Matthew D. Layne, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Biochemistry

PhD, Boston University School of Medicine

Pronouns: he/him/his



The primary goal of our laboratory is to identify novel pathways that control extracellular matrix (ECM) synthesis and assembly as they relate to fibroproliferative and connective tissue diseases. Our long term goal is to use this knowledge to develop therapeutic strategies for these conditions. Fibroproliferative responses are similar to wound healing processes involving accumulation of contractile myofibroblasts and ECM secretion and assembly. Because organ fibrosis, cardiovascular, metabolic/obesity, and cancer pathologies are now recognized to be impacted by fibroblast-myofibroblast differentiation and ECM remodeling our research is examining novel pathways and control mechanisms in these diseases. In collaborative work, we are investigating the mechanisms of adipose tissue fibrosis and remodeling. Central to our studies is determining the function of Aortic Carboxypeptidase-like Protein (ACLP), a secreted, collagen-binding protein that enhances fibrosis and myofibroblast differentiation through mechanisms that involve stimulating the transforming growth factor ß (TGFß) receptor signaling complex and controlling mechanical signaling and ECM remodeling. Recent work is uncovering the role of ACLP (and AEBP1 genetic mutations in the connective tissue disease Ehlers-Danlos syndrome. There are several active projects in the lab including:

• Investigating the mechanisms of how ACLP/AEBP1 mutations cause Ehlers-Danlos syndrome (EDS)
• Defining the the role of ACLP in mechanotransduction pathways that control progenitor differentiation.
• Developing strategies to organ fibrosis through targeting ACLP
• Uncovering new mechanisms that control adipose tissue fibrosis.

Assistant Dean for Research
Boston University Chobanian & Avedisian School of Medicine


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Member of the Molecular Medicine Program
Boston University Chobanian & Avedisian School of Medicine


Member
Boston University
Genome Science Institute




Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular niche
04/15/2022 - 03/31/2026 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R01DK132080-01

Optical biosensor platforms for the direct interrogation of GPCR signaling in cardiovascular cells
01/01/2022 - 12/31/2023 (Key Person / Mentor)
American Heart Association


Generation of a novel transgenic mouse line for studying adipose tissue fibrosis
10/01/2018 - 05/31/2020 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
3P30DK046200-26S2

Development of Tumor-Directed Therapies
05/01/2015 - 04/30/2019 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Role of ACLP in adipocyte determination and fibrosis
01/21/2016 - 03/31/2017 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
4P30DK046200-24

ACLP-mediated Vascular Advential Fibroblast Differentiation and Remodeling
01/01/2014 - 12/31/2016 (PI)
American Heart Association


Inhibitors of Aortic Carboxypeptides-like Proten to Treat Fibroproliferative Diseases
01/01/2015 - 07/02/2016 (PI)
Pfizer, Inc.


Enhancing Energy Expending Adipocytes in White Adipose Tissue
04/01/2013 - 03/31/2016 (Key Person)
PI: Stephen Farmer, PhD
NIH/National Diabetes & Digestive & Kidney Diseases
4R01DK098830-04

Role of ACLP in adipocyte determination and fibrosis
04/01/2012 - 03/31/2014 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20



Title


Yr Title Project-Sub Proj Pubs
2022 Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular niche 1R01DK132080-01
2011 Role of ACLP in Vascular Smooth Muscle Biology 5R01HL078869-06 12
2010 Role of ACLP in Vascular Smooth Muscle Biology 5R01HL078869-05 12
2009 Role of ACLP in Vascular Smooth Muscle Biology 3R01HL078869-04S1 12
2009 Role of ACLP in Vascular Smooth Muscle Biology 5R01HL078869-04 12
2008 Role of ACLP in Vascular Smooth Muscle Biology 5R01HL078869-03 12
2007 Role of ACLP in Vascular Smooth Muscle Biology 1R01HL078869-01A2 12
2007 Role of ACLP in Vascular Smooth Muscle Biology 7R01HL078869-02 12
2004 Role of ACLP in dermal wound healing 5K01AR047861-04 4
2003 Role of ACLP in dermal wound healing 5K01AR047861-03 4
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Chen CH, Ho HH, Jiang WC, Ao-Ieong WS, Wang J, Orekhov AN, Sobenin IA, Layne MD, Yet SF. Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice. J Biomed Sci. 2022 Apr 12; 29(1):25. PMID: 35414069; PMCID: PMC9004090; DOI: 10.1186/s12929-022-00808-z;
     
  2. Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 05; 5(5).View Related Profiles. PMID: 35181634; PMCID: PMC8860101; DOI: 10.26508/lsa.202101286;
     
  3. Downs M, Sethi MK, Raghunathan R, Layne MD, Zaia J. Matrisome changes in Parkinson's disease. Anal Bioanal Chem. 2022 Apr; 414(9):3005-3015.View Related Profiles. PMID: 35112150; PMCID: PMC8944212; DOI: 10.1007/s00216-022-03929-4;
     
  4. Dance YW, Meshulam T, Seibel AJ, Obenreder MC, Layne MD, Nelson CM, Tien J. Adipose Stroma Accelerates the Invasion and Escape of Human Breast Cancer Cells from an Engineered Microtumor. Cell Mol Bioeng. 2022 Feb; 15(1):15-29.View Related Profiles. PMID: 35096184; PMCID: PMC8761189; DOI: 10.1007/s12195-021-00697-6;
     
  5. Wang D, Rabhi N, Yet SF, Farmer SR, Layne MD. Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A. Sci Rep. 2021 02 17; 11(1):3948.View Related Profiles. PMID: 33597582; PMCID: PMC7889889; DOI: 10.1038/s41598-021-82941-7;
     
  6. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;
     
  7. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;
     
  8. Jiang WC, Chen CM, Hamdin CD, Orekhov AN, Sobenin IA, Layne MD, Yet SF. Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases. Antioxidants (Basel). 2020 Nov 19; 9(11). PMID: 33228202; PMCID: PMC7699558; DOI: 10.3390/antiox9111150;
     
  9. Zeng C, Motta-Ribeiro GC, Hinoshita T, Lessa MA, Winkler T, Grogg K, Kingston NM, Hutchinson JN, Sholl LM, Fang X, Varelas X, Layne MD, Baron RM, Vidal Melo MF. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology. 2020 11 01; 133(5):1060-1076.View Related Profiles. PMID: 32796202; PMCID: PMC7572680; DOI: 10.1097/ALN.0000000000003491;
     
  10. Vishwanath N, Monis WJ, Hoffmann GA, Ramachandran B, DiGiacomo V, Wong JY, Smith ML, Layne MD. Mechanisms of aortic carboxypeptidase-like protein secretion and identification of an intracellularly retained variant associated with Ehlers-Danlos syndrome. J Biol Chem. 2020 07 10; 295(28):9725-9735.View Related Profiles. PMID: 32482891; PMCID: PMC7363150; DOI: 10.1074/jbc.RA120.013902;
     
Showing 10 of 81 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 81 publications over 26 distinct years, with a maximum of 9 publications in 2001

YearPublications
19931
19941
19951
19971
19985
19994
20004
20019
20027
20034
20043
20053
20062
20071
20083
20092
20103
20113
20122
20133
20143
20152
20184
20204
20213
20223


2022 Graduate Medical Sciences. Boston University School of Medicine: Educator of the Year Award, PhD Program
2018 Graduate Medical Sciences, Boston University School of Medicine: Faculty Recognition Award
2011 Fellow of the American Heart Association
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Extracellular Matrix Proteins, Ehlers-Danlos syndrome, fibrosis, mechanostransduction, collagen
adipose tissue

My research interests include mechanisms of smooth muscle changes in vascular disease, fibrosis, and now cancer. In a research or laboratory setting I have mentored numerous scientists at the undergraduate, graduate, and postdoctoral levels and have participated on more than 25 PhD dissertation committees.

In 2021, I was appointed as the Assistant Dean for Research. In this role, I mentor BUSM medical students in their research.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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