Keywords
Last Name

Jean Maguire van Seventer, VMD

TitleClinical Associate Professor
InstitutionBoston University School of Public Health
DepartmentEnvironmental Health
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6493
ORCID ORCID Icon0000-0002-6694-0666
 Research Expertise & Professional Interests
Dr. van Seventer started her professional career as a veterinary practitioner, while taking part in research projects at the Woods Hole Oceanographic Institution and Marine Biological Laboratory. She subsequently received fellowship training in pathology and immunology at Harvard Medical School and the National Cancer Institute. Dr. van Seventer started her career as an independent investigator at the University of Chicago, and joined the Department of Environmental Health at BUSPH in 2000. Her research at BU concentrated on characterizing the molecular mechanisms by which the human innate immune response regulate subsequent adaptive immunity. Research studies primarily focused on the role of type I interferons (IFN), IFN-alpha and IFN-beta, in regulating human dendritic cell and T cell functions, with emphasis placed on translating basic research findings to autoimmune diseases (multiple sclerosis (MS) and systemic lupus erythematosus (SLE)) and infectious diseases that result in septic shock.

In 2011, Dr. van Seventer turned her primary focus towards developing new curricula, new teaching strategies, and teaching courses in physiology and infectious diseases to students in the BUSPH, as well as to students in a joint BU Metropolitan College-College of Communication on-line masters program. A particular teaching interest is in examining the role of the environment in infectious disease endemicity, emergence, and spread.

Dr. van Seventer started her professional career as a veterinary practitioner, while taking part in research projects at the Woods Hole Oceanographic Institution and Marine Biological Laboratory. She subsequently received fellowship training in pathology and immunology at Harvard Medical School and the National Cancer Institute. Dr. van Seventer started her career as an independent investigator at the University of Chicago, and joined the Department of Environmental Health at BUSPH in 2000. Her research at BU concentrated on characterizing the molecular mechanisms by which the human innate immune response regulate subsequent adaptive immunity. Research studies primarily focused on the role of type I interferons (IFN), IFN-alpha and IFN-beta, in regulating human dendritic cell and T cell functions, with emphasis placed on translating basic research findings to autoimmune diseases (multiple sclerosis (MS) and systemic lupus erythematosus (SLE)) and infectious diseases that result in septic shock.

In 2011, Dr. van Seventer turned her primary focus towards developing new curricula, new teaching strategies, and teaching courses in physiology and infectious diseases to students in the BUSPH, as well as to students in a joint BU Metropolitan College-College of Communication on-line masters program. A particular teaching interest is in examining the role of the environment in infectious disease endemicity, emergence, and spread. Dr. van Seventer is involved in running a Public Health Lab series for the Upward Bound Math/Science Summer Program, a program whose purpose is to prepare low-income and first-generation college bound students for success in higher education. She also enjoys giving talks to area secondary school students, introducing them to public health and showing them the many careers they might pursue in order to be part of the work force addressing public health problems and issues.


 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. van Seventer JM, Hamer DH. In Hamer DH. Editor-in-chief. Griffiths JK, Heggenhougen HK, Maguire JH, and Quah SR, editors. Elsevier, San Diego, 2010. From seasonal to pandemic influenza. Infectious Disease and Public Health. Elsevier. San Diego. 2010; 394-405.
  2. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76. PMID: 19587008.
    View in: PubMed
  3. Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8. PMID: 19124725.
    View in: PubMed
  4. van Seventer JM, DeLouiereo A, Hamer DH. Review. Emerging new infections: importance in child health. . 2009; (67):103-118.
  5. Mangini AJ, Lafyatis R, Van Seventer JM. Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus. Ann N Y Acad Sci. 2007 Jun; 1108:11-23. PMID: 17893966.
    View in: PubMed
  6. York MR, Nagai T, Mangini AJ, Lemaire R, van Seventer JM, Lafyatis R. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum. 2007 Mar; 56(3):1010-20. PMID: 17328080.
    View in: PubMed
  7. Nagai T, Devergne O, van Seventer GA, van Seventer JM. Interferon-beta mediates opposing effects on interferon-gamma-dependent Interleukin-12 p70 secretion by human monocyte-derived dendritic cells. Scand J Immunol. 2007 Feb; 65(2):107-17. PMID: 17257215.
    View in: PubMed
  8. Meyers JA, Mangini AJ, Nagai T, Roff CF, Sehy D, van Seventer GA, van Seventer JM. Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC. Cytokine. 2006 Sep; 35(5-6):235-46. PMID: 17052915.
    View in: PubMed
  9. Nagai T, Devergne O, Mueller TF, Perkins DL, van Seventer JM, van Seventer GA. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol. 2003 Nov 15; 171(10):5233-43. PMID: 14607924.
    View in: PubMed
  10. Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78. PMID: 12517963.
    View in: PubMed
  11. van Seventer JM, Nagai T, van Seventer GA. Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells. J Neuroimmunol. 2002 Dec; 133(1-2):60-71. PMID: 12446009.
    View in: PubMed
  12. Farrokh-Siar L, Rezai KA, Palmer EM, van Seventer J, Hamann KJ, Rajadurai H, Patel SC, Ernest JT, van Seventer GA. Human fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL. Curr Eye Res. 2002 Mar; 24(3):206-13. PMID: 12221529.
    View in: PubMed
  13. van Seventer GA, Salmen HJ, Law SF, O'Neill GM, Mullen MM, Franz AM, Kanner SB, Golemis EA, van Seventer JM. Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. Eur J Immunol. 2001 May; 31(5):1417-27. PMID: 11465098.
    View in: PubMed
  14. McRae BL, Nagai T, Semnani RT, van Seventer JM, van Seventer GA. Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors. Blood. 2000 Jul 1; 96(1):210-7. PMID: 10891453.
    View in: PubMed
  15. Kulkarni S, Holman PO, Kopelan A, van Seventer GA, van Seventer JM, Kranz DM, Woodle ES. Programmed cell death signaling via cell-surface expression of a single-chain antibody transgene. Transplantation. 2000 Mar 27; 69(6):1209-17. PMID: 10762228.
    View in: PubMed
  16. van Seventer JM, van Seventer GA. Induction of T-cell signaling by immobilized integrin ligands. Methods Mol Biol. 2000; 134:265-75. PMID: 10730264.
    View in: PubMed
  17. Tabassam FH, Umehara H, Huang JY, Gouda S, Kono T, Okazaki T, van Seventer JM, Domae N. Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells. Cell Immunol. 1999 May 1; 193(2):179-84. PMID: 10222060.
    View in: PubMed
  18. van Seventer GA, Semnani RT, Palmer EM, McRae BL, van Seventer JM. Integrins and T helper cell activation. Transplant Proc. 1998 Dec; 30(8):4270-4. PMID: 9865361.
    View in: PubMed
  19. van Seventer GA, Mullen MM, van Seventer JM. Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes. Eur J Immunol. 1998 Nov; 28(11):3867-77. PMID: 9842930.
    View in: PubMed
  20. Kulkarni S, Holman P, Kranz D, Zhou N, Van Seventer J, Woodle ES. Construction of a single-chain antibody derived from 5H7, a monoclonal antibody specific for a death signaling domain of human class I major histocompatibility complex. Transplant Proc. 1998 Jun; 30(4):1081. PMID: 9636438.
    View in: PubMed
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