Keywords
Last Name

Joseph Kaserman, MD

TitlePostdoctoral Fellow
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 East Concord Street, R-304
Boston MA 02118
Phone(617) 638-4860
 Research Expertise & Professional Interests
Alpha1 antitrypsin deficiency is the most common cause of hereditary liver disease, however, only about 10% of patients with the mutation develop liver disease. The mechanism for why certain patients develop liver disease remains poorly understood. Using hiPS cells we will correct the Z AAT mutation using the CRISPR/Cas9 system to compare syngeneic daughter clones. This will reduce variation due to other genetic differences allowing for a more precise evaluation of the effects from the mutant protein and allow for the creation of a disease signature.

 Self-Described Keywords
  • Alpha1 Antitrypsin Deficiency
  • Liver Disease Diagnosis
  • iPSCs
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Garcia MI, Kaserman J, Chung YH, Jung JU, Lee SH. Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J Virol. 2007 Mar; 81(6):2663-74. PMID: 17182673.
    View in: PubMed
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