Last Name

Frederic F. Little, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
ORCID ORCID Icon0000-0003-4342-7007
Other Positions
TitleActive Staff Privileges
InstitutionBoston Medical Center
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

 Research Expertise & Professional Interests
Dr. Little is an Assistant Professor in the Department of Medicine. He attends on the Allergy Consultation Service as well as the Medical Intensive Care Unit and Pulmonary Consultation Service at Boston Medical Center . His outpatient activity is concentrated in the Adult Asthma and Allergy Clinics.

Dr. Little’s longstanding clinical interests and research efforts are focused on examining the nature of airway inflammation in allergic asthma, and translational approaches to diagnostics of allergic disease.

Prior to coming to Boston University, during a postdoctoral fellowship at the UCSF Cardiovascular Research Institute , he investigated the effect of causing an experimental cold in asthmatic and healthy volunteers, followed by concurrent examination of clinical asthma markers (e.g., spirometry, symptoms) and airway secretions by nasal lavage and sputum induction.

In the laboratory, he used key cytokine transgenic and knockout mice to investigate antigen-dependent and -independent allergic airway inflammation. Specifically, he investigated interleukin-16, a major CD4 ligand, as a paradigm for downregulation of antigen-dependent TH2 inflammation.

His translational research continues at Boston University as a principle investigator in a clinic-based study to develop a rapid saliva diagnostics platform for determining the causes of deterioration in asthma control. This study has expanded to both Emergency Room populations at B.U. and cohorts of pediatric asthmatics in collaboration Dr. Elizabeth Matsui, Pediatric Allergy/Immunology at Johns Hopkins. This translational approach has also been used in developing a point of care device to accurately and rapidly quantify allergen-specific IgE using component-resolved diagnostics. This latter ongoing effort is in collaboration with Drs. M. Selim Unlü in the Boston University College of Engineering.

He has also participated as a Co-Investigator in immunotherapy trials with the NHLBI-funded Inner City Asthma Consortium, in collaboration with the BUMC site PI, Dr. George O’Connor.

Dr. Little’s educational and administrative responsibilities include directing the Boston University Allergy/Immunology Fellowship Training Program and being the Medical Director of the Pulmonary, Allergy and Sleep Clinics. He is also the Clinical Director of Allergy at Boston Medical Center, a role that touches on care delivery in the inpatient and outpatient settings.

Research interests include:
-Pulmonary Immunology
-Salivary Diagnostics of Lung Disease
-Point of Care Diagnostics of Allergic Disease

Clinical interests include:
-Critical Care Medicine
-Eosinophilic Disorders

 Self-Described Keywords
  • Clinical Asthma
  • Biomarkers, Asthma
  • Hypersensitivity, Immediate
  • Allergic Airway Inflammation - Mouse models
  • Asthma - Translational Studies
  • Allergy/Immunology
  • Rapid Diagnostics/Biomarkers of Lung and Allergic Disease
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2014 Nov; 124(11):5085. PMID: 25365075.
    View in: PubMed
  2. Reddy D, Little FF. Glucocorticoid-resistant asthma: more than meets the eye. J Asthma. 2013 Dec; 50(10):1036-44. PMID: 23923995.
    View in: PubMed
  3. Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012 Jan 15; 188(2):854-63. PMID: 22156343.
    View in: PubMed
  4. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49. PMID: 22080865.
    View in: PubMed
  5. Richmond J, Finkel M, Studwell A, Little F, Cruikshank W. Introduction of pro-interleukin-16 inhibits T-lymphoblastic leukemia growth in mice. J Cancer Res Clin Oncol. 2011 Oct; 137(10):1581-5. PMID: 21818556.
    View in: PubMed
  6. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F, Thannickal VJ, Cardoso WV, Lü J. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):287-94. PMID: 20971881.
    View in: PubMed
  7. Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 2009 Mar 15; 81(6):2106-14. PMID: 19192965.
    View in: PubMed
  8. Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1035-42. PMID: 18326826.
    View in: PubMed
  9. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):133-41. PMID: 18323534.
    View in: PubMed
  10. Cruikshank W, Little F. lnterleukin-16: the ins and outs of regulating T-cell activation. Crit Rev Immunol. 2008; 28(6):467-83. PMID: 19265505.
    View in: PubMed
  11. Walt DR, Blicharz TM, Hayman RB, Rissin DM, Bowden M, Siqueira WL, Helmerhorst EJ, Grand-Pierre N, Oppenheim FG, Bhatia JS, Little FF, Brody JS. Microsensor arrays for saliva diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:389-400. PMID: 17435144.
    View in: PubMed
  12. Little FF, Wilson KC, Berman JS, Center DM. Lymphocyte- and macrophage-mediated inflammation in the lung. In: Fishman’s Pulmonary Diseases and Disorders, 4th ed, Fishman A.P. et al, eds. McGraw-Hill. New York. 2007.
  13. Little FF, Hollingsworth HM. Anaphylaxis. In: Intensive Care Medicine, 6th edit. Irwin, R.S and Rippe, J.M., eds. Lippincott Williams & Wilkins. Philadelphia. 2007.
  14. Little FF. Treating acute asthma with antibiotics--not quite yet. N Engl J Med. 2006 Apr 13; 354(15):1632-4. PMID: 16611955.
    View in: PubMed
  15. Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006 Jan; 117(1):86-91. PMID: 16387589.
    View in: PubMed
  16. Little FF, Cruikshank WW, Center DM. IL-16. In: Encyclopedia of Respiratory Medicine, Laurent, G.J and Shapiro, S.D., eds. Elsevier. Oxford. 2006.
  17. Little FF, Cruikshank WW. Interleukin-16 and peptide derivatives as immunomodulatory therapy in allergic lung disease. Expert Opin Biol Ther. 2004 Jun; 4(6):837-46. PMID: 15174966.
    View in: PubMed
  18. Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 Dec; 14(6):489-502. PMID: 14563351.
    View in: PubMed
  19. Little FF, Center DM. Induced sputum analysis for T helper type 2 cell regulation: closing the loop. Chest. 2003 Jun; 123(6):1786-8. PMID: 12796149.
    View in: PubMed
  20. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S. PMID: 12629022.
    View in: PubMed
  21. Little FF, Lynch E, Fine G, Center DM, Cruikshank WW. Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):354-62. PMID: 12594062.
    View in: PubMed
  22. Little FF, Hollingsworth HM. Anaphylaxis. In: Intensive Care Medicine, 5th edit. Irwin, R.S and Rippe, J.M., eds. Lippincott Williams & Wilkins. Philadelphia. 2003.
  23. Little FF, Cruikshank WW, Center DM. IL-16 and airway hyperresponsiveness in asthma. In: Biology of Airway Inflammation – Therapeutic Targets, Eissa, N.T., ed. Series: Lung Biology in Health and Disease. Marcel Dekker. New York. 2003; 177.
  24. De Bie JJ, Jonker EH, Henricks PA, Hoevenaars J, Little FF, Cruikshank WW, Nijkamp FP, Van Oosterhout AJ. Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia and Th2-type cytokine production in mice. Clin Exp Allergy. 2002 Nov; 32(11):1651-8. PMID: 12569988.
    View in: PubMed
  25. Little FF, Cruikshank WW, Center DM. Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001 Sep; 25(3):347-52. PMID: 11588013.
    View in: PubMed
  26. Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA. Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med. 1999 Jul; 160(1):100-8. PMID: 10390386.
    View in: PubMed
  27. Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB. Sister chromatid exchange in painters recently exposed to solvents. Environ Res. 1989 Dec; 50(2):248-55. PMID: 2583070.
    View in: PubMed
  28. Kelsey KT, Wiencke JK, Little FF, Baker EL, Little JB. Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters. Environ Mol Mutagen. 1988; 11(3):389-99. PMID: 3356184.
    View in: PubMed
  29. Nagasawa H, Burke MJ, Little FF, McCone EF, Chan GL, Little JB. Multiple abnormalities in the ultraviolet light response of cultured fibroblasts derived from patients with the basal cell nevus syndrome. Teratog Carcinog Mutagen. 1988; 8(1):25-33. PMID: 2897722.
    View in: PubMed
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