Keywords
Last Name

Richard E. Fine, PhD

TitleEmeritus Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4191
Other Positions
InstitutionBedford VA - Edith Nourse Rogers Memorial VA Hosp

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhu H, Wang X, Wallack M, Li H, Carreras I, Dedeoglu A, Hur JY, Zheng H, Li H, Fine R, Mwamburi M, Sun X, Kowall N, Stern RA, Qiu WQ. Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease. Mol Psychiatry. 2015 Feb; 20(2):252-62. PMID: 24614496.
    View in: PubMed
  2. Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aß 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aß 11 forming the central core. Neurosci Lett. 2011 Nov 14; 505(2):109-12. PMID: 22001577.
    View in: PubMed
  3. Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, Wells JM, Morin PJ. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis. 2011 Aug; 43(2):338-45. PMID: 21515373.
    View in: PubMed
  4. Yaar M, Zhai S, Panova I, Fine RE, Eisenhauer PB, Blusztajn JK, Lopez-Coviella I, Gilchrest BA. A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death. Neuropathol Appl Neurobiol. 2007 Oct; 33(5):533-43. PMID: 17596181.
    View in: PubMed
  5. Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. J Neurosci Res. 2006 May 15; 83(7):1262-70. PMID: 16511862.
    View in: PubMed
  6. Carreras I, Garrett-Young R, Ullman MD, Eisenhauer PB, Fine RE, Wells JM, Conn KJ. Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells. J Neurosci Res. 2005 Feb 15; 79(4):495-502. PMID: 15635600.
    View in: PubMed
  7. Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neurosci Lett. 2004 Nov 16; 371(1):6-11. PMID: 15500957.
    View in: PubMed
  8. Conn KJ, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain Res. 2004 Oct 1; 1022(1-2):164-72. PMID: 15353226.
    View in: PubMed
  9. Eisenhauer PB, Jacewicz MS, Conn KJ, Koul O, Wells JM, Fine RE, Newburg DS. Escherichia coli Shiga toxin 1 and TNF-alpha induce cytokine release by human cerebral microvascular endothelial cells. Microb Pathog. 2004 Apr; 36(4):189-96. PMID: 15001224.
    View in: PubMed
  10. Conn KJ, Ullman MD, Larned MJ, Eisenhauer PB, Fine RE, Wells JM. cDNA microarray analysis of changes in gene expression associated with MPP+ toxicity in SH-SY5Y cells. Neurochem Res. 2003 Dec; 28(12):1873-81. PMID: 14649730.
    View in: PubMed
  11. Conn KJ, Gao WW, Ullman MD, McKeon-O'Malley C, Eisenhauer PB, Fine RE, Wells JM. Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. J Neurosci Res. 2002 Jun 15; 68(6):755-60. PMID: 12111836.
    View in: PubMed
  12. Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, Gilchrest BA. Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling. J Biol Chem. 2002 Mar 8; 277(10):7720-5. PMID: 11756426.
    View in: PubMed
  13. Conn KJ, Ullman MD, Eisenhauer PB, Fine RE, Wells JM. Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium -treated human neuroblastoma SH-SY5Y cells. Neurosci Lett. 2001 Jun 29; 306(3):145-8. PMID: 11406316.
    View in: PubMed
  14. Johnson RJ, Xiao G, Shanmugaratnam J, Fine RE. Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein. Neurobiol Aging. 2001 May-Jun; 22(3):387-95. PMID: 11378243.
    View in: PubMed
  15. Eisenhauer PB, Chaturvedi P, Fine RE, Ritchie AJ, Pober JS, Cleary TG, Newburg DS. Tumor necrosis factor alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin. Infect Immun. 2001 Mar; 69(3):1889-94. PMID: 11179369.
    View in: PubMed
  16. Berg EA, Johnson RJ, Leeman SE, Boyd N, Kimerer L, Fine RE. Isolation and characterization of substance P-containing dense core vesicles from rabbit optic nerve and termini. J Neurosci Res. 2000 Dec 15; 62(6):830-9. PMID: 11107168.
    View in: PubMed
  17. Davies TA, Long HJ, Eisenhauer PB, Hastey R, Cribbs DH, Fine RE, Simons ER. Beta amyloid fragments derived from activated platelets deposit in cerebrovascular endothelium: usage of a novel blood brain barrier endothelial cell model system. Amyloid. 2000 Sep; 7(3):153-65. PMID: 11019856.
    View in: PubMed
  18. Bartolák-Suki E, Sipe JD, Fine RE, Rosene DL, Moss MB. Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: an immunohistochemical study. Amyloid. 2000 Jun; 7(2):111-7. PMID: 10842713.
    View in: PubMed
  19. Chung TF, Sipe JD, McKee A, Fine RE, Schreiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid. 2000 Jun; 7(2):105-10. PMID: 10842712.
    View in: PubMed
  20. Hara M, Yaar M, Byers HR, Goukassian D, Fine RE, Gonsalves J, Gilchrest BA. Kinesin participates in melanosomal movement along melanocyte dendrites. J Invest Dermatol. 2000 Mar; 114(3):438-43. PMID: 10692101.
    View in: PubMed
  21. Xiao G, Chung TF, Fine RE, Johnson RJ. Calreticulin is transported to the surface of NG108-15 cells where it forms surface patches and is partially degraded in an acidic compartment. J Neurosci Res. 1999 Dec 1; 58(5):652-62. PMID: 10561693.
    View in: PubMed
  22. Schreiber BM, Veverbrants M, Fine RE, Blusztajn JK, Salmona M, Patel A, Sipe JD. Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis. Biochem J. 1999 Nov 15; 344 Pt 1:7-13. PMID: 10548527.
    View in: PubMed
  23. Xiao G, Chung TF, Pyun HY, Fine RE, Johnson RJ. KDEL proteins are found on the surface of NG108-15 cells. Brain Res Mol Brain Res. 1999 Oct 1; 72(2):121-8. PMID: 10529470.
    View in: PubMed
  24. Thoidis G, Kupriyanova T, Cunningham JM, Chen P, Cadel S, Foulon T, Cohen P, Fine RE, Kandror KV. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. J Biol Chem. 1999 May 14; 274(20):14062-6. PMID: 10318820.
    View in: PubMed
  25. Abraham CR, Marshall DC, Tibbles HE, Otto K, Long HJ, Billingslea AM, Hastey R, Johnson R, Fine RE, Smith SJ, Simons ER, Davies TA. Platelets and DAMI megakaryocytes possess beta-secretase-like activity. J Lab Clin Med. 1999 May; 133(5):507-15. PMID: 10235134.
    View in: PubMed
  26. Fine RE. The biochemistry of Alzheimer disease. Alzheimer Dis Assoc Disord. 1999 Apr-Jun; 13 Suppl 1:S82-7. PMID: 10369525.
    View in: PubMed
  27. Davies TA, Billingslea AM, Long HJ, Tibbles H, Wells JM, Eisenhauer PB, Smith SJ, Cribbs DH, Fine RE, Simons ER. Brain endothelial cell enzymes cleave platelet-retained amyloid precursor protein. J Lab Clin Med. 1998 Oct; 132(4):341-50. PMID: 9794706.
    View in: PubMed
  28. Simons ER, Marshall DC, Long HJ, Otto K, Billingslea A, Tibbles H, Wells J, Eisenhauer P, Fine RE, Cribbs DH, Davies TA, Abraham CR. Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. Amyloid. 1998 Sep; 5(3):153-62. PMID: 9818052.
    View in: PubMed
  29. Thoidis G, Chen P, Pushkin AV, Vallega G, Leeman SE, Fine RE, Kandror KV. Two distinct populations of synaptic-like vesicles from rat brain. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):183-8. PMID: 9419350.
    View in: PubMed
  30. Johnson RJ, Liu N, Shanmugaratnam J, Fine RE. Increased calreticulin stability in differentiated NG-108-15 cells correlates with resistance to apoptosis induced by antisense treatment. Brain Res Mol Brain Res. 1998 Jan; 53(1-2):104-11. PMID: 9473613.
    View in: PubMed
  31. Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, Gilchrest BA. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest. 1997 Nov 1; 100(9):2333-40. PMID: 9410912.
    View in: PubMed
  32. Shanmugaratnam J, Berg E, Kimerer L, Johnson RJ, Amaratunga A, Schreiber BM, Fine RE. Retinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles. Brain Res Mol Brain Res. 1997 Oct 15; 50(1-2):113-20. PMID: 9406925.
    View in: PubMed
  33. Liang JS, Sloane JA, Wells JM, Abraham CR, Fine RE, Sipe JD. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neurosci Lett. 1997 Apr 4; 225(2):73-6. PMID: 9147377.
    View in: PubMed
  34. Davies TA, Long HJ, Sgro K, Rathbun WH, McMenamin ME, Seetoo K, Tibbles H, Billingslea AM, Fine RE, Fishman JB, Levesque CA, Smith SJ, Wells JM, Simons ER. Activated Alzheimer disease platelets retain more beta amyloid precursor protein. Neurobiol Aging. 1997 Mar-Apr; 18(2):147-53. PMID: 9258891.
    View in: PubMed
  35. Davies TA, Long HJ, Tibbles HE, Sgro KR, Wells JM, Rathbun WH, Seetoo KF, McMenamin ME, Smith SJ, Feldman RG, Levesque CA, Fine RE, Simons ER. Moderate and advanced Alzheimer's patients exhibit platelet activation differences. Neurobiol Aging. 1997 Mar-Apr; 18(2):155-62. PMID: 9258892.
    View in: PubMed
  36. Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM, Fine RE. Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J Biol Chem. 1996 Mar 8; 271(10):5628-32. PMID: 8621425.
    View in: PubMed
  37. Liang JS, Fine RE, Abraham CR, Sipe JD. The fibril forming region of the beta-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids. Biochem Biophys Res Commun. 1996 Feb 27; 219(3):962-7. PMID: 8645287.
    View in: PubMed
  38. Amaratunga AP, Kosik KS, Rittenhouse PA, Leeman SE, Fine RE. Antisense inhibition of protein synthesis and function : rabbit retinal protein. Methods Mol Med. 1996; 1:109-19. PMID: 21359719.
    View in: PubMed
  39. Amaratunga A, Fine RE. Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve. J Biol Chem. 1995 Jul 21; 270(29):17268-72. PMID: 7542234.
    View in: PubMed
  40. Amaratunga A, Leeman SE, Kosik KS, Fine RE. Inhibition of kinesin synthesis in vivo inhibits the rapid transport of representative proteins for three transport vesicle classes into the axon. J Neurochem. 1995 May; 64(5):2374-6. PMID: 7536813.
    View in: PubMed
  41. Liu N, Fine RE, Simons E, Johnson RJ. Decreasing calreticulin expression lowers the Ca2+ response to bradykinin and increases sensitivity to ionomycin in NG-108-15 cells. J Biol Chem. 1994 Nov 18; 269(46):28635-9. PMID: 7961812.
    View in: PubMed
  42. Bielinski DF, Pyun HY, Linko-Stentz K, Macara IG, Fine RE. Ral and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis. Biochim Biophys Acta. 1993 Sep 19; 1151(2):246-56. PMID: 8373799.
    View in: PubMed
  43. Liu N, Fine RE, Johnson RJ. Comparison of cDNAs from bovine brain coding for two isoforms of calreticulin. Biochim Biophys Acta. 1993 Sep 3; 1202(1):70-6. PMID: 8373827.
    View in: PubMed
  44. Amaratunga A, Morin PJ, Kosik KS, Fine RE. Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleotide. J Biol Chem. 1993 Aug 15; 268(23):17427-30. PMID: 7688725.
    View in: PubMed
  45. Morin PJ, Abraham CR, Amaratunga A, Johnson RJ, Huber G, Sandell JH, Fine RE. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J Neurochem. 1993 Aug; 61(2):464-73. PMID: 7687653.
    View in: PubMed
  46. Davies TA, Fine RE, Johnson RJ, Levesque CA, Rathbun WH, Seetoo KF, Smith SJ, Strohmeier G, Volicer L, Delva L, et al. Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem Biophys Res Commun. 1993 Jul 15; 194(1):537-43. PMID: 8333868.
    View in: PubMed
  47. Morin PJ, Johnson RJ, Fine RE. Kinesin is rapidly transported in the optic nerve as a membrane associated protein. Biochim Biophys Acta. 1993 Mar 14; 1146(2):275-81. PMID: 8452861.
    View in: PubMed
  48. Johnson RJ, Pyun HY, Lytton J, Fine RE. Differences in the subcellular localization of calreticulin and organellar Ca(2+)-ATPase in neurons. Brain Res Mol Brain Res. 1993 Jan; 17(1-2):9-16. PMID: 8381914.
    View in: PubMed
  49. Johnson RJ, Liu NG, Fishman JB, Dixon JD, Fine RE. Isolation of a calreticulin-like calcium binding protein from bovine brain. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):69-76. PMID: 1312207.
    View in: PubMed
  50. Morin PJ, Liu NG, Johnson RJ, Leeman SE, Fine RE. Isolation and characterization of rapid transport vesicle subtypes from rabbit optic nerve. J Neurochem. 1991 Feb; 56(2):415-27. PMID: 1824859.
    View in: PubMed
  51. Morin PJ, Johnson RJ, Shachar I, Fine RE, Leeman SE. Characteristics of tachykinin transport vesicles in the optic nerve. Ann N Y Acad Sci. 1991; 632:442-3. PMID: 1952634.
    View in: PubMed
  52. Bielinski DF, Morin PJ, Dickey BF, Fine RE. Low molecular weight GTP-binding proteins are associated with neuronal organelles involved in rapid axonal transport and exocytosis. J Biol Chem. 1989 Nov 5; 264(31):18363-7. PMID: 2478544.
    View in: PubMed
  53. Fine RE. Vesicles without clathrin: intermediates in bulk flow exocytosis. Cell. 1989 Aug 25; 58(4):609-10. PMID: 2670245.
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  54. Thomas K, Navarro J, Benson RJ, Campbell KP, Rotundo RL, Fine RE. Newly synthesized calsequestrin, destined for the sarcoplasmic reticulum, is contained in early/intermediate Golgi-derived clathrin-coated vesicles. J Biol Chem. 1989 Feb 25; 264(6):3140-5. PMID: 2563378.
    View in: PubMed
  55. Fishman JB, Dickey BF, Fine RE. Purification and characterization of the rat liver vasopressin (V1) receptor. J Biol Chem. 1987 Oct 15; 262(29):14049-55. PMID: 2958456.
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  56. Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res. 1987; 18(2):299-304. PMID: 3694713.
    View in: PubMed
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