Keywords
Last Name

Shi Yang, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionAnatomic Pathology
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 414-5057
ORCID ORCID Icon0000-0001-8316-6484
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise in molecular pathology.

 Self-Described Keywords
  • Member of ASCB
  • Member of USCAP
  • Member of AMP
  • Diagnostic Molecular Pathology
  • Cancer Research: GI Cancer/Breast Cancer/Melanoma
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Frydenlund N, Leone D, Yang S, Hoang MP, Deng A, Hernandez-Perez M, Singh R, Biswas A, Yaar R, Mahalingam M. Tumoral PD-L1 expression in desmoplastic melanoma is associated with depth of invasion, tumor-infiltrating CD8 cytotoxic lymphocytes and the mixed cytomorphological variant. Mod Pathol. 2017 Mar; 30(3):357-369. PMID: 28084337.
    View in: PubMed
  2. Josenia Tan, Antonio de las Morenas , Shi Yang and Huihong Xu. Comparison of the clinicopathologic features of solitary and multifocal papillary thyroid carcinoma and the utility of testing an additional tumor nodule for BRAFV600E in multifocal cases. J Mod Hum Pathol. 2017; 2(1):1-6.
    View in: External Website
  3. Mitchell B, Leone D, Yang S, Khan A, Mahalingam M, Dhingra J. BRAF and epithelial-mesenchymal transition in papillary thyroid carcinoma - challenging the roles of Snail and E-Cadherin? Am J Transl Res. 2016; 8(11):5076-5086. PMID: 27904709.
    View in: PubMed
  4. Yang S, Leone D, Frydenlund N, Hoang M, Deng A, Hernandez-Perez M, Biswas A, Singh R, Yaar R, Mahalingam M. Frequency of telomerase reverse transcripter promoter mutations in desmoplastic melanoma subtypes: analyses of 76 cases. Melanoma Res. 2016 Aug; 26(4):361-6. PMID: 27244099.
    View in: PubMed
  5. Kadokura A, Frydenlund N, Leone DA, Yang S, Hoang MP, Deng A, Hernandez-Perez M, Biswas A, Singh R, Yaar R, Mahalingam M. Neurofibromin protein loss in desmoplastic melanoma subtypes: implicating NF1 allelic loss as a distinct genetic driver? Hum Pathol. 2016 Jul; 53:82-90. PMID: 26980030.
    View in: PubMed
  6. Mitchell B, Leone DA, Feller JK, Yang S, Mahalingam M. BRAF and epithelial-mesenchymal transition in primary cutaneous melanoma: a role for Snail and E-cadherin? Hum Pathol. 2016 Jun; 52:19-27. PMID: 26980024.
    View in: PubMed
  7. Chung HJ, Yang S, Succaria F, Bhawan J. Telomerase (TERT) promoter mutations are infrequent in Merkel cell carcinomas. J Am Acad Dermatol. 2015 Nov; 73(5):864-5. PMID: 26475538.
    View in: PubMed
  8. Frydenlund N, Leone DA, Mitchell B, Yang S, Deng A, Hoang MP, Mahalingam M. Neurotrophin receptors and perineural invasion in desmoplastic melanoma. J Am Acad Dermatol. 2015 May; 72(5):851-8. PMID: 25752716.
    View in: PubMed
  9. Wu H, Sun Y, Ye H, Yang S, Lee SL, de las Morenas A. Anaplastic thyroid cancer: outcome and the mutation/expression profiles of potential targets. Pathol Oncol Res. 2015 Jul; 21(3):695-701. PMID: 25588542.
    View in: PubMed
  10. Mitchell B, Leone D, Feller JK, Bondzie P, Yang S, Park HY, Mahalingam M. Correlation of chemokine receptor CXCR4 mRNA in primary cutaneous melanoma with established histopathologic prognosticators and the BRAF status. Melanoma Res. 2014 Dec; 24(6):621-5. PMID: 25211166.
    View in: PubMed
  11. O'Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway cancers and precursors. Histopathology. 2015 Jan; 66(1):49-65. PMID: 25263173.
    View in: PubMed
  12. Aung PP, Leone D, Feller JK, Yang S, Hernandez M, Yaar R, Singh R, Helm T, Mahalingam M. Microvessel density, lymphovascular density, and lymphovascular invasion in primary cutaneous melanoma-correlation with histopathologic prognosticators and BRAF status. Hum Pathol. 2015 Feb; 46(2):304-12. PMID: 25537974.
    View in: PubMed
  13. Aguilera P, Malvehy J, Carrera C, Palou J, Puig-Butillé JA, Alòs L, Badenas C, Puig S. Clinical and Histopathological Characteristics between Familial and Sporadic Melanoma in Barcelona, Spain. J Clin Exp Dermatol Res. 2014 Sep; 5(5):231. PMID: 25893138.
    View in: PubMed
  14. Brogly SB, Perkins RB, Zepf D, Longtine J, Yang S. Human papillomavirus vaccination and cervical cytology in young minority women. Sex Transm Dis. 2014 Aug; 41(8):511-4. PMID: 25013981.
    View in: PubMed
  15. Mitchell B, Leone D, Feller K, Menon S, Bondzie P, Yang S, Park HY, Mahalingam M. Protein expression of the chemokine receptor CXCR4 and its ligand CXCL12 in primary cutaneous melanoma--biomarkers of potential utility? Hum Pathol. 2014 Oct; 45(10):2094-100. PMID: 25130395.
    View in: PubMed
  16. Aung PP, Batrani M, Yang S, Mahalingam M. Apoptosis and in situ and invasive squamous cell carcinoma in sun-exposed sites. Am J Dermatopathol. 2013 Dec; 35(8):797-803. PMID: 23455334.
    View in: PubMed
  17. Zhao Y, Kumbrink J, Lin BT, Bouton AH, Yang S, Toselli PA, Kirsch KH. Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis. 2013 Dec; 34(12):2880-90. PMID: 23825155.
    View in: PubMed
  18. Drew DA, Devers T, Horelik N, Yang S, O'Brien M, Wu R, Rosenberg DW. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Proteomics. 2013 May; 13(9):1428-36. PMID: 23467982.
    View in: PubMed
  19. Feller JK, Yang S, Mahalingam M. Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma. Mod Pathol. 2013 Mar; 26(3):414-20. PMID: 23041829.
    View in: PubMed
  20. Feller K, Yang S, Tung N, Lee J, Mahalingam M. c-myc in Kaposi's sarcoma: analyses by fluorescent in situ hybridization and immunohistochemistry. J Eur Acad Dermatol Venereol. 2014 Jan; 28(1):120-4. PMID: 22882520.
    View in: PubMed
  21. Roehrl MH, Hernandez M, Yang S, Christensen TG, Morera C, Wang JY. Helicobacter heilmannii gastritis in a young patient with a pet. Gastrointest Endosc. 2012 Aug; 76(2):421-2. PMID: 22817795.
    View in: PubMed
  22. Park E, Yang S, Emley A, DeCarlo K, Richards J, Mahalingam M. Lack of correlation between immunohistochemical expression of CKIT and KIT mutations in atypical acral nevi. Am J Dermatopathol. 2012 Feb; 34(1):41-6. PMID: 22094233.
    View in: PubMed
  23. Miller DD, Emley A, Yang S, Richards JE, Lee JE, Deng A, Hoang MP, Mahalingam M. Mixed versus pure variants of desmoplastic melanoma: a genetic and immunohistochemical appraisal. Mod Pathol. 2012 Apr; 25(4):505-15. PMID: 22157936.
    View in: PubMed
  24. Emley A, Nguyen LP, Yang S, Mahalingam M. Somatic mutations in GNAQ in amelanotic/hypomelanotic blue nevi. Hum Pathol. 2011 Jan; 42(1):136-40. PMID: 21056896.
    View in: PubMed
  25. Huang CS, Farraye FA, Yang S, O'Brien MJ. The clinical significance of serrated polyps. Am J Gastroenterol. 2011 Feb; 106(2):229-40; quiz 241. PMID: 21045813.
    View in: PubMed
  26. Hetzel JT, Huang CS, Coukos JA, Omstead K, Cerda SR, Yang S, O'Brien MJ, Farraye FA. Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol. 2010 Dec; 105(12):2656-64. PMID: 20717107.
    View in: PubMed
  27. Decarlo K, Yang S, Emley A, Wajapeyee N, Green M, Mahalingam M. Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7--challenging the concept of dysplastic nevi as precursor lesions? Hum Pathol. 2010 Jun; 41(6):886-94. PMID: 20233623.
    View in: PubMed
  28. Emley A, Yang S, Wajapeyee N, Green MR, Mahalingam M. Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations. J Cutan Pathol. 2010 Mar; 37(3):344-9. PMID: 19788444.
    View in: PubMed
  29. Lee JC, Yang S, Zou Y, Joseph L. Erythroid/B-cell biphenotypic acute leukemia first case report. Leukemia. 2009 Oct; 23(10):1920-3. PMID: 19458630.
    View in: PubMed
  30. Kovacheva VP, Davison JM, Mellott TJ, Rogers AE, Yang S, O'Brien MJ, Blusztajn JK. Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J. 2009 Apr; 23(4):1054-63. PMID: 19047067.
    View in: PubMed
  31. Dadzie OE, Yang S, Emley A, Keady M, Bhawan J, Mahalingam M. RAS and RAF mutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis. Br J Dermatol. 2009 Feb; 160(2):368-75. PMID: 18945298.
    View in: PubMed
  32. Michael J O’Brien, Shi Yang, Christopher S Huang, Courtney Shepherd, Sandra Cerda, Francis A Farraye . The Serrated Polyp Pathway to Colorectal Carcinoma. Diagnostic Histopathology . 2008; 14(2):78-93.
  33. Belguise K, Guo S, Yang S, Rogers AE, Seldin DC, Sherr DH, Sonenshein GE. Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res. 2007 Dec 15; 67(24):11742-50. PMID: 18089804.
    View in: PubMed
  34. Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res. 2007 Apr 15; 67(8):3551-4. PMID: 17440063.
    View in: PubMed
  35. O'Brien MJ, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, Amorosino M, Farraye FA. Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol. 2006 Dec; 30(12):1491-501. PMID: 17122504.
    View in: PubMed
  36. Sharov AA, Sharova TY, Mardaryev AN, Tommasi di Vignano A, Atoyan R, Weiner L, Yang S, Brissette JL, Dotto GP, Botchkarev VA. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18166-71. PMID: 17114283.
    View in: PubMed
  37. Murray SA, Yang S, Demicco E, Ying H, Sherr DH, Hafer LJ, Rogers AE, Sonenshein GE, Xiao ZX. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005 Aug 1; 95(5):875-84. PMID: 15844214.
    View in: PubMed
  38. Huang CS, O'brien MJ, Yang S, Farraye FA. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol. 2004 Nov; 99(11):2242-55. PMID: 15555008.
    View in: PubMed
  39. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ. BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol. 2004 Nov; 28(11):1452-9. PMID: 15489648.
    View in: PubMed
  40. O'Brien MJ, Yang S, Clebanoff JL, Mulcahy E, Farraye FA, Amorosino M, Swan N. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol. 2004 Apr; 28(4):423-34. PMID: 15087661.
    View in: PubMed
  41. Trombino AF, Near RI, Matulka RA, Yang S, Hafer LJ, Toselli PA, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Breast Cancer Res Treat. 2000 Sep; 63(2):117-31. PMID: 11097088.
    View in: PubMed
  42. Robles R, Morita Y, Mann KK, Perez GI, Yang S, Matikainen T, Sherr DH, Tilly JL. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology. 2000 Jan; 141(1):450-3. PMID: 10614669.
    View in: PubMed
  43. Mulligan NJ, Yang S, Andry C, Klein M, O'Brien MJ. The role of p21ras in pancreatic neoplasia and chronic pancreatitis. Hum Pathol. 1999 Jun; 30(6):602-10. PMID: 10374765.
    View in: PubMed
  44. Rogers AE, Hafer LJ, Iskander YS, Yang S. Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets. Carcinogenesis. 1998 Jul; 19(7):1269-73. PMID: 9683188.
    View in: PubMed
  45. Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao XJ, Tilly JL, Near RI, Sherr DH. Induction of PreB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures. Toxicol Appl Pharmacol. 1997 Dec; 147(2):190-203. PMID: 9439715.
    View in: PubMed
  46. Schroy PC, Brown-Shimer S, Kim K, Johnson KA, Murnane MJ, Yang S, O'Brien MJ, Carney WP, Kupchik HZ. Detection of p21ras mutations in colorectal adenomas and carcinomas by enzyme-linked immunosorbent assay. Cancer. 1995 Jul 15; 76(2):201-9. PMID: 8625092.
    View in: PubMed
  47. Kelly CP, O'Keane JC, Orellana J, Schroy PC, Yang S, LaMont JT, Brady HR. Human colon cancer cells express ICAM-1 in vivo and support LFA-1-dependent lymphocyte adhesion in vitro. Am J Physiol. 1992 Dec; 263(6 Pt 1):G864-70. PMID: 1362041.
    View in: PubMed
  48. Yang S. [Papilloma of forestomach induced by Fusarium T-2 toxin in mice]. Zhonghua Zhong Liu Za Zhi. 1988 Sep; 10(5):339-41. PMID: 3248499.
    View in: PubMed
  49. Yang S, Xia QJ. [Studies on the promoting and initiating effects of Fusarium T-2 toxin]. Zhonghua Bing Li Xue Za Zhi. 1988 Jun; 17(2):107-10. PMID: 3145156.
    View in: PubMed
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