Jan Blusztajn | Profiles RNS

Jan K. Blusztajn, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Pathology & Laboratory Medicine

Other Pathology

PhD, Massachusetts Institute of Technology
MS, University of Warsaw

Websites

	Pathology & Laboratory Medicine Faculty
	ResearchGate

ORCID : 0000-0001-8438-3122

Jan K. Blusztajn, PhD is a Professor of Pathology in the Department of Pathology & Laboratory Medicine at the Chobanian and Avedisian School of Medicine. Dr. Blusztajn received his PhD in Neural and Endocrine Regulation from the Massachusetts Institute of Technology. Dr. Blusztajn's research is in prenatal programming of brain development and aging by essential nutrient availability during gestation.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Psychiatry

Member
Boston University
BU-BMC Cancer Center

Investigator
Framingham Heart Study

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
11/01/2023 - 08/31/2025 (Multi-PI)
PI: Jan K. Blusztajn, PhD
NIH/National Institute on Aging
7RF1AG078299-02

Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 08/31/2024 (Multi-PI)
PI: Jan K. Blusztajn, PhD
NIH/National Institute on Aging
1RF1AG057768-01A1

MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
09/01/2022 - 08/18/2023 (Subcontract PI)
Rhode Island Hospital NIH NIA
1RF1AG078299-01

Regulation of the hippocampal DNA methylation clock by choline nutrition in a mouse model of Alzheimer's disease
08/01/2018 - 06/30/2021 (PI)
NIH/National Institute on Aging
5R21AG059195-02

BMP9 as a juvenile protective factor in cognitive aging
06/01/2014 - 05/31/2020 (PI)
NIH/National Institute on Aging
5R01AG045031-05

Age-Associated Lipidomic Changes in Alzheimer's Disease
09/30/2017 - 01/31/2019 (Multi-PI)
PI: Jan K. Blusztajn, PhD
NIH/National Institute on Aging
1R56AG057768-01

Personnel Agreement for Research Services of Jan Blusztajn
09/01/2017 - 08/31/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Jan Blusztajn
09/01/2017 - 08/31/2018 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Jan Blusztajn
10/01/2013 - 06/30/2017 (Key Person)
PI: Daniel G. Remick Jr., MD
VA Boston Healthcare System

Personnel Agreement for Research Services of Jan Blusztajn
10/01/2013 - 06/30/2017 (Key Person)
PI: Daniel G. Remick Jr., MD
VA Boston Healthcare System

Showing 10 of 15 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias	1R01AG084624-01
2022	MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease	7RF1AG078299-02
2021	Age-Associated Lipidomic Changes in Alzheimer's Disease	3RF1AG057768-01A1S1	4
2019	Age-Associated Lipidomic Changes in Alzheimer's Disease	1RF1AG057768-01A1	4
2019	Regulation of the hippocampal epigenetic DNA methylation clock by choline nutrition in a mouse model of Alzheimer's disease	5R21AG059195-02
2018	Regulation of the hippocampal epigenetic DNA methylation clock by choline nutrition in a mouse model of Alzheimer's disease	1R21AG059195-01A1
2018	BMP9 as a juvenile protective factor in cognitive aging	5R01AG045031-05	11
2017	Age-Associated Lipidomic Changes in Alzheimer's Disease	1R56AG057768-01	7
2017	BMP9 as a juvenile protective factor in cognitive aging	5R01AG045031-04	11
2017	BMP9 as a juvenile protective factor in cognitive aging	3R01AG045031-04S1	11

Showing 10 of 68 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers. Alzheimers Dement. 2024 Nov; 20(11):7698-7714.View Related Profiles.

Lin, Honghuang
Delalle, Ivana
Blusztajn, Jan

PMID: 39291737; PMCID: PMC11567826; DOI: 10.1002/alz.14230;

Krüger DM, Pena-Centeno T, Liu S, Park T, Kaurani L, Pradhan R, Huang YN, Risacher SL, Burkhardt S, Schütz AL, Wan Y, Shaw LM, Brodsky AS, DeStefano AL, Lin H, Schroeder R, Krunic A, Hempel N, Sananbenesi F, Blusztajn JK, Saykin AJ, Delalle I, Nho K, Fischer A. The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals. Alzheimers Dement. 2024 Sep 18.View Related Profiles.

DeStefano, Anita
Lin, Honghuang
Delalle, Ivana
Blusztajn, Jan

PMID: 39291752; PMCID: PMC11567822; DOI: 10.1002/alz.14157;

Bellio TA, Laguna-Torres JY, Campion MS, Chou J, Yee S, Blusztajn JK, Mellott TJ. Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aß42 deposition in AppNL-G-F Alzheimer's disease model mice. PLoS One. 2024; 19(2):e0297289.View Related Profiles.

Blusztajn, Jan
Bellio, Thomas
Mellott, Tiffany

PMID: 38315685; PMCID: PMC10843108; DOI: 10.1371/journal.pone.0297289;

Obeid R, Schön C, Derbyshire E, Jiang X, Mellott TJ, Blusztajn JK, Zeisel SH. A Narrative Review on Maternal Choline Intake and Liver Function of the Fetus and the Infant; Implications for Research, Policy, and Practice. Nutrients. 2024 Jan 15; 16(2).View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 38257153; PMCID: PMC10820518; DOI: 10.3390/nu16020260;

Yuan J, Liu X, Liu C, Ang AF, Massaro J, Devine SA, Auerbach SH, Blusztajn JK, Au R, Jacques PF. Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. Am J Clin Nutr. 2022 Nov; 116(5):1201-1207.View Related Profiles.

Liu, Chunyu
Blusztajn, Jan
Yuan, Jin
Au, Rhoda
Auerbach, Sanford
Devine, Sherral

PMID: 37208066; PMCID: PMC9630864; DOI: 10.1093/ajcn/nqac193;

Blusztajn JK, Aytan N, Rajendiran T, Mellott TJ, Soni T, Burant CF, Serrano GE, Beach TG, Lin H, Stein TD. Cerebral Gray and White Matter Monogalactosyl Diglyceride Levels Rise with the Progression of Alzheimer's Disease. J Alzheimers Dis. 2023; 95(4):1623-1634.View Related Profiles.

Lin, Honghuang
Blusztajn, Jan
Aytan, Nurgul
Stein, Thor
Mellott, Tiffany

PMID: 37718815; PMCID: PMC10911245; DOI: 10.3233/JAD-230543;

Blusztajn JK, Slack BE. Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease. J Alzheimers Dis. 2023; 93(4):1285-1289.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 37182883; PMCID: PMC10885637; DOI: 10.3233/JAD-230061;

Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang JB, Tian H, Zhu S, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA, Qiu WQ. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell. 2021 11; 20(11):e13501.View Related Profiles.

Emili, Andrew
Wolozin, Benjamin
Blusztajn, Jan
Tao, Qiushan
Stein, Thor
Qiu, Wendy
Zhang, Xiaoling
Alekseyev, Yuriy

PMID: 34687487; PMCID: PMC8590103; DOI: 10.1111/acel.13501;

Kanach C, Blusztajn JK, Fischer A, Delalle I. MicroRNAs as Candidate Biomarkers for Alzheimer's Disease. Noncoding RNA. 2021 Feb 01; 7(1).View Related Profiles.

Delalle, Ivana
Blusztajn, Jan

PMID: 33535543; PMCID: PMC7930943; DOI: 10.3390/ncrna7010008;

Anderson KE, Bellio TA, Aniskovich E, Adams SL, Blusztajn JK, Delalle I. The Expression of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) in Hippocampal Arterioles Declines During Progression of Alzheimer's Disease. Cereb Cortex Commun. 2020; 1(1):tgaa031.View Related Profiles.

Delalle, Ivana
Blusztajn, Jan
Bellio, Thomas

PMID: 32974611; PMCID: PMC7497413; DOI: 10.1093/texcom/tgaa031;

Showing 10 of 175 results. Show More

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Zeisel SH. Choline: The Neurocognitive Essential Nutrient of Interest to Obstetricians and Gynecologists. J Diet Suppl. 2020; 17(6):733-752. PMID: 31385730

Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts. J Alzheimers Dis. 2019; 68(1):357-365.View Related Profiles.

Beiser, Alexa
Delalle, Ivana
Blusztajn, Jan
Himali, Jayandra
Yang, Qiong
Seshadri, Sudha

PMID: 30775993; PMCID: PMC6481535; DOI: 10.3233/JAD-180977;

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Natker E, Zeisel SH, Zelman KM. Choline: The Underconsumed and Underappreciated Essential Nutrient. Nutr Today. 2018 Nov-Dec; 53(6):240-253. PMID: 30853718; PMCID: PMC6259877; DOI: 10.1097/NT.0000000000000302;

Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Corrigendum to "Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease" [Brain Res. 1681 (2018) 34-43]. Brain Res. 2018 06 01; 1688:113-115.View Related Profiles.

Dedeoglu, Alpaslan
Carreras, Isabel
Blusztajn, Jan
Leite-Morris, Kimberly
Aytan, Nurgul
Mellott, Tiffany

PMID: 29526415

Aytan N, Choi JK, Carreras I, Crabtree L, Nguyen B, Lehar M, Blusztajn JK, Jenkins BG, Dedeoglu A. Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer's disease. Eur J Pharmacol. 2018 Jun 05; 828:9-17.View Related Profiles.

Dedeoglu, Alpaslan
Carreras, Isabel
Blusztajn, Jan
Aytan, Nurgul

PMID: 29510124; PMCID: PMC5971844; DOI: 10.1016/j.ejphar.2018.02.045;

Adams SL, Benayoun L, Tilton K, Mellott TJ, Seshadri S, Blusztajn JK, Delalle I. Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of Alzheimer's Disease. J Alzheimers Dis. 2018; 63(4):1433-1443.View Related Profiles.

Delalle, Ivana
Blusztajn, Jan
Seshadri, Sudha
Mellott, Tiffany

PMID: 29843236; PMCID: PMC5988976; DOI: 10.3233/JAD-171065;

Tao Q, Zhu H, Chen X, Stern RA, Kowall N, Au R, Blusztajn JK, Qiu WQ. Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease. J Alzheimers Dis. 2018; 62(2):597-609.View Related Profiles.

Zhu, Haihao
Blusztajn, Jan
Kowall, Neil
Tao, Qiushan
Au, Rhoda
Stern, Robert

PMID: 29480193; PMCID: PMC5956916; DOI: 10.3233/JAD-170948;

Carreras I, Aytan N, Mellott T, Choi JK, Lehar M, Crabtree L, Leite-Morris K, Jenkins BG, Blusztajn JK, Dedeoglu A. Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease. Brain Res. 2018 02 15; 1681:34-43.View Related Profiles.

Dedeoglu, Alpaslan
Carreras, Isabel
Blusztajn, Jan
Leite-Morris, Kimberly
Aytan, Nurgul
Mellott, Tiffany

PMID: 29277710; PMCID: PMC5971846; DOI: 10.1016/j.brainres.2017.12.030;

Blusztajn JK, Slack BE, Mellott TJ. Neuroprotective Actions of Dietary Choline. Nutrients. 2017 Jul 28; 9(8).View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28788094; PMCID: PMC5579609; DOI: 10.3390/nu9080815;

Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(3):e0174875.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28334015; PMCID: PMC5363934; DOI: 10.1371/journal.pone.0174875;

Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(1):e0170450.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Mellott, Tiffany

PMID: 28103298; PMCID: PMC5245895; DOI: 10.1371/journal.pone.0170450;

Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. J Alzheimers Dis. 2017; 60(1):43-56.View Related Profiles.

Delalle, Ivana
Blusztajn, Jan
Himali, Jayandra
Chavez, Olivia
Seshadri, Sudha

PMID: 28777754; PMCID: PMC5922439; DOI: 10.3233/JAD-170459;

Wang E, Zhu H, Wang X, Gower AC, Wallack M, Blusztajn JK, Kowall N, Qiu WQ. Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2017; 56(1):47-61.View Related Profiles.

Gower, Adam
Zhu, Haihao
Blusztajn, Jan
Kowall, Neil
Wang, Xiaofan

PMID: 27911303; PMCID: PMC5331853; DOI: 10.3233/JAD-160677;

Mathew RS, Mullan H, Blusztajn JK, Lehtinen MK. Comment on "Multiple repressive mechanisms in the hippocampus during memory formation". Science. 2016 Jul 29; 353(6298):453. PMID: 27482552; PMCID: PMC5026305

Blusztajn JK, Rinnofner J. Intrinsic Cholinergic Neurons in the Hippocampus: Fact or Artifact? Front Synaptic Neurosci. 2016; 8:6. PMID: 27014052; PMCID: PMC4785141; DOI: 10.3389/fnsyn.2016.00006;

Langley EA, Krykbaeva M, Blusztajn JK, Mellott TJ. High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism. Behav Brain Res. 2015 Feb 1; 278:210-20.View Related Profiles.

Langley, Erika
Blusztajn, Jan
Mellott, Tiffany

PMID: 25300468; DOI: 10.1016/j.bbr.2014.09.043;

Mellott TJ, Pender SM, Burke RM, Langley EA, Blusztajn JK. IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice. PLoS One. 2014; 9(4):e94287.View Related Profiles.

Langley, Erika
Blusztajn, Jan
Burke, Rebecca
Mellott, Tiffany

PMID: 24732467; PMCID: PMC3986048; DOI: 10.1371/journal.pone.0094287;

Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Burke, Rebecca
Leeman, Susan
Haydar, Tarik
Mellott, Tiffany
Norman, Timothy

PMID: 24218590; PMCID: PMC3845152; DOI: 10.1073/pnas.1319297110;

Blusztajn JK, Mellott TJ. Neuroprotective actions of perinatal choline nutrition. Clin Chem Lab Med. 2013 Mar 1; 51(3):591-9.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 23314544; PMCID: PMC5612418; DOI: 10.1515/cclm-2012-0635;

Blusztajn JK, Mellott TJ. Choline nutrition programs brain development via DNA and histone methylation. Cent Nerv Syst Agents Med Chem. 2012 Jun; 12(2):82-94.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 22483275; PMCID: PMC5612430

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012 May 16; 4(134):134ra60.View Related Profiles.

Budson, Andrew
McKee, Ann
Wolozin, Benjamin
Nowinski, Christopher
Blusztajn, Jan
Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Kowall, Neil
Casey, Noel
Minaeva, Olga
Stern, Robert
Cantu, Robert
Stein, Thor
Ikezu, Tsuneya

PMID: 22593173; PMCID: PMC3739428; DOI: 10.1126/scitranslmed.3003716;

Wong-Goodrich SJ, Tognoni CM, Mellott TJ, Glenn MJ, Blusztajn JK, Williams CL. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain Res. 2011 Sep 21; 1413:84-97.View Related Profiles.

Tognoni, Christina
Blusztajn, Jan
Mellott, Tiffany

PMID: 21840511; PMCID: PMC3166969; DOI: 10.1016/j.brainres.2011.07.042;

Lopez-Coviella I, Mellott TJ, Schnitzler AC, Blusztajn JK. BMP9 protects septal neurons from axotomy-evoked loss of cholinergic phenotype. PLoS One. 2011; 6(6):e21166.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 21695154; PMCID: PMC3113905; DOI: 10.1371/journal.pone.0021166;

Carey RM, Blusztajn JK, Slack BE. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC Cell Biol. 2011; 12:20.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 21586144; PMCID: PMC3118186; DOI: 10.1186/1471-2121-12-20;

Blusztajn JK . Choline in fetal programming. In: “Vitamins in the Prevention of Human Diseases” Rima Obeid and Wolfgang Hermann, eds. Walter de Gruyter. Berlin. 2011; 612-627.

Crivello NA, Blusztajn JK, Joseph JA, Shukitt-Hale B, Smith DE. Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age. Nutr Res. 2010 Oct; 30(10):722-30. PMID: 21056288; PMCID: PMC3000554; DOI: 10.1016/j.nutres.2010.09.008;

Schnitzler AC, Mellott TJ, Lopez-Coviella I, Tallini YN, Kotlikoff MI, Follettie MT, Blusztajn JK. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. J Neurosci. 2010 Jun 16; 30(24):8221-8.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 20554873; PMCID: PMC2927324; DOI: 10.1523/JNEUROSCI.5611-09.2010;

Johnson AR, Craciunescu CN, Guo Z, Teng YW, Thresher RJ, Blusztajn JK, Zeisel SH. Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J. 2010 Aug; 24(8):2752-61. PMID: 20371614; PMCID: PMC2909292; DOI: 10.1096/fj.09-153718;

Wong-Goodrich SJ, Glenn MJ, Mellott TJ, Liu YB, Blusztajn JK, Williams CL. Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood. Hippocampus. 2011 Jun; 21(6):584-608.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 20232399; PMCID: PMC2972409; DOI: 10.1002/hipo.20783;

Kovacheva VP, Davison JM, Mellott TJ, Rogers AE, Yang S, O'Brien MJ, Blusztajn JK. Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J. 2009 Apr; 23(4):1054-63.View Related Profiles.

Rogers, Adrianne
Blusztajn, Jan
O'Brien, Michael
Yang, Shi
Mellott, Tiffany

PMID: 19047067; PMCID: PMC2660648; DOI: 10.1096/fj.08-122168;

Davison JM, Mellott TJ, Kovacheva VP, Blusztajn JK. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem. 2009 Jan 23; 284(4):1982-9.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 19001366; PMCID: PMC2629111; DOI: 10.1074/jbc.M807651200;

Schnitzler AC, Lopez-Coviella I, Blusztajn JK. Differential modulation of nerve growth factor receptor (p75) and cholinergic gene expression in purified p75-expressing and non-expressing basal forebrain neurons by BMP9. Brain Res. 2008 Dec 30; 1246:19-28. PMID: 18952073; PMCID: PMC2637380; DOI: 10.1016/j.brainres.2008.09.085;

Madziar B, Shah S, Brock M, Burke R, Lopez-Coviella I, Nickel AC, Cakal EB, Blusztajn JK, Berse B. Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway. J Neurochem. 2008 Dec; 107(5):1284-93.View Related Profiles.

Berse, Brygida
Blusztajn, Jan
Burke, Rebecca

PMID: 18793330; PMCID: PMC5912896; DOI: 10.1111/j.1471-4159.2008.05681.x;

Wong-Goodrich SJ, Glenn MJ, Mellott TJ, Blusztajn JK, Meck WH, Williams CL. Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. Brain Res. 2008 Oct 27; 1237:153-66.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 18778697; PMCID: PMC2674276; DOI: 10.1016/j.brainres.2008.08.074;

Napoli I, Blusztajn JK, Mellott TJ. Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. Brain Res. 2008 Oct 27; 1237:124-35.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 18786520; DOI: 10.1016/j.brainres.2008.08.046;

Glenn MJ, Kirby ED, Gibson EM, Wong-Goodrich SJ, Mellott TJ, Blusztajn JK, Williams CL. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain Res. 2008 Oct 27; 1237:110-23.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 18786518; PMCID: PMC2677022; DOI: 10.1016/j.brainres.2008.08.049;

Slack BE, Blusztajn JK. Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. J Cell Biochem. 2008 Aug 1; 104(5):1818-31.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 18348264; DOI: 10.1002/jcb.21745;

Meck WH, Williams CL, Cermak JM, Blusztajn JK. Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Front Integr Neurosci. 2007; 1:7. PMID: 18958235; PMCID: PMC2526009; DOI: 10.3389/neuro.07.007.2007;

Wong-Goodrich SJ, Mellott TJ, Glenn MJ, Blusztajn JK, Williams CL. Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus. Neurobiol Dis. 2008 May; 30(2):255-69.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 18353663; PMCID: PMC2413180; DOI: 10.1016/j.nbd.2008.01.008;

Schnitzler AC, Lopez-Coviella I, Blusztajn JK. Purification and culture of nerve growth factor receptor (p75)-expressing basal forebrain cholinergic neurons. Nat Protoc. 2008; 3(1):34-40. PMID: 18193019; DOI: 10.1038/nprot.2007.477;

Kovacheva VP, Mellott TJ, Davison JM, Wagner N, Lopez-Coviella I, Schnitzler AC, Blusztajn JK. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007 Oct 26; 282(43):31777-88.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 17724018

Yaar M, Zhai S, Panova I, Fine RE, Eisenhauer PB, Blusztajn JK, Lopez-Coviella I, Gilchrest BA. A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death. Neuropathol Appl Neurobiol. 2007 Oct; 33(5):533-43.View Related Profiles.

Gilchrest, Barbara
Blusztajn, Jan
Yaar, Mina
Fine, Richard

PMID: 17596181

Glenn MJ, Gibson EM, Kirby ED, Mellott TJ, Blusztajn JK, Williams CL. Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. Eur J Neurosci. 2007 Apr; 25(8):2473-82.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 17445242; PMCID: PMC2435208; DOI: 10.1111/j.1460-9568.2007.05505.x;

Mellott TJ, Kowall NW, Lopez-Coviella I, Blusztajn JK. Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain Res. 2007 Jun 2; 1151:1-11.View Related Profiles.

Blusztajn, Jan
Kowall, Neil
Mellott, Tiffany

PMID: 17399691; PMCID: PMC1952662; DOI: 10.1016/j.brainres.2007.03.004;

Brock M, Nickel AC, Madziar B, Blusztajn JK, Berse B. Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways. Brain Res. 2007 May 11; 1145:1-10.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 17320829; PMCID: PMC1911187; DOI: 10.1016/j.brainres.2007.01.119;

Mellott TJ, Follettie MT, Diesl V, Hill AA, Lopez-Coviella I, Blusztajn JK. Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB J. 2007 May; 21(7):1311-23.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 17264169

Slack BE, Siniaia MS, Blusztajn JK. Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. J Cell Biochem. 2006 Jun 1; 98(3):672-84.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 16440311; PMCID: PMC2593136; DOI: 10.1002/jcb.20812;

Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res. 2006 May 9; 1088(1):49-56.View Related Profiles.

Slack, Barbara
Berse, Brygida
Blusztajn, Jan

PMID: 16626664

Durcan N, Costello RW, McLean WG, Blusztajn J, Madziar B, Fenech AG, Hall IP, Gleich GJ, McGarvey L, Walsh MT. Eosinophil-mediated cholinergic nerve remodeling. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):775-86. PMID: 16456188

Berse B, Szczecinska W, Lopez-Coviella I, Madziar B, Zemelko V, Kaminski R, Kozar K, Lips KS, Pfeil U, Blusztajn JK. Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro. Brain Res Dev Brain Res. 2005 Jun 30; 157(2):132-40.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 15885806

Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6984-9.View Related Profiles.

Slack, Barbara
Berse, Brygida
Blusztajn, Jan
Mellott, Tiffany

PMID: 15870197; PMCID: PMC1088172; DOI: 10.1073/pnas.0502097102;

Kaczmarek E, Erb L, Koziak K, Jarzyna R, Wink MR, Guckelberger O, Blusztajn JK, Trinkaus-Randall V, Weisman GA, Robson SC. Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost. 2005 Apr; 93(4):735-42.View Related Profiles.

Blusztajn, Jan
Trinkaus-Randall, Vickery

PMID: 15841322; PMCID: PMC2830093; DOI: 10.1267/THRO05040735;

Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage FH, Blusztajn JK. Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci. 2004 Jun 16; 24(24):5459-66.View Related Profiles.

Berse, Brygida
Blusztajn, Jan
Mellott, Tiffany

PMID: 15201317

Mellott TJ, Williams CL, Meck WH, Blusztajn JK. Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. FASEB J. 2004 Mar; 18(3):545-7.View Related Profiles.

Blusztajn, Jan
Mellott, Tiffany

PMID: 14715695

Schueler UH, Kolter T, Kaneski CR, Blusztajn JK, Herkenham M, Sandhoff K, Brady RO. Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. Neurobiol Dis. 2003 Dec; 14(3):595-601. PMID: 14678774

Song P, Sekhon HS, Proskocil B, Blusztajn JK, Mark GP, Spindel ER. Synthesis of acetylcholine by lung cancer. Life Sci. 2003 Mar 28; 72(18-19):2159-68. PMID: 12628474

Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindel ER. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res. 2003 Jan 1; 63(1):214-21. PMID: 12517800

Mellott T, Lopez-Coviella I, Blusztajn JK, Berse B. Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. Eur J Biochem. 2002 Feb; 269(3):850-8.View Related Profiles.

Berse, Brygida
Blusztajn, Jan
Mellott, Tiffany

PMID: 11846786

Holmes GL, Yang Y, Liu Z, Cermak JM, Sarkisian MR, Stafstrom CE, Neill JC, Blusztajn JK. Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. Epilepsy Res. 2002 Jan; 48(1-2):3-13. PMID: 11823105

Guo-Ross SX, Clark S, Montoya DA, Jones KH, Obernier J, Shetty AK, White AM, Blusztajn JK, Wilson WA, Swartzwelder HS. Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci. 2002 Jan 1; 22(1):RC195. PMID: 11756524

López-Coviella I, Berse B, Thies RS, Blusztajn JK. Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line. J Physiol Paris. 2002 Jan-Mar; 96(1-2):53-9.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 11755783

López-Coviella I, Blusztajn JK. [Bone morphogenetic proteins and cholinergic neurons in the central nervous system]. Rev Neurol. 2001 Dec 1-15; 33(11):1054-60. PMID: 11785034

Zhao D, Frohman MA, Blusztajn JK. Generation of choline for acetylcholine synthesis by phospholipase D isoforms. BMC Neurosci. 2001; 2:16. PMID: 11734063; PMCID: PMC60648

Martínez-Morales JR, López-Coviella I, Hernández-Jiménez JG, Reyes R, Bello AR, Hernández G, Blusztajn JK, Alonso R. Sex steroids modulate luteinizing hormone-releasing hormone secretion in a cholinergic cell line from the basal forebrain. Neuroscience. 2001; 103(4):1025-31. PMID: 11301209

Blusztajn JK . Phosphatidylcholine, an essential phospholipid. In: "Soy and Health 2000 Clinical Evidence - Dietetic Applications." Descheemaeker K, Debruyne I, eds. Garant Publishers. Leuven. 2001; 145-156.

Yang Y, Liu Z, Cermak JM, Tandon P, Sarkisian MR, Stafstrom CE, Neill JC, Blusztajn JK, Holmes GL. Protective effects of prenatal choline supplementation on seizure-induced memory impairment. J Neurosci. 2000 Nov 15; 20(22):RC109. PMID: 11069978

Farber SA, Slack BE, Blusztajn JK. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J. 2000 Nov; 14(14):2198-206.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 11053240

Montoya DA, White AM, Williams CL, Blusztajn JK, Meck WH, Swartzwelder HS. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain Res Dev Brain Res. 2000 Sep 30; 123(1):25-32. PMID: 11020547

Malik MA, Greenwood CE, Blusztajn JK, Berse B. Cholinergic differentiation triggered by blocking cell proliferation and treatment with all-trans-retinoic acid. Brain Res. 2000 Aug 25; 874(2):178-85.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 10960602

López-Coviella I, Berse B, Krauss R, Thies RS, Blusztajn JK. Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science. 2000 Jul 14; 289(5477):313-6.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 10894782

Fiucci G, Czarny M, Lavie Y, Zhao D, Berse B, Blusztajn JK, Liscovitch M. Changes in phospholipase D isoform activity and expression in multidrug-resistant human cancer cells. Int J Cancer. 2000 Mar 15; 85(6):882-8.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 10709112

Blusztajn JK, Berse B. The cholinergic neuronal phenotype in Alzheimer's disease. Metab Brain Dis. 2000 Mar; 15(1):45-64.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 10885540

Koziak K, Kaczmarek E, Kittel A, Sévigny J, Blusztajn JK, Schulte Am Esch J, Imai M, Guckelberger O, Goepfert C, Qawi I, Robson SC. Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae. J Biol Chem. 2000 Jan 21; 275(3):2057-62. PMID: 10636909

Malik MA, Blusztajn JK, Greenwood CE. Nutrients as trophic factors in neurons and the central nervous system: role of retinoic acid. J Nutr Biochem. 2000 Jan; 11(1):2-13. PMID: 15539337

Schreiber BM, Veverbrants M, Fine RE, Blusztajn JK, Salmona M, Patel A, Sipe JD. Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis. Biochem J. 1999 Nov 15; 344 Pt 1:7-13.View Related Profiles.

Schreiber, Barbara
Blusztajn, Jan
Fine, Richard

PMID: 10548527; PMCID: PMC1220607

Berse B, Lopez-Coviella I, Blusztajn JK. Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor. Biochem J. 1999 Sep 1; 342 ( Pt 2):301-8.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 10455015; PMCID: PMC1220465

Szutowicz A, Jankowska A, Blusztajn JK, Tomaszewicz M. Acetylcholine and acetyl-CoA metabolism in differentiating SN56 septal cell line. J Neurosci Res. 1999 Jul 1; 57(1):131-6. PMID: 10397643

Cermak JM, Blusztajn JK, Meck WH, Williams CL, Fitzgerald CM, Rosene DL, Loy R. Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. Dev Neurosci. 1999; 21(2):94-104.View Related Profiles.

Rosene, Douglas
Blusztajn, Jan

PMID: 10449981

Blusztajn JK, Slack BE . Signal transduction in neurons by phospholipid breakdown products. In: Elsevier’s Encyclopedia of Neuroscience. 2nd enlarged and revised edition. Adelman G, Smith Bh eds. Elsevier Science B.V. Amsterdam. 1999; 1855-1860.

Zhao D, Berse B, Holler T, Cermak JM, Blusztajn JK. Developmental changes in phospholipase D activity and mRNA levels in rat brain. Brain Res Dev Brain Res. 1998 Aug 8; 109(2):121-7.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 9729325

Blusztajn JK. Choline, a vital amine. Science. 1998 Aug 7; 281(5378):794-5. PMID: 9714685

Blusztajn JK, Cermak JM, Holler T, Jackson DA. Imprinting of hippocampal metabolism of choline by its availability during gestation: implications for cholinergic neurotransmission. J Physiol Paris. 1998 Jun-Aug; 92(3-4):199-203. PMID: 9789808

Johnson PI, Blusztajn JK. Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency. Neurochem Res. 1998 May; 23(5):583-7. PMID: 9566595

Cermak JM, Holler T, Jackson DA, Blusztajn JK. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB J. 1998 Mar; 12(3):349-57. PMID: 9506479

Blusztajn JK, Holler T, Cermak JM, Jackson DJ . Neurochemical effects of altered prenatal choline availability in rats. In: Proceedings of the 7th International Congress on Phospholipids. "Choline, Phospholipids, Health, and Disease" Szuhaj B, Zeisel SH, eds. AOCS Press. Champaign,IL. 1998; 69-78.

Pedersen WA, Blusztajn JK. Characterization of the acetylcholine-reducing effect of the amyloid-beta peptide in mouse SN56 cells. Neurosci Lett. 1997 Dec 19; 239(2-3):77-80. PMID: 9469660

Li H, Leeman SE, Slack BE, Hauser G, Saltsman WS, Krause JE, Blusztajn JK, Boyd ND. A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9475-80.View Related Profiles.

Slack, Barbara
Blusztajn, Jan
Leeman, Susan

PMID: 9256507; PMCID: PMC23228

Berse B, Blusztajn JK. Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specific. FEBS Lett. 1997 Jun 30; 410(2-3):175-9.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 9237624

Ross BM, Moszczynska A, Blusztajn JK, Sherwin A, Lozano A, Kish SJ. Phospholipid biosynthetic enzymes in human brain. Lipids. 1997 Apr; 32(4):351-8. PMID: 9113621

Jankowska A, Blusztajn JK, Szutowicz A. Activities of enzymes of acetyl-CoA and acetylcholine metabolism in SN56 hybrid cholinergic cell line differentiated by dibutyryl cyclic AMP and all-trans retinoic acid. Folia Neuropathol. 1997; 35(4):247-9. PMID: 9833404

Blusztajn JK. Inter- and intracellular signaling by choline-containing compounds. Hot Spots in Neurochemistry ISN News. 1997.

Veronesi B, Ehrich M, Blusztajn JK, Oortgiesen M, Durham H. Cell culture models of interspecies selectivity to organophosphorous insecticides. Neurotoxicology. 1997; 18(1):283-97. PMID: 9216006

Holler T, Cermak JM, Blusztajn JK. Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring. FASEB J. 1996 Dec; 10(14):1653-9. PMID: 9002559

Pedersen WA, Kloczewiak MA, Blusztajn JK. Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):8068-71. PMID: 8755604; PMCID: PMC38876

Holler T, Berse B, Cermak JM, Diebler MF, Blusztajn JK. Differences in the developmental expression of the vesicular acetylcholine transporter and choline acetyltransferase in the rat brain. Neurosci Lett. 1996 Jul 12; 212(2):107-10.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 8832650

Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis. 1996 Feb; 3(1):16-32. PMID: 9173910

Gruber JR, Desai S, Blusztajn JK, Niles RM. Retinoic acid specifically increases nuclear PKC alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells. Exp Cell Res. 1995 Dec; 221(2):377-84. PMID: 7493637

Berse B, Blusztajn JK. Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line. J Biol Chem. 1995 Sep 22; 270(38):22101-4.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 7673184

Brotschi EA, Hilbinger CL, Kahl EA, Vaules WA, Midis NA, Blusztajn JK, Zeisel SH. Radioactive choline metabolism in guinea pig gallbladder. Is there measurable acetylcholine release? Dig Dis Sci. 1995 Sep; 40(9):1982-9.View Related Profiles.

Brotschi, Erica
Blusztajn, Jan

PMID: 7555453

Pedersen WA, Berse B, Schüler U, Wainer BH, Blusztajn JK. All-trans- and 9-cis-retinoic acid enhance the cholinergic properties of a murine septal cell line: evidence that the effects are mediated by activation of retinoic acid receptor-alpha. J Neurochem. 1995 Jul; 65(1):50-8.View Related Profiles.

Berse, Brygida
Blusztajn, Jan

PMID: 7790895

Blusztajn JK, Davis RO. Use of differentiated cholinergic and second messenger endpoints to evaluate cholinesterase inhibitors. Clin Exp Pharmacol Physiol. 1995 May; 22(5):368-9. PMID: 7554433

Hudson PL, Pedersen WA, Saltsman WS, Liscovitch M, MacLaughlin DT, Donahoe PK, Blusztajn JK. Modulation by sphingolipids of calcium signals evoked by epidermal growth factor. J Biol Chem. 1994 Aug 26; 269(34):21885-90. PMID: 8063833

Lavie Y, Blusztajn JK, Liscovitch M. Formation of endogenous free sphingoid bases in cells induced by changing medium conditions. Biochim Biophys Acta. 1994 Feb 17; 1220(3):323-8. PMID: 8305506

Blusztajn JK. Alzheimer's disease: prevention, models, and diagnostic tools. Neurobiol Aging. 1994; 15 Suppl 2:S37-9. PMID: 7700457

Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr. 1994; 14:269-96. PMID: 7946521

Blusztajn JK, Hudson PL, Slack BE . Sphingoid-base-containing modulators of biological signaling. In Signal-activated phospholipases. Liscovitch M ed. R.G. Landes Biomedical Publishers. Austin,TX. 1994; 213-223.
Blusztajn JK, Berse B, Follettie M, Venturini A, Jackson DA, Schüler U, Lee HJ, Wainer BH . Cholinergic cell lines as models for testing drug efficacy and toxicity. In “Final scientific reports of CAAT grantees. Technical report no. 6 of the Johns Hopkins Center for Alternatives to Animal Testing (CAAT). Baltimore,MD. 1994; 5-10.

Lee HC, Fellenz-Maloney MP, Liscovitch M, Blusztajn JK. Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line. Proc Natl Acad Sci U S A. 1993 Nov 1; 90(21):10086-90. PMID: 8234260; PMCID: PMC47718

Nitsch RM, Blusztajn JK, Doyle FM, Robitaille Y, Wurtman RJ, Growdon JH, Kish SJ. Phospholipid metabolite levels are altered in cerebral cortex of patients with dominantly inherited olivopontocerebellar atrophy. Neurosci Lett. 1993 Oct 29; 161(2):191-4. PMID: 8272265

da Costa KA, Cochary EF, Blusztajn JK, Garner SC, Zeisel SH. Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats. J Biol Chem. 1993 Jan 25; 268(3):2100-5. PMID: 8420980

Blusztajn JK, Venturini A, Jackson DA, Schüler U, Lee HJ, Wainer BH. Cholinergic cell lines as models for testing drug efficacy and toxicity. in Alternative Methods in Toxicology, J.K. Blusztajn, cv, Page 14. Mary Ann Liebert Inc. New York,NY. 1993; 9:3-8.
Blusztajn JK, Slack BE . Signal transduction in neurons by phospholipid breakdown products. In: Neuroscience Year 1992: Supplement to the Encyclopedia of Neuroscience. Adelman G, Smith B eds. Birkhäuser. Boston,MA. 1993; 148-153.

Zhang J, Blusztajn JK, Zeisel SH. Measurement of the formation of betaine aldehyde and betaine in rat liver mitochondria by a high pressure liquid chromatography-radioenzymatic assay. Biochim Biophys Acta. 1992 Oct 27; 1117(3):333-9. PMID: 1420283

Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1671-5.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 1311847; PMCID: PMC48514

Blusztajn JK, Venturini A, Jackson DA, Lee HJ, Wainer BH. Acetylcholine synthesis and release is enhanced by dibutyryl cyclic AMP in a neuronal cell line derived from mouse septum. J Neurosci. 1992 Mar; 12(3):793-9. PMID: 1312135

Blusztajn JK, Growdon JH, Lee H.-C, Liscovitch M, Logue M, Lopez G-Coviella I, Mauron C, Richardson UI, Ulus I, Wurtman RJ . Abnormal phospholipid metabolism and the pathophysiology of Alzheimer’s disease. In: Alzheimer’s disease: New treatment strategies. Kchachaturian ZS, Blass JP eds. Marcel Dekker. New York,NY. 1992; 213-222.
Blusztajn JK, Venturini A, Lee HJ, Wainer BH . Cholinergic phenotype of septal cell lines. In: The treatment of dementias: a new generation of progress. Meyer EM, Simpkins JW, Yamamoto J, Crews FT eds. Plenum Press. New York,NY. 1992; 463-469.
Blusztajn JK, Growdon JH, Lee H.-C, Liscovitch M, Logue M, Lopez G-Coviella I, Mauron C, Richardson UI, Ulus I, Wurtman RJ . Phospholipide und Pathophysiologie bei der Alzheimer-Krenkheit. In: Demenz: Herausforderung für Forschung, Medizin und Gesellschaft. E. Lungershausen ed. Springer-Verlag. Berlin. 1992; 58-66.

Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ. Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:110-3.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 1663712

Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ . Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer’s disease. Ann. NY Acad. Sci. 640. 1991; 110-113.

Blusztajn JK, Lopez Gonzalez-Coviella I, Logue M, Growdon JH, Wurtman RJ. Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients. Brain Res. 1990 Dec 17; 536(1-2):240-4. PMID: 2150771

Blusztajn JK, Lopez Gonzalez-Coviella I, Logue M, Growdon JH, Wurtman RJ . Abnormal phospholipid metabolism in neurodegenerative diseases: elevations in glycerophosphocholine and glycerophosphoethanolamine levels in brain of Alzheimer’s disease but not in Down syndrome patients. In: Basic, clinical and therapeutic aspects of Alzheimer’s and Parkinson’s diseases. Nagatsu T, Fisher A, Yoshida M, eds. Plenum Press. New York,NY. 1990; 133-138.

Wurtman RJ, Blusztajn JK, Ulus IH, Coviella IL, Buyukuysal RL, Growdon JH, Slack BE. Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. Adv Neurol. 1990; 51:117-25.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 2403709

Wurtman RJ, Ulus IH, Mauron C, Blusztajn JK . Use of choline in cholinergic neurons to form accetylcholine or phosphatidylcholine: implications for the pathogenesis of agerelated memory disorders. In: Aging brain and dementia: new trends in diagnosis and therapy.Alan Liss. 1990; 215-238.
Wurtman RJ, Ulus IH, Blusztajn RJ, Lopez G.-Coviella I, Logue M, Mauron C, Growdon JH . Choline levels, the regulation of acetylcholine synthesis and phosphatidylcholine synthesis, and Alzheimer’s disease. In: Alzheimer’s disease: epidemiology, neuropathology, neurochemistry, and clinics. Maurer K, Riederer P, Beckmann H, eds. Springer. Vienna. 1990; 211-224.
Blusztajn JK, Growdon JH, Lee H.-C, Liscovitch M, Logue M, Lopez G-Coviella I, Mauron C, Richardson UI, Ulus I, Wurtman RJ. Abnormal phospholipid turnover and pathophysiology of Alzheimer’s disease. Bulletin of Clinical Neurosciences 55. 1990; 91-98.

Slack BE, Liscovitch M, Blusztajn JK, Wurtman RJ. Uptake of exogenous phosphatidylserine by human neuroblastoma cells stimulates the incorporation of [methyl-14C]choline into phosphatidylcholine. J Neurochem. 1989 Aug; 53(2):472-81.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 2746233

Ulus IH, Wurtman RJ, Mauron C, Blusztajn JK. Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Res. 1989 Apr 10; 484(1-2):217-27. PMID: 2713682

Blusztajn JK, Zeisel SH. 1,2-sn-diacylglycerol accumulates in choline-deficient liver. A possible mechanism of hepatic carcinogenesis via alteration in protein kinase C activity? FEBS Lett. 1989 Jan 30; 243(2):267-70. PMID: 2917651

Richardson UI, Liscovitch M, Blusztajn JK. Acetylcholine synthesis and secretion by LA-N-2 human neuroblastoma cells. Brain Res. 1989 Jan 9; 476(2):323-31. PMID: 2702472

Wurtman RJ, Blusztajn JK, Ulus I, Lopez G-Coviella I, Buyukuysal RL, Growdon JH, Slack BE . Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. In: Alzheimer’s disease. Wurtman RJ, Corkin SC, Growdon JH, Ritter-Walker E, eds. CBSMCT. Cambridge,MA. 1989; 193-208.
Miatto O, Blusztajn JK, Logue M, Gonzalez G, Buonanno F, Growdon JH . Detection of phospholipids in brain tissue using 31P NMR spectroscopy. In: Phospholipids in the nervous system: Biochemical and molecular pathology. Bazan NG, Horrocks LA, Toffano G, eds. Liviana Press. Padua. 1989; 243-250.
Blusztajn JK . Die Cholinerge Hypothese der Demenz vom Alzheimer-Typ und daraus abzuleitende Behandlungsstrategien. In: Zugänge zu Ursachen, Klinik und Pharmakotherapie der Demenz vom Alzheimer-Typ. S. Hoyer ed. Vieweg,. Braunschweig. 1989; 41-51.
Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Ulus I, Wurtman RJ . Phosphatidylcholine as a necessary component of biological membranes and as a store of choline for acetylcholine synthesis. In: Phospholipids in the nervous system: Biochemical and molecular pathology. Bazan NG, Horrocks LA, Toffano G eds. Liviana Press. Padua. 1989; 205-215.

Yang EK, Blusztajn JK, Pomfret EA, Zeisel SH. Rat and human mammary tissue can synthesize choline moiety via the methylation of phosphatidylethanolamine. Biochem J. 1988 Dec 15; 256(3):821-8. PMID: 3223955; PMCID: PMC1135489

Liscovitch M, Slack B, Blusztajn JK, Wurtman RJ. Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells. J Biol Chem. 1987 Dec 25; 262(36):17487-91.View Related Profiles.

Slack, Barbara
Blusztajn, Jan

PMID: 3693364

Blusztajn JK, Liscovitch M, Richardson UI. Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5474-7. PMID: 3474663; PMCID: PMC298880

Blusztajn JK, Richardson UI, Liscovitch M, Mauron C, Wurtman RJ . Phospholipids in cellular survival and growth. In: Lecithin: technological, biological and therapeutic aspects. Hanin I, Ansell GB eds. Plenum Press. New York,NY. 1987; 85-94.
Wurtman RJ, Blusztajn JK, Holbrook PG, Lakher M, Liscovitch M, Maire J-C, Mauron C, Richardson UI, Tacconi M . Use of choline in cholinergic neurons to form acetylcholine and membrane phospholipids: possible implications for Alzheimer’s disease. In: Advancing Frontiers in Alzheimer’s Disease Research. Glenner G, Wurtman RJ eds. University of Texas Press. Austin,TX. 1987; 1-9.

Liscovitch M, Blusztajn JK, Freese A, Wurtman RJ. Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate. Biochem J. 1987 Jan 1; 241(1):81-6. PMID: 3566713; PMCID: PMC1147527

Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Wurtman RJ. Phosphatidylcholine as a precursor of choline for acetylcholine synthesis. J Neural Transm Suppl. 1987; 24:247-59. PMID: 3316498

Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Wurtman RJ . Phosphatidylcholine as a precursor of choline for acetylcholine synthesis. In: Alzheimer’s disease: advances in basic research and therapies. Wurtman RJ, Corkin SH, Growdon JH eds. CBSMCT. Cambridge, MA. 1987; 247-262.

Liscovitch M, Freese A, Blusztajn JK, Wurtman RJ. Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. J Neurochem. 1986 Dec; 47(6):1936-41. PMID: 3772385

Blusztajn JK, Holbrook PG, Lakher M, Liscovitch M, Maire J-C, Mauron C, Richardson UI, Tacconi MT, Wurtman RJ . Relationships between acetylcholine release and membrane phosphatidylcholine turnover in brain and in cultured cholinergic neurons. In: Phospholipids in the nervous system: Biochemical and molecular pharmacology. Horrocks LA, Freysz L, Toffano G, eds. Liviana Press, Padua and Springer Verlag. Berlin. 1986; 283-290.
Lakher M, Wurtman RJ, Blusztajn JK, Holbrook P, Mauron C, Maire J-C, Tacconi M . Brain phosphatidylcholine pools as possible sources of free choline for acetylcholine synthesis. In: Biological methylation and drug design. Borchardt RT, Creveling CR, Ueland PM eds. Humana Press. Clifton, NJ. 1986; 101-110.
Blusztajn JK, Holbrook PG, Liscovitch M, Maire J-C, Mauron C, Richardson UI, Tacconi MT, Wurtman RJ . Pathogenesis: Possible role of choline phospholipids. In: Treatment development strategies for Alzheimer’s disease. Crook T, Bartus R, Ferris S, Gershon S, eds. Mark Pawley Associates. Madison,CT. 1986; 539-552.
Wurtman RJ, Blusztajn JK, Maire J-C . The “autocannibalism” of cholinecontaining membrane phospholipids in the pathogenesis of Alzheimer’s disease. In: Alzheimer’s and Parkinson’s disease. Fisher A, Hanin I, Lachman C, eds. Plenum Press. New York,NY. 1986; 69-73.

Blusztajn JK, Holbrook PG, Lakher M, Liscovitch M, Maire JC, Mauron C, Richardson UI, Tacconi M, Wurtman RJ. "Autocannibalism" of membrane choline-phospholipids: physiology and pathology. Psychopharmacol Bull. 1986; 22(3):781-6. PMID: 3025910

Wurtman RJ, Blusztajn JK, Maire J-C . The “autocannibalism” of cholinecontaining membrane phospholipids in the pathogenesis of Alzheimer’s disease. In: New concepts in Alzheimer’s disease. Briley M, Kato A, Weber M, eds. Macmillan Press. Houndmills. 1986; 17-22.
Maire J-C, Blusztajn JK, Wurtman RJ . Effects of exogenous choline on acetylcholine and choline release in striatal slices. In: Dynamics of cholinergic function. Hanin I, ed. Plenum Press. New York,NY. 1986; 575-581.

Blusztajn JK, Zeisel SH, Wurtman RJ. Developmental changes in the activity of phosphatidylethanolamine N-methyltransferases in rat brain. Biochem J. 1985 Dec 1; 232(2):505-11. PMID: 4091805; PMCID: PMC1152909

Liscovitch M, Freese A, Blusztajn JK, Wurtman RJ. High-performance liquid chromatography of water-soluble choline metabolites. Anal Biochem. 1985 Nov 15; 151(1):182-7. PMID: 4091278

Wurtman RJ, Blusztajn JK, Maire JC. "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis. Neurochem Int. 1985; 7(2):369-72. PMID: 20492936

Blusztajn JK, Tacconi MT, Zeisel SH, Wurtman RJ . Are phospholipids in cholinergic neurons a source of choline for acetylcholine synthesis. In: Phospholipids in the nervous system. Physiological Roles. Horrocks LA, Kanfer JN, Porcellati G eds. Raven Press. New York,NY. 1985; 2:229-236.
Blusztajn JK, Maire JC, Tacconi M, Wurtman RJ . The possible role of neuronal choline metabolism in the pathophysiology of Alzheimer’s disease: a hypothesis. In: Alzheimer’s disease: advances in basic research and therapies. Wurtman RJ, Corkin SH, Growdon JH eds., CBSMCT. Cambridge,MA. 1984; 183-198.

Blusztajn JK, Wurtman RJ. Choline and cholinergic neurons. Science. 1983 Aug 12; 221(4611):614-20. PMID: 6867732

Zeisel SH, Wishnok JS, Blusztajn JK. Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther. 1983 May; 225(2):320-4. PMID: 6842395

Leprohon CE, Blusztajn JK, Wurtman RJ. Dopamine stimulation of phosphatidylcholine (lecithin) biosynthesis in rat brain neurons. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):2063-6. PMID: 6572961; PMCID: PMC393753

Blusztajn JK, Wurtman RJ . The Syntheses of Choline and Acetylcholine in Brain. In: Handbook Of Neurochemistry, A. Lajtha ed. Plenum. New York,NY. 1983; 5:295-310.
Blusztajn JK, Zeisel SH, Wurtman RJ . Phospholipid methylation and cholinergic neurons. In: Biochemistry of S-adenosylmethionine and related compounds. Borchardt R, Usdin E, Creveling C eds. MacMillan Press. London,UK. 1982; 155-164.

Blusztajn JK, Wurtman RJ. Choline biosynthesis by a preparation enriched in synaptosomes from rat brain. Nature. 1981 Apr 2; 290(5805):417-8. PMID: 7219528

Zeisel SH, Milunsky A, Blusztajn JK. Prenatal diagnosis of neural tube defects. V. The value of amniotic fluid cholinesterase studies. Am J Obstet Gynecol. 1980 Jun 15; 137(4):481-5.View Related Profiles.

Milunsky, Aubrey
Blusztajn, Jan

PMID: 6155784

Blusztajn JK, Zeisel SH, Wurtman RJ. Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain. Brain Res. 1979 Dec 28; 179(2):319-27. PMID: 509240

Milunsky A, Blusztajn JK, Zeisel SH. Amniotic-fluid total cholinesterase and neural-tube defects. Lancet. 1979 Jul 7; 2(8132):36.View Related Profiles.

Milunsky, Aubrey
Blusztajn, Jan

PMID: 87905

Zeisel SH, Blusztajn JK, Wurtman RJ. Brain lecithin synthesis: evidence that bovine brain can make choline molecules. In: Nutrition and the Brain, Barbeau A, Growdon JH, Wurtman RJ eds. Raven Press. New York. 1979; 5:47-56.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 172 publications over 42 distinct years, with a maximum of 11 publications in 2008

Bar chart showing 172 publications over 42 distinct years, with a maximum of 11 publications in 2008

Year	Publications
1980	1
1981	1
1982	1
1983	4
1984	1
1985	4
1986	8
1987	7
1988	1
1989	8
1990	6
1991	2
1992	6
1993	5
1994	6
1995	5
1996	4
1997	7
1998	6
1999	5
2000	9
2001	4
2002	4
2003	3
2004	2
2005	3
2006	3
2007	6
2008	11
2010	4
2011	4
2012	2
2013	2
2014	2
2016	2
2017	6
2018	5
2019	2
2020	1
2021	2
2023	3
2024	4

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