Rhiannon Bree Werder | Profiles RNS

Rhiannon Bree Werder, PhD

Postdoctoral Fellow (previously held)

Boston University

Center for Regenerative Medicine

Websites

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	Loop Profile
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ORCID : 0000-0002-6432-4587

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Turner DL, Amoozadeh S, Baric H, Stanley E, Werder RB. Building a human lung from pluripotent stem cells to model respiratory viral infections. Respir Res. 2024 Jul 15; 25(1):277. PMID: 39010108; PMCID: PMC11251358; DOI: 10.1186/s12931-024-02912-0;

Werder RB, Zhou X, Cho MH, Wilson AA. Breathing new life into the study of COPD with genes identified from genome-wide association studies. Eur Respir Rev. 2024 Apr 30; 33(172).View Related Profiles.

Wilson, Andrew
Werder, Rhiannon Bree

PMID: 38811034; PMCID: PMC11134200; DOI: 10.1183/16000617.0019-2024;

Guo F, Zhang L, Yu Y, Gong L, Tao S, Werder RB, Mishra S, Zhou Y, Anamika WJ, Lao T, Inuzuka H, Zhang Y, Pham B, Liu T, Tufenkjian TS, Richmond BW, Wei W, Mou H, Wilson AA, Hu M, Chen W, Zhou X. Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells. EBioMedicine. 2024 Mar; 101:105026.View Related Profiles.

Wilson, Andrew
Werder, Rhiannon Bree

PMID: 38417378; PMCID: PMC10944180; DOI: 10.1016/j.ebiom.2024.105026;

Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Werder, Rhiannon Bree
Lyons, Shawn

PMID: 37734371; PMCID: PMC10577075; DOI: 10.1016/j.ajhg.2023.08.017;

Sikder MAA, Rashid RB, Ahmed T, Sebina I, Howard DR, Ullah MA, Rahman MM, Lynch JP, Curren B, Werder RB, Simpson J, Bissell A, Morrison M, Walpole C, Radford KJ, Kumar V, Woodruff TM, Ying TH, Ali A, Kaiko GE, Upham JW, Hoelzle RD, Cuív PÓ, Holt PG, Dennis PG, Phipps S. Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity. 2023 May 09; 56(5):1098-1114.e10. PMID: 37003256

Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775.View Related Profiles.

Wilson, Andrew
Hollenberg, Anthony
Kotton, Darrell
Bullitt, Esther
Kaserman, Joseph
Werder, Rhiannon Bree
Matte, Taylor

PMID: 36476855; PMCID: PMC9780780; DOI: 10.1016/j.celrep.2022.111775;

Phipps S, Howard DR, Werder RB. Eosinophils apply a handbrake to plasmacytoid dendritic cell antiviral immunity in asthma. J Allergy Clin Immunol. 2022 Sep; 150(3):589-591. PMID: 35917933

Werder RB, Liu T, Abo KM, Lindstrom-Vautrin J, Villacorta-Martin C, Huang J, Hinds A, Boyer N, Bullitt E, Liesa M, Silverman EK, Kotton DN, Cho MH, Zhou X, Wilson AA. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022 Jul 15; 8(28):eabo6566.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Bullitt, Esther
Huang, Jessie
Werder, Rhiannon Bree

PMID: 35857525; PMCID: PMC9278866; DOI: 10.1126/sciadv.abo6566;

Werder RB, Huang J, Abo KM, Hix OT, Minakin K, Alysandratos KD, Merritt C, Berthiaume K, Alber AB, Burgess CL, Kotton DN, Wilson AA. Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells. J Vis Exp. 2022 Apr 15; (182).View Related Profiles.

Alber, Andrea
Wilson, Andrew
Kotton, Darrell
Huang, Jessie
Werder, Rhiannon Bree

PMID: 35499347

Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Bullitt, Esther
Huang, Jessie
Werder, Rhiannon Bree

PMID: 35315362; PMCID: PMC8986076; DOI: 10.1172/jci.insight.155589;

Showing 10 of 37 results. Show More

Miorin L, Mire CE, Ranjbar S, Hume AJ, Huang J, Crossland NA, White KM, Laporte M, Kehrer T, Haridas V, Moreno E, Nambu A, Jangra S, Cupic A, Dejosez M, Abo KA, Tseng AE, Werder RB, Rathnasinghe R, Mutetwa T, Ramos I, de Aja JS, de Alba Rivas CG, Schotsaert M, Corley RB, Falvo JV, Fernandez-Sesma A, Kim C, Rossignol JF, Wilson AA, Zwaka T, Kotton DN, Mühlberger E, García-Sastre A, Goldfeld AE. The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters. bioRxiv. 2022 Feb 09.View Related Profiles.

Hume, Adam
Wilson, Andrew
Mire, Chad
Kotton, Darrell
Muhlberger, Elke
Crossland, Nicholas
Werder, Rhiannon Bree
Corley, Ronald

PMID: 35169796; PMCID: PMC8845418; DOI: 10.1101/2022.02.08.479634;

Werder RB, Ullah MA, Rahman MM, Simpson J, Lynch JP, Collinson N, Rittchen S, Rashid RB, Sikder MAA, Handoko HY, Curren BF, Sebina I, Hartel G, Bissell A, Ngo S, Yarlagadda T, Hasnain SZ, Lu W, Sohal SS, Martin M, Bowler S, Burr LD, Martinez LO, Robaye B, Spann K, Ferreira MAR, Phipps S. Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma. Am J Respir Crit Care Med. 2022 02 01; 205(3):300-312. PMID: 34860143

Sauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nat Commun. 2022 01 25; 13(1):494.View Related Profiles.

Wilson, Andrew
Werder, Rhiannon Bree

PMID: 35078977; PMCID: PMC8789871; DOI: 10.1038/s41467-022-28062-9;

Wang R, Hume AJ, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Le Suer J, Huang J, Olejnik J, Villacorta-Martin C, Bullitt E, Hinds A, Ghaedi M, Rollins S, Werder RB, Abo KM, Wilson AA, Mühlberger E, Kotton DN, Hawkins FJ. Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L462-L478.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Bullitt, Esther
Hawkins, Finn
Huang, Jessie
Olejnik, Judith
Werder, Rhiannon Bree

PMID: 35020534; PMCID: PMC8917936; DOI: 10.1152/ajplung.00397.2021;

Werder RB, Kaserman JE, Packer MS, Lindstrom-Vautrin J, Villacorta-Martin C, Young LE, Aratyn-Schaus Y, Gregoire F, Wilson AA. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021 11 03; 29(11):3219-3229.View Related Profiles.

Wilson, Andrew
Kaserman, Joseph
Werder, Rhiannon Bree

PMID: 34217893; PMCID: PMC8571173; DOI: 10.1016/j.ymthe.2021.06.021;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 12 03; 27(6):962-973.e7.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Burks, Eric
Bullitt, Esther
Hawkins, Finn
Huang, Jessie
Olejnik, Judith
Bosmann, Markus
Saeed, Mohsan
Werder, Rhiannon Bree

PMID: 32979316; PMCID: PMC7500949; DOI: 10.1016/j.stem.2020.09.013;

Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles.

Andry, Christopher
Murphy, George
Vanuytsel, Kim
Miller, Nancy
Werder, Rhiannon Bree
Matte, Taylor

PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;

Loh Z, Simpson J, Ullah A, Zhang V, Gan WJ, Lynch JP, Werder RB, Sikder AA, Lane K, Sim CB, Porrello E, Mazzone SB, Sly PD, Steptoe RJ, Spann KM, Sukkar MB, Upham JW, Phipps S. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLoS Pathog. 2020 07; 16(7):e1008651. PMID: 32658914; PMCID: PMC7377495; DOI: 10.1371/journal.ppat.1008651;

Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Burks, Eric
Bullitt, Esther
Hawkins, Finn
Olejnik, Judith
Bosmann, Markus
Saeed, Mohsan
Werder, Rhiannon Bree

PMID: 32637964; PMCID: PMC7337394; DOI: 10.1101/2020.06.30.175695;

Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo
Huang, Jessie
Werder, Rhiannon Bree
Matte, Taylor

PMID: 32577635; PMCID: PMC7302183; DOI: 10.1101/2020.06.03.132639;

Simpson J, Loh Z, Ullah MA, Lynch JP, Werder RB, Collinson N, Zhang V, Dondelinger Y, Bertrand MJM, Everard ML, Blyth CC, Hartel G, Van Oosterhout AJ, Gough PJ, Bertin J, Upham JW, Spann KM, Phipps S. Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 06 01; 201(11):1358-1371. PMID: 32105156

Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. Rapid Implementation of a SARS-CoV-2 Diagnostic Quantitative Real-Time PCR Test with Emergency Use Authorization at a Large Academic Safety Net Hospital. Med (N Y). 2020 Dec 18; 1(1):152-157.e3.View Related Profiles.

Murphy, George
Vanuytsel, Kim
Miller, Nancy
Werder, Rhiannon Bree
Matte, Taylor

PMID: 32838351; PMCID: PMC7235561; DOI: 10.1016/j.medj.2020.05.001;

Lynch JP, Werder RB, Curren BF, Sikder MAA, Ullah A, Sebina I, Rashid RB, Zhang V, Upham JW, Hill GR, Steptoe RJ, Phipps S. Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunol. 2020 07; 13(4):652-664. PMID: 32066837

Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 04 02; 26(4):593-608.e8.View Related Profiles.

Wilson, Andrew
Jacob, Anjali
Kotton, Darrell
Mostoslavsky, Gustavo
Huang, Jessie
Herriges, Michael
Werder, Rhiannon Bree
Sun, Yuliang

PMID: 32004478; PMCID: PMC7469703; DOI: 10.1016/j.stem.2019.12.009;

Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S. PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-? production. Sci Transl Med. 2018 05 09; 10(440). PMID: 29743346

Lynch JP, Werder RB, Loh Z, Sikder MAA, Curren B, Zhang V, Rogers MJ, Lane K, Simpson J, Mazzone SB, Spann K, Hayball J, Diener K, Everard ML, Blyth CC, Forstner C, Dennis PG, Murtaza N, Morrison M, Ó Cuív P, Zhang P, Haque A, Hill GR, Sly PD, Upham JW, Phipps S. Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. J Exp Med. 2018 02 05; 215(2):537-557. PMID: 29273643; PMCID: PMC5789405; DOI: 10.1084/jem.20170298;

Werder RB, Zhang V, Lynch JP, Snape N, Upham JW, Spann K, Phipps S. Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity. J Allergy Clin Immunol. 2018 05; 141(5):1607-1619.e9. PMID: 28947081

Al-Kouba J, Wilkinson AN, Starkey MR, Rudraraju R, Werder RB, Liu X, Law SC, Horvat JC, Brooks JF, Hill GR, Davies JM, Phipps S, Hansbro PM, Steptoe RJ. Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570267; PMCID: PMC5453705; DOI: 10.1172/jci.insight.85742;

Simpson J, Lynch JP, Loh Z, Zhang V, Werder RB, Spann K, Phipps S. The Absence of Interferon-ß Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice. Sci Rep. 2017 05 24; 7(1):2353. PMID: 28539639; PMCID: PMC5443759; DOI: 10.1038/s41598-017-02564-9;

Lynch JP, Sikder MA, Curren BF, Werder RB, Simpson J, Cuív PÓ, Dennis PG, Everard ML, Phipps S. The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma-Food for Thought? Front Immunol. 2017; 8:156. PMID: 28261214; PMCID: PMC5311067; DOI: 10.3389/fimmu.2017.00156;

Arikkatt J, Ullah MA, Short KR, Zhang V, Gan WJ, Loh Z, Werder RB, Simpson J, Sly PD, Mazzone SB, Spann KM, Ferreira MA, Upham JW, Sukkar MB, Phipps S. RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. Elife. 2017 01 18; 6. PMID: 28099113; PMCID: PMC5243115; DOI: 10.7554/eLife.21199;

Ferreira MA, Jansen R, Willemsen G, Penninx B, Bain LM, Vicente CT, Revez JA, Matheson MC, Hui J, Tung JY, Baltic S, Le Souëf P, Montgomery GW, Martin NG, Robertson CF, James A, Thompson PJ, Boomsma DI, Hopper JL, Hinds DA, Werder RB, Phipps S. Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. J Allergy Clin Immunol. 2017 Apr; 139(4):1148-1157. PMID: 27554816; PMCID: PMC5471111; DOI: 10.1016/j.jaci.2016.07.017;

Lynch JP, Werder RB, Simpson J, Loh Z, Zhang V, Haque A, Spann K, Sly PD, Mazzone SB, Upham JW, Phipps S. Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. J Allergy Clin Immunol. 2016 11; 138(5):1326-1337. PMID: 27236500

Edwards CL, Zhang V, Werder RB, Best SE, Sebina I, James KR, Faleiro RJ, de Labastida Rivera F, Amante FH, Engwerda CR, Phipps S, Haque A. Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung. Clin Vaccine Immunol. 2015 May; 22(5):477-83. PMID: 25716232; PMCID: PMC4412948; DOI: 10.1128/CVI.00051-15;

Spann KM, Loh Z, Lynch JP, Ullah A, Zhang V, Baturcam E, Werder RB, Khajornjiraphan N, Rudd P, Loo YM, Suhrbier A, Gale M, Upham JW, Phipps S. IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol. 2014 Jun; 184(6):1795-806. PMID: 24726644

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 10 distinct years, with a maximum of 10 publications in 2020

Bar chart showing 37 publications over 10 distinct years, with a maximum of 10 publications in 2020

Year	Publications
2014	1
2015	1
2016	2
2017	6
2018	1
2020	10
2021	2
2022	9
2023	2
2024	3

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