Rachel Fearns, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of St Andrews



Expertise in paramyxovirus genome transcription and replication mechanisms.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Initiation and regulation of RSV mRNA transcription and genome replication
08/07/2014 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infe
5R01AI113321-03

Development of an in ivtro assay for paramyxovirus polymerases
05/16/2014 - 05/15/2018 (PI)
Alios BioPharma, Inc.


The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2018 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Inst
1R61HL137081-01

Treating Respiratory Syncytial Virus Infection by Targeting a Virus-Associated Kinase
04/01/2015 - 03/31/2018 (PI)
The Hartwell Foundation


Development of a non-radioactive assay for the RSV polymerase
11/12/2015 - 11/11/2017 (PI)
Merck, Sharp & Dohme Corp


A structure analysis of the intact viron and replicative complexes of human respiratory syncytial virus
11/30/2014 - 08/31/2017 (PI)
University Glasgow Medical Resrch Coun


The development of respiratory syncytial virus polymerase assay and mechanism of action studies
07/15/2013 - 09/15/2015 (PI)
AstraZeneca


Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions
09/30/2008 - 08/31/2013 (PI)
NIH/National Institute of Allergy & Infe
5R01AI074903-04




Yr Title Project-Sub Proj Pubs
2017 The B cell repertoire as a window into the nature and impact of the lung virome 1R61HL137081-01
2017 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-04 3
2016 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-03 3
2015 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-02 3
2014 Initiation and regulation of RSV mRNA transcription and genome replication 1R01AI113321-01 3
2011 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-04 5
2010 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-03 5
2009 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-02 5
2009 Mechanism for non-templated initiation by a paramyxovirus polymerase 5R21AI079328-02 2
2008 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 1R01AI074903-01A1 5
Showing 10 of 11 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Fearns R, Plemper RK. Polymerases of paramyxoviruses and pneumoviruses. Virus Res. 2017 Apr 15; 234:87-102. PMID: 28104450; DOI: 10.1016/j.virusres.2017.01.008;.
  2. Fearns R, Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral Res. 2016 Oct; 134:63-76. PMID: 27575793; DOI: 10.1016/j.antiviral.2016.08.006;.
  3. Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA. Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. J Virol. 2016 May 15; 90(10):4876-88. PMID: 26656699; PMCID: PMC4859727; DOI: 10.1128/JVI.02349-15;.
  4. Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA. Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen. Antiviral Res. 2016 Jul; 131:19-25. PMID: 27059228; PMCID: PMC4937797; DOI: 10.1016/j.antiviral.2016.03.015;.
  5. Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5. PMID: 26934220; DOI: 10.1038/nature17180;.
  6. McCutcheon KM, Jordan R, Mawhorter ME, Noton SL, Powers JG, Fearns R, Cihlar T, Perron M. The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment. J Virol. 2016 Feb; 90(4):1705-17.View Related Profiles. PMID: 26608311; PMCID: PMC4733981; DOI: 10.1128/JVI.02417-15;.
  7. Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2''-Fluoro-4''-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun; 11(6):e1004995. PMID: 26098424; PMCID: PMC4476725; DOI: 10.1371/journal.ppat.1004995;.
  8. Noton SL, Nagendra K, Dunn EF, Mawhorter ME, Yu Q, Fearns R. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug; 89(15):7786-98.View Related Profiles. PMID: 25995255; PMCID: PMC4505683; DOI: 10.1128/JVI.00530-15;.
  9. Dickey LL, Duncan JK, Hanley TM, Fearns R. Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. Virology. 2015 Jul; 481:199-209. PMID: 25796077; PMCID: PMC4437874; DOI: 10.1016/j.virol.2015.02.043;.
  10. Noton SL, Fearns R. Initiation and regulation of paramyxovirus transcription and replication. Virology. 2015 May; 479-480:545-54.View Related Profiles. PMID: 25683441; PMCID: PMC4424093; DOI: 10.1016/j.virol.2015.01.014;.
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 18 distinct years, with a maximum of 5 publications in 2015

YearPublications
19941
19951
19961
19972
19993
20001
20021
20053
20061
20092
20103
20111
20121
20132
20143
20155
20164
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

mononegavirales
paramyxovirus
processing bodies
RNA dependent RNA polymerase
stress granules
transcription

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:


72 E. Concord St Housman (R)
Boston MA 02118
Google Map


Fearns's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department