Kei Yasuda, PhD
|Institution||Boston University School of Medicine|
|Address||650 Albany St Evans Biomed Research Ctr|
Boston MA 02118
|Institution||Boston Medical Center|
Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by the presence of autoantibodies against nucleic acids (DNA and RNA). These autoantibodies form immune complexes with nucleic acids and stimulate immune cells to induce inflammation.
I am interested in the role of interferon regulatory factor-5 (IRF5) in the pathogenesis of SLE in mice and humans. I have shown that IRF5 in plasmacytoid dendritic cells is involved in the production of type I interferons (IFNs), which are pathogenic cytokines in SLE. In addition, I found that IRF5 contributes to the formation of antibody-producing plasma cells in lupus-prone mice. Currently I investigate how IRF5 is involved in the plasma cell development. In addition, I investigate how IRF5 is involved in T cell differentiation.
- Interferon regulatory factor-5
- Systemic lupus erythematosus
- plasmacytoid dendritic cells
- plasma cells
- Toll-like receptor-7
- Toll-like receptor-9
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