Keywords
Last Name

Richard I. Near, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 414-1826
ORCID ORCID Icon0000-0003-3307-9619
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise includes: Molecular biology as applied to signal transduction in cancer; Mouse genetics; Lentiviral cloning and expression; Zinc finger proteins and RNA zipcodes.

 Self-Described Keywords
  • Breast Cancer
  • Knock-out Mice
  • Lentivirus
  • Prostate Cancer
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Makkinje A, Vanden Borre P, Near RI, Patel PS, Lerner A. Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem. 2012 Aug 10; 287(33):27703-14. PMID: 22711540.
    View in: PubMed
  2. Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40. PMID: 21262352.
    View in: PubMed
  3. Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35. PMID: 19454314.
    View in: PubMed
  4. Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009; 15:685-99. PMID: 19365570.
    View in: PubMed
  5. Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol. 2007 Sep; 212(3):655-65. PMID: 17427198.
    View in: PubMed
  6. Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 2005 Jan; 3(1):32-41. PMID: 15671247.
    View in: PubMed
  7. Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res. 2003 Oct 15; 63(20):6802-8. PMID: 14583477.
    View in: PubMed
  8. Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78. PMID: 12517963.
    View in: PubMed
  9. Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Clin Cancer Res. 2002 Feb; 8(2):589-95. PMID: 11839681.
    View in: PubMed
  10. Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Res Treat. 2000 Sep; 63(2):117-31. PMID: 11097088.
    View in: PubMed
  11. Near RI, Matulka RA, Mann KK, Gogate SU, Trombino AF, Sherr DH. Regulation of preB cell apoptosis by aryl hydrocarbon receptor/transcription factor-expressing stromal/adherent cells. Proc Soc Exp Biol Med. 1999 Jul; 221(3):242-52. PMID: 10404042.
    View in: PubMed
  12. Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao XJ, Tilly JL, Near RI, Sherr DH. Induction of PreB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures. Toxicol Appl Pharmacol. 1997 Dec; 147(2):190-203. PMID: 9439715.
    View in: PubMed
  13. Yamaguchi K, Near RI, Matulka RA, Shneider A, Toselli P, Trombino AF, Sherr DH. Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. J Immunol. 1997 Mar 1; 158(5):2165-73. PMID: 9036962.
    View in: PubMed
  14. Yamaguchi K, Near R, Shneider A, Cui H, Ju ST, Sherr DH. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol. 1996 Jul; 139(1):144-52. PMID: 8685897.
    View in: PubMed
  15. Schildbach JF, Shaw SY, Bruccoleri RE, Haber E, Herzenberg LA, Jager GC, Jeffrey PD, Panka DJ, Parks DR, Near RI, et al. Contribution of a single heavy chain residue to specificity of an anti-digoxin monoclonal antibody. Protein Sci. 1994 May; 3(5):737-49. PMID: 8061604.
    View in: PubMed
  16. Schildbach JF, Near RI, Bruccoleri RE, Haber E, Jeffrey PD, Ng SC, Novotny J, Sheriff S, Margolies MN. Heavy chain position 50 is a determinant of affinity and specificity for the anti-digoxin antibody 26-10. J Biol Chem. 1993 Oct 15; 268(29):21739-47. PMID: 7691815.
    View in: PubMed
  17. Near RI, Mudgett-Hunter M, Novotny J, Bruccoleri R, Ng SC. Characterization of an anti-digoxin antibody binding site by site-directed in vitro mutagenesis. Mol Immunol. 1993 Mar; 30(4):369-77. PMID: 8455637.
    View in: PubMed
  18. Schillbach JF, Near RI, Bruccoleri RE, Haber E, Jeffrey PD, Novotny J, Sheriff S, Margolies MN. Modulation of antibody affinity by a non-contact residue. Protein Sci. 1993 Feb; 2(2):206-14. PMID: 8443598.
    View in: PubMed
  19. Wu XC, Ng SC, Near RI, Wong SL. Efficient production of a functional single-chain antidigoxin antibody via an engineered Bacillus subtilis expression-secretion system. Biotechnology (N Y). 1993 Jan; 11(1):71-6. PMID: 7763487.
    View in: PubMed
  20. Anthony J, Near R, Wong SL, Iida E, Ernst E, Wittekind M, Haber E, Ng SC. Production of stable anti-digoxin Fv in Escherichia coli. Mol Immunol. 1992 Oct; 29(10):1237-47. PMID: 1528194.
    View in: PubMed
  21. Near RI. Gene conversion of immunoglobulin variable regions in mutagenesis cassettes by replacement PCR mutagenesis. Biotechniques. 1992 Jan; 12(1):88-97. PMID: 1734930.
    View in: PubMed
  22. Near RI, Bruccoleri R, Novotny J, Hudson NW, White A, Mudgett-Hunter M. The specificity properties that distinguish members of a set of homologous anti-digoxin antibodies are controlled by H chain mutations. J Immunol. 1991 Jan 15; 146(2):627-33. PMID: 1898959.
    View in: PubMed
  23. Near RI, Ng SC, Mudgett-Hunter M, Hudson NW, Margolies MN, Seidman JG, Haber E, Jacobson MA. Heavy and light chain contributions to antigen binding in an anti-digoxin chain recombinant antibody produced by transfection of cloned anti-digoxin antibody genes. Mol Immunol. 1990 Sep; 27(9):901-9. PMID: 2120577.
    View in: PubMed
  24. Becker ML, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick SM. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 1989 Sep 8; 58(5):911-21. PMID: 2528411.
    View in: PubMed
  25. Near RI, Haber E. Characterization of the heavy and light chain immunoglobulin variable region genes used in a set of anti-digoxin antibodies. Mol Immunol. 1989 Apr; 26(4):371-82. PMID: 2497340.
    View in: PubMed
  26. Near RI, Manser T, Gefter ML. The generation of major and minor idiotype-bearing families of anti-p-azophenylarsonate antibodies; stochastic utilization of VH gene segments. J Immunol. 1985 Mar; 134(3):2004-9. PMID: 3918116.
    View in: PubMed
  27. Manser T, Wysocki LJ, Gridley T, Near RI, Gefter ML. The molecular evolution of the immune response. Immunol Today. 1985 Mar; 6(3):94-101. PMID: 25291538.
    View in: PubMed
  28. Juszczak E, Near RI, Gefter ML, Margolies MN. Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous. J Immunol. 1984 Nov; 133(5):2603-9. PMID: 6207237.
    View in: PubMed
  29. Near RI, Juszczak EC, Huang SY, Sicari SA, Margolies MN, Gefter ML. Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2167-71. PMID: 6326109.
    View in: PubMed
  30. Gefter ML, Margolies MN, Near RI, Wysocki LJ. Analysis of the anti-azobenzenearsonate response at the molecular level. Ann Immunol (Paris). 1984 Jan-Feb; 135C(1):17-30. PMID: 6712160.
    View in: PubMed
  31. Margolies MN, Juszczak EC, Near R, Marshak-Rothstein A, Rothstein TL, Sato VL, Siekevitz M, Smith JA, Wysocki LJ, Gefter ML. Structural correlates of idiotypy in the arsonate system. Ann N Y Acad Sci. 1983; 418:48-64. PMID: 6424532.
    View in: PubMed
  32. Near RI, Storb U. Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice. Biochemistry. 1981 Apr 28; 20(9):2386-94. PMID: 6165381.
    View in: PubMed
  33. Storb U, Near R, Putnam D, Clagett J. Immunoglobulin messenger RNAs of T lymphocytes. Mol Immunol. 1980 Jul; 17(7):947-57. PMID: 6971400.
    View in: PubMed
  34. Near RI, Storb U. RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes. Biochemistry. 1979 Mar 20; 18(6):964-72. PMID: 106877.
    View in: PubMed
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