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VMD, University of Pennsylvania

Websites

	School of Public Health Faculty
	Boston University Superfund Research Program
	Boston University Upward Bound Math Science
	BUSPH Infectious Disease Certificate
	BUSPH Environmental Health Seminar

ORCID : 0000-0002-6694-0666

Upward Bound Math Science
09/01/2022 - 08/31/2027 (Multi-PI)
PI: Jean Maguire van Seventer, VMD
Department of Education

Upward Bound Math and Science
09/01/2017 - 08/31/2022 (Multi-PI)
PI: Jean Maguire van Seventer, VMD
Department of Education

Title

Boston University Superfund Research Program
04/01/2017 - 03/31/2019 (Co-Leader of Training Core)
National Institute of Environmental Health Sciences
P42ES007381

Yr	Title	Project-Sub Proj	Pubs
2005	Type I interferon in LPS/CpG-induced lethal toxic shock	5R21AI061433-02	3
2004	Type I interferon in LPS/CpG-induced lethal toxic shock	1R21AI061433-01	3

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

van Seventer JM, Hamer DH. In: Quah SR and Cockerham WC (eds.). The International Encyclopedia of Public Health. Foodborne Diseases. Academic Press. Oxford. 2017; 3:160-173.
van Seventer JM, Hochberg NS. In: Quah SR and Cockerham WC (eds.). The International Encyclopedia of Public Health. Principles of Infectious Diseases: Transmission, Diagnosis, Prevention, and Control. Academic Press. Oxford. 2017; 6:22-39.
van Seventer JM, Hamer DH. In Hamer DH. Editor-in-chief. Griffiths JK, Heggenhougen HK, Maguire JH, and Quah SR, editors. Elsevier, San Diego, 2010. From seasonal to pandemic influenza. Infectious Disease and Public Health. Elsevier. San Diego. 2010; 394-405.

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
van Seventer, Jean
Connor, John
Yasuda, Kei

PMID: 19587008; PMCID: PMC2929820; DOI: 10.4049/jimmunol.0803899;

Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8.View Related Profiles.

Watkins, Amanda
Rifkin, Ian
van Seventer, Jean
Yasuda, Kei
Lafyatis, Robert

PMID: 19124725; PMCID: PMC2858919; DOI: 10.4049/jimmunol.182.2.820;

van Seventer JM, DeLouiereo A, Hamer DH. Review. Emerging new infections: importance in child health. . 2009; (67):103-118.

Mangini AJ, Lafyatis R, Van Seventer JM. Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus. Ann N Y Acad Sci. 2007 Jun; 1108:11-23.View Related Profiles.

van Seventer, Jean
Lafyatis, Robert

PMID: 17893966

York MR, Nagai T, Mangini AJ, Lemaire R, van Seventer JM, Lafyatis R. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007 Mar; 56(3):1010-20.View Related Profiles.

van Seventer, Jean
York, Michael
Lafyatis, Robert

PMID: 17328080

Nagai T, Devergne O, van Seventer GA, van Seventer JM. Interferon-beta mediates opposing effects on interferon-gamma-dependent Interleukin-12 p70 secretion by human monocyte-derived dendritic cells. Scand J Immunol. 2007 Feb; 65(2):107-17. PMID: 17257215

Meyers JA, Mangini AJ, Nagai T, Roff CF, Sehy D, van Seventer GA, van Seventer JM. Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC. Cytokine. 2006 Sep; 35(5-6):235-46.View Related Profiles.

van Seventer, Jean
Meyers, John

PMID: 17052915

Showing 10 of 40 results. Show More

Nagai T, Devergne O, Mueller TF, Perkins DL, van Seventer JM, van Seventer GA. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol. 2003 Nov 15; 171(10):5233-43. PMID: 14607924

Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78.View Related Profiles.

Lerner, Adam
van Seventer, Jean
Near, Richard

PMID: 12517963

van Seventer JM, Nagai T, van Seventer GA. Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J Neuroimmunol. 2002 Dec; 133(1-2):60-71. PMID: 12446009

Farrokh-Siar L, Rezai KA, Palmer EM, van Seventer J, Hamann KJ, Rajadurai H, Patel SC, Ernest JT, van Seventer GA. Human fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL. Curr Eye Res. 2002 Mar; 24(3):206-13. PMID: 12221529

Palmer EM, Farrokh-Siar L, Maguire van Seventer J, van Seventer GA. IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1. I. IL-12 alters caspase processing and inhibits enzyme function. J Immunol. 2001 Jul 15; 167(2):749-58. PMID: 11441079

van Seventer GA, Salmen HJ, Law SF, O'Neill GM, Mullen MM, Franz AM, Kanner SB, Golemis EA, van Seventer JM. Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. Eur J Immunol. 2001 May; 31(5):1417-27. PMID: 11465098

McRae BL, Nagai T, Semnani RT, van Seventer JM, van Seventer GA. Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors. Blood. 2000 Jul 1; 96(1):210-7. PMID: 10891453

Kulkarni S, Holman PO, Kopelan A, van Seventer GA, van Seventer JM, Kranz DM, Woodle ES. Programmed cell death signaling via cell-surface expression of a single-chain antibody transgene. Transplantation. 2000 Mar 27; 69(6):1209-17. PMID: 10762228

van Seventer JM, van Seventer GA. Induction of T-cell signaling by immobilized integrin ligands. Methods Mol Biol. 2000; 134:265-75. PMID: 10730264

Tabassam FH, Umehara H, Huang JY, Gouda S, Kono T, Okazaki T, van Seventer JM, Domae N. Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells. Cell Immunol. 1999 May 1; 193(2):179-84. PMID: 10222060

van Seventer GA, Semnani RT, Palmer EM, McRae BL, van Seventer JM. Integrins and T helper cell activation. Transplant Proc. 1998 Dec; 30(8):4270-4. PMID: 9865361

van Seventer GA, Mullen MM, van Seventer JM. Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes. Eur J Immunol. 1998 Nov; 28(11):3867-77. PMID: 9842930

Kulkarni S, Holman P, Kranz D, Zhou N, Van Seventer J, Woodle ES. Construction of a single-chain antibody derived from 5H7, a monoclonal antibody specific for a death signaling domain of human class I major histocompatibility complex. Transplant Proc. 1998 Jun; 30(4):1081. PMID: 9636438

Jarvis LJ, Maguire JE, LeBien TW. Contact between human bone marrow stromal cells and B lymphocytes enhances very late antigen-4/vascular cell adhesion molecule-1-independent tyrosine phosphorylation of focal adhesion kinase, paxillin, and ERK2 in stromal cells. Blood. 1997 Aug 15; 90(4):1626-35. PMID: 9269782

Gray JX, Haino M, Roth MJ, Maguire JE, Jensen PN, Yarme A, Stetler-Stevenson MA, Siebenlist U, Kelly K. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J Immunol. 1996 Dec 15; 157(12):5438-47. PMID: 8955192

Beckner ME, Krutzsch HC, Klipstein S, Williams ST, Maguire JE, Doval M, Liotta LA. AAMP, a newly identified protein, shares a common epitope with alpha-actinin and a fast skeletal muscle fiber protein. Exp Cell Res. 1996 Jun 15; 225(2):306-14. PMID: 8660919; DOI: 10.1006/excr.1996.0181;

Santoro T, Maguire J, McBride OW, Avraham KB, Copeland NG, Jenkins NA, Kelly K. Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. Genomics. 1995 Dec 10; 30(3):558-64. PMID: 8825643; DOI: 10.1006/geno.1995.1277;

Maguire JE, Danahey KM, Burkly LC, van Seventer GA. T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. J Exp Med. 1995 Dec 01; 182(6):2079-90. PMID: 7500053; PMCID: PMC2192271

Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K. Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994 Jul 08; 265(5169):241-4. PMID: 7912851

Maguire, J.E., G.A. van Seventer. Lymphocyte Adhesion Molecules (Y Shimizu, ed.). Adhesion molecules as signal transducers in T cell activation. Chapter 13. R.G. Landes Company. Austin. 1993; 313-331.

Maguire JE, Frels WI, Richardson JC, Weissman JD, Singer DS. In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene. Mol Cell Biol. 1992 Jul; 12(7):3078-86. PMID: 1620117; PMCID: PMC364522

Maguire JE, McCarthy SA, Singer A, Singer DS. Inverse correlation between steady-state RNA and cell surface T cell receptor levels. FASEB J. 1990 Oct; 4(13):3131-4. PMID: 1698681

Bonifacino JS, McCarthy SA, Maguire JE, Nakayama T, Singer DS, Klausner RD, Singer A. Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4. Nature. 1990 Mar 15; 344(6263):247-51. PMID: 1690353; DOI: 10.1038/344247a0;

Maguire JE, Gresser I, Williams AH, Kielpinski GL, Colvin RB. Modulation of expression of MHC antigens in the kidneys of mice by murine interferon-alpha/beta. Transplantation. 1990 Jan; 49(1):130-4. PMID: 2301004

Maguire JE, Ehrlich R, Frels WI, Singer DS. Regulation of expression of a class I major histocompatibility complex transgene. J Reprod Fertil Suppl. 1990; 41:59-62. PMID: 2213716

Singer DS, Maguire JE. Regulation of the expression of class I MHC genes. Crit Rev Immunol. 1990; 10(3):235-57. PMID: 2085409

Maguire, J.E., R. Ehrlich, W.I. Frels, D.S. Singer. Transgenic Mice and Mutants in MHC Research (I.K. Egororv, C.S. David, eds.). Regulation of class I MHC expression: In vivo function of regulatory DNA sequence elements in transgenic mice. Springer-Verlag. Berlin. 1990.

Moses RD, Beschorner WE, Singer D, Maguire JE, Orr KS, Bacher JD, Gress RE. Restriction fragment length polymorphism analysis with a cross-reactive HLA class II DR-beta gene probe for the detection of engraftment of MHC-mismatched marrow in the rhesus monkey. Bone Marrow Transplant. 1989 Sep; 4(5):475-81. PMID: 2571376

Ehrlich R, Sharrow SO, Maguire JE, Singer DS. Expression of a class I MHC transgene: effects of in vivo alpha/beta-interferon treatment. Immunogenetics. 1989; 30(1):18-26. PMID: 2473029

Ehrlich R, Maguire JE, Singer DS. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene. Mol Cell Biol. 1988 Feb; 8(2):695-703. PMID: 2832733; PMCID: PMC363195

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2017

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2017

Year	Publications
1990	1
1993	1
2009	1
2010	1
2017	2

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