Frederic F. Little, MD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Tufts University School of Medicine



Dr. Little is an Assistant Professor in the Department of Medicine. He attends on the Allergy Consultation Service as well as the Medical Intensive Care Unit and Pulmonary Consultation Service at Boston Medical Center . His outpatient activity is concentrated in the Adult Asthma and Allergy Clinics.

Dr. Little’s longstanding clinical interests and research efforts are focused on examining the nature of airway inflammation in allergic asthma, and translational approaches to diagnostics of allergic disease.

Prior to coming to Boston University, during a postdoctoral fellowship at the UCSF Cardiovascular Research Institute , he investigated the effect of causing an experimental cold in asthmatic and healthy volunteers, followed by concurrent examination of clinical asthma markers (e.g., spirometry, symptoms) and airway secretions by nasal lavage and sputum induction.

In the laboratory, he used key cytokine transgenic and knockout mice to investigate antigen-dependent and -independent allergic airway inflammation. Specifically, he investigated interleukin-16, a major CD4 ligand, as a paradigm for downregulation of antigen-dependent TH2 inflammation.

His translational research continues at Boston University as a principle investigator in a clinic-based study to develop a rapid saliva diagnostics platform for determining the causes of deterioration in asthma control. This study has expanded to both Emergency Room populations at B.U. and cohorts of pediatric asthmatics in collaboration Dr. Elizabeth Matsui, Pediatric Allergy/Immunology at Johns Hopkins. This translational approach has also been used in developing a point of care device to accurately and rapidly quantify allergen-specific IgE using component-resolved diagnostics. This latter ongoing effort is in collaboration with Drs. M. Selim Unlü in the Boston University College of Engineering.

He has also participated as a Co-Investigator in immunotherapy trials with the NHLBI-funded Inner City Asthma Consortium, in collaboration with the BUMC site PI, Dr. George O’Connor.

Dr. Little’s educational and administrative responsibilities include directing the Boston University Allergy/Immunology Fellowship Training Program and being the Medical Director of the Pulmonary, Allergy and Sleep Clinics. He is also the Clinical Director of Allergy at Boston Medical Center, a role that touches on care delivery in the inpatient and outpatient settings.

Research interests include:
-Pulmonary Immunology
-Salivary Diagnostics of Lung Disease
-Point of Care Diagnostics of Allergic Disease

Clinical interests include:
-Asthma/Allergy
-Critical Care Medicine
-Eosinophilic Disorders

Active Staff Privileges
Boston Medical Center
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine



Rapid Disposable Microchip for Complete Blood Count
07/01/2012 - 06/30/2014 (Co-PI)
General Hospital Corp d/b/a Massachusett NIH NIBIB
5U54EB015408-02

Effect of IL-16 on the Murine Allergic Airway Response
07/01/2003 - 06/30/2009 (PI)
NIH/National Heart, Lung, and Blood Institute
5 K08 HL71607 05

The Role of Airway Epithelial Expression of IL-16 in Th2-mediated Lung Inflammation
07/01/2002 - 06/30/2005 (PI)
Parker B. Francis Foundation


Microsensor Arrays for Salivary Diagnostics
09/01/2006 - 02/28/2013 (PI)
Tufts University NIH-NIDCR


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Reddy D, Little FF. Glucocorticoid-resistant asthma: more than meets the eye. J Asthma. 2013 Dec; 50(10):1036-44. PMID: 23923995; DOI: 10.3109/02770903.2013.831870;.
  2. Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012 Jan 15; 188(2):854-63.View Related Profiles. PMID: 22156343; PMCID: PMC3253176; DOI: 10.4049/jimmunol.1100426;.
  3. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.View Related Profiles. PMID: 22080865; PMCID: PMC3225985; DOI: 10.1172/JCI41769;.
  4. Richmond J, Finkel M, Studwell A, Little F, Cruikshank W. Introduction of pro-interleukin-16 inhibits T-lymphoblastic leukemia growth in mice. J Cancer Res Clin Oncol. 2011 Oct; 137(10):1581-5.View Related Profiles. PMID: 21818556; DOI: 10.1007/s00432-011-1017-x;.
  5. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94.View Related Profiles. PMID: 20971881; PMCID: PMC3175558; DOI: 10.1165/rcmb.2010-0323OC;.
  6. Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 2009 Mar 15; 81(6):2106-14.View Related Profiles. PMID: 19192965; PMCID: PMC2765577; DOI: 10.1021/ac802181j;.
  7. Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1035-42.View Related Profiles. PMID: 18326826; PMCID: PMC3575679; DOI: 10.1152/ajplung.00397.2007;.
  8. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):133-41.View Related Profiles. PMID: 18323534; PMCID: PMC2542452; DOI: 10.1165/rcmb.2007-0133OC;.
  9. Cruikshank W, Little F. lnterleukin-16: the ins and outs of regulating T-cell activation. Crit Rev Immunol. 2008; 28(6):467-83.View Related Profiles. PMID: 19265505.
  10. Walt DR, Blicharz TM, Hayman RB, Rissin DM, Bowden M, Siqueira WL, Helmerhorst EJ, Grand-Pierre N, Oppenheim FG, Bhatia JS, Little FF, Brody JS. Microsensor arrays for saliva diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:389-400.View Related Profiles. PMID: 17435144.
Showing 10 of 28 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 28 publications over 14 distinct years, with a maximum of 6 publications in 2003

YearPublications
19882
19891
19991
20011
20021
20036
20041
20063
20073
20083
20091
20101
20113
20131
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Boston MA 02118
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