Andrew A. Wilson, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Texas Southwestern Medical School




I am a pulmonary and critical care clinician-scientist with a long-standing focus on regenerative medicine and stem cell biology. My goal is to advance understanding of and treatment for genetic causes of chronic obstructive pulmonary disease (COPD) and the most common genetic cause of COPD, alpha-1 antitrypsin deficiency (AATD). To accomplish this goal, I have established an integrated clinical and research program here at BU and BMC that includes the following components: 1) The Alpha-1 Center which I direct and co-founded with Dr. Darrell Kotton has become a nationally recognized center of excellence for the care of AATD patients and their families; 2) Patient stem cell repositories: I have overseen the creation of and direct two large stem cell repositories, housed at the CReM. First, we house the world’s largest AATD patient-specific induced pluripotent stem cell (iPSC) repository, comprised of iPSCs and reprogrammable blood samples from over 100 AATD patients linked to phenotypic data including imaging, pulmonary function, and liver biopsy results. Second, in collaboration with the Framingham Heart Study (FHS) and Vasan Ramachandran, the CReM now houses the FHS iPSC Repository that includes iPSCs and reprogrammable blood samples from >6500 highly phenotyped participants in the FHS; 3) Clinical-epidemological AATD Research: Under my direction as site PI, BU is one three sites in the country funded by the Alpha-1 Foundation to recruit 100 AATD subjects to undergo liver biopsy, detailed phenotyping, and 5 years of follow-up to define the prevalence of, risk factors for, and non-invasive biomarkers associated with AATD-associated liver disease; 4) Translational bench research: my lab in the CReM is focused on the application of patient-derived iPSCs to study AATD and COPD.

The 4 core areas of my research are: I) to confirm the clinical significance of the iPSC platform to model in vivo patient biology and demonstrate its potential for testing potential therapeutic agents; II) to better understand the genetic factors and mechanistic drivers that predispose subsets of AATD patients to develop clinical disease; III) to elucidate the mechanistic contribution of putative COPD susceptibility genes to lung disease pathogenesis; and IV) to develop gene or cell-based therapies for AATD.


Research interests include:
-Alpha-1 antitrypsin deficiency
-COPD pathogenesis
-Gene therapy
-Pluripotent stem cells

Clinical interests include:
-Alpha-1 antitrypsin deficiency

Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Center for Regenerative Medicine


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Thyroid Hormone Signaling in Human Hepatocytes
04/01/2019 - 01/31/2023 (Subcontract PI)
Weill Medical College of Cornell University NIH NIDDK
1R01DK117940-01A1

Novel Gene and Stem Cell Therapy for Type 1 Diabetes
08/01/2019 - 05/31/2022 (Subcontract PI)
Medical University of South Carolina NIH NIDDK
5R01DK120394-02

A National iPS cell network with deep phenotyping for translational research
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Andrew A. Wilson, MD
NIH/National Center for Advancing Translational Sciences
5U01TR001810-04

Application of Isogenic CRISPR-corrected Patient iPSCs to Determine Whether ZAAT-Induced Gain of Function Toxicity Renders MZ or ZZ Lung Epithelium Susceptible to Cigarette Smoke Injury
05/09/2019 - 05/08/2021 (PI)
Grifols Inc


Base Editing in Patient-derived Pluripotent Stem Cells for Disease Modeling and Therapeutic Development
04/12/2019 - 04/12/2021 (PI)
Beam Therapeutics, Inc.


Functional characterization of risk modifier gene MAN1B1 in patient-derived hepatocytes
07/01/2018 - 06/30/2020 (PI)
Alpha 1 Foundation


Personalized therapy for AATD-associated liver disease via IPS modeling
07/01/2015 - 06/30/2020 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK101501-05

Contribution of Gain of Function Toxicity to AATD Lung Disease Pathogenesis
10/01/2018 - 09/30/2019 (PI)
Alpha 1 Foundation


CRISPR-DIRECTED Editing Of Patient-iPSCs To Determine Genetic Contributors
07/01/2016 - 06/30/2018 (PI)
Alpha 1 Foundation


Characterization of AATD iPSC Repository
05/15/2017 - 05/14/2018 (PI)
Alpha 1 Foundation


Showing 10 of 20 results. Show All Results

ALPHA-1 Antitrypsin Deficiency Adult Clinical
01/01/2015 - 07/23/2020 (PI)
Alpha-1 Foundation

Alpha-1 Antitrypsin Deficiency Adult Clinical and Genetic Linkage Study
01/01/2015 - 11/30/2018 (PI)
St. Louis University Alpha-1 Foundation


Title


Yr Title Project-Sub Proj Pubs
2020 Thyroid Hormone Signaling in Human Hepatocytes 5R01DK117940-02
2019 Thyroid Hormone Signaling in Human Hepatocytes 1R01DK117940-01A1
2019 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-04 12
2019 Personalized therapy for AATD-associated liver disease via IPS modeling 5R01DK101501-05 3
2018 A National iPS Cell Network with Deep Phenotyping for Translational Research 3U01TR001810-03S1 12
2018 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-03 12
2018 Personalized therapy for AATD-associated liver disease via IPS modeling 5R01DK101501-04 3
2017 A National iPS Cell Network with Deep Phenotyping for Translational Research 5U01TR001810-02 12
2017 Personalized therapy for AATD-associated liver disease via IPS modeling 5R01DK101501-03 3
2016 A National iPS Cell Network with Deep Phenotyping for Translational Research 1U01TR001810-01 12
Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR, Wilson AA, Connors LH, Kotton DN, Wiseman RL, Murphy GJ. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports. 2020 08 11; 15(2):515-528.View Related Profiles. PMID: 32735824
     
  2. Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 07 14; 15(1):242-255.View Related Profiles. PMID: 32619491
     
  3. Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles. PMID: 32637964
     
  4. Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles. PMID: 32577635
     
  5. Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. 2020 Apr 02; 26(4):593-608.e8.View Related Profiles. PMID: 32004478
     
  6. Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG. Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity. J Immunol. 2019 04 15; 202(8):2240-2253.View Related Profiles. PMID: 30796179
     
  7. Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG. Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations. Am J Respir Crit Care Med. 2018 10 15; 198(8):1099-1102.View Related Profiles. PMID: 30011228
     
  8. Kaserman JE, Wilson AA. Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery. Chronic Obstr Pulm Dis. 2018 Sep 15; 5(4):258-266.View Related Profiles. PMID: 30723783
     
  9. Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid. 2018 Sep; 25(3):148-155.View Related Profiles. PMID: 30032658
     
  10. Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860.View Related Profiles. PMID: 29879455
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 12 distinct years, with a maximum of 5 publications in 2020

YearPublications
19931
20083
20091
20121
20132
20141
20152
20161
20173
20184
20191
20205
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

alpha-1 antitrypsin
gene therapy
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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