Rachel Fearns, PhD
Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of St Andrews




Expertise in paramyxovirus genome transcription and replication mechanisms.

Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Mechanisms of Marburg virus gene expression
05/08/2018 - 04/30/2023 (Multi-PI)
PI: Rachel Fearns, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI133486-02

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2019 - 04/30/2022 (Multi-PI)
PI: Rachel Fearns, PhD
NIH/National Heart, Lung, and Blood Institute
4R33HL137081-03

Initiation and regulation of RSV mRNA transcription and genome replication
08/07/2014 - 07/31/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113321-04

Developing Combination Therapies against Pneumo- and Paramyxoviruses Causing Severe Respiratory Infection
07/01/2018 - 06/30/2020 (Subcontract PI)
Georgia State University NIH NIAID
2R01AI071002-12

Evaluating the mechanism of actino of RSV L inhibitors targeting the CRV region
05/03/2019 - 05/02/2020 (PI)
Janssen Sciences Ireland


Mechanism of action of an RSV N protein inhibitor
04/01/2018 - 10/15/2019 (PI)
Enanta Pharmaceuticals, Inc


The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2019 (Multi-PI)
PI: Rachel Fearns, PhD
NIH/National Heart, Lung, and Blood Institute
5R61HL137081-02

Treating Respiratory Syncytial Virus Infection by Targeting a Virus-Associated Kinase
04/01/2015 - 03/31/2019 (PI)
The Hartwell Foundation


A structure analysis of the intact viron and replicative complexes of human respiratory syncytial virus
11/30/2014 - 03/31/2019 (Subcontract PI)
University Glasgow Medical Resrch Coun


Development of an in ivtro assay for paramyxovirus polymerases
05/16/2014 - 11/04/2018 (PI)
Alios BioPharma, Inc.


Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Interplay between respiratory syncytial virus and nucleotide biosynthesis pathways 1R21AI147659-01A1
2020 Interplay between respiratory syncytial virus and nucleotide biosynthesis pathways 1R21AI147659-01A1
2020 Mechanisms of Marburg virus gene expression 5R01AI133486-03 3
2020 The B cell repertoire as a window into the nature and impact of the lung virome 5R33HL137081-04
2019 Mechanisms of Marburg virus gene expression 5R01AI133486-02 3
2019 The B cell repertoire as a window into the nature and impact of the lung virome 4R33HL137081-03
2018 Mechanisms of Marburg virus gene expression 1R01AI133486-01A1 3
2018 The B cell repertoire as a window into the nature and impact of the lung virome 5R61HL137081-02 3
2017 The B cell repertoire as a window into the nature and impact of the lung virome 1R61HL137081-01 3
2017 Initiation and regulation of RSV mRNA transcription and genome replication 5R01AI113321-04 7
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kleiner VA, Fearns R. RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges. Structure. 2020 Sep 01; 28(9):977-978. PMID: 32877647
     
  2. Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature. 2020 01; 577(7789):275-279.View Related Profiles. PMID: 31698413
     
  3. Ludeke B, Fearns R. The respiratory syncytial virus polymerase can perform RNA synthesis with modified primers and nucleotide analogs. Virology. 2020 01 15; 540:66-74. PMID: 31739186
     
  4. Fearns R. The Respiratory Syncytial Virus Polymerase: A Multitasking Machine. Trends Microbiol. 2019 12; 27(12):969-971. PMID: 31672264
     
  5. Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E. Ebolavirus polymerase uses an unconventional genome replication mechanism. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8535-8543.View Related Profiles. PMID: 30962389
     
  6. Noton SL, Tremaglio CZ, Fearns R. Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication. PLoS Pathog. 2019 02; 15(2):e1007548.View Related Profiles. PMID: 30817806
     
  7. Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R. Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral Res. 2019 02; 162:142-150. PMID: 30597184
     
  8. Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 10 26; 293(43):16761-16777. PMID: 30206124
     
  9. Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter. Nucleic Acids Res. 2018 07 27; 46(13):6785-6796.View Related Profiles. PMID: 29873775
     
  10. Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK. Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses. Antimicrob Agents Chemother. 2018 08; 62(8). PMID: 29891600
     
Showing 10 of 48 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 48 publications over 21 distinct years, with a maximum of 5 publications in 2015 and 2018 and 2019

YearPublications
19941
19951
19961
19972
19993
20001
20021
20053
20061
20092
20103
20111
20121
20132
20143
20155
20164
20172
20185
20195
20201
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

mononegavirales
paramyxovirus
processing bodies
RNA dependent RNA polymerase
stress granules
transcription

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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