Milos Janicek, MD, PhD, serves as an Associate Professor of Radiology in Body Imaging at the Chobanian and Avedisian School of Medicine. For several years he served as Section Chief in the department of Radiology. As a former fellow at the Dana Farber Cancer Institute, he developed a special interest in tumor Imaging and infrared imaging application in tumor biology and continues to conduct research in these subfields. Dr. Janicek holds duel certification in diagnostic radiology and nuclear medicine by the American Board of Radiology.
Research/Scholarship:
I have chosen the field of Radiology with intention to combine clinical contribution with my strong interest in research. Looking back at my very diverse, yet, productive carrier, I believe that I have accomplished a lot nearing my goal: In 1986, I joined BWH, HMS as a research fellow. I explored modeling of new vessel formation after arterial occlusion, investigating the natural history of endothelial injury, and clinical implications of platelet activation. My proudest cooperation was that with J. Folkman’s laboratory exploring the angiogenesis inhibition. At the DFCI, I focused on the imaging of secondary malignant skeletal disease and of aggressive malignant lymphoma. My interest in oncologic imaging, particularly related to prognostication of sequential imaging is the essence of my current BMC research of Immuno-Therapies on model of Malignant Melanoma applying prior experience from PET-CT and gallium-67 in lymphoma. I developed a novel imaging application using infrared imaging for re-staging of cancer patients, using tumor perfusion assessment with PET and Doppler ultrasound as an index of very early therapy response in multi-center trial of Gastrointestinal Stromal Tumor in collaboration with Novartis Pharmaceuticals. I served in CALGB panels of Lymphoma Experts on imaging in Immunotherapy for low grade lymphomas (LEXCOR group) organized by IDEC pharmaceutical, San Diego, CA leading to one of major modern epics: RITUXAN and ZEVALIN therapy of multiple tumors. At BMC, I was involved in organizing my own multidisciplinary team around Neuroendocrine Tumor, monitoring and therapeutic implications of functional imaging, Y-90 therapy, and bridging to Ga-68 DOTATATE. It was a foundation of my current interest in a novel approach to RECIST scoring in era of Immune therapies (IT). Replacing traditional restaging with measure of “therapeutic Impact” of treatments discussed at ASCO 2019 and ASCO-SITC 2020 and ARRS 2023. Focusing on Malignant melanoma and IT with our Oncology Group will test our research on upcoming multicenter biomarker driven Anti-PD-1 therapy in Melanoma.
Diversity, Equity, Inclusion and Accessibility
Diversity, Equity, Inclusion & Justice: After my Medical School, my career started in Sanaa, Yemen exploring my leadership skills with newly acquired Radiology foundation in Peace Corps type operation with load of social responsibility. Everybody included and Justice done based on dire need. After 3 years, I transitioned to Research fellowship bridging to the most advanced medical world, BWH, HMS. Treating my patients as equal, I was accepted in this country as equal given the opportunity to work hard and contribute. I honor systems as foundation of success. Joined VA Hospitals as a model of inclusion, ongoing project from my HSPH, same as breast MRI imaging in InMed Women’s imaging group, working on new algorithms of use of MRI in regional community group practice. Along these lines of accessibility & effectiveness of screening algorithms for lung cancer at BMC comparing our achievements with European Pulmology Society, where I was invited to present in 2019. My future plans include linking diverse chapters of my research and teaching into a concept of modern functional approach to imaging. Rich and diverse foundation of BMC/BU has given me a solid foundation for the past 18 years. The ultimate promotion it attainable only if/when the Individual values the Institution as much as the Institution values his/her Contribution.
Publications listed below are automatically derived from MEDLINE/PubMed and other
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Janicek MJ, Camaya VM. Probably benign findings, BIRADS category 3 (MR-Bi3), on magnetic resonance imaging of the breast (BrMR): Is repeated MRI an alternative to biopsy? J Clin Oncol. 2011 Sep 20; 29(27_suppl):21. PMID: 27958027
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Janicek MJ, Camaya VM, Naddaff D. Value of close follow-up for "probably benign findings," BIRADS category 3 (MR-Bi3), on magnetic resonance imaging of the breast (BrMR). J Clin Oncol. 2011 May 20; 29(15_suppl):e11060. PMID: 28023441
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Hirsch AE, Cuaron JJ, Janicek MJ, Mui K, Lee RJ, Wang DS, Babayan RK, Zumwalt AC, Gignac GA, Tao W, Ozonoff A, Zietman AL. Anatomic differences after robotic-assisted radical prostatectomy and open prostatectomy: implications for radiation field design. Pract Radiat Oncol. 2011 Apr-Jun; 1(2):115-25.View Related Profiles. PMID: 24673925; DOI: 10.1016/j.prro.2010.11.007;
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Teneriello MG, Gordon AN, Lim P, Janicek M. Phase III trial of induction gemcitabine (G) or paclitaxel (T) plus carboplatin (C) followed by elective T consolidation in advanced ovarian cancer (OC): Final safety and efficacy report. J Clin Oncol. 2010 Jun 20; 28(18_suppl):LBA5008. PMID: 27937443
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Mendelson DS, Brewer M, Janicek M, Breitenbach E, Barrett E, Hamilton M, Ptazynski M, van Duym C, Gordon M. Phase I study of OSI-211 (liposomal lurtotecan) in combination with liposomal doxorubicin (LD) every 3 weeks in patients (pts) with advanced solid tumors; final analysis suggests benefit in refractory ovarian cancer (OC). J Clin Oncol. 2005 Jun; 23(16_suppl):2074. PMID: 27946920
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Janicek MJ, Demetri G, Janicek MR, Shaffer K, Fauci MA. Dynamic infrared imaging of newly diagnosed malignant lymphoma compared with Gallium-67 and Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography. Technol Cancer Res Treat. 2003 Dec; 2(6):571-8.View Related Profiles. PMID: 14640768
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Eder JP, Supko JG, Clark JW, Puchalski TA, Garcia-Carbonero R, Ryan DP, Shulman LN, Proper J, Kirvan M, Rattner B, Connors S, Keogan MT, Janicek MJ, Fogler WE, Schnipper L, Kinchla N, Sidor C, Phillips E, Folkman J, Kufe DW. Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily. J Clin Oncol. 2002 Sep 15; 20(18):3772-84. PMID: 12228197
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Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002 Aug 15; 347(7):472-80. PMID: 12181401
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Oh WK, Loda M, Kantoff PW, Janicek M. Progressive sclerosis of isolated foot metastasis of prostate cancer. J Urol. 2002 Mar; 167(3):1392. PMID: 11832744
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Howard OM, Gribben JG, Neuberg DS, Grossbard M, Poor C, Janicek MJ, Shipp MA. Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival. J Clin Oncol. 2002 Mar 1; 20(5):1288-94. PMID: 11870171
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Janicek MJ, Shaffer K. Manifestations of toxic lung effects on Ga-67 scans in aggressive non-Hodgkin's lymphoma with high-dose CHOP chemotherapy. Clin Nucl Med. 2000 Sep; 25(9):734-5.View Related Profiles. PMID: 10983770
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Jänne PA, Janicek MJ, Brown F. Meningeal carcinomatosis in lung cancer. Case 2. Carcinomatous meningitis. J Clin Oncol. 2000 Aug; 18(15):2927-9. PMID: 10920142
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Blobe GC, Mantel M, Janicek M, Demetri GD. Two patients with sarcoma. Case 2. Uterine sarcoma. J Clin Oncol. 2000 Jun; 18(11):2343-4. PMID: 10829056
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Attar EC, Ervin T, Janicek M, Deykin A, Godleski J. Side effects of chemotherapy. Case 3. Acute interstitial pneumonitis related to gemcitabine. J Clin Oncol. 2000 Feb; 18(3):697-8. PMID: 10653887
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Shapiro CL, Keating J, Angell JE, Janicek M, Gelman R, Hayes D, LeBoff MS. Monitoring therapeutic response in skeletal metastases using dual-energy x-ray absorptiometry: a prospective feasibility study in breast cancer patients. Cancer Invest. 1999; 17(8):566-74. PMID: 10592763
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Schoell WM, Pieber D, Reich O, Lahousen M, Janicek M, Guecer F, Winter R. Tumor angiogenesis as a prognostic factor in ovarian carcinoma: quantification of endothelial immunoreactivity by image analysis. Cancer. 1997 Dec 15; 80(12):2257-62. PMID: 9404702
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Burstein HJ, Janicek MJ, Skarin AT. Hypertrophic osteoarthropathy. J Clin Oncol. 1997 Jul; 15(7):2759-60. PMID: 9215850
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Janicek M, Kaplan W, Neuberg D, Canellos GP, Shulman LN, Shipp MA. Early restaging gallium scans predict outcome in poor-prognosis patients with aggressive non-Hodgkin's lymphoma treated with high-dose CHOP chemotherapy. J Clin Oncol. 1997 Apr; 15(4):1631-7. PMID: 9193363
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Roach PJ, Janicek MJ, Kaplan WD. Bone lymphoma. Comparison of Tl-201 and Ga-67 citrate scintigraphy in assessment of treatment response. Clin Nucl Med. 1996 Sep; 21(9):689-94. PMID: 8879868
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Better N, Janicek MJ, Annese ML, Kaplan WD. Mediastinal tumor presenting as a cardiac halo on equilibrium radionuclide angiography. A differential diagnosis to pericardial effusion. Clin Nucl Med. 1996 Apr; 21(4):334-5. PMID: 8925627
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Shipp MA, Neuberg D, Janicek M, Canellos GP, Shulman LN. High-dose CHOP as initial therapy for patients with poor-prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study. J Clin Oncol. 1995 Dec; 13(12):2916-23. PMID: 8523055
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Janicek MJ, Shaffer K. Scintigraphic and radiographic patterns of skeletal metastases in breast cancer: value of sequential imaging in predicting outcome. Skeletal Radiol. 1995 Nov; 24(8):597-600.View Related Profiles. PMID: 8614859
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Janicek MJ, Hayes DF, Kaplan WD. Healing flare in skeletal metastases from breast cancer. Radiology. 1994 Jul; 192(1):201-4. PMID: 8208938
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Janicek MJ, Schwartz RB, Carvalho PA, Garada B, Holman BL. Tc-99m HMPAO brain perfusion SPECT in acute aphasia. Correlation with clinical and structural findings. Clin Nucl Med. 1993 Dec; 18(12):1032-8. PMID: 8293621
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Larar GN, Janicek MJ, Kaplan WD. Ga-67 scintigraphy after bone marrow harvest. Significance of "sacroiliac" asymmetry in the lymphoma patient. Clin Nucl Med. 1993 Feb; 18(2):126-9. PMID: 8432056
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Janicek MJ, O'Tuama LA, Treves ST. Quantitative evaluation of 99mTc-hexamethylpropylenamineoxime brain SPECT in childhood-onset epilepsy. J Nucl Biol Med. 1992 Oct-Dec; 36(4):319-23. PMID: 1296771
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O'Tuama LA, Urion DK, Janicek MJ, Treves ST, Bjornson B, Moriarty JM. Regional cerebral perfusion in Landau-Kleffner syndrome and related childhood aphasias. J Nucl Med. 1992 Oct; 33(10):1758-65. PMID: 1383478
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Janicek MJ, Meyerovitz M, Harrington DP, Hollenberg NK. Arterial response to ketanserin and aspirin in patients with advanced peripheral atherosclerosis. Invest Radiol. 1992 Jun; 27(6):415-21. PMID: 1607256
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Janicek MJ, Van den Abbeele AD, DeSisto WC, Kassis AI, Holman BL, Tumeh SS, Hollenberg NK. Embolization of platelets after endothelial injury to the aorta in rabbits. Assessment with 111indium-labeled platelets and angiography. Invest Radiol. 1991 Jul; 26(7):655-9. PMID: 1885272
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O'Tuama LA, Janicek MJ, Barnes PD, Scott RM, Black PM, Sallan SE, Tarbell NJ, Kupsky WJ, Wagenaar D, Ulanski JS, et al. 201Tl/99mTc-HMPAO SPECT imaging of treated childhood brain tumors. Pediatr Neurol. 1991 Jul-Aug; 7(4):249-57. PMID: 1930415
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Janicek MJ, Van den Abbeele AD, Hollenberg NK, Kassis AI, Holman BL, Tumeh SS. Platelet activation and aggregation after endothelial injury. Assessment with indium-111-labeled platelets and angiography. Invest Radiol. 1990 Sep; 25(9):988-93. PMID: 2211057
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Janicek M, Grassi CJ, Meyerovitz M, Callahan MB, Sandor T, Whittemore A, Mannick J, Harrington DP, Hollenberg NK. Atherosclerosis, peripheral arterial disease and the vascular response to ketanserin. Invest Radiol. 1990 May; 25(5):495-503. PMID: 2345079
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
Year | Publications |
---|
1990 | 2 |
1991 | 2 |
1992 | 3 |
1993 | 2 |
1994 | 1 |
1995 | 2 |
1996 | 2 |
1997 | 3 |
1999 | 1 |
2000 | 4 |
2002 | 4 |
2003 | 1 |
2005 | 1 |
2010 | 1 |
2011 | 3 |
2014 | 1 |
Teaching/Mentoring: My teaching is focusing on translation of my research and clinical experience to practicality and principles, based on truth and self-respect. Combining my Health Care Management skills from HSPH degree program, I have developed more focused curriculum of my teaching and mentoring after being recruited to BU/BMC by A. Norbash, my fellow MHCM graduate (2005).
Available to Mentor as: (Review Mentor Role Definitions):
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Advisor
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Career Mentor
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Co-Mentor or Peer Mentor
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Diversity Mentor
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Education Mentor
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Work / Life Integration Mentor