large myocardial infarction: can the beneficial effect be enhanced by ACE-inhibitor therapy? Eur J Heart Fail. 2007 Jun-Jul; 9(6-7):558-67. PMID: 17398154; DOI: 10.1016/j.ejheart.2007.02.003;

Oliveira KJ, Paula GS, Costa-e-Sousa RH, Souza LL, Moraes DC, Curty FH, Pazos-Moura CC. Peptide YY (PYY)3-36 modulates thyrotropin secretion in rats. J Endocrinol. 2006 Nov; 191(2):459-63. PMID: 17088415; DOI: 10.1677/joe.1.06784;

Werneck-de-Castro JP, Costa-E-Sousa RH, de Oliveira PF, Pinho-Ribeiro V, Mello DB, Peçanha R, Mattos E, Olivares EL, Maia AC, Mill JG, Dos Santos Goldenberg RC, Campos-de-Carvalho AC. G-CSF does not improve systolic function in a rat model of acute myocardial infarction. Basic Res Cardiol. 2006 Nov; 101(6):494-501. PMID: 16783485; DOI: 10.1007/s00395-006-0605-4;

Ribeiro KC, Mattos EC, Werneck-de-Castro JPS, Ribeiro VP, Costa-E-Sousa RH, Miranda A, Olivares EL, Farina M, Mill JG, Dos Santos Goldenberg RC, Masuda MO, de Carvalho ACC. Ectopic Ossification in the Scar Tissue of Rats with Myocardial Infarction. Cell Transplant. 2006 May; 15(5):389-397. PMID: 28871866; DOI: 10.3727/000000006783981864;

Ribeiro KC, Mattos EC, Werneck-de-castro JP, Ribeiro VP, Costa-e-Sousa RH, Miranda A, Olivares EL, Farina M, Mill JG, Goldenberg JR, Masuda MO, de Carvalho AC. Ectopic ossification in the scar tissue of rats with myocardial infarction. Cell Transplant. 2006; 15(5):389-97. PMID: 16970281

Pereira-Junior PP, Chaves EA, Costa-E-Sousa RH, Masuda MO, de Carvalho AC, Nascimento JH. Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid. Eur J Appl Physiol. 2006 Mar; 96(5):487-94. PMID: 16344939; DOI: 10.1007/s00421-005-0111-7;

Cedraz-Mercez PL, Almeida AC, Costa-e-Sousa RH, Badauê-Passos Júnior D, Castilhos LR, Olivares EL, Marinho Júnior A, Medeiros MA, Reis LC. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Braz J Biol. 2005 Nov; 65(4):589-95. PMID: 16532182; DOI: 10.1590/s1519-69842005000400005;

Cavalcante-Lima HR, Badauê-Passos D, de-Lucca W, Lima HR, Costa-e-Sousa RH, Olivares EL, Cedraz-Mercez PL, Reis RO, Medeiros MA, Côrtes WS, Reis LC. Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite. Braz J Med Biol Res. 2005 Nov; 38(11):1669-75. PMID: 16258637; DOI: 10.1590/s0100-879x2005001100015;

Costa-E-Sousa RH, Pereira-Junior PP, Oliveira PF, Olivares EL, Werneck-de-Castro JP, Mello DB, Nascimento JH, Campos-de-Carvalho AC. Cardiac effects of oxytocin: is there a role for this peptide in cardiovascular homeostasis? Regul Pept. 2005 Dec 15; 132(1-3):107-12. PMID: 16213606; DOI: 10.1016/j.regpep.2005.09.011;

Medeiros MA, Costa-e-Sousa RH, Olivares EL, Côrtes WS, Reis LC. A reassessment of the role of serotonergic system in the control of feeding behavior. An Acad Bras Cienc. 2005 Mar; 77(1):103-11. PMID: 15692681; DOI: 10.1590/s0001-37652005000100008;

Cavalcante-Lima HR, Lima HR, Costa-e-Sousa RH, Olivares EL, Cedraz-Mercez PL, Reis RO, Badauê-Passos D, De-Lucca W, de Medeiros MA, Côrtes Wda S, Reis LC. Dipsogenic stimulation in ibotenic DRN-lesioned rats induces concomitant sodium appetite. Neurosci Lett. 2005 Feb 01; 374(1):5-10. PMID: 15631886; DOI: 10.1016/j.neulet.2004.10.017;

Lima HR, Cavalcante-Lima HR, Cedraz-Mercez PL, Costa-E-Sousa RH, Olivares EL, Badauê-Passos D, Medeiros MA, Côrtes WS, Reis LC. Brain serotonin depletion enhances the sodium appetite induced by sodium depletion or beta-adrenergic stimulation. An Acad Bras Cienc. 2004 Mar; 76(1):85-92. PMID: 15048197; DOI: 10.1590/s0001-37652004000100008;

Olivares EL, Costa-E-Sousa RH, Cavalcante-Lima HR, Lima HR, Cedraz-Mercez PL, Reis LC. Effect of electrolytic lesion of the dorsal raphe nucleus on water intake and sodium appetite. Braz J Med Biol Res. 2003 Dec; 36(12):1709-16. PMID: 14666256; DOI: 10.1590/s0100-879x2003001200013;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 31 publications over 13 distinct years, with a maximum of 7 publications in 2007