Anthony Hollenberg, MD
John Wade Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine

MD, University of Calgary
AB, Harvard College



The focus of my research program is the thyroid with a focus on the role of gland development and the actions of its hormones. To accomplish these goals we have built a unique program in thyroid gland development from endoderm in order to derive new therapies for hypothyroidism. Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. Furthermore, we have used our understanding of thyroid hormone signaling to identify new biomarkers of its action.

My laboratory has a long-standing interest in how thyroid hormone mediates its effects in context of genomic regulation. Specifically we were amongst the first to begin to differentiate how thyroid hormone is able to stimulate both positive and negative gene regulation. Studies in this area allowed us to be able to characterize the interaction of the thyroid hormone receptor with its cofactors which are necessary for genomic regulation.

We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. This has important ramifications for thyroid/steroid action in general. Furthermore these studies have allowed us to better understand the specificity of coregulator interactions with the thyroid hormone receptor and their role in disease.

In addition to our work on thyroid hormone action we have also had a long standing interest in the intersection of the regulation of biomarkers of thyroid hormone action including the regulation of the hypothalamic pituitary thyroid axis by thyroid hormone and other metabolic pathways. Our work has demonstrated that these pathways and others are linked at the molecular and physiological level. Furthermore, they must be considered when trying to understand the effects of thyroid hormone signaling.

Most recently, because of our interest in defining the etiology of the set point of the HPT axis, we became interested in creating a durable thyroid follicular cell model. To accomplish this we began a complete collaboration with the Kotton laboratory at Boston University and have successfully developed the molecular paradigm to develop thyroid follicular cells from ESCs or IPSCs across multiple species. Additionally we have established that these derived cells function in vivo.

Chair
Boston University Chobanian & Avedisian School of Medicine
Medicine


Physician-in-Chief
Boston Medical Center




Thyroid Follicular Cell Signaling and Development in Humans
05/01/2023 - 04/30/2025 (Multi-PI)
PI: Anthony Hollenberg, MD
NIH/National Diabetes & Digestive & Kidney Diseases
7R01DK105029-08

Master Faculty and Staff Support Contract-VA Center for Healthcare Organization and Implementation Research
04/14/2022 - 03/15/2024 (PI)
Department of Veterans Affairs


Thyroid Hormone Signaling in Human Hepatocytes
06/30/2023 - 01/31/2024 (Multi-PI)
PI: Anthony Hollenberg, MD
NIH/National Diabetes & Digestive & Kidney Diseases
7R01DK117940-05

Corepressor regulation of nuclear receptor action
01/01/2023 - 12/31/2023 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7R01DK056123-22



Title


Yr Title Project-Sub Proj Pubs
2023 Hypothalamic regulation by thyroid hormone receptor phosphorylation 1R01DK136661-01
2023 Thyroid Follicular Cell Signaling and Development in Humans 7R01DK105029-08
2023 Corepressor regulation of nuclear receptor action 7R01DK056123-22
2022 Thyroid Hormone Signaling in Human Hepatocytes 7R01DK117940-05
2022 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-04
2022 Thyroid Follicular Cell Signaling and Development in Humans 5R01DK105029-07
2022 Corepressor regulation of nuclear receptor action 5R01DK056123-21
2021 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-03
2021 Thyroid Follicular Cell Signaling and Development in Humans 2R01DK105029-06 6
2021 Corepressor regulation of nuclear receptor action 5R01DK056123-20 38
Showing 10 of 56 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Cho YW, Fu Y, Huang CJ, Wu X, Ng L, Kelley KA, Vella KR, Berg AH, Hollenberg AN, Liu H, Forrest D. Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland. Commun Biol. 2023 Dec 11; 6(1):1253. PMID: 38081939; PMCID: PMC10713718; DOI: 10.1038/s42003-023-05546-y;
     
  2. Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA, Korach KS, Cain DW, Hollenberg AN, Webb P, Forrest D, Jetten AM, Edwards DP, Grimm SL, Hartig S, Lange CA, Richer JK, Sartorius CA, Tetel M, Billon C, Elgendy B, Hegazy L, Griffett K, Peinetti N, Burnstein KL, Hughes TS, Sitaula S, Stayrook KR, Culver A, Murray MH, Finck BN, Cidlowski JA. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. Pharmacol Rev. 2023 Nov; 75(6):1233-1318. PMID: 37586884; PMCID: PMC10595025; DOI: 10.1124/pharmrev.121.000436;
     
  3. Hu Y, Bruinstroop E, Hollenberg AN, Fliers E, Boelen A. The role of WD40 repeat-containing proteins in endocrine (dys)function. J Mol Endocrinol. 2023 Jul 01; 71(1). PMID: 37256579
     
  4. Costa-E-Sousa RH, Rorato R, Hollenberg AN, Vella KR. Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. Thyroid. 2023 Jul; 33(7):867-876.View Related Profiles. PMID: 37166378; PMCID: PMC10354708; DOI: 10.1089/thy.2023.0173;
     
  5. Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775.View Related Profiles. PMID: 36476855; PMCID: PMC9780780; DOI: 10.1016/j.celrep.2022.111775;
     
  6. Shimizu H, Horibata Y, Amano I, Ritter MJ, Domae M, Ando H, Sugimoto H, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT acts as a strong regulator of both ß-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. PLoS One. 2022; 17(12):e0277830.View Related Profiles. PMID: 36454860; PMCID: PMC9714868; DOI: 10.1371/journal.pone.0277830;
     
  7. Bredella MA, McGroarty KM, Kolessin L, Bard LF, Hollenberg AN, Rutkove SB. Impact of the KL2/Catalyst Medical Research Investigator Training (CMeRIT) Program on the careers of early-stage clinical and translational investigators. J Clin Transl Sci. 2022; 6(1):e16. PMID: 35291214; PMCID: PMC8889229; DOI: 10.1017/cts.2022.7;
     
  8. Mendoza A, Tang C, Choi J, Acuña M, Logan M, Martin AG, Al-Sowaimel L, Desai BN, Tenen DE, Jacobs C, Lyubetskaya A, Fu Y, Liu H, Tsai L, Cohen DE, Forrest D, Wilson AA, Hollenberg AN. Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. Sci Signal. 2021 11 16; 14(709):eabh3839.View Related Profiles. PMID: 34784250; PMCID: PMC8853622; DOI: 10.1126/scisignal.abh3839;
     
  9. Vella KR, Hollenberg AN. Early Life Stress Affects the HPT Axis Response in a Sexually Dimorphic Manner. Endocrinology. 2021 09 01; 162(9). PMID: 34214171; PMCID: PMC8315292; DOI: 10.1210/endocr/bqab137;
     
  10. Ritter MJ, Amano I, Imai N, Soares De Oliveira L, Vella KR, Hollenberg AN. Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Mol Metab. 2021 11; 53:101315.View Related Profiles. PMID: 34390859; PMCID: PMC8429965; DOI: 10.1016/j.molmet.2021.101315;
     
Showing 10 of 131 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 131 publications over 34 distinct years, with a maximum of 10 publications in 2017

YearPublications
19841
19911
19921
19932
19943
19952
19962
19975
19982
19992
20005
20013
20024
20037
20046
20051
20061
20071
20084
20095
20104
20115
20126
20138
20144
20156
20165
201710
20183
20195
20205
20215
20223
20234

2018 Weill Cornell Medical College: Sanford I. Weill Chair of Medicine
2018 New York-Presbyterian Hospital-Weill Cornell Medical Center: Physician-in-Chief
2018 American Thyroid Association: Sidney Ingbar Award
2011-2018 Beth Israel Deaconess Medical Center: Chief, Division of Endocrinology, Diabetes and Metabolism
2008 Harvard University: Honorary Phi Beta Kappa member
2000-2018 Beth Israel Deaconess Medical Center: Chief, Thyroid Unit
2000 American Thyroid Association: Van Meter Award
1998 Harvard University: Milton Award
Contact for Mentoring:

72 East Concord Street, Evans 113
Boston MA 02118-2308
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617.358.3509 (fax)

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