Gregory A. Viglianti, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Minnesota



Research in my laboratory focuses on two main areas: 1) co-factors that influence the mucosal transmission of HIV-1; and 2) the role of endogenous nucleic acid autoantigens as mediators of systemic lupus erythematosus.

1) Mucosal immune responses of the lower female reproductive tract to sexually transmitted pathogenic microorganisms leads to an inflammatory response that enhances the heterosexual transmission of HIV-1. Inflammation is initiated largely by signaling through members of the Toll-like family of innate immune receptors (TLR) that are activated by pathogen-encoded ligands. This inflammatory response enhances HIV-1 transmission by inducing the recruitment of target immune cells such as Langerhans/dendritic cells (LC/DC), macrophages (MØ)‚ and T lymphocytes to the mucosa and by direct activation of these cells. Recent findings have demonstrated that activation of certain nuclear receptors (NR), including peroxisome proliferator activated receptor (PPAR), liver X receptor (LXR), and glucocorticoid receptor (GR)) potently inhibits TLR-induced inflammatory gene expression in MØ, LC/DC, and epithelial cells. Studies in our laboratory are directed toward evaluating: 1) the ability of ligand-activated NR to inhibit the mucosal transmission of HIV-1, in particular LC/DC-mediated trans-infection of T cells; and 2) the molecular mechanism(s) of how ligand-activated NR inhibit TLR-induced transcription of both HIV-1 and inflammatory cytokine genes.

2) Autoimmune diseases such as systemic lupus erythematosus (SLE) are characterized by the overproduction of antibodies, many of which recognize ribonucleoprotein and/or chromatin related autoantigens. A common feature of these autoantigens is that they include DNA or RNA. Our laboratory, in collaboration with Dr. Ann Marshak-Rothstein, is defining the protein and nucleic acid composition of these immunostimulatory autoantigens and determining whether different forms of apoptosis are capable of selectively releasing these autoantigens from cells, thereby making them accessible to autoreactive B cells.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Oral Macrophage Function in the Context of Periodontal Disease and HIV Infection
09/25/2013 - 08/31/2016 (PI)
Boston Medical Center Corporation NIH NIDCR
R56DE023950-02

Endogenous Nucleic Acid TLR Ligands in SLE
02/11/2010 - 06/30/2014 (PI)
University of Massachusetts, Medical School NIH NIAMS
5P01AR050256-11

DNA and RNA associated Autoantigens in the Activation of Human B Cells
12/01/2012 - 04/30/2014 (PI)
University of Massachusetts, Worcester Lupus Research Inst

Co-Factors in HIV Mucosal Infection
03/01/2011 - 02/28/2014 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI073149-05

Retinoid Repression of HIV Through Chromatin Remodeling
07/01/2001 - 05/31/2006 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5 R01 AI49098 04

Repression of HIV-1 Expression in the Lung
09/29/1996 - 07/31/2001 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL57882 05




Yr Title Project-Sub Proj Pubs
2013 REAGENT / VECTOR CORE 5P01AR050256-11-6677 41
2012 Co-factors in HIV Mucosal Infection 5R01AI073149-05 3
2012 REAGENT / VECTOR CORE 5P01AR050256-10-6677 41
2011 REAGENT / VECTOR CORE 5P01AR050256-09-6677 41
2011 Co-factors in HIV Mucosal Infection 5R01AI073149-04 3
2010 REAGENT / VECTOR CORE 5P01AR050256-08-6677 41
2010 Co-factors in HIV Mucosal Infection 5R01AI073149-03 3
2009 Co-factors in HIV Mucosal Infection 5R01AI073149-02 3
2009 REAGENT / VECTOR CORE 2P01AR050256-06-6677 41
2009 REAGENT / VECTOR CORE 7P01AR050256-07-6677 41
Showing 10 of 28 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Agosto LM, Hirnet JB, Michaels DH, Shaik-Dasthagirisaheb YB, Gibson FC, Viglianti G, Henderson AJ. Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages. Virology. 2016 Dec; 499:72-81.View Related Profiles. PMID: 27639573; DOI: 10.1016/j.virol.2016.09.007;.
  2. Papadopoulos G, Shaik-Dasthagirisaheb YB, Huang N, Viglianti GA, Henderson AJ, Kantarci A, Gibson FC. Immunologic environment influences macrophage response to Porphyromonas gingivalis. Mol Oral Microbiol. 2017 Jun; 32(3):250-261.View Related Profiles. PMID: 27346827; DOI: 10.1111/omi.12168;.
  3. Moody KL, Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. Methods Mol Biol. 2016; 1390:249-72.View Related Profiles. PMID: 26803634; DOI: 10.1007/978-1-4939-3335-8_16;.
  4. Kaczmarek Michaels K, Natarajan M, Euler Z, Alter G, Viglianti G, Henderson AJ. Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells. J Immunol. 2015 Apr 1; 194(7):3267-74.View Related Profiles. PMID: 25710909; PMCID: PMC4369419; DOI: 10.4049/jimmunol.1402581;.
  5. Uccellini MB, Busto P, Debatis M, Marshak-Rothstein A, Viglianti GA. Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence. Immunol Lett. 2012 Mar 30; 143(1):85-91.View Related Profiles. PMID: 22285306; PMCID: PMC3655556; DOI: 10.1016/j.imlet.2012.01.003;.
  6. Hanley TM, Viglianti GA. Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms. J Virol. 2011 Oct; 85(20):10834-50. PMID: 21849441; PMCID: PMC3187477; DOI: 10.1128/JVI.00789-11;.
  7. Avalos AM, Uccellini MB, Lenert P, Viglianti GA, Marshak-Rothstein A. Fc?RIIB regulation of BCR/TLR-dependent autoreactive B-cell responses. Eur J Immunol. 2010 Oct; 40(10):2692-8.View Related Profiles. PMID: 20809520; PMCID: PMC3060940; DOI: 10.1002/eji.200940184;.
  8. Hanley TM, Blay Puryear W, Gummuluru S, Viglianti GA. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog. 2010; 6:e1000981.View Related Profiles. PMID: 20617179; PMCID: PMC2895661; DOI: 10.1371/journal.ppat.1000981;.
  9. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17.View Related Profiles. PMID: 19648272; PMCID: PMC2860771; DOI: 10.4049/jimmunol.0900399;.
  10. Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-like receptor-dependent immune complex activation of B cells and dendritic cells. Methods Mol Biol. 2009; 517:363-80.View Related Profiles. PMID: 19378022; DOI: 10.1007/978-1-59745-541-1_22;.
Showing 10 of 40 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 39 publications over 23 distinct years, with a maximum of 4 publications in 1997 and 2004

YearPublications
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20163

Available to Mentor as: (Review Mentor Role Definitions):
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  • Research / Scholarly Mentor
Contact for Mentoring:


72 E. Concord St Housman (R)
Boston MA 02118
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