Anthony Hollenberg, MD
John Wade Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine

MD, University of Calgary



The focus of my research program is the thyroid with a focus on the role of gland development and the actions of its hormones. To accomplish these goals we have built a unique program in thyroid gland development from endoderm in order to derive new therapies for hypothyroidism. Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. Furthermore, we have used our understanding of thyroid hormone signaling to identify new biomarkers of its action.

My laboratory has a long-standing interest in how thyroid hormone mediates its effects in context of genomic regulation. Specifically we were amongst the first to begin to differentiate how thyroid hormone is able to stimulate both positive and negative gene regulation. Studies in this area allowed us to be able to characterize the interaction of the thyroid hormone receptor with its cofactors which are necessary for genomic regulation.

We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. This has important ramifications for thyroid/steroid action in general. Furthermore these studies have allowed us to better understand the specificity of coregulator interactions with the thyroid hormone receptor and their role in disease.

In addition to our work on thyroid hormone action we have also had a long standing interest in the intersection of the regulation of biomarkers of thyroid hormone action including the regulation of the hypothalamic pituitary thyroid axis by thyroid hormone and other metabolic pathways. Our work has demonstrated that these pathways and others are linked at the molecular and physiological level. Furthermore, they must be considered when trying to understand the effects of thyroid hormone signaling.

Most recently, because of our interest in defining the etiology of the set point of the HPT axis, we became interested in creating a durable thyroid follicular cell model. To accomplish this we began a complete collaboration with the Kotton laboratory at Boston University and have successfully developed the molecular paradigm to develop thyroid follicular cells from ESCs or IPSCs across multiple species. Additionally we have established that these derived cells function in vivo.

Chair
Boston University Chobanian & Avedisian School of Medicine
Medicine


Physician-in-Chief
Boston Medical Center






Title


Yr Title Project-Sub Proj Pubs
2022 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-04
2022 Thyroid Follicular Cell Signaling and Development in Humans 5R01DK105029-07
2022 Corepressor regulation of nuclear receptor action 5R01DK056123-21
2021 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-03
2021 Thyroid Follicular Cell Signaling and Development in Humans 2R01DK105029-06 6
2021 Corepressor regulation of nuclear receptor action 5R01DK056123-20 38
2020 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-02
2020 Corepressor regulation of nuclear receptor action 2R01DK056123-19A1 38
2019 Thyroid Hormone Signaling in Human Hepatocytes 1R01DK117940-01A1
2019 Thyroid Follicular Cell Development in Mice and Humans 5R01DK105029-05 6
Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bredella MA, McGroarty KM, Kolessin L, Bard LF, Hollenberg AN, Rutkove SB. Impact of the KL2/Catalyst Medical Research Investigator Training (CMeRIT) Program on the careers of early-stage clinical and translational investigators. J Clin Transl Sci. 2022; 6(1):e16. PMID: 35291214; PMCID: PMC8889229; DOI: 10.1017/cts.2022.7;
     
  2. Mendoza A, Tang C, Choi J, Acuña M, Logan M, Martin AG, Al-Sowaimel L, Desai BN, Tenen DE, Jacobs C, Lyubetskaya A, Fu Y, Liu H, Tsai L, Cohen DE, Forrest D, Wilson AA, Hollenberg AN. Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. Sci Signal. 2021 11 16; 14(709):eabh3839.View Related Profiles. PMID: 34784250; PMCID: PMC8853622; DOI: 10.1126/scisignal.abh3839;
     
  3. Vella KR, Hollenberg AN. Early Life Stress Affects the HPT Axis Response in a Sexually Dimorphic Manner. Endocrinology. 2021 09 01; 162(9). PMID: 34214171; PMCID: PMC8315292; DOI: 10.1210/endocr/bqab137;
     
  4. Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg AN. Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Mol Metab. 2021 11; 53:101315. PMID: 34390859; PMCID: PMC8429965; DOI: 10.1016/j.molmet.2021.101315;
     
  5. Finn PW, Abel D, Amin A, Anderson ME, Carethers JM, Coleman DL, Curtis AB, Geraci MW, Gladwin MT, Hollenberg A, Parmacek MS, Robbins RJ. Voices for Social Justice and Against Racism: An AAIM Perspective. Am J Med. 2021 07; 134(7):930-934.View Related Profiles. PMID: 33848502
     
  6. Posabella A, Alber AB, Undeutsch HJ, Droeser RA, Hollenberg AN, Ikonomou L, Kotton DN. Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Front Endocrinol (Lausanne). 2021; 12:666565.View Related Profiles. PMID: 33959101; PMCID: PMC8095374; DOI: 10.3389/fendo.2021.666565;
     
  7. Major-Pedersen A, McCullen MK, Sabol ME, Adetunji O, Massaro J, Neugut AI, Sosa JA, Hollenberg AN. A joint industry-sponsored data monitoring committee model for observational, retrospective drug safety studies in the real-world setting. Pharmacoepidemiol Drug Saf. 2021 01; 30(1):9-16.View Related Profiles. PMID: 33179845; PMCID: PMC8247341; DOI: 10.1002/pds.5172;
     
  8. Kahn JH, Goddi A, Sharma A, Heiman J, Carmona A, Li Y, Hoffman A, Schoenfelt K, Ye H, Bobe AM, Becker L, Hollenberg AN, Cohen RN. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10). PMID: 32770234; PMCID: PMC7478322; DOI: 10.1210/endocr/bqaa132;
     
  9. Gulick RM, Sobieszczyk ME, Landry DW, Hollenberg AN. Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City. J Clin Invest. 2020 09 01; 130(9):4522-4524. PMID: 32692726; PMCID: PMC7456231; DOI: 10.1172/JCI142151;
     
  10. Ritter MJ, Amano I, Hollenberg AN. Thyroid Hormone Signaling and the Liver. Hepatology. 2020 08; 72(2):742-752. PMID: 32343421; DOI: 10.1002/hep.31296;
     
Showing 10 of 125 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 125 publications over 33 distinct years, with a maximum of 10 publications in 2017

YearPublications
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2018 Weill Cornell Medical College: Sanford I. Weill Chair of Medicine
2018 New York-Presbyterian Hospital-Weill Cornell Medical Center: Physician-in-Chief
2018 American Thyroid Association: Sidney Ingbar Award
2011-2018 Beth Israel Deaconess Medical Center: Chief, Division of Endocrinology, Diabetes and Metabolism
2008 Harvard University: Honorary Phi Beta Kappa member
2000-2018 Beth Israel Deaconess Medical Center: Chief, Thyroid Unit
2000 American Thyroid Association: Van Meter Award
1998 Harvard University: Milton Award
Contact for Mentoring:

72 East Concord Street, Evans 113
Boston MA 02118-2308
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617.358.3509 (fax)

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