Keywords
Last Name

Hugues J.P. Ryser, MD

TitleEmeritus Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4503
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ryser HJ, Fl├╝ckiger R. Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15; 10(16):1085-94. PMID: 16182193.
    View in: PubMed
  2. Gallina A, Hanley TM, Mandel R, Trahey M, Broder CC, Viglianti GA, Ryser HJ. Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem. 2002 Dec 27; 277(52):50579-88. PMID: 12218051.
    View in: PubMed
  3. Merkel BJ, Mandel R, Ryser HJ, McCoy KL. Characterization of fibroblasts with a unique defect in processing antigens with disulfide bonds. J Immunol. 1995 Jan 1; 154(1):128-36. PMID: 7995932.
    View in: PubMed
  4. Ryser HJ, Levy EM, Mandel R, DiSciullo GJ. Inhibition of human immunodeficiency virus infection by agents that interfere with thiol-disulfide interchange upon virus-receptor interaction. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4559-63. PMID: 8183947.
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  5. Mandel R, Ryser HJ, Ghani F, Wu M, Peak D. Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):4112-6. PMID: 8387210.
    View in: PubMed
  6. Ryser HJ, Mandel R, Ghani F. Cell surface sulfhydryls are required for the cytotoxicity of diphtheria toxin but not of ricin in Chinese hamster ovary cells. J Biol Chem. 1991 Oct 5; 266(28):18439-42. PMID: 1655751.
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  7. Mandel R, Ryser HJ, Niaki B, Ghani F, Shen WC. Isolation of variants of Chinese hamster ovary cells with abnormally low levels of GSH: decreased ability to cleave endocytosed disulfide bonds. J Cell Physiol. 1991 Oct; 149(1):60-5. PMID: 1939347.
    View in: PubMed
  8. Feener EP, Shen WC, Ryser HJ. Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes. J Biol Chem. 1990 Nov 5; 265(31):18780-5. PMID: 2229041.
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  9. Persiani S, Ballou B, Shen WC, Ryser HJ, Reiland JM, Hakala TR. In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma. Cancer Immunol Immunother. 1989; 29(3):167-70. PMID: 2567209.
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  10. Ryser HJ, Li W, Mandel R, Shen WC. Stable variant of LM fibroblast defective in fluid-phase but competent in receptor-mediated endocytosis. J Cell Physiol. 1988 Dec; 137(3):490-6. PMID: 2461380.
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  11. Ryser HJ, Mandel R, Hacobian A, Shen WC. Methotrexate-poly(lysine) as a selective agent for mutants of Chinese hamster ovary cells defective in endocytosis. J Cell Physiol. 1988 May; 135(2):277-84. PMID: 3372597.
    View in: PubMed
  12. Wade GG, Mandel R, Ryser HJ. Marked synergism of dimethylnitrosamine carcinogenesis in rats exposed to cadmium. Cancer Res. 1987 Dec 15; 47(24 Pt 1):6606-13. PMID: 3677096.
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  13. Mandel R, Ryser HJ. Mechanisms of synergism in the mutagenicity of cadmium and N-methyl-N-nitrosourea in Salmonella typhimurium: the effect of pH. Mutat Res. 1987 Jan; 176(1):1-10. PMID: 3540647.
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  14. Shen WC, Ballou B, Ryser HJ, Hakala TR. Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells. Cancer Res. 1986 Aug; 46(8):3912-6. PMID: 2873883.
    View in: PubMed
  15. Li WD, Ryser HJ, Shen WC. Altered endocytosis in a mutant of LM fibroblasts defective in cell-cell fusion. J Cell Physiol. 1986 Feb; 126(2):161-6. PMID: 3944203.
    View in: PubMed
  16. Ryser H. [Health promotion on the federal level. Goals, structures and main effort of the section for the prevention of the Federal Department for Public Health]. Soz Praventivmed. 1986; 31(4-5):207-12. PMID: 3765863.
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  17. Ballou B, Reiland JM, Levine G, Taylor RJ, Shen WC, Ryser HJ, Solter D, Hakala TR. Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments. J Surg Oncol. 1986 Jan; 31(1):1-12. PMID: 2868158.
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  18. Shen WC, Ryser HJ, LaManna L. Disulfide spacer between methotrexate and poly(D-lysine). A probe for exploring the reductive process in endocytosis. J Biol Chem. 1985 Sep 15; 260(20):10905-8. PMID: 4030773.
    View in: PubMed
  19. Shen WC, Yang D, Ryser HJ. Colorimetric determination of microgram quantities of polylysine by trypan blue precipitation. Anal Biochem. 1984 Nov 1; 142(2):521-4. PMID: 6549372.
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  20. Mandel R, Ryser HJ. Mutagenicity of cadmium in Salmonella typhimurium and its synergism with two nitrosamines. Mutat Res. 1984 Oct; 138(1):9-16. PMID: 6387480.
    View in: PubMed
  21. Morad N, Ryser HJ, Shen WC. Binding sites and endocytosis of heparin and polylysine are changed when the two molecules are given as a complex to Chinese hamster ovary cells. Biochim Biophys Acta. 1984 Sep 7; 801(1):117-26. PMID: 6087917.
    View in: PubMed
  22. Shen WC, Ryser HJ. Selective killing of Fc-receptor-bearing tumor cells through endocytosis of a drug-carrying immune complex. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1445-7. PMID: 6369328.
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  23. Ryser HJ, Morad N, Shen WC. Heparin interaction with cultured cells: possible role of fibronectin in uncoupling surface binding and endocytosis. Cell Biol Int Rep. 1983 Nov; 7(11):923-30. PMID: 6317205.
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  24. Ryser HJ, Drummond I, Shen WC. The cellular uptake of horseradish peroxidase and its poly(lysine) conjugate by cultured fibroblasts is qualitatively similar despite a 900-fold difference in rate. J Cell Physiol. 1982 Oct; 113(1):167-78. PMID: 6127344.
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  25. Shen WC, Ryser HJ. Poly(L-lysine) has different membrane transport and drug-carrier properties when complexed with heparin. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7589-93. PMID: 6950400.
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  26. Shen WC, Ryser HJ. cis-Aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate. Biochem Biophys Res Commun. 1981 Oct 15; 102(3):1048-54. PMID: 7306187.
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  27. Shen WC, Ryser HJ. Selective protection against the cytotoxicity of methotrexate and methotrexate-poly(lysine) by thiamine pyrophosphate, heparin and leucovorin. Life Sci. 1981 Mar 16; 28(11):1209-14. PMID: 6971979.
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  28. Ryser HJ, Shen WC. Conjugation of methotrexate to poly (L-lysine) as a potential way to overcome drug resistance. Cancer. 1980 Mar 15; 45(5 Suppl):1207-11. PMID: 7357512.
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  29. Shen WC, Ryser HJ. Poly (L-lysine) and poly (D-lysine) conjugates of methotrexate: different inhibitory effect on drug resistant cells. Mol Pharmacol. 1979 Sep; 16(2):614-22. PMID: 514261.
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  30. Ryser HJ, Shen WC. Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):3867-70. PMID: 279001.
    View in: PubMed
  31. Ryser HJ, Shen WC, Merk FB. Membrane transport of macromolecules: new carrier functions of proteins and poly(amino acids). Life Sci. 1978 Apr 3-17; 22(13-15):1253-60. PMID: 351319.
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  32. Shen WC, Ryser HJ. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Proc Natl Acad Sci U S A. 1978 Apr; 75(4):1872-6. PMID: 273916.
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  33. Ryser HJ, Termini TE, Barnes PR. Polynucleotide aggregates enhance the transport of protein at the surface of cultured mammalian cells. J Cell Physiol. 1975 Dec; 87(2):221-8. PMID: 1214004.
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  34. Petitpierre-Gabathuler MP, Ryser HJ. Cellular uptake of soluble and aggregated ferritin: distinction between pinocytosis and phagocytosis. J Cell Sci. 1975 Oct; 19(1):141-56. PMID: 1176545.
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  35. Ryser HJ. Special report: chemical carcinogenesis. CA Cancer J Clin. 1974 Nov-Dec; 24(6):351-60. PMID: 4216395.
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  36. Ryser HJ. Chemical carcinogenesis. N Engl J Med. 1971 Sep 23; 285(13):721-34. PMID: 4942982.
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  37. Ryser HJ. Uptake of foreign proteins by mammalian cells and the functions of pinocytosis. Bull Schweiz Akad Med Wiss. 1969 Jul; 24(5):363-84. PMID: 5376057.
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  38. Gabathuler MP, Ryser HJ. The digestive function of lysosomes as studies by the turnover of ingested foreign macromolecules. Proc R Soc Lond B Biol Sci. 1969 Apr 15; 173(30):95-8. PMID: 4389356.
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  39. Ryser HJ. Uptake of protein by mammalian cells: an underdeveloped area. The penetration of foreign proteins into mammalian cells can be measured and their functions explored. Science. 1968 Jan 26; 159(3813):390-6. PMID: 4169262.
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  40. Ryser HJ. A membrane effect of basic polymers dependent on molecular size. Nature. 1967 Aug 26; 215(5104):934-6. PMID: 6055419.
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  41. Ryser HJ. Studies on protein uptake by isolated tumor cells. 3. Apparent stimulations due to pH, hypertonicity, polycations, or dehydration and their relation to the enhanced penetration of infectious nucleic acids. J Cell Biol. 1967 Mar; 32(3):737-50. PMID: 6034487.
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  42. Hancock R, Ryser HJ. Histones in prophase and their possible role in nuclear membrane breakdown. Nature. 1967 Feb 18; 213(5077):701-2. PMID: 6031777.
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  43. Ryser HJ, Hancock R. Histones and basic polyamino acids stimulate the uptake of albumin by tumor cells in culture. Science. 1965 Oct 22; 150(3695):501-3. PMID: 5835786.
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  44. EYBL V, RYSER H. THE ACUTE TOXICITY OF CRYSTALLIZED FERRITIN, CADMIUM-FREE FERRITIN AND CDCL2 ON EHRLICH ASCITES CARCINOMA CELLS. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 May 11; 248:153-65. PMID: 14214595.
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  45. RYSER HJ. COMPARISON OF THE INCORPORATION OF TYROSINE AND ITS IODINATED ANALOGS INTO THE PROTEINS OF EHRLICH ASCITES TUMOR CELLS AND RAT-LIVER SLICES. Biochim Biophys Acta. 1963 Dec 13; 78:759-62. PMID: 14089463.
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  46. RYSER HJ. THE MEASUREMENT OF I131-SERUM ALBUMIN UPTAKE BY TUMOR CELLS IN TISSUE CULTURE. Lab Invest. 1963 Oct; 12:1009-17. PMID: 14084841.
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  47. RYSER H, AUB JC, CAULFIELD JB. Studies on protein uptake by isolated tumor cells. II. Quantitative data on the adsorption and uptake of I-131-serum albumin by Ehrlich ascites tumor cells. J Cell Biol. 1962 Dec; 15:437-49. PMID: 13983280.
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  48. RYSER H, CAULFIELD JB, AUB JC. Studies on protein uptake by isolated tumor cells. I. Electron microscopic evidence of ferritin uptake by Ehrlich ascites tumor cells. J Cell Biol. 1962 Aug; 14:255-68. PMID: 14495656.
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  49. ROOF BS, RYSER H, AUB JC. Isolated cells: normal and tumor. III. Effects of bathing media upon intracellular uptake of glycine and upon protein synthesis. Cancer Res. 1960 Nov; 20:1446-50. PMID: 13743154.
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  50. RYSER H, BOREL C, FREI J, CSANK I, VANNOTTI A. [Value of the determination of lactic dehydrase in the etiological diagnosis of serous effusions]. Helv Med Acta. 1958 Oct; 25(4):407-9. PMID: 13610218.
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  51. RYSER H, FREI J, VANNOTTI A. Enzymic studies in small amounts of human tissue with the help of microanalytical methods. III. Energetic metabolism of cirrhotic and precirrhotic liver tissue removed by needle biopsy. Clin Chim Acta. 1958 Sep; 3(5):486-93. PMID: 13585625.
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  52. FREI J, RYSER H. Enzymic studies in small amounts of human tissue with the help of microanalytical methods. II. Oxidative phosphorylation in human liver samples removed by biopsy puncture. Clin Chim Acta. 1958 May; 3(3):294-7. PMID: 13547422.
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  53. FREI J, RYSER H. Enzymic studies in small amounts of human tissue with the help of microanalytical methods. I. A microrespirometer for the measurement of oxygen consumption of human liver tissue samples removed by biopsy puncture. Clin Chim Acta. 1958 May; 3(3):288-93. PMID: 13547421.
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  54. BOREL C, RYSER H, FREI J. [Increase of two hepatic transaminases considered as an enzymatic adaptation in the rat on a meat diet]. Schweiz Med Wochenschr. 1958 Feb 8; 88(6):135-7. PMID: 13528982.
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  55. RYSER H, FREI J, MAGNENAT P. [New possibilites of direct enzyme studies in the human liver; measurement of phosphorylating oxidation in cirrhosis]. Helv Med Acta. 1957 Oct; 24(4):491-4. PMID: 13480661.
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  56. ABELIN I, RYSER H. [Not Available]. Helv Med Acta. 1957 Sep; 24(3):231-40. PMID: 13474553.
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  57. FREI J, RYSER H. [Micro-analytic methods applied to the biochemical study of human hepatic tissue]. Helv Physiol Pharmacol Acta. 1957; 15(4):C 62-4. PMID: 13512968.
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  58. BOREL C, RYSER H, FREI J. [Influence of meat diet on the activity of seven hepatic enzymes in rats; increase of transaminases as an example of enzymatic adaptation]. Helv Physiol Pharmacol Acta. 1957; 15(2):C12-4. PMID: 13474580.
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  59. RYSER H, FREY J. [Direct measurement of enzyme levels in normal and pathological human liver]. Helv Physiol Pharmacol Acta. 1957; 15(4):C 77-9. PMID: 13512975.
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  60. FREI J, RYSER H. [The relation between oxidative ATP-resynthesis and mitochondrial structure of the liver in rats with vitamin B1 and B2 deficiency]. Experientia. 1956 Mar 15; 12(3):105-7. PMID: 13317887.
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  61. RYSER H, FREI J. [Intracellular incorporation and distribution of labeled thiamine (S35) in liver of normal and thiamine-deficient rats]. Helv Physiol Pharmacol Acta. 1956; 14(4):424-9. PMID: 13405363.
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  62. RYSER H, SCHMIDLI B, ZUPPINGER A, AEBI H. [Oxidative phosphorylation and synthesis of citrulline in the liver mitochondria of rats exposed to a lethal dose of x-rays (1000r)]. Helv Physiol Pharmacol Acta. 1955; 13(3):270-5. PMID: 13306106.
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  63. RYSER H, AEBI H, ZUPPINGER A. [Modifications in the mitochondrial fraction of rat liver after total-body irradiation and after liver irradiation (1000 r)]. Experientia. 1954 Jul 15; 10(7):304-5. PMID: 13183081.
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  64. RYSER H, WILBRANDT W. [The action of recosen on the coronary resistance of guinea pig hearts perfused according to Langendorff's method and its significance in the sense of a regression antagonism]. Arch Int Pharmacodyn Ther. 1953 Nov 1; 96(2):131-60. PMID: 13139718.
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  65. WILBRANDT W, RYSER H. [Continous registration of the resistance and debt of the coronary arteries of the isolated guinea pig heart prepared by the Langendorff method]. Helv Physiol Pharmacol Acta. 1952 Sep; 10(3):C 31-3. PMID: 12999129.
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  66. WILBRANDT W, RYSER H, WITT PN. [The tendon of the rat tail; a test object for astringents]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1952; 215(5-6):469-82. PMID: 12977241.
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  67. RYSER H, WILBRANDT W, WITT PN. [Modifications of extensibility as a measure of the effect of astringents]. Helv Physiol Pharmacol Acta. 1950; 8(4):C70-2. PMID: 14802978.
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