Rachel Fearns, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of St Andrews



Expertise in paramyxovirus genome transcription and replication mechanisms.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




MECHANISMS OF MARBURG VIRUS GENE EXPRESSION
05/08/2018 - 04/30/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R01AI133486-01A1

INITIATION AND REGULATION OF RSV MRNA TRANSCRIPTION AND GENOME REPLICATION
08/07/2014 - 07/31/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113321-04

DEVELOPING COMBINATION THERAPIES AGAINST PNEUMO- AND PARAMYXOVIRUSES CAUSING SEVERE RESPIRATORY INFECTION
07/01/2018 - 06/30/2019 (PI)
Georgia State University NIH NIAID
2R01AI071002-12

DEVELOPMENT OF AN IN IVTRO ASSAY FOR PARAMYXOVIRUS POLYMERASES
05/16/2014 - 05/15/2019 (PI)
Alios BioPharma, Inc.

THE B CELL REPERTOIRE AS A WINDOW INTO THE NATURE AND IMPACT OF THE LUNG VIROME
05/01/2017 - 04/30/2019 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Institute
5R61HL137081-02

TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTION BY TARGETING A VIRUS-ASSOCIATED KINASE
04/01/2015 - 03/31/2019 (PI)
The Hartwell Foundation

A STRUCTURE ANALYSIS OF THE INTACT VIRON AND REPLICATIVE COMPLEXES OF HUMAN RESPIRATORY SYNCYTIAL VIRUS
11/30/2014 - 03/31/2019 (PI)
University Glasgow Medical Resrch Coun

MECHANISM OF ACTION OF AN RSV N PROTEIN INHIBITOR
04/01/2018 - 10/01/2018 (PI)
Enanta Pharmaceuticals, Inc

DEVELOPMENT OF A NON-RADIOACTIVE ASSAY FOR THE RSV POLYMERASE
11/12/2015 - 11/11/2017 (PI)
Merck, Sharp & Dohme Corp

THE DEVELOPMENT OF RESPIRATORY SYNCYTIAL VIRUS POLYMERASE ASSAY AND MECHANISM OF ACTION STUDIES
07/15/2013 - 09/30/2017 (PI)
AstraZeneca

Showing 10 of 11 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Mechanisms of Marburg virus gene expression 1R01AI133486-01A1
2018 The B cell repertoire as a window into the nature and impact of the lung virome 5R61HL137081-02
2017 The B cell repertoire as a window into the nature and impact of the lung virome 1R61HL137081-01
2017 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-04 3
2016 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-03 3
2015 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-02 3
2014 Initiation and regulation of RSV mRNA transcription and genome replication 1R01AI113321-01 3
2011 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-04 5
2010 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-03 5
2009 Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions 5R01AI074903-02 5
Showing 10 of 13 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 Oct 26; 293(43):16761-16777. PMID: 30206124.
     
  2. Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter. Nucleic Acids Res. 2018 Jul 27; 46(13):6785-6796.View Related Profiles. PMID: 29873775.
     
  3. Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK. Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses. Antimicrob Agents Chemother. 2018 Aug; 62(8). PMID: 29891600.
     
  4. Atienza BJP, Jensen LD, Noton SL, Ansalem AKV, Hobman T, Fearns R, Marchant DJ, West FG. Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry. J Org Chem. 2018 Jul 06; 83(13):6829-6842.View Related Profiles. PMID: 29663810.
     
  5. Braun MR, Deflubé LR, Noton SL, Mawhorter ME, Tremaglio CZ, Fearns R. RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V. PLoS Pathog. 2017 12; 13(12):e1006803.View Related Profiles. PMID: 29281742.
     
  6. Fearns R, Plemper RK. Polymerases of paramyxoviruses and pneumoviruses. Virus Res. 2017 Apr 15; 234:87-102. PMID: 28104450; DOI: 10.1016/j.virusres.2017.01.008;.
     
  7. Fearns R, Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral Res. 2016 Oct; 134:63-76. PMID: 27575793; DOI: 10.1016/j.antiviral.2016.08.006;.
     
  8. Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA. Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. J Virol. 2016 May 15; 90(10):4876-88. PMID: 26656699; PMCID: PMC4859727; DOI: 10.1128/JVI.02349-15;.
     
  9. Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA. Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen. Antiviral Res. 2016 Jul; 131:19-25. PMID: 27059228; PMCID: PMC4937797; DOI: 10.1016/j.antiviral.2016.03.015;.
     
  10. Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5. PMID: 26934220; DOI: 10.1038/nature17180;.
     
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 19 distinct years, with a maximum of 5 publications in 2015

YearPublications
19941
19951
19961
19972
19993
20001
20021
20053
20061
20092
20103
20111
20121
20132
20143
20155
20164
20172
20184
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

mononegavirales
paramyxovirus
processing bodies
RNA dependent RNA polymerase
stress granules
transcription

Available to Mentor as: (Review Mentor Role Definitions):
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Contact for Mentoring:


72 E. Concord St Housman (R)
Boston MA 02118
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