Keywords
Last Name

Barbara A. Seaton, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address700 Albany St
Boston MA 02118
Phone(617) 638-5061
ORCID ORCID Icon0000-0003-4654-7709
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Self-Described Keywords
  • influenza
  • molecular modeling
  • surfactant proteins
  • x-ray crystallography
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-Cell Epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847.
    View in: PubMed
  2. Nikolaidis NM, White MR, Allen K, Tripathi S, Qi L, McDonald B, Taubenberger J, Seaton BA, McCormack FX, Crouch EC, Hartshorn KL. Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11):L1036-44.
    View in: PubMed
  3. Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, Crouch EC, Calin O, Seeberger PH, Schulten K, Seaton BA. Molecular mechanisms of inhibition of influenza by surfactant protein d revealed by large-scale molecular dynamics simulation. Biochemistry. 2013 Nov 26; 52(47):8527-38.
    View in: PubMed
  4. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.
    View in: PubMed
  5. Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94.
    View in: PubMed
  6. van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. J Biol Chem. 2012 Aug 3; 287(32):26666-77.
    View in: PubMed
  7. Yu P, Strug I, Cafarella TR, Seaton BA, Krantz A. Site-specific crosslinking of annexin proteins by 1,4-benzoquinone: a novel crosslinker for the formation of protein dimers and diverse protein conjugates. Org Biomol Chem. 2012 Jun 21; 10(23):4500-4.
    View in: PubMed
  8. Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92.
    View in: PubMed
  9. van Eijk M, Bruinsma L, Hartshorn KL, White MR, Rynkiewicz MJ, Seaton BA, Hemrika W, Romijn RA, van Balkom BW, Haagsman HP. Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses. J Biol Chem. 2011 Jun 10; 286(23):20137-51.
    View in: PubMed
  10. Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. J Biol Chem. 2011 Jan 7; 286(1):757-65.
    View in: PubMed
  11. Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: Structural determinants of pattern recognition by lung collectins. Innate Immun. 2010 Jun; 16(3):143-50.
    View in: PubMed
  12. Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger PH, Head J. Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21; 48(15):3335-45.
    View in: PubMed
  13. Shi X, Shao C, Zhang X, Zambonelli C, Redfield AG, Head JF, Seaton BA, Roberts MF. Modulation of Bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface. J Biol Chem. 2009 Jun 5; 284(23):15607-18.
    View in: PubMed
  14. Wang L, Brauner JW, Mao G, Crouch E, Seaton B, Head J, Smith K, Flach CR, Mendelsohn R. Interaction of recombinant surfactant protein D with lipopolysaccharide: conformation and orientation of bound protein by IRRAS and simulations. Biochemistry. 2008 Aug 5; 47(31):8103-13.
    View in: PubMed
  15. Guo S, Zhang X, Seaton BA, Roberts MF. Role of helix B residues in interfacial activation of a bacterial phosphatidylinositol-specific phospholipase C. Biochemistry. 2008 Apr 8; 47(14):4201-10.
    View in: PubMed
  16. Shao C, Novakovic VA, Head JF, Seaton BA, Gilbert GE. Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif. J Biol Chem. 2008 Mar 14; 283(11):7230-41.
    View in: PubMed
  17. Wang H, Head J, Kosma P, Brade H, Müller-Loennies S, Sheikh S, McDonald B, Smith K, Cafarella T, Seaton B, Crouch E. Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d. Biochemistry. 2008 Jan 15; 47(2):710-20.
    View in: PubMed
  18. Crouch E, McDonald B, Smith K, Roberts M, Mealy T, Seaton B, Head J. Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D. Biochemistry. 2007 May 1; 46(17):5160-9.
    View in: PubMed
  19. Shao C, Shi X, Wehbi H, Zambonelli C, Head JF, Seaton BA, Roberts MF. Dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase C. J Biol Chem. 2007 Mar 23; 282(12):9228-35.
    View in: PubMed
  20. Shao C, Zhang F, Kemp MM, Linhardt RJ, Waisman DM, Head JF, Seaton BA. Crystallographic analysis of calcium-dependent heparin binding to annexin A2. J Biol Chem. 2006 Oct 20; 281(42):31689-95.
    View in: PubMed
  21. Crouch E, McDonald B, Smith K, Cafarella T, Seaton B, Head J. Contributions of phenylalanine 335 to ligand recognition by human surfactant protein D: ring interactions with SP-D ligands. J Biol Chem. 2006 Jun 30; 281(26):18008-14.
    View in: PubMed
  22. Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 2003 Sep; 10(9):751-6.
    View in: PubMed
  23. Head JF, Mealy TR, McCormack FX, Seaton BA. Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A. J Biol Chem. 2003 Oct 31; 278(44):43254-60.
    View in: PubMed
  24. Stieglitz KA, Seaton BA, Head JF, Stec B, Roberts MF. Unexpected similarity in regulation between an archaeal inositol monophosphatase/fructose bisphosphatase and chloroplast fructose bisphosphatase. Protein Sci. 2003 Apr; 12(4):760-7.
    View in: PubMed
  25. Mo Y, Campos B, Mealy TR, Commodore L, Head JF, Dedman JR, Seaton BA. Interfacial basic cluster in annexin V couples phospholipid binding and trimer formation on membrane surfaces. J Biol Chem. 2003 Jan 24; 278(4):2437-43.
    View in: PubMed
  26. Stieglitz KA, Johnson KA, Yang H, Roberts MF, Seaton BA, Head JF, Stec B. Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J Biol Chem. 2002 Jun 21; 277(25):22863-74.
    View in: PubMed
  27. Stieglitz KA, Seaton BA, Roberts MF. Binding of proteolytically processed phospholipase D from Streptomyces chromofuscus to phosphatidylcholine membranes facilitates vesicle aggregation and fusion. Biochemistry. 2001 Nov 20; 40(46):13954-63.
    View in: PubMed
  28. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF. The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution. Nat Struct Biol. 2001 Aug; 8(8):710-4.
    View in: PubMed
  29. Kaetzel MA, Mo YD, Mealy TR, Campos B, Bergsma-Schutter W, Brisson A, Dedman JR, Seaton BA. Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation. Biochemistry. 2001 Apr 3; 40(13):4192-9.
    View in: PubMed
  30. Capila I, Hernáiz MJ, Mo YD, Mealy TR, Campos B, Dedman JR, Linhardt RJ, Seaton BA. Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces. Structure. 2001 Jan 10; 9(1):57-64.
    View in: PubMed
  31. Stieglitz K, Seaton B, Roberts MF. The role of interfacial binding in the activation of Streptomyces chromofuscus phospholipase D by phosphatidic acid. J Biol Chem. 1999 Dec 10; 274(50):35367-74.
    View in: PubMed
  32. Campos B, Wang S, Retzinger GS, Kaetzel MA, Seaton BA, Karin NJ, Johnson JD, Dedman JR. Mutation of highly conserved arginine residues disrupts the structure and function of annexin V. Arch Med Res. 1999 Sep-Oct; 30(5):360-7.
    View in: PubMed
  33. Capila I, VanderNoot VA, Mealy TR, Seaton BA, Linhardt RJ. Interaction of heparin with annexin V. FEBS Lett. 1999 Mar 12; 446(2-3):327-30.
    View in: PubMed
  34. Wu F, Flach CR, Seaton BA, Mealy TR, Mendelsohn R. Stability of annexin V in ternary complexes with Ca2+ and anionic phospholipids: IR studies of monolayer and bulk phases. Biochemistry. 1999 Jan 12; 38(2):792-9.
    View in: PubMed
  35. Seaton BA, Dedman JR. Annexins. Biometals. 1998 Dec; 11(4):399-404.
    View in: PubMed
  36. Campos B, Mo YD, Mealy TR, Li CW, Swairjo MA, Balch C, Head JF, Retzinger G, Dedman JR, Seaton BA. Mutational and crystallographic analyses of interfacial residues in annexin V suggest direct interactions with phospholipid membrane components. Biochemistry. 1998 Jun 2; 37(22):8004-10.
    View in: PubMed
  37. Wu F, Gericke A, Flach CR, Mealy TR, Seaton BA, Mendelsohn R. Domain structure and molecular conformation in annexin V/1,2-dimyristoyl-sn-glycero-3-phosphate/Ca2+ aqueous monolayers: a Brewster angle microscopy/infrared reflection-absorption spectroscopy study. Biophys J. 1998 Jun; 74(6):3273-81.
    View in: PubMed
  38. Jin L, Seaton BA, Head JF. Crystal structure at 2.8 A resolution of anabolic ornithine transcarbamylase from Escherichia coli. Nat Struct Biol. 1997 Aug; 4(8):622-5.
    View in: PubMed
  39. Rynkiewicz MJ, Seaton BA. Chemical rescue by guanidine derivatives of an arginine-substituted site-directed mutant of Escherichia coli ornithine transcarbamylase. Biochemistry. 1996 Dec 17; 35(50):16174-9.
    View in: PubMed
  40. Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA. Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat Struct Biol. 1995 Nov; 2(11):968-74.
    View in: PubMed
  41. Swairjo MA, Roberts MF, Campos MB, Dedman JR, Seaton BA. Annexin V binding to the outer leaflet of small unilamellar vesicles leads to altered inner-leaflet properties: 31P- and 1H-NMR studies. Biochemistry. 1994 Sep 13; 33(36):10944-50.
    View in: PubMed
  42. Seaton BA, Head JF. Shaking hands with yourself. Nat Struct Biol. 1994 Jun; 1(6):350-1.
    View in: PubMed
  43. Swairjo MA, Seaton BA, Roberts MF. Effect of vesicle composition and curvature on the dissociation of phosphatidic acid in small unilamellar vesicles--a 31P-NMR study. Biochim Biophys Acta. 1994 May 11; 1191(2):354-61.
    View in: PubMed
  44. Swairjo MA, Seaton BA. Annexin structure and membrane interactions: a molecular perspective. Annu Rev Biophys Biomol Struct. 1994; 23:193-213.
    View in: PubMed
  45. Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA. Rat annexin V crystal structure: Ca(2+)-induced conformational changes. Science. 1993 Sep 3; 261(5126):1321-4.
    View in: PubMed
  46. Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA. Annexin V forms calcium-dependent trimeric units on phospholipid vesicles. FEBS Lett. 1992 Dec 14; 314(2):159-62.
    View in: PubMed
  47. Davenport RC, Bash PA, Seaton BA, Karplus M, Petsko GA, Ringe D. Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. Biochemistry. 1991 Jun 18; 30(24):5821-6.
    View in: PubMed
  48. Ke HM, Thorpe CM, Seaton Ba, Lipscomb WN, Marcus F. Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution. J Mol Biol. 1990 Apr 5; 212(3):513-39.
    View in: PubMed
  49. Seaton BA, Head JF, Kaetzel MA, Dedman JR. Purification, crystallization, and preliminary X-ray diffraction analysis of rat kidney annexin V, a calcium-dependent phospholipid-binding protein. J Biol Chem. 1990 Mar 15; 265(8):4567-9.
    View in: PubMed
  50. Kuo LC, Seaton BA. X-ray diffraction analysis on single crystals of recombinant Escherichia coli ornithine transcarbamoylase. J Biol Chem. 1989 Sep 25; 264(27):16246-8.
    View in: PubMed
  51. Kataoka M, Head JF, Seaton BA, Engelman DM. Melittin binding causes a large calcium-dependent conformational change in calmodulin. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):6944-8.
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  52. Ke H, Thorpe CM, Seaton BA, Marcus F, Lipscomb WN. Molecular structure of fructose-1,6-bisphosphatase at 2.8-A resolution. Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1475-9.
    View in: PubMed
  53. Seaton BA, Head JF, Engelman DM, Richards FM. Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle X-ray scattering. Biochemistry. 1985 Nov 19; 24(24):6740-3.
    View in: PubMed
  54. Ringe D, Seaton BA, Gelb MH, Abeles RH. Inactivation of chymotrypsin by 5-benzyl-6-chloro-2-pyrone: 13C NMR and X-ray diffraction analyses of the inactivator-enzyme complex. Biochemistry. 1985 Jan 1; 24(1):64-8.
    View in: PubMed
  55. Seaton BA, Campbell RL, Petsko GA, Rose DR, Edelstein I, Marcus F. Preliminary X-ray crystallographic studies of pig kidney fructose-1,6-bisphosphatase. J Biol Chem. 1984 Jul 25; 259(14):8915-6.
    View in: PubMed
  56. Rose DR, Seaton BA, Petsko GA, Novotný J, Margolies MN, Locke E, Haber E. Crystallization of the Fab fragment of a monoclonal anti-digoxin antibody and its complex with digoxin. J Mol Biol. 1983 Mar 25; 165(1):203-6.
    View in: PubMed
  57. Seaton BA, Head JF, Lord RC, Petsko GA. Studies of calmodulin structure: laser raman spectroscopy of biomolecules. Biochemistry. 1983 Feb 15; 22(4):973-8.
    View in: PubMed
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