Keywords
Last Name

Virginia R. Litle, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentSurgery
DivisionCardiothoracic Surgery
Address88 E. Newton St Newton Pavilion
Boston MA 02118
Phone(617) 638-5600
 Research Expertise & Professional Interests
VTE prevention
Barrett's esophagus
Minimally invasive thoracic surgery
miRNA profiling
Surgical education
Mentoring

 Self-Described Keywords
  • General Surgery
  • Thoracic Surgery
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ebright MI, Sridhar P, Litle VR, Narsule CK, Daly BD, Fernando HC. Endoscopic Fundoplication: Effectiveness for Controlling Symptoms of Gastroesophageal Reflux Disease. Innovations (Phila). 2017 Mar 14. PMID: 28296655.
    View in: PubMed
  2. Muñoz-Largacha JA, Sterbling HM, Laklouk I, Zhao Q, Litle VR. A Moroccan Cattleman with Chronic Cough, Persistent Hemoptysis, and a Cavitary Lung Mass. Ann Am Thorac Soc. 2017 Feb; 14(2):279-282. PMID: 28146378.
    View in: PubMed
  3. Bhatt N, Sloan JM, O'Hara CJ, Oommen R, Steiling K, Litle VR. Extranodal Marginal Zone Endobronchial Lymphoma Associated With Hepatitis C. Ann Thorac Surg. 2016 Nov; 102(5):e407-e408. PMID: 27772593.
    View in: PubMed
  4. Datta S, Muñoz-Largacha JA, Li L, Zhao GQ, Litle VR. Subcutaneous metastases from early stage esophageal adenocarcinoma case report. Int J Surg Case Rep. 2016; 29:108-112. PMID: 27837701.
    View in: PubMed
  5. Litle VR. When the sum of the parts is greater than the whole. J Thorac Cardiovasc Surg. 2016 Sep; 152(3):754-5. PMID: 27436093.
    View in: PubMed
  6. Muñoz-Largacha JA, O'Hara CJ, Sloan JM, Fernando HC, Litle VR. Surgical Management of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Associated With Light-Chain Deposition Disease. Ann Thorac Surg. 2016 Jun; 101(6):e207-10. PMID: 27211983.
    View in: PubMed
  7. Litle VR. Don't look now! Risk stratify first. J Thorac Cardiovasc Surg. 2016 Aug; 152(2):533-4. PMID: 27131849.
    View in: PubMed
  8. Muñoz-Largacha JA, Hess DT, Litle VR, Fernando HC. Lower Esophageal Magnetic Sphincter Augmentation for Persistent Reflux After Roux-en-Y Gastric Bypass. Obes Surg. 2016 Feb; 26(2):464-6. PMID: 26667163.
    View in: PubMed
  9. Mella-Catinchi JR, Sachs TE, Pistey R, Litle VR. A Malignant Incarcerated Bochdalek Hernia. Ann Thorac Surg. 2016 Jan; 101(1):366. PMID: 26694283.
    View in: PubMed
  10. Antonoff MB, David EA, Donington JS, Colson YL, Litle VR, Lawton JS, Burgess NL. Women in Thoracic Surgery: 30 Years of History. Ann Thorac Surg. 2016 Jan; 101(1):399-409. PMID: 26694290.
    View in: PubMed
  11. Hachey KJ, Sterbling H, Choi DS, Pinjic E, Hewes PD, Munoz J, McAneny D, Tripodis Y, Fernando HC, Litle VR. Prevention of Postoperative Venous Thromboembolism in Thoracic Surgical Patients: Implementation and Evaluation of a Caprini Risk Assessment Protocol. J Am Coll Surg. 2016 Jun; 222(6):1019-27. PMID: 26775163.
    View in: PubMed
  12. Hachey KJ, Hewes PD, Porter LP, Ridyard DG, Rosenkranz P, McAneny D, Fernando HC, Litle VR. Caprini venous thromboembolism risk assessment permits selection for postdischarge prophylactic anticoagulation in patients with resectable lung cancer. J Thorac Cardiovasc Surg. 2016 Jan; 151(1):37-44.e1. PMID: 26386868.
    View in: PubMed
  13. Hewes PD, Hachey KJ, Zhang XW, Tripodis Y, Rosenkranz P, Ebright MI, McAneny D, Fernando HC, Litle VR. Evaluation of the Caprini Model for Venothromboembolism in Esophagectomy Patients. Ann Thorac Surg. 2015 Dec; 100(6):2072-8. PMID: 26279363.
    View in: PubMed
  14. Litle VR. Esophagectomy first: a shift in the treatment algorithm for regionally advanced cancer? Only with brains and brawn. J Thorac Cardiovasc Surg. 2015 Feb; 149(2):412-3. PMID: 25467370.
    View in: PubMed
  15. Sridhar P, Steenkamp DW, Lee SL, Ebright MI, Litle VR, Fernando HC. Mediastinal parathyroid adenoma with osteitis fibrosis cystica: robot-assisted thoracic surgical resection. Innovations (Phila). 2014 Nov-Dec; 9(6):445-7. PMID: 25438109.
    View in: PubMed
  16. Pham DT, Stephens EH, Antonoff MB, Colson YL, Dildy GA, Gaur P, Correa AM, Litle VR, Blackmon SH. Birth trends and factors affecting childbearing among thoracic surgeons. Ann Thorac Surg. 2014 Sep; 98(3):890-5. PMID: 25087932.
    View in: PubMed
  17. Bandla S, Peters JH, Ruff D, Chen SM, Li CY, Song K, Thoms K, Litle VR, Watson T, Chapurin N, Lada M, Pennathur A, Luketich JD, Peterson D, Dulak A, Lin L, Bass A, Beer DG, Godfrey TE, Zhou Z. Comparison of cancer-associated genetic abnormalities in columnar-lined esophagus tissues with and without goblet cells. Ann Surg. 2014 Jul; 260(1):72-80. PMID: 24509200.
    View in: PubMed
  18. Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Momi N, Backman V, Roy HK. Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications. Int J Oncol. 2014 Sep; 45(3):1209-15. PMID: 24919547.
    View in: PubMed
  19. Guzman R, Ding L, Watson TJ, Hobbs SK, Litle VR. Spontaneous esophageal hematoma in a patient with atrial fibrillation. Ann Thorac Surg. 2013 Mar; 95(3):1089-91. PMID: 23438542.
    View in: PubMed
  20. Pennathur A, Xi L, Litle VR, Gooding WE, Krasinskas A, Landreneau RJ, Godfrey TE, Luketich JD. Gene expression profiles in esophageal adenocarcinoma predict survival after resection. J Thorac Cardiovasc Surg. 2013 Feb; 145(2):505-12; discussion 512-3. PMID: 23321130.
    View in: PubMed
  21. Wilshire CL, Salvador R, Sepesi B, Niebisch S, Watson TJ, Litle VR, Peyre CG, Jones CE, Peters JH. Reflux-associated oxygen desaturations: usefulness in diagnosing reflux-related respiratory symptoms. J Gastrointest Surg. 2013 Jan; 17(1):30-8. PMID: 23143640.
    View in: PubMed
  22. Wilshire CL, Niebisch S, Watson TJ, Litle VR, Peyre CG, Jones CE, Peters JH. Dysphagia postfundoplication: more commonly hiatal outflow resistance than poor esophageal body motility. Surgery. 2012 Oct; 152(4):584-92; discussion 592-4. PMID: 22939748.
    View in: PubMed
  23. Donington JS, Litle VR, Sesti J, Colson YL. The WTS report on the current status of women in cardiothoracic surgery. Ann Thorac Surg. 2012 Aug; 94(2):452-8; discussion 458-9. PMID: 22698775.
    View in: PubMed
  24. Niebisch S, Fleming FJ, Galey KM, Wilshire CL, Jones CE, Litle VR, Watson TJ, Peters JH. Perioperative risk of laparoscopic fundoplication: safer than previously reported-analysis of the American College of Surgeons National Surgical Quality Improvement Program 2005 to 2009. J Am Coll Surg. 2012 Jul; 215(1):61-8; discussion 68-9. PMID: 22578304.
    View in: PubMed
  25. Bandla S, Pennathur A, Luketich JD, Beer DG, Lin L, Bass AJ, Godfrey TE, Litle VR. Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. Ann Thorac Surg. 2012 Apr; 93(4):1101-6. PMID: 22450065.
    View in: PubMed
  26. Iannuzzi J, Watson TJ, Litle VR. Emphysematous gastritis: A young diabetic's recovery. Int J Surg Case Rep. 2012; 3(4):125-7. PMID: 22297191.
    View in: PubMed
  27. Galey KM, Wilshire CL, Watson TJ, Schneider MD, Kaul V, Jones CE, Litle VR, Ullah A, Peters JH. Endoscopic management of early esophageal neoplasia: an emerging standard. J Gastrointest Surg. 2011 Oct; 15(10):1728-35. PMID: 21811883.
    View in: PubMed
  28. Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE, Kalatskaya I, Stein L, D'Souza M, Litle VR, Peters JH, Pennathur A, Luketich JD, Godfrey TE. Early G1 cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma. Clin Cancer Res. 2011 Jul 1; 17(13):4513-22. PMID: 21593195.
    View in: PubMed
  29. Galey KM, Wilshire CL, Niebisch S, Jones CE, Raymond DP, Litle VR, Watson TJ, Peters JH. Atypical variants of classic achalasia are common and currently under-recognized: a study of prevalence and clinical features. J Am Coll Surg. 2011 Jul; 213(1):155-61; discussion 162-3. PMID: 21435920.
    View in: PubMed
  30. Feber A, Xi L, Pennathur A, Gooding WE, Bandla S, Wu M, Luketich JD, Godfrey TE, Litle VR. MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma. Ann Thorac Surg. 2011 May; 91(5):1523-30. PMID: 21420070.
    View in: PubMed
  31. Litle VR, Rice TW. The esophagus: do sex and gender matter? Semin Thorac Cardiovasc Surg. 2011; 23(2):131-6. PMID: 22041043.
    View in: PubMed
  32. Dubecz A, Sepesi B, Salvador R, Polomsky M, Watson TJ, Raymond DP, Jones CE, Litle VR, Wisnivesky JP, Peters JH. Surgical resection for locoregional esophageal cancer is underutilized in the United States. J Am Coll Surg. 2010 Dec; 211(6):754-61. PMID: 20980174.
    View in: PubMed
  33. Wu M, Gordon RE, Herbert R, Padilla M, Moline J, Mendelson D, Litle V, Travis WD, Gil J. Case report: Lung disease in World Trade Center responders exposed to dust and smoke: carbon nanotubes found in the lungs of World Trade Center patients and dust samples. Environ Health Perspect. 2010 Apr; 118(4):499-504. PMID: 20368128.
    View in: PubMed
  34. Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg. 2010 Apr; 210(4):418-27. PMID: 20347733.
    View in: PubMed
  35. Polomsky M, Hu R, Sepesi B, O'Connor M, Qui X, Raymond DP, Litle VR, Jones CE, Watson TJ, Peters JH. A population-based analysis of emergent vs. elective hospital admissions for an intrathoracic stomach. Surg Endosc. 2010 Jun; 24(6):1250-5. PMID: 20033732.
    View in: PubMed
  36. Polomsky M, Jones CE, Sepesi B, O'Connor M, Matousek A, Hu R, Raymond DP, Litle VR, Watson TJ, Peters JH. Should elective repair of intrathoracic stomach be encouraged? J Gastrointest Surg. 2010 Feb; 14(2):203-10. PMID: 19957207.
    View in: PubMed
  37. Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the value of PET-CT extend beyond pretreatment staging? An analysis of survival in surgical patients with esophageal cancer. J Gastrointest Surg. 2009 Dec; 13(12):2121-7. PMID: 19795177.
    View in: PubMed
  38. Morrow DJ, Avissar NE, Toia L, Redmond EM, Watson TJ, Jones C, Raymond DP, Litle V, Peters JH. Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. Surgery. 2009 Oct; 146(4):714-21; discussion 721-2. PMID: 19789031.
    View in: PubMed
  39. Watson TJ, Jones CE, Litle VR. Benign diseases of the esophagus. In brief. Curr Probl Surg. 2009 Mar; 46(3):190-3. PMID: 19150522.
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  40. Watson TJ, Jones CE, Litle VR. Benign diseases of the esophagus. Curr Probl Surg. 2009 Mar; 46(3):195-259. PMID: 19150523.
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  41. Padilla ML, Litle VR. Advanced lung disease: meeting the challenges. Mt Sinai J Med. 2009 Feb; 76(1):1. PMID: 19170132.
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  42. Liptay MJ, D'amico TA, Nwogu C, Demmy TL, Wang XF, Gu L, Litle VR, Swanson SJ, Kohman LJ. Intraoperative sentinel node mapping with technitium-99 in lung cancer: results of CALGB 140203 multicenter phase II trial. J Thorac Oncol. 2009 Feb; 4(2):198-202. PMID: 19179896.
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  43. Shapiro M, Vidal C, Lipskar AM, Gil J, Litle VR. Placental transmogrification of the lung presenting as emphysema and a lung mass. Ann Thorac Surg. 2009 Feb; 87(2):615-6. PMID: 19161794.
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  44. Pashinsky YY, Jaffin BW, Litle VR. Gastroesophageal reflux disease and idiopathic pulmonary fibrosis. Mt Sinai J Med. 2009 Feb; 76(1):24-9. PMID: 19170215.
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  45. Xi L, Feber A, Gupta V, Wu M, Bergemann AD, Landreneau RJ, Litle VR, Pennathur A, Luketich JD, Godfrey TE. Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer. Nucleic Acids Res. 2008 Nov; 36(20):6535-47. PMID: 18927117.
    View in: PubMed
  46. Greenstein AJ, Wisnivesky JP, Litle VR. Effect of local therapy for the treatment of superficial esophageal cancer in non-operative candidates. Dis Esophagus. 2008; 21(8):673-8. PMID: 18459986.
    View in: PubMed
  47. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, Wisnivesky JP. Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. Cancer. 2008 Mar 15; 112(6):1239-46. PMID: 18224663.
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  48. Nicastri DG, Wisnivesky JP, Litle VR, Yun J, Chin C, Dembitzer FR, Swanson SJ. Thoracoscopic lobectomy: report on safety, discharge independence, pain, and chemotherapy tolerance. J Thorac Cardiovasc Surg. 2008 Mar; 135(3):642-7. PMID: 18329487.
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  49. Weiser TS, Hyman K, Yun J, Litle V, Chin C, Swanson SJ. Electromagnetic navigational bronchoscopy: a surgeon's perspective. Ann Thorac Surg. 2008 Feb; 85(2):S797-801. PMID: 18222220.
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  50. Litle VR. Laparoscopic Heller myotomy for achalasia: a review of the controversies. Ann Thorac Surg. 2008 Feb; 85(2):S743-6. PMID: 18222208.
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  51. Chin CS, Litle V, Yun J, Weiser T, Swanson SJ. Airway stents. Ann Thorac Surg. 2008 Feb; 85(2):S792-6. PMID: 18222219.
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  52. Shaw JP, Dembitzer FR, Wisnivesky JP, Litle VR, Weiser TS, Yun J, Chin C, Swanson SJ. Video-assisted thoracoscopic lobectomy: state of the art and future directions. Ann Thorac Surg. 2008 Feb; 85(2):S705-9. PMID: 18222201.
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  53. Feber A, Xi L, Luketich JD, Pennathur A, Landreneau RJ, Wu M, Swanson SJ, Godfrey TE, Litle VR. MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):255-60; discussion 260. PMID: 18242245.
    View in: PubMed
  54. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, Wisnivesky JP. Prognostic significance of the number of lymph node metastases in esophageal cancer. J Am Coll Surg. 2008 Feb; 206(2):239-46. PMID: 18222375.
    View in: PubMed
  55. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, McGinn TG, Wisnivesky JP. Racial disparities in esophageal cancer treatment and outcomes. Ann Surg Oncol. 2008 Mar; 15(3):881-8. PMID: 17987341.
    View in: PubMed
  56. Litle VR, Swanson SJ. Postoperative bleeding: coagulopathy, bleeding, hemothorax. Thorac Surg Clin. 2006 Aug; 16(3):203-7, v. PMID: 17004547.
    View in: PubMed
  57. Xi L, Coello MC, Litle VR, Raja S, Gooding WE, Yousem SA, El-Hefnawy T, Landreneau RJ, Luketich JD, Godfrey TE. A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patients. Clin Cancer Res. 2006 Apr 15; 12(8):2484-91. PMID: 16638856.
    View in: PubMed
  58. de Hoyos A, Litle VR, Luketich JD. Minimally invasive esophagectomy. Surg Clin North Am. 2005 Jun; 85(3):631-47. PMID: 15927657.
    View in: PubMed
  59. Xi L, Luketich JD, Raja S, Gooding WE, Litle VR, Coello MC, Finkelstein SD, Chestney ML, Landreneau RJ, Hughes SJ, Godfrey TE. Molecular staging of lymph nodes from patients with esophageal adenocarcinoma. Clin Cancer Res. 2005 Feb 1; 11(3):1099-109. PMID: 15709177.
    View in: PubMed
  60. Fernando HC, Hoyos AD, Litle V, Belani CP, Luketich JD. Radiofrequency ablation: identification of the ideal patient. Clin Lung Cancer. 2004 Nov; 6(3):149-53. PMID: 15555215.
    View in: PubMed
  61. Coello MC, Luketich JD, Litle VR, Godfrey TE. Prognostic significance of micrometastasis in non-small-cell lung cancer. Clin Lung Cancer. 2004 Jan; 5(4):214-25. PMID: 14967073.
    View in: PubMed
  62. Litle VR, Luketich JD, Christie NA, Buenaventura PO, Alvelo-Rivera M, McCaughan JS, Nguyen NT, Fernando HC. Photodynamic therapy as palliation for esophageal cancer: experience in 215 patients. Ann Thorac Surg. 2003 Nov; 76(5):1687-92; discussion 1692-3. PMID: 14602313.
    View in: PubMed
  63. Luketich JD, Alvelo-Rivera M, Buenaventura PO, Christie NA, McCaughan JS, Litle VR, Schauer PR, Close JM, Fernando HC. Minimally invasive esophagectomy: outcomes in 222 patients. Ann Surg. 2003 Oct; 238(4):486-94; discussion 494-5. PMID: 14530720.
    View in: PubMed
  64. Litle VR, Christie NA, Fernando HC, Buenaventura PO, Ferson PF, Luketich JD. Photodynamic therapy for endobronchial metastases from nonbronchogenic primaries. Ann Thorac Surg. 2003 Aug; 76(2):370-5; discussion 375. PMID: 12902066.
    View in: PubMed
  65. Pierre AF, Luketich JD, Fernando HC, Christie NA, Buenaventura PO, Litle VR, Schauer PR. Results of laparoscopic repair of giant paraesophageal hernias: 200 consecutive patients. Ann Thorac Surg. 2002 Dec; 74(6):1909-15; discussion 1915-6. PMID: 12643372.
    View in: PubMed
  66. Litle VR, Buenaventura PO, Luketich JD. Minimally invasive resection for esophageal cancer. Surg Clin North Am. 2002 Aug; 82(4):711-28. PMID: 12472126.
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  67. Litle VR, Buenaventura PO, Luketich JD. Laparoscopic repair of giant paraesophageal hernia. Adv Surg. 2001; 35:21-38. PMID: 11579812.
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  68. Litle VR, Leavenworth JD, Darragh TM, Kosinski LA, Moore DH, Smith-McCune KK, Warren RS, Palefsky JM, Welton ML. Angiogenesis, proliferation, and apoptosis in anal high-grade squamous intraepithelial lesions. Dis Colon Rectum. 2000 Mar; 43(3):346-52. PMID: 10733116.
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  69. Litle VR, Barbour S, Schrock TR, Welton ML. The continent ileostomy: long-term durability and patient satisfaction. J Gastrointest Surg. 1999 Nov-Dec; 3(6):625-32. PMID: 10554370.
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  70. Litle VR, Warren RS, Moore D, Pallavicini MG. Molecular cytogenetic analysis of cytokeratin 20-labeled cells in primary tumors and bone marrow aspirates from colorectal carcinoma patients. Cancer. 1997 May 1; 79(9):1664-70. PMID: 9128980.
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  71. Litle VR, Reilly LM, Ramos TK. Preoperative embolization of carotid body tumors: when is it appropriate? Ann Vasc Surg. 1996 Sep; 10(5):464-8. PMID: 8905066.
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  72. Litle VR, Lockett SJ, Pallavicini MG. Genotype/phenotype analyses of low frequency tumor cells using computerize image microscopy. Cytometry. 1996 Apr 1; 23(4):344-9. PMID: 8900478.
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  73. Weinstock MA, Bogaars HA, Ashley M, Litle V, Bilodeau E, Kimmel S. Inaccuracies in certification of nonmelanoma skin cancer deaths. Am J Public Health. 1992 Feb; 82(2):278-81. PMID: 1739165.
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  74. Weinstock MA, Bogaars HA, Ashley M, Litle V, Bilodeau E, Kimmel S. Nonmelanoma skin cancer mortality. A population-based study. Arch Dermatol. 1991 Aug; 127(8):1194-7. PMID: 1863078.
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