Keywords
Last Name

Jacqueline Sharon, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionOther Pathology
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4652
ORCID ORCID Icon0000-0002-8950-1615
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

 Self-Described Keywords
  • immunology
  • infectious disease
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45. PMID: 25171003.
    View in: PubMed
  2. Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847. PMID: 24968190.
    View in: PubMed
  3. Sharon J, Rynkiewicz MJ, Lu Z, Yang CY. Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. Immunology. 2014 May; 142(1):1-23. PMID: 24219801.
    View in: PubMed
  4. Lu Z, Perkins HM, Sharon J. Antibodies to both terminal and internal B-cell epitopes of Francisella tularensis O-polysaccharide produced by patients with tularemia. Clin Vaccine Immunol. 2014 Feb; 21(2):227-33. PMID: 24351753.
    View in: PubMed
  5. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89. PMID: 23844703.
    View in: PubMed
  6. Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94. PMID: 22747335.
    View in: PubMed
  7. Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60. PMID: 22486311.
    View in: PubMed
  8. Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50. PMID: 22091710.
    View in: PubMed
  9. Roche MI, Lu Z, Hui JH, Sharon J. Characterization of monoclonal antibodies to terminal and internal O-antigen epitopes of Francisella tularensis lipopolysaccharide. Hybridoma (Larchmt). 2011 Feb; 30(1):19-28. PMID: 21466282.
    View in: PubMed
  10. Liebman MA, Roche MI, Williams BR, Kim J, Pageau SC, Sharon J. Antibody treatment of human tumor xenografts elicits active anti-tumor immunity in nude mice. Immunol Lett. 2007 Nov 30; 114(1):16-22. PMID: 17920694.
    View in: PubMed
  11. Lu Z, Roche MI, Hui JH, Unal B, Felgner PL, Gulati S, Madico G, Sharon J. Generation and characterization of hybridoma antibodies for immunotherapy of tularemia. Immunol Lett. 2007 Oct 15; 112(2):92-103. PMID: 17764754.
    View in: PubMed
  12. Wiberg FC, Rasmussen SK, Frandsen TP, Rasmussen LK, Tengbjerg K, Coljee VW, Sharon J, Yang CY, Bregenholt S, Nielsen LS, Haurum JS, Tolstrup AB. Production of target-specific recombinant human polyclonal antibodies in mammalian cells. Biotechnol Bioeng. 2006 Jun 5; 94(2):396-405. PMID: 16596663.
    View in: PubMed
  13. Sharon J, Liebman MA, Williams BR. Recombinant polyclonal antibodies for cancer therapy. J Cell Biochem. 2005 Oct 1; 96(2):305-13. PMID: 16052504.
    View in: PubMed
  14. Liebman MA, Williams BR, Daley KM, Sharon J. Generation and preliminary characterization of an antibody library with preferential reactivity to human colorectal cancer cells as compared to normal human blood cells. Immunol Lett. 2004 Feb 15; 91(2-3):179-88. PMID: 15019288.
    View in: PubMed
  15. Chen L, Liebman MA, Teodorescu-Frumosu S, Schnitzler AC, Sharon J. Expression of a prototypic anti-colorectal cancer polyclonal antibody library in mammalian cells. Immunol Lett. 2003 Aug 5; 88(2):135-40. PMID: 12880683.
    View in: PubMed
  16. Chen L, Williams BR, Yang CY, Cevallos AM, Bhat N, Ward H, Sharon J. Polyclonal Fab phage display libraries with a high percentage of diverse clones to Cryptosporidium parvum glycoproteins. Int J Parasitol. 2003 Mar; 33(3):281-91. PMID: 12670513.
    View in: PubMed
  17. Williams BR, Sompuram SR, Sharon J. Generation of anti-colorectal cancer fab phage display libraries with a high percentage of diverse antigen-reactive clones. Comb Chem High Throughput Screen. 2002 Sep; 5(6):489-99. PMID: 12470278.
    View in: PubMed
  18. Williams BR, Sharon J. Polyclonal anti-colorectal cancer Fab phage display library selected in one round using density gradient centrifugation to separate antigen-bound and free phage. Immunol Lett. 2002 Apr 22; 81(2):141-8. PMID: 11852119.
    View in: PubMed
  19. Sharon J, Sompuram SR, Yang CY, Williams BR, Sarantopoulos S. Construction of polyclonal antibody libraries using phage display. Methods Mol Biol. 2002; 178:101-12. PMID: 11968479.
    View in: PubMed
  20. Sharon J, Sarantopoulos S, Den W, Kao CY, Baecher-Allan CM, Santora KE, Sompuram SR, Petersen-Mahrt S, Williams BR. Recombinant polyclonal antibody libraries. Comb Chem High Throughput Screen. 2000 Jun; 3(3):185-96. PMID: 10903378.
    View in: PubMed
  21. Yao J, Baecher-Allan CM, Sharon J. Serpins identified as cell growth inhibitors in human plasma. Mol Cell Biol Res Commun. 2000 Feb; 3(2):76-81. PMID: 10775503.
    View in: PubMed
  22. Santora KE, Sarantopoulos S, Den W, Petersen-Mahrt S, Sompuram SR, Sharon J. Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20. Comb Chem High Throughput Screen. 2000 Feb; 3(1):51-7. PMID: 10702614.
    View in: PubMed
  23. Baecher-Allan CM, Santora K, Sarantopoulos S, Den W, Sompuram SR, Sharon J, Cevallos AM, Bhat N, Ward H. Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. Comb Chem High Throughput Screen. 1999 Dec; 2(6):319-25. PMID: 10644857.
    View in: PubMed
  24. Den W, Sompuram SR, Sarantopoulos S, Sharon J. A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries. J Immunol Methods. 1999 Jan 1; 222(1-2):45-57. PMID: 10022371.
    View in: PubMed
  25. Gulati S, McQuillen DP, Sharon J, Rice PA. Experimental immunization with a monoclonal anti-idiotope antibody that mimics the Neisseria gonorrhoeae lipooligosaccharide epitope 2C7. J Infect Dis. 1996 Dec; 174(6):1238-48. PMID: 8940214.
    View in: PubMed
  26. Sompuram SR, Den W, Sharon J. Analysis of antigen binding and idiotypic expression by antibodies with polyglycine-replaced complementarity-determining regions. J Immunol. 1996 Feb 1; 156(3):1071-81. PMID: 8557981.
    View in: PubMed
  27. Sarantopoulos S, Kao CY, Den W, Sharon J. A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries. J Immunol. 1994 Jun 1; 152(11):5344-51. PMID: 8189052.
    View in: PubMed
  28. Jacobson BA, Sharon J, Shan H, Shlomchik M, Weigert MG, Marshak-Rothstein A. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. J Immunol. 1994 May 1; 152(9):4489-99. PMID: 8157964.
    View in: PubMed
  29. Kao CY, Sharon J. Chimeric antibodies with anti-dextran-derived complementarity-determining regions and anti-p-azophenylarsonate-derived framework regions. J Immunol. 1993 Aug 15; 151(4):1968-78. PMID: 7688391.
    View in: PubMed
  30. Sompuram SR, Sharon J. Verification of a model of a F(ab) complex with phenylarsonate by oligonucleotide-directed mutagenesis. J Immunol. 1993 Mar 1; 150(5):1822-8. PMID: 8436817.
    View in: PubMed
  31. Nisonoff A, Oliveira TM, Sharon J. An analysis of idiotype expression in a high-affinity, somatically mutated variant of a germline-encoded anti-p-azobenzenearsonate antibody. Int Immunol. 1993 Jan; 5(1):1-9. PMID: 8443119.
    View in: PubMed
  32. Sharon J, Kao CY, Sompuram SR. Oligonucleotide-directed mutagenesis of antibody combining sites. Int Rev Immunol. 1993; 10(2-3):113-27. PMID: 8360579.
    View in: PubMed
  33. Rashid A, Auchincloss H, Sharon J. Comparison of GK1.5 and chimeric rat/mouse GK1.5 anti-CD4 antibodies for prolongation of skin allograft survival and suppression of alloantibody production in mice. J Immunol. 1992 Mar 1; 148(5):1382-8. PMID: 1538121.
    View in: PubMed
  34. Strong RK, Petsko GA, Sharon J, Margolies MN. Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 2. Structural basis of hapten binding and idiotypy. Biochemistry. 1991 Apr 16; 30(15):3749-57. PMID: 2015230.
    View in: PubMed
  35. Strong RK, Campbell R, Rose DR, Petsko GA, Sharon J, Margolies MN. Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. Biochemistry. 1991 Apr 16; 30(15):3739-48. PMID: 2015229.
    View in: PubMed
  36. Fish S, Fleming M, Sharon J, Manser T. Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response. J Exp Med. 1991 Mar 1; 173(3):665-72. PMID: 1705280.
    View in: PubMed
  37. Parhami-Seren B, Wysocki LJ, Margolies MN, Sharon J. Clustered H chain somatic mutations shared by anti-p-azophenylarsonate antibodies confer enhanced affinity and ablate the cross-reactive idiotype. J Immunol. 1990 Oct 1; 145(7):2340-6. PMID: 2118935.
    View in: PubMed
  38. Sharon J. Structural characterization of idiotopes by using antibody variants generated by site-directed mutagenesis. J Immunol. 1990 Jun 15; 144(12):4863-9. PMID: 2351832.
    View in: PubMed
  39. Sharon J. Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4814-7. PMID: 2352950.
    View in: PubMed
  40. Parhami-Seren B, Sharon J, Margolies MN. Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodies. J Immunol. 1990 Jun 1; 144(11):4426-33. PMID: 2111347.
    View in: PubMed
  41. Sharon J, Gefter ML, Wysocki LJ, Margolies MN. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten. J Immunol. 1989 Jan 15; 142(2):596-601. PMID: 2911012.
    View in: PubMed
  42. Sharon J. The invariant tryptophan in an H chain V region is not essential to antibody binding. J Immunol. 1988 Apr 15; 140(8):2666-9. PMID: 3128602.
    View in: PubMed
  43. Sharon J, Gefter ML, Manser T, Ptashne M. Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2628-31. PMID: 3085101.
    View in: PubMed
  44. Wims LA, Sharon J, Newman B, Kabat EA, Morrison SL. C57BL/6 x BALB/c hybridomas produce IgA which assembles into molecules with covalent bonds between heavy chains (H) and light chains (L), and into molecules lacking covalent bonds between H and L. Mol Immunol. 1985 Dec; 22(12):1379-86. PMID: 3938526.
    View in: PubMed
  45. Sharon J, Gefter ML, Manser T, Morrison SL, Oi VT, Ptashne M. Expression of a VHC kappa chimaeric protein in mouse myeloma cells. Nature. 1984 May 24-30; 309(5966):364-7. PMID: 6328310.
    View in: PubMed
  46. Berger CL, Morrison S, Chu A, Patterson J, Estabrook A, Takezaki S, Sharon J, Warburton D, Irigoyen O, Edelson RL. Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor-associated antigens. J Clin Invest. 1982 Dec; 70(6):1205-15. PMID: 6217214.
    View in: PubMed
  47. Sharon J, Kabat EA, Morrison SL. Association constants of hybridoma antibodies specific for alpha (1 leads to 6) linked dextran determined by affinity electrophoresis. Mol Immunol. 1982 Mar; 19(3):389-97. PMID: 6178962.
    View in: PubMed
  48. Sharon J, Kabat EA, Morrison SL. Immunochemical characterization of binding sites of hybridoma antibodies specific for alpha (1 leads to 6) linked dextran. Mol Immunol. 1982 Mar; 19(3):375-88. PMID: 6178961.
    View in: PubMed
  49. Sharon J, D'Hoostelaere L, Potter M, Kabat EA, Morrison SL. A cross-reactive idiotype, QUPC52 IdX, present on most but not all anti-alpha (1 replaced by 6) dextran-specific IgM and IgA hybridoma antibodies with combining sites of different sizes. J Immunol. 1982 Jan; 128(1):498-500. PMID: 6172490.
    View in: PubMed
  50. Matsuuchi L, Sharon J, Morrison SL. An analysis of heavy chain glycopeptides of hybridoma antibodies: correlation between antibody specificity and sialic acid content. J Immunol. 1981 Nov; 127(5):2188-90. PMID: 6795268.
    View in: PubMed
  51. Sharon J, Kabat EA, Morrison SL. Studies on mouse hybridomas secreting IgM or IgA antibodies to alpha(1 to 6)-linked dextran. Mol Immunol. 1981 Sep; 18(9):831-46. PMID: 6175897.
    View in: PubMed
  52. Sharon J, Morrison SL, Kabat EA. Formation of hybridoma clones in soft agarose: effect of pH and of medium. Somatic Cell Genet. 1980 May; 6(3):435-41. PMID: 7190739.
    View in: PubMed
  53. Sharon J, Morrison SL, Kabat EA. Detection of specific hybridoma clones by replica immunoadsorption of their secreted antibodies. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1420-4. PMID: 286325.
    View in: PubMed
  54. Givol D, Sharon J, Hochman J, Gavish M, Inbar D, Pecht I, Steinberg IZ, Schlessinger J. Folding, association, and interactions of domains in the antibody molecule. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:667-75. PMID: 268251.
    View in: PubMed
  55. Sharon J, Givol D. Preparation of Fv fragment from the mouse myeloma XRPC-25 immunoglobulin possessing anti-dinitrophenyl activity. Biochemistry. 1976 Apr 6; 15(7):1591-4. PMID: 4096.
    View in: PubMed
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