Richard I. Near, PhD
Research Assistant Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology Section

PhD, University of Washington
MS, University of Washington



Expertise includes: Molecular biology as applied to signal transduction in cancer; Mouse genetics; Lentiviral cloning and expression; Zinc finger proteins and RNA zipcodes.

Boston Medical Center





Cell Line Engineering with Genomics Tools
07/01/2015 - 06/30/2017 (PI)
Antagen Institute for Biomed Research



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Makkinje A, Vanden Borre P, Near RI, Patel PS, Lerner A. Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem. 2012 Aug 10; 287(33):27703-14.View Related Profiles. PMID: 22711540; PMCID: PMC3431688; DOI: 10.1074/jbc.M112.389981;.
  2. Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40.View Related Profiles. PMID: 21262352; PMCID: PMC3062698; DOI: 10.1016/j.cellsig.2011.01.018;.
  3. Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35.View Related Profiles. PMID: 19454314; PMCID: PMC2740797; DOI: 10.1016/j.cellsig.2009.05.006;.
  4. Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009; 15:685-99.View Related Profiles. PMID: 19365570; PMCID: PMC2666772.
  5. Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol. 2007 Sep; 212(3):655-65.View Related Profiles. PMID: 17427198; PMCID: PMC2640322.
  6. Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 2005 Jan; 3(1):32-41.View Related Profiles. PMID: 15671247.
  7. Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res. 2003 Oct 15; 63(20):6802-8.View Related Profiles. PMID: 14583477.
  8. Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78.View Related Profiles. PMID: 12517963.
  9. Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Clin Cancer Res. 2002 Feb; 8(2):589-95.View Related Profiles. PMID: 11839681.
  10. Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Res Treat. 2000 Sep; 63(2):117-31.View Related Profiles. PMID: 11097088.
Showing 10 of 34 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 22 distinct years, with a maximum of 4 publications in 1993

YearPublications
19801
19811
19831
19843
19852
19892
19901
19911
19922
19934
19941
19961
19972
19991
20001
20021
20032
20051
20071
20092
20111
20121
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Breast Cancer
Knock-out Mice
Lentivirus
Prostate Cancer

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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