Joseph Kaserman, MD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Vermont College of Medicine
BS, Cornell University



Dr. Kaserman is an Assistant Professor of Medicine at the Chobanian and Avedisian School of Medicine and a member of the Pulmonary, Allergy, Sleep and Critical Care Medicine section as well as a researcher in the Wilson Lab at the Center for Regenerative Medicine of Boston University and Boston Medical Center. His research has focused on studying the biological underpinnings of the genetic disease alpha-1 antitrypsin deficiency using pluripotent stem cell models combined with gene editing technology in order to rationally develop potential future disease modifying and curative therapies.

Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine




Mechanisms of Metabolic Dysregulation in ZZ Alpha-1 Antitrypsin Deficiency Associated Liver Disease
09/01/2025 - 05/31/2030 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1K08DK140640-01A1

Mechanisms of Hepatic Heterogeneity and ATF6 Mediated Metabolic Dysfunction in AATD
07/01/2022 - 06/30/2024 (PI)
Alpha-1 Foundation


Defining PiMZ AATD Liver Disease Susceptibility with CRISPR Targeted Syngeneic iPSCs
07/01/2018 - 06/30/2021 (PI)
Alpha-1 Foundation


CRISPR-DIRECTED Editing Of Patient-iPSCs To Determine Genetic Contributors
07/01/2016 - 06/30/2018 (Key Person / Fellow)
PI: Andrew A. Wilson, MD
Alpha-1 Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Soares De Oliveira L, Kaserman JE, Van Der Spek AH, Lee NJ, Undeutsch HJ, Werder RB, Wilson AA, Hollenberg AN. Thyroid hormone receptor beta (THRß1) is the major regulator of T3 action in human iPSC-derived hepatocytes. Mol Metab. 2024 Dec; 90:102057.View Related Profiles. PMID: 39481850; PMCID: PMC11615914; DOI: 10.1016/j.molmet.2024.102057;
     
  2. Hu Y, Soares De Oliveira L, Falize K, Paul van Trotsenburg AS, Fliers E, Kaserman JE, Wilson AA, Hollenberg AN, Bruinstroop E, Boelen A. Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. Eur Thyroid J. 2024 Oct 01; 13(5).View Related Profiles. PMID: 39316725; PMCID: PMC11558919; DOI: 10.1530/ETJ-24-0162;
     
  3. Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 06; 41(10):111775.View Related Profiles. PMID: 36476855; PMCID: PMC9780780; DOI: 10.1016/j.celrep.2022.111775;
     
  4. Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11; 17(10):2286-2302.View Related Profiles. PMID: 36084636; PMCID: PMC9561183; DOI: 10.1016/j.stemcr.2022.08.003;
     
  5. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659.View Related Profiles. PMID: 35749346; PMCID: PMC9231773; DOI: 10.1371/journal.ppat.1010659;
     
  6. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268.View Related Profiles. PMID: 35120176; PMCID: PMC8849519; DOI: 10.1371/journal.ppat.1010268;
     
  7. Werder RB, Kaserman JE, Packer MS, Lindstrom-Vautrin J, Villacorta-Martin C, Young LE, Aratyn-Schaus Y, Gregoire F, Wilson AA. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021 11 03; 29(11):3219-3229.View Related Profiles. PMID: 34217893; PMCID: PMC8571173; DOI: 10.1016/j.ymthe.2021.06.021;
     
  8. Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 07 14; 15(1):242-255.View Related Profiles. PMID: 32619491; PMCID: PMC7363960; DOI: 10.1016/j.stemcr.2020.06.006;
     
  9. Kaserman JE, Wilson AA. Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery. Chronic Obstr Pulm Dis. 2018 Sep 15; 5(4):258-266.View Related Profiles. PMID: 30723783; PMCID: PMC6361479; DOI: 10.15326/jcopdf.5.4.2017.0179;
     
  10. Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860.View Related Profiles. PMID: 29879455; PMCID: PMC6562205; DOI: 10.1016/j.jhep.2018.05.028;
     
Showing 10 of 12 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 12 publications over 7 distinct years, with a maximum of 4 publications in 2022

YearPublications
20061
20171
20182
20201
20211
20224
20242


2018 John W. Walsh Translational Research Award
2016 Second Place Laboratory Basic Research Award: Second Place Laboratory Basic Research Award
2010 Alpha Omega Alpha: Inductee
2009 Gold Humanism Honor Society: Inductee
2008 McGraw-Hill/Lange Medical Student Award
2008 Phorplus Wasserman 1951 Prize
2008 Ernest H. Buttles Award for Excellence in Pathology
2008 Ephraim Woll Award for Excellence in Pathology
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Alpha1 Antitrypsin Deficiency
iPSCs
CRISPR-Cas Systems
Liver Disease Diagnosis
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