Barbara Seaton | Profiles RNS

Barbara A. Seaton, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

PhD, Massachusetts Institute of Technology
BS, Brooklyn College

Websites

Pharmacology, Physiology & Biophysics Faculty

ORCID : 0000-0003-4654-7709

Member
Boston University
Pulmonary Center

BU Research
NIH RePORTER Research

Enhancing Collectin-Mediated Defense Against Influenza
08/11/2011 - 06/30/2015 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI
5R01HL069031-13

X-Ray Analysis of Pulmonary Surfactant Protein A
12/01/2001 - 11/30/2006 (PI)
University of Cincinnati NIH NHLBI

Annexin Crystal Structures and Membrane Interactions
07/01/1998 - 11/30/2003 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM44554 13

X-ray Studies of Prothrombin
06/01/1998 - 06/30/2003 (PI)
Beth Israel Deaconess Medical Center NIH NHLBI

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/09/1999 - 08/08/2001 (PI)
Paratek Pharmaceuticals Inc

Title

Yr	Title	Project-Sub Proj	Pubs
2010	Collectins and Innate Defense against Inhaled Pathogens	5P01AI083222-02	24
2009	Collectins and Innate Defense against Inhaled Pathogens	3P01AI083222-01A2S1	24
2009	Collectins and Innate Defense against Inhaled Pathogens	1P01AI083222-01A2	24
2003	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	5R01GM044554-13	10
2002	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	5R01GM044554-12	10
2001	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	5R01GM044554-11	10
2000	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	2R01GM044554-10	10
1999	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	3R01GM044554-09S1	10
1998	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	5R01GM044554-09	10
1997	ANNEXIN CRYSTAL STRUCTURES AND MEMBRANE INTERACTIONS	5R01GM044554-08	10

Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 07 06; 293(27):10646-10662.View Related Profiles.

Seaton, Barbara
Zaia, Joseph
Hartshorn, Kevan
Khatri, Kshitij
Rynkiewicz, Michael
Leymarie, Nancy

PMID: 29769321; PMCID: PMC6036198; DOI: 10.1074/jbc.RA117.001430;

Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. 2017 Aug 08; 56(31):4095-4105.View Related Profiles.

Seaton, Barbara
Head, James
Rynkiewicz, Michael

PMID: 28719181

Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 05; 55(26):3692-701.View Related Profiles.

Seaton, Barbara
Rynkiewicz, Michael

PMID: 27324153; PMCID: PMC5663190; DOI: 10.1021/acs.biochem.6b00048;

Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. PLoS One. 2015; 10(8):e0133454.View Related Profiles.

Seaton, Barbara
Hartshorn, Kevan
Rynkiewicz, Michael
Tripathi, Shweta

PMID: 26308522; PMCID: PMC4550355; DOI: 10.1371/journal.pone.0133454;

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45.View Related Profiles.

Seaton, Barbara
Madico, Guillermo
Sharon, Jacqueline
Rynkiewicz, Michael
Lu, Zhaohua

PMID: 25171003; PMCID: PMC4151076; DOI: 10.1089/mab.2014.0022;

Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847.View Related Profiles.

Seaton, Barbara
Madico, Guillermo
Sharon, Jacqueline
Rynkiewicz, Michael
Lu, Zhaohua

PMID: 24968190; PMCID: PMC4072690; DOI: 10.1371/journal.pone.0099847;

Nikolaidis NM, White MR, Allen K, Tripathi S, Qi L, McDonald B, Taubenberger J, Seaton BA, McCormack FX, Crouch EC, Hartshorn KL. Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L1036-44.View Related Profiles.

Seaton, Barbara
Hartshorn, Kevan
Tripathi, Shweta

PMID: 24705721; PMCID: PMC4042192; DOI: 10.1152/ajplung.00035.2014;

Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA. Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation. Biochemistry. 2013 Nov 26; 52(47):8527-38.View Related Profiles.

Seaton, Barbara
Hartshorn, Kevan
Rynkiewicz, Michael

PMID: 24224757; PMCID: PMC3927399; DOI: 10.1021/bi4010683;

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.View Related Profiles.

Seaton, Barbara
Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Rynkiewicz, Michael
Wang, Qi
Lu, Zhaohua

PMID: 23844703; PMCID: PMC3800442; DOI: 10.1111/imm.12150;

Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94.View Related Profiles.

Seaton, Barbara
Sharon, Jacqueline
Rynkiewicz, Michael
Lu, Zhaohua

PMID: 22747335; PMCID: PMC3566871; DOI: 10.1021/bi201711m;

Showing 10 of 62 results. Show More

van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. J Biol Chem. 2012 Aug 3; 287(32):26666-77.View Related Profiles.

Seaton, Barbara
Head, James
Hartshorn, Kevan
Rynkiewicz, Michael

PMID: 22685299; PMCID: PMC3411006; DOI: 10.1074/jbc.M112.368571;

Yu P, Strug I, Cafarella TR, Seaton BA, Krantz A. Site-specific crosslinking of annexin proteins by 1,4-benzoquinone: a novel crosslinker for the formation of protein dimers and diverse protein conjugates. Org Biomol Chem. 2012 Jun 21; 10(23):4500-4. PMID: 22573340; DOI: 10.1039/c2ob25460c;

Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92.View Related Profiles.

Seaton, Barbara
Zaia, Joseph
Hartshorn, Kevan
Rynkiewicz, Michael
Leymarie, Nancy

PMID: 21965658; PMCID: PMC3220461; DOI: 10.1074/jbc.M111.300673;

van Eijk M, Bruinsma L, Hartshorn KL, White MR, Rynkiewicz MJ, Seaton BA, Hemrika W, Romijn RA, van Balkom BW, Haagsman HP. Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses. J Biol Chem. 2011 Jun 10; 286(23):20137-51.View Related Profiles.

Seaton, Barbara
Hartshorn, Kevan
Rynkiewicz, Michael

PMID: 21489996; PMCID: PMC3121484; DOI: 10.1074/jbc.M111.224469;

Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. J Biol Chem. 2011 Jan 7; 286(1):757-65.View Related Profiles.

Seaton, Barbara
Head, James
Rynkiewicz, Michael

PMID: 21047777; PMCID: PMC3013034; DOI: 10.1074/jbc.M110.175265;

Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: Structural determinants of pattern recognition by lung collectins. Innate Immun. 2010 Jun; 16(3):143-50.View Related Profiles.

Seaton, Barbara
Head, James
Hartshorn, Kevan

PMID: 20423923; DOI: 10.1177/1753425910368716;

Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger PH, Head J. Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21; 48(15):3335-45.View Related Profiles.

Seaton, Barbara
Head, James
Hartshorn, Kevan

PMID: 19249874; PMCID: PMC2720784; DOI: 10.1021/bi8022703;

Shi X, Shao C, Zhang X, Zambonelli C, Redfield AG, Head JF, Seaton BA, Roberts MF. Modulation of Bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface. J Biol Chem. 2009 Jun 5; 284(23):15607-18.View Related Profiles.

Year	Publications
1983	2
1984	1
1985	2
1989	3
1990	2
1991	1
1992	1
1993	1
1994	4
1995	1
1996	1
1997	1
1998	3
1999	4
2001	4
2002	2
2003	3
2006	2
2007	4
2008	2
2009	2
2010	2
2011	2
2012	3
2013	2
2014	3
2015	1
2016	1
2017	1
2018	1