Keywords
Last Name

David A. Goukassian, MD, PhD

TitleAdjunct Research Associate Professor
InstitutionBoston University School of Medicine
DepartmentDermatology
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 414-2390
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. He S, Zhao T, Guo H, Meng Y, Qin G, Goukassian DA, Han J, Gao X, Zhu Y. Coordinated Activation of VEGF/VEGFR-2 and PPARd Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice. PLoS One. 2016; 11(12):e0167305. PMID: 27930695.
    View in: PubMed
  2. Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, Goukassian DA. Corrigendum to "Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells". Stem Cells Int. 2016; 2016:7958361. PMID: 26880990.
    View in: PubMed
  3. Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Correction: Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants. PLoS One. 2015; 10(11):e0144213. PMID: 26619137.
    View in: PubMed
  4. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA. Corrigendum: Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Front Oncol. 2015; 5:255. PMID: 26636037.
    View in: PubMed
  5. Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2015 Nov 6; 290(45):27014. PMID: 26546693.
    View in: PubMed
  6. Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. Correction: Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation. PLoS One. 2015; 10(11):e0142764. PMID: 26544605.
    View in: PubMed
  7. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA. Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Front Oncol. 2015; 5:231. PMID: 26528440.
    View in: PubMed
  8. Coleman MA, Sasi SP, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev YO, Yan X, Goukassian DA. Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1947-63. PMID: 26408534.
    View in: PubMed
  9. Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, Goukassian DA. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int. 2015; 2015:496512. PMID: 26074973.
    View in: PubMed
  10. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. 2015 Jun; 225(3):181-9. PMID: 25934704.
    View in: PubMed
  11. Sasi SP, Rahimi L, Yan X, Silver M, Qin G, Losordo DW, Kishore R, Goukassian DA. Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia model. FASEB J. 2015 Apr; 29(4):1208-19. PMID: 25466901.
    View in: PubMed
  12. Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, Goukassian DA. Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One. 2014; 9(10):e110269. PMID: 25337914.
    View in: PubMed
  13. Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2014 May 16; 289(20):14178-93. PMID: 24711449.
    View in: PubMed
  14. Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, Goukassian DA. Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants. PLoS One. 2014; 9(3):e92373. PMID: 24664144.
    View in: PubMed
  15. Sasi SP, Yan X, Lee J, Sisakyan H, Carrozza J, Goukassian DA. Radiation-associated degenerative cardiovascular risks during normal aging and after adverse CV event 10 months post-initial exposure. J Radiat Res. 2014 Mar 1; 55 Suppl 1:i111-i112. PMID: 24585952.
    View in: PubMed
  16. Sasi SP, Song J, Enderling H, Yan X, Goukassian DA. TNF-a and IL-1a but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs. J Radiat Res. 2014 Mar 1; 55 Suppl 1:i122-i123. PMID: 24585960.
    View in: PubMed
  17. Yan X, Sasi SP, Gee H, Lee J, Yang Y, Song J, Carrozza J, Goukassian DA. Radiation-associated cardiovascular risks for future deep-space missions. J Radiat Res. 2014 Mar 1; 55 Suppl 1:i37-i39. PMID: 24585984.
    View in: PubMed
  18. Shtifman A, Pezone MJ, Sasi SP, Agarwal A, Gee H, Song J, Perepletchikov A, Yan X, Kishore R, Goukassian DA. Divergent modification of low-dose 56Fe-particle and proton radiation on skeletal muscle. Radiat Res. 2013 Nov; 180(5):455-64. PMID: 24131063.
    View in: PubMed
  19. Zhou J, Cheng M, Liao YH, Hu Y, Wu M, Wang Q, Qin B, Wang H, Zhu Y, Gao XM, Goukassian D, Zhao TC, Tang YL, Kishore R, Qin G. Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells. PLoS One. 2013; 8(5):e63126. PMID: 23704894.
    View in: PubMed
  20. Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X. Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart. Front Pharmacol. 2012; 3:113. PMID: 22754526.
    View in: PubMed
  21. Goukassian DA, Sharov A, Rhodes J, Coleman C, Eller MS, Sharova T, Bhawan J, Gilchrest BA. Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas. J Invest Dermatol. 2012 Nov; 132(11):2664-6. PMID: 22696052.
    View in: PubMed
  22. Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Breaking the 'harmony' of TNF-a signaling for cancer treatment. Oncogene. 2012 Sep 13; 31(37):4117-27. PMID: 22158049.
    View in: PubMed
  23. Kishore R, Tkebuchava T, Sasi SP, Silver M, Gilbert HY, Yoon YS, Park HY, Thorne T, Losordo DW, Goukassian DA. Tumor necrosis factor-a signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium. Adv Exp Med Biol. 2011; 691:433-48. PMID: 21153348.
    View in: PubMed
  24. Coleman C, Levine D, Kishore R, Qin G, Thorne T, Lambers E, Sasi SP, Yaar M, Gilchrest BA, Goukassian DA. Inhibition of melanoma angiogenesis by telomere homolog oligonucleotides. J Oncol. 2010; 2010:928628. PMID: 20652008.
    View in: PubMed
  25. Zattra E, Coleman C, Arad S, Helms E, Levine D, Bord E, Guillaume A, El-Hajahmad M, Zwart E, van Steeg H, Gonzalez S, Kishore R, Goukassian DA. Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice. Am J Pathol. 2009 Nov; 175(5):1952-61. PMID: 19808641.
    View in: PubMed
  26. Aprahamian T, Takemura Y, Goukassian D, Walsh K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin Exp Immunol. 2008 Jun; 152(3):448-55. PMID: 18422728.
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  27. Arad S, Zattra E, Hebert J, Epstein EH, Goukassian DA, Gilchrest BA. Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice. Am J Pathol. 2008 May; 172(5):1248-55. PMID: 18403589.
    View in: PubMed
  28. Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian DA, Pathak MA, González S. Dietary lutein/zeaxanthin partially reduces photoaging and photocarcinogenesis in chronically UVB-irradiated Skh-1 hairless mice. Skin Pharmacol Physiol. 2007; 20(6):283-91. PMID: 17717424.
    View in: PubMed
  29. Arad S, Konnikov N, Goukassian DA, Gilchrest BA. Quantification of inducible SOS-like photoprotective responses in human skin. J Invest Dermatol. 2007 Nov; 127(11):2629-36. PMID: 17522706.
    View in: PubMed
  30. Rajasingh J, Bord E, Qin G, Ii M, Silver M, Hamada H, Ahluwalia D, Goukassian D, Zhu Y, Losordo DW, Kishore R. Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice. Endocrinology. 2007 Aug; 148(8):3618-24. PMID: 17478555.
    View in: PubMed
  31. Goukassian DA, Qin G, Dolan C, Murayama T, Silver M, Curry C, Eaton E, Luedemann C, Ma H, Asahara T, Zak V, Mehta S, Burg A, Thorne T, Kishore R, Losordo DW. Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation. 2007 Feb 13; 115(6):752-62. PMID: 17261656.
    View in: PubMed
  32. Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R. IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J. 2006 Oct; 20(12):2112-4. PMID: 16935932.
    View in: PubMed
  33. Arad S, Konnikov N, Goukassian DA, Gilchrest BA. T-oligos augment UV-induced protective responses in human skin. FASEB J. 2006 Sep; 20(11):1895-7. PMID: 16877521.
    View in: PubMed
  34. Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, Thorne T, Hanley A, Curry C, Heyd L, Dinesh D, Kearney M, Martelli F, Murayama T, Goukassian DA, Zhu Y, Losordo DW. Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):11015-20. PMID: 16835303.
    View in: PubMed
  35. Qin G, Ii M, Silver M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, Asahara T, Kearney M, Thorne T, Curry C, Eaton L, Heyd L, Dinesh D, Kishore R, Zhu Y, Losordo DW. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med. 2006 Jan 23; 203(1):153-63. PMID: 16401693.
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  36. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, Thorne T, Takenaka H, Aikawa R, Goukassian D, von Samson P, Hamada H, Yoon YS, Silver M, Eaton E, Ma H, Heyd L, Kearney M, Munger W, Porter JA, Kishore R, Losordo DW. Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med. 2005 Nov; 11(11):1197-204. PMID: 16244652.
    View in: PubMed
  37. Marwaha V, Chen YH, Helms E, Arad S, Inoue H, Bord E, Kishore R, Sarkissian RD, Gilchrest BA, Goukassian DA. T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. J Biol Chem. 2005 Sep 16; 280(37):32379-88. PMID: 16046401.
    View in: PubMed
  38. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M, Gavin M, Yoon YS, Goukassian D, Goukassain D, Losordo DW. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. J Clin Invest. 2005 Jul; 115(7):1785-96. PMID: 15965500.
    View in: PubMed
  39. Luedemann C, Bord E, Qin G, Zhu Y, Goukassian D, Losordo DW, Kishore R. Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanol. Alcohol Clin Exp Res. 2005 Jun; 29(6):930-8. PMID: 15976518.
    View in: PubMed
  40. Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Díaz F, Mihm MC, Fitzpatrick TB, González S. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004 Dec; 51(6):910-8. PMID: 15583582.
    View in: PubMed
  41. Goukassian DA, Helms E, van Steeg H, van Oostrom C, Bhawan J, Gilchrest BA. Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3933-8. PMID: 14999099.
    View in: PubMed
  42. Goukassian DA, Gilchrest BA. The interdependence of skin aging, skin cancer, and DNA repair capacity: a novel perspective with therapeutic implications. Rejuvenation Res. 2004; 7(3):175-85. PMID: 15588518.
    View in: PubMed
  43. Kishore R, Luedemann C, Bord E, Goukassian D, Losordo DW. Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways. Circ Res. 2003 Nov 14; 93(10):932-40. PMID: 14576193.
    View in: PubMed
  44. González S, Astner S, An W, Goukassian D, Pathak MA. Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. J Invest Dermatol. 2003 Aug; 121(2):399-405. PMID: 12880433.
    View in: PubMed
  45. Goukassian DA, Kishore R, Krasinski K, Dolan C, Luedemann C, Yoon YS, Kearney M, Hanley A, Ma H, Asahara T, Isner JM, Losordo DW. Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth. Circ Res. 2003 Jul 25; 93(2):162-9. PMID: 12829616.
    View in: PubMed
  46. Goukassian DA, Bagheri S, el-Keeb L, Eller MS, Gilchrest BA. DNA oligonucleotide treatment corrects the age-associated decline in DNA repair capacity. FASEB J. 2002 May; 16(7):754-6. PMID: 11923222.
    View in: PubMed
  47. Goukassian D, Díez-Juan A, Asahara T, Schratzberger P, Silver M, Murayama T, Isner JM, Andrés V. Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis. FASEB J. 2001 Sep; 15(11):1877-85. PMID: 11532967.
    View in: PubMed
  48. Goukassian D, Sanz-González SM, Pérez-Roger I, Font de Mora J, Ureña J, Andrés V. Inhibition of the cyclin D1/E2F pathway by PCA-4230, a potent repressor of cellular proliferation. Br J Pharmacol. 2001 Apr; 132(7):1597-605. PMID: 11264255.
    View in: PubMed
  49. Andrés V, Ureña J, Poch E, Chen D, Goukassian D. Role of Sp1 in the induction of p27 gene expression in vascular smooth muscle cells in vitro and after balloon angioplasty. Arterioscler Thromb Vasc Biol. 2001 Mar; 21(3):342-7. PMID: 11231912.
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  50. Goukassian D, Gad F, Yaar M, Eller MS, Nehal US, Gilchrest BA. Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J. 2000 Jul; 14(10):1325-34. PMID: 10877825.
    View in: PubMed
  51. Hara M, Yaar M, Byers HR, Goukassian D, Fine RE, Gonsalves J, Gilchrest BA. Kinesin participates in melanosomal movement along melanocyte dendrites. J Invest Dermatol. 2000 Mar; 114(3):438-43. PMID: 10692101.
    View in: PubMed
  52. Goukassian DA, Eller MS, Yaar M, Gilchrest BA. Thymidine dinucleotide mimics the effect of solar simulated irradiation on p53 and p53-regulated proteins. J Invest Dermatol. 1999 Jan; 112(1):25-31. PMID: 9886259.
    View in: PubMed
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