Keywords
Last Name

Susan E. Leeman, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Building A
Boston MA 02118
Phone(617) 638-4364
ORCID ORCID Icon0000-0002-0951-5364
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Awards and Honors

Start-EndDescription
2006American Association for the Advancement of Science: Fellow
2005Mika Salpeter Lifetime Achievement Award, Women in Neuroscience
199914th Annual Isadore Rosenberg Lecture
1994Fogarty Scholar-in-Residence
1994197th Lilly Lecture
1994Fred Conrad Koch Award
1993Goucher Gollege, Towson, Maryland: Honorary Degree
1993FASEB, Excellence in Science Award
1992State University of New York, Institute of Technology at Utica/Rome: Honorary Degree, Doctor of Science
1992University of Kentucky: Burroughs Wellcome Visiting Professorship Award
1991National Academy of Sciences: Member
1987American Academy of Arts & Sciences: Fellow
1984Mt. Holyoke College: Christianna Smith Lecture
1984Boston Veterans Administration Medical Center: Charles C. Pinderhughes Lecture
1983New York Academy of Sciences: The Louis and Bert Freedman Foundation Award for Research in Biochemistry
1983Texas Tech University: Distinguished Neuroscientist, Tarbox Lecture Series
1982College of Physicians and Surgeons of Columbia University: Van Dyke Award
1981University of Calgary: Alberta Heritage for Medical Research Visiting Professor Award
1981The Endocrine Society: Astwood Award
 Research Expertise & Professional Interests
Dr. Susan Leeman is a Professor in the Department of Pharmacology & Experimental Therapeutics, and the Director of the Neuropeptide Laboratory in the Pharmacology Department at the Boston University School of Medicine. Dr. Leeman has been a Member of the National Academy of Sciences since 1991.

Dr. Leeman’s research focuses on the two peptides, substance P (SP) and neurotensin, that were isolated and chemically defined in this laboratory. Previous projects that are currently underway relating to the biochemistry and pharmacology of SP include studies to determine the binding domains of SP with its receptor using photoactivatable derivatives of SP containing the photoreactive amino acid benzoylphenlalanine; studies to determine the binding domains of an antagonist of SP, CP 96,345 using a photoactivatable derivative of this compound; the characterization of calcium signals generated by administration of SP to CHO cells transfected with mRNA encoding the full-length SP receptor; the roles of SP in several models of inflammation in the gastrointestinal tract using non-peptide SP antagonists; a truncated form of the SP receptor and several mutant receptors. A new direction of research involves studies directed towards the chemical characterization and function of the carbohydrate moieties on the SP receptor.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Patel AB, Tsilioni I, Leeman SE, Theoharides TC. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A. 2016 Sep 23. PMID: 27663735.
    View in: PubMed
  2. Yuan H, Zelka S, Burkatovskaya M, Gupte R, Leeman SE, Amar S. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5059-68. PMID: 24324141.
    View in: PubMed
  3. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72. PMID: 24218590.
    View in: PubMed
  4. Amar S, Leeman S. Periodontal innate immune mechanisms relevant to obesity. Mol Oral Microbiol. 2013 Oct; 28(5):331-41. PMID: 23911141.
    View in: PubMed
  5. Bhargava A, Clifton MS, Mhaske P, Mhsake P, Liao M, Pothoulakis C, Leeman SE, Grady EF. Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):731-6. PMID: 23267070.
    View in: PubMed
  6. Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF. Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. J Crohns Colitis. 2013 Jun; 7(5):403-11. PMID: 22921465.
    View in: PubMed
  7. Merrill JC, You J, Constable C, Leeman SE, Amar S. Whole-body deletion of LPS-induced TNF-a factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21247-52. PMID: 22160695.
    View in: PubMed
  8. Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF, Becker JM. Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17420-5. PMID: 21969570.
    View in: PubMed
  9. Bushell KN, Leeman SE, Gillespie E, Gower AC, Reed KL, Stucchi AF, Becker JM, Amar S. LITAF mediation of increased TNF-a secretion from inflamed colonic lamina propria macrophages. PLoS One. 2011; 6(9):e25849. PMID: 21984950.
    View in: PubMed
  10. Meshki J, Douglas SD, Hu M, Leeman SE, Tuluc F. Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. PLoS One. 2011; 6(9):e25332. PMID: 21966499.
    View in: PubMed
  11. Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuño M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 2011 Jun; 152(6):2197-205. PMID: 21467195.
    View in: PubMed
  12. Zhang B, Alysandratos KD, Angelidou A, Asadi S, Sismanopoulos N, Delivanis DA, Weng Z, Miniati A, Vasiadi M, Katsarou-Katsari A, Miao B, Leeman SE, Kalogeromitros D, Theoharides TC. Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis. J Allergy Clin Immunol. 2011 Jun; 127(6):1522-31.e8. PMID: 21453958.
    View in: PubMed
  13. Zhou Q, Leeman SE, Amar S. Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2867-72. PMID: 21282635.
    View in: PubMed
  14. Douglas SD, Leeman SE. Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann N Y Acad Sci. 2011 Jan; 1217:83-95. PMID: 21091716.
    View in: PubMed
  15. Srinivasan S, Leeman SE, Amar S. Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol. 2010 May; 17(5):699-704. PMID: 20219876.
    View in: PubMed
  16. Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4448-53. PMID: 20160089.
    View in: PubMed
  17. Zhou Q, Leeman SE, Amar S. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10740-5. PMID: 19541650.
    View in: PubMed
  18. Leeman SE. Chapter in The History of Neuroscience in Autobiography. Society for Neuroscience, Larry R. Squire, Editor. Oxford University Press. 2008; 6:319-340.
  19. Leeman SE. Diversity of neuropathogenic mechanisms and implications for neuromediation of diseases. Ann N Y Acad Sci. 2008 Nov; 1144:113-5. PMID: 19076370.
    View in: PubMed
  20. Reed KL, Stucchi AF, Leeman SE, Becker JM. Inhibitory effects of a neurokinin-1 receptor antagonist on postoperative peritoneal adhesion formation. Ann N Y Acad Sci. 2008 Nov; 1144:116-26. PMID: 19076371.
    View in: PubMed
  21. Lim R, Morrill JM, Lynch RC, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM. Practical limitations of bioresorbable membranes in the prevention of intra-abdominal adhesions. J Gastrointest Surg. 2009 Jan; 13(1):35-41; discussion 41-2. PMID: 18854958.
    View in: PubMed
  22. Ohtsuka N, Tansky MF, Kuang H, Kourrich S, Thomas MJ, Rubenstein JL, Ekker M, Leeman SE, Tsien JZ. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):12961-6. PMID: 18728179.
    View in: PubMed
  23. Lai JP, Lai S, Tuluc F, Tansky MF, Kilpatrick LE, Leeman SE, Douglas SD. Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12605-10. PMID: 18713853.
    View in: PubMed
  24. Lim R, Morrill JM, Prushik SG, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM. An FDA approved neurokinin-1 receptor antagonist is effective in reducing intraabdominal adhesions when administered intraperitoneally, but not orally. J Gastrointest Surg. 2008 Oct; 12(10):1754-61. PMID: 18709513.
    View in: PubMed
  25. Amar S, Zhou Q, Shaik-Dasthagirisaheb Y, Leeman S. Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20466-71. PMID: 18077329.
    View in: PubMed
  26. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19796-801. PMID: 18056631.
    View in: PubMed
  27. Cohen PA, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL. A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen. 2007 Nov-Dec; 15(6):800-8. PMID: 18028127.
    View in: PubMed
  28. Tansky MF, Pothoulakis C, Leeman SE. Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10691-6. PMID: 17563389.
    View in: PubMed
  29. Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N. A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5413-8. PMID: 17372230.
    View in: PubMed
  30. Prushik SG, Aarons CB, Matteotti R, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM. A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation. Surg Endosc. 2007 Oct; 21(10):1790-5. PMID: 17356938.
    View in: PubMed
  31. Cohen PA, Aarons CB, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL. The effectiveness of a single intraperitoneal infusion of a neurokinin-1 receptor antagonist in reducing postoperative adhesion formation is time dependent. Surgery. 2007 Mar; 141(3):368-75. PMID: 17349849.
    View in: PubMed
  32. Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF, Becker JM. Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg. 2007 Feb; 245(2):176-84. PMID: 17245169.
    View in: PubMed
  33. Tang X, Metzger D, Leeman S, Amar S. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13777-82. PMID: 16954198.
    View in: PubMed
  34. Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S, Becker J. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 2006 Jul; 12(7):581-7. PMID: 16804395.
    View in: PubMed
  35. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5207-12. PMID: 16549770.
    View in: PubMed
  36. Tang X, Marciano DL, Leeman SE, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5132-7. PMID: 15793005.
    View in: PubMed
  37. Reed KL, Fruin AB, Gower AC, Stucchi AF, Leeman SE, Becker JM. A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9115-20. PMID: 15187234.
    View in: PubMed
  38. Leeman E, Leeman S. Elements of dynamics IV: neuronal metaphors--probing neurobiology for psychodynamic meaning. J Am Acad Psychoanal Dyn Psychiatry. 2004; 32(4):645-59. PMID: 15585423.
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  39. Stucchi AF, Shebani KO, Leeman SE, Wang CC, Reed KL, Fruin AB, Gower AC, McClung JP, Andry CD, O'Brien MJ, Pothoulakis C, Becker JM. A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1259-67. PMID: 12893626.
    View in: PubMed
  40. Kennedy PG, Rodgers J, Bradley B, Hunt SP, Gettinby G, Leeman SE, de Felipe C, Murray M. Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain. 2003 Jul; 126(Pt 7):1683-90. PMID: 12805119.
    View in: PubMed
  41. Reed KL, Fruin AB, Bishop-Bartolomei KK, Gower AC, Nicolaou M, Stucchi AF, Leeman SE, Becker JM. Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation. J Surg Res. 2002 Nov; 108(1):165-72. PMID: 12443729.
    View in: PubMed
  42. Bremer AA, Tansky MF, Wu M, Boyd ND, Leeman SE. Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. Eur J Pharmacol. 2001 Jul 6; 423(2-3):143-7. PMID: 11448478.
    View in: PubMed
  43. Bremer AA, Leeman SE, Boyd ND. Evidence for spatial proximity of two distinct receptor regions in the substance P (SP)*neurokinin-1 receptor (NK-1R) complex obtained by photolabeling the NK-1R with p-benzoylphenylalanine3-SP. J Biol Chem. 2001 Jun 22; 276(25):22857-61. PMID: 11294866.
    View in: PubMed
  44. Macdonald D, Mierke DF, Li H, Pellegrini M, Sachais B, Krause JE, Leeman SE, Boyd ND. Photoaffinity labeling of mutant neurokinin-1 receptors reveals additional structural features of the substance P/NK-1 receptor complex. Biochemistry. 2001 Feb 27; 40(8):2530-9. PMID: 11327875.
    View in: PubMed
  45. Berg EA, Johnson RJ, Leeman SE, Boyd N, Kimerer L, Fine RE. Isolation and characterization of substance P-containing dense core vesicles from rabbit optic nerve and termini. J Neurosci Res. 2000 Dec 15; 62(6):830-9. PMID: 11107168.
    View in: PubMed
  46. Li H, Macdonald DM, Hronowski X, Costello CE, Leeman SE, Boyd ND. Further definition of the substance P (SP)/neurokinin-1 receptor complex. MET-174 is the site of photoinsertion p-benzoylphenylalanine4 SP. J Biol Chem. 2001 Apr 6; 276(14):10589-93. PMID: 11116140.
    View in: PubMed
  47. Bremer AA, Leeman SE, Boyd ND. The common C-terminal sequences of substance P and neurokinin A contact the same region of the NK-1 receptor. FEBS Lett. 2000 Dec 1; 486(1):43-8. PMID: 11108840.
    View in: PubMed
  48. Stucchi AF, Shofer S, Leeman S, Materne O, Beer E, McClung J, Shebani K, Moore F, O'Brien M, Becker JM. NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1298-306. PMID: 11093954.
    View in: PubMed
  49. Leeman SE, Ferguson SL. Substance P: an historical perspective. Neuropeptides. 2000 Oct; 34(5):249-54. PMID: 11049728.
    View in: PubMed
  50. Benoliel R, Eliav E, Mannes AJ, Caudle RM, Leeman S, Iadarola MJ. Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain. Pain. 1999 Feb; 79(2-3):243-53. PMID: 10068170.
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  51. Alexander MJ, Leeman SE. Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor. J Comp Neurol. 1998 Dec 28; 402(4):475-500. PMID: 9862322.
    View in: PubMed
  52. Pothoulakis C, Castagliuolo I, Leeman SE, Wang CC, Li H, Hoffman BJ, Mezey E. Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats. Am J Physiol. 1998 Jul; 275(1 Pt 1):G68-75. PMID: 9655686.
    View in: PubMed
  53. Pothoulakis C, Castagliuolo I, Leeman SE. Neuroimmune mechanisms of intestinal responses to stress. Role of corticotropin-releasing factor and neurotensin. Ann N Y Acad Sci. 1998 May 1; 840:635-48. PMID: 9629290.
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  54. Thoidis G, Chen P, Pushkin AV, Vallega G, Leeman SE, Fine RE, Kandror KV. Two distinct populations of synaptic-like vesicles from rat brain. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):183-8. PMID: 9419350.
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  55. Li H, Leeman SE, Slack BE, Hauser G, Saltsman WS, Krause JE, Blusztajn JK, Boyd ND. A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9475-80. PMID: 9256507.
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  56. Castagliuolo I, Keates AC, Qiu B, Kelly CP, Nikulasson S, Leeman SE, Pothoulakis C. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4788-93. PMID: 9114070.
    View in: PubMed
  57. Kennedy PG, Rodgers J, Jennings FW, Murray M, Leeman SE, Burke JM. A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):4167-70. PMID: 9108123.
    View in: PubMed
  58. Kohlmann O, Cesaretti ML, Ginoza M, Tavares A, Zanella MT, Ribeiro AB, Ramos OL, Leeman SE, Gavras I, Gavras H. Role of substance P in blood pressure regulation in salt-dependent experimental hypertension. Hypertension. 1997 Jan; 29(1 Pt 2):506-9. PMID: 9039150.
    View in: PubMed
  59. Castagliuolo I, Leeman SE, Bartolak-Suki E, Nikulasson S, Qiu B, Carraway RE, Pothoulakis C. A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12611-5. PMID: 8901630.
    View in: PubMed
  60. Kage R, Leeman SE, Krause JE, Costello CE, Boyd ND. Identification of methionine as the site of covalent attachment of a p-benzoyl-phenylalanine-containing analogue of substance P on the substance P (NK-1) receptor. J Biol Chem. 1996 Oct 18; 271(42):25797-800. PMID: 8824208.
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  61. Fisher CE, Sutherland JA, Krause JE, Murphy JR, Leeman SE, vanderSpek JC. Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance P receptors. Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14):7341-5. PMID: 8692995.
    View in: PubMed
  62. Rittenhouse PA, Markle RA, Marchand JE, Kream RM, Leeman SE. Streptozotocin-induced diabetes produces a decrease in pituitary substance P content and preprotachykinin mRNA. Neurosci Lett. 1996 Jun 21; 211(2):77-80. PMID: 8830848.
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  63. Zhu GF, Chancellor-Freeland C, Berman AS, Kage R, Leeman SE, Beller DI, Black PH. Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages. J Neurosci. 1996 Jun 1; 16(11):3745-52. PMID: 8642417.
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  64. MacDonald D, Silberman SC, Lowe JA, Drozda SE, Leeman SE, Boyd ND. Photoaffinity labeling of the human substance P (neurokinin-1) receptor with [3H2]azido-CP-96,345, a photoreactive derivative of a nonpeptide antagonist. Mol Pharmacol. 1996 May; 49(5):808-13. PMID: 8622630.
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  65. Li H, Hsu P, Sachais BS, Krause JE, Leeman SE, Boyd ND. Identification of the site in the substance P (NK-1) receptor for modulation of peptide binding by sulfhydryl reagents. J Biol Chem. 1996 Jan 26; 271(4):1950-6. PMID: 8567643.
    View in: PubMed
  66. Boyd ND, Kage R, Dumas JJ, Krause JE, Leeman SE. The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond. Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1):433-7. PMID: 8552654.
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  67. Amaratunga AP, Kosik KS, Rittenhouse PA, Leeman SE, Fine RE. Antisense inhibition of protein synthesis and function : rabbit retinal protein. Methods Mol Med. 1996; 1:109-19. PMID: 21359719.
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  68. Rittenhouse PA, Marchand JE, Chen J, Kream RM, Leeman SE. Streptozotocin-induced diabetes is associated with altered expression of peptide-encoding mRNAs in rat sensory neurons. Peptides. 1996; 17(6):1017-22. PMID: 8899822.
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  69. Chancellor-Freeland C, Zhu GF, Kage R, Beller DI, Leeman SE, Black PH. Substance P and stress-induced changes in macrophages. Ann N Y Acad Sci. 1995 Dec 29; 771:472-84. PMID: 8597423.
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  70. Kohlmann O, Ginoza M, Cezaretti ML, Zanella MT, Ribeiro AB, Tavares A, Ramos OL, Leeman SE, Gavras I, Gavras H. Cardiovascular effects of a specific nonpeptide antagonist of substance P (NK-1) receptor in DOCA-salt hypertension. Hypertension. 1995 Dec; 26(6 Pt 2):1186-9. PMID: 7498993.
    View in: PubMed
  71. Boyd ND, Kage R, Dumas JJ, Silberman SC, Krause JE, Leeman SE. Localization of the peptide binding domain of the NK-1 tachykinin receptor using photoreactive analogues of substance P. Ann N Y Acad Sci. 1995 May 10; 757:405-9. PMID: 7541973.
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  72. Amaratunga A, Leeman SE, Kosik KS, Fine RE. Inhibition of kinesin synthesis in vivo inhibits the rapid transport of representative proteins for three transport vesicle classes into the axon. J Neurochem. 1995 May; 64(5):2374-6. PMID: 7536813.
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  73. Watts TL, Beards Cf, Ewing PD, Leeman S. Periodontal disease activity: a development strategy for its investigation by means of accurate 3-dimensional clinical measurement. J Clin Periodontol. 1995 Mar; 22(3):201-7. PMID: 7790525.
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  74. Kage R, Hershey AD, Krause JE, Boyd ND, Leeman SE. Characterization of the substance P (NK-1) receptor in tunicamycin-treated transfected cells using a photoaffinity analogue of substance P. J Neurochem. 1995 Jan; 64(1):316-21. PMID: 7528264.
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  75. Vijayan E, Carraway R, Leeman SE, McCann SM. Physiological significance of neurotensin in pituitary glycoprotein hormone release as revealed by in vivo and in vitro studies with neurotensin antiserum. Neuroendocrinology. 1994 Aug; 60(2):157-64. PMID: 7969773.
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  76. Alexander MJ, Leeman SE. Estrogen-inducible neurotensin immunoreactivity in the preoptic area of the female rat. J Comp Neurol. 1994 Jul 22; 345(4):496-509. PMID: 7962697.
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  77. Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O'Keane JC, Snider RM, Leeman SE. CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3):947-51. PMID: 7508124.
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  78. Luber-Narod J, Kage R, Leeman SE. Substance P enhances the secretion of tumor necrosis factor-alpha from neuroglial cells stimulated with lipopolysaccharide. J Immunol. 1994 Jan 15; 152(2):819-24. PMID: 7506735.
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  79. Lantz RC, Lemen RJ, Dey RD, Rodd A, Bowers M, Chen H, Witten ML, Quan SF, Kage R, Leeman SE. Nedocromil preserves neuropeptides in neurons associated with airway smooth muscle and reduces adenovirus-induced airway hyperreactivity. Regul Pept. 1993 Jul 2; 46(1-2):211-3. PMID: 7692493.
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  80. Kage R, Leeman SE, Boyd ND. Biochemical characterization of two different forms of the substance P receptor in rat submaxillary gland. J Neurochem. 1993 Jan; 60(1):347-51. PMID: 8380195.
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  81. Leeman SE, Munson PL. Thoughts concerning women in science. FASEB J. 1992 Dec; 6(15):3327. PMID: 1464367.
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  82. Shamgochian MD, Leeman SE. Substance P stimulates luteinizing hormone secretion from anterior pituitary cells in culture. Endocrinology. 1992 Aug; 131(2):871-5. PMID: 1379165.
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  83. Jonassen JA, Mullikin-Kilpatrick D, Hoogasian J, Benoit SE, Leeman SE. Regulation of adenohypophyseal messenger RNAs in female rats by age, hypothyroidism, estradiol and neonatal androgenization. Mol Cell Endocrinol. 1992 Mar; 84(1-2):55-64. PMID: 1379201.
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  84. Alexander MJ, Leeman SE. Neurotensin gene expression in the rat preoptic area. Implications for the regulation of reproduction. Ann N Y Acad Sci. 1992; 668:70-89. PMID: 1463289.
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  85. Snider RM, Longo KP, Drozda SE, Lowe JA, Leeman SE. Effect of CP-96,345, a nonpeptide substance P receptor antagonist, on salivation in rats. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10042-4. PMID: 1719543.
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  86. Chung ES, Leeman SE, Cuénoud HF. The effect of neonatal treatment with capsaicin on focal arteriolar insudation. Microvasc Res. 1991 Nov; 42(3):316-24. PMID: 1779885.
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  87. Alexander MJ, Kiraly ZJ, Leeman SE. Sexually dimorphic distribution of neurotensin/neuromedin N mRNA in the rat preoptic area. J Comp Neurol. 1991 Sep 1; 311(1):84-96. PMID: 1939736.
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  88. Morin PJ, Liu NG, Johnson RJ, Leeman SE, Fine RE. Isolation and characterization of rapid transport vesicle subtypes from rabbit optic nerve. J Neurochem. 1991 Feb; 56(2):415-27. PMID: 1824859.
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  89. Boyd ND, White CF, Cerpa R, Kaiser ET, Leeman SE. Photoaffinity labeling the substance P receptor using a derivative of substance P containing p-benzoylphenylalanine. Biochemistry. 1991 Jan 15; 30(2):336-42. PMID: 1703017.
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  90. Boyd ND, MacDonald SG, Kage R, Luber-Narod J, Leeman SE. Substance P receptor. Biochemical characterization and interactions with G proteins. Ann N Y Acad Sci. 1991; 632:79-93. PMID: 1659301.
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  91. Morin PJ, Johnson RJ, Shachar I, Fine RE, Leeman SE. Characteristics of tachykinin transport vesicles in the optic nerve. Ann N Y Acad Sci. 1991; 632:442-3. PMID: 1952634.
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  92. Jonassen JA, Leeman SE. Developmental and hormonal regulation of the sex difference in preprotachykinin gene expression in rat anterior pituitaries. Ann N Y Acad Sci. 1991; 632:1-9. PMID: 1719856.
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  93. Luber-Narod J, Boyd ND, Leeman SE. Guanine nucleotides decrease the affinity of substance P binding to its receptor. Eur J Pharmacol. 1990 Apr 25; 188(4-5):185-91. PMID: 1694776.
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  94. Oblas B, Boyd ND, Luber-Narod J, Reyes VE, Leeman SE. Isolation and identification of a polypeptide in the Hsp 70 family that binds substance P. Biochem Biophys Res Commun. 1990 Jan 30; 166(2):978-83. PMID: 1689156.
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  95. Alexander MJ, Dobner PR, Miller MA, Bullock BP, Dorsa DM, Leeman SE. Estrogen induces neurotensin/neuromedin N messenger ribonucleic acid in a preoptic nucleus essential for the preovulatory surge of luteinizing hormone in the rat. Endocrinology. 1989 Oct; 125(4):2111-7. PMID: 2791980.
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  96. Alexander MJ, Miller MA, Dorsa DM, Bullock BP, Melloni RH, Dobner PR, Leeman SE. Distribution of neurotensin/neuromedin N mRNA in rat forebrain: unexpected abundance in hippocampus and subiculum. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):5202-6. PMID: 2740352.
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  97. Peachey SE, Skrinar GS, Leeman SE, Pehrson J, Evans WJ, Bullen BA. Effect of acute exercise on plasma neurotensin levels. Peptides. 1989 Jul-Aug; 10(4):753-6. PMID: 2587418.
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  98. Prabhakar NR, Landis SC, Kumar GK, Mullikin-Kilpatrick D, Cherniack NS, Leeman S. Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2. Brain Res. 1989 Mar 6; 481(2):205-14. PMID: 2470465.
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  99. Alexander MJ, Mahoney PD, Ferris CF, Carraway RE, Leeman SE. Evidence that neurotensin participates in the central regulation of the preovulatory surge of luteinizing hormone in the rat. Endocrinology. 1989 Feb; 124(2):783-8. PMID: 2912701.
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  100. Barber DL, Buchan AM, Leeman SE, Soll AH. Canine enteric submucosal cultures: transmitter release from neurotensin-immunoreactive neurons. Neuroscience. 1989; 32(1):245-53. PMID: 2511502.
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  101. Vijayan E, Carraway R, Leeman SE, McCann SM. Use of antiserum to neurotensin reveals a physiological role for the peptide in rat prolactin release. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9866-9. PMID: 3200862.
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  102. Floor E, Schaeffer SF, Feist BE, Leeman SE. Synaptic vesicles from mammalian brain: large-scale purification and physical and immunochemical characterization. J Neurochem. 1988 May; 50(5):1588-96. PMID: 3361314.
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  103. Floor E, Leeman SE. Identification and characterization of the major proteins of mammalian brain synaptic vesicles. J Neurochem. 1988 May; 50(5):1597-604. PMID: 3129538.
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  104. Naftchi NE, Maker H, Lapin E, Sleis J, Lajtha A, Leeman S. Acute reduction of brain substance P induced by nicotine. Neurochem Res. 1988 Apr; 13(4):305-9. PMID: 2455873.
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  105. Aronin N, Leeman SE, Clements RS. Diminished flare response in neuropathic diabetic patients. Comparison of effects of substance P, histamine, and capsaicin. Diabetes. 1987 Oct; 36(10):1139-43. PMID: 2443407.
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  106. Canick JA, Tobet SA, Baum MJ, Vaccaro DE, Ryan KJ, Leeman SE, Fox TO. Studies on the role of catecholamines in the regulation of the developmental pattern of hypothalamic aromatase. Steroids. 1987 Oct-Dec; 50(4-6):509-21. PMID: 3504614.
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  107. Jonassen JA, Mullikin-Kilpatrick D, McAdam A, Leeman SE. Thyroid hormone status regulates preprotachykinin-A gene expression in male rat anterior pituitary. Endocrinology. 1987 Oct; 121(4):1555-61. PMID: 2820702.
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  108. Boyd ND, Leeman SE. Multiple actions of substance P that regulate the functional properties of acetylcholine receptors of clonal rat PC12 cells. J Physiol. 1987 Aug; 389:69-97. PMID: 2445982.
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  109. Moskowitz MA, Kuo C, Leeman SE, Jessen ME, Derian CK. Desensitization to substance P-induced vasodilation in vitro is not shared by endogenous tachykinin neurokinin A. J Neurosci. 1987 Aug; 7(8):2344-51. PMID: 2441006.
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  110. Armstrong MJ, Parker MC, Ferris CF, Leeman SE. Neurotensin stimulates [3H]oleic acid translocation across rat small intestine. Am J Physiol. 1986 Dec; 251(6 Pt 1):G823-9. PMID: 3789148.
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  111. Perney TM, Hirning LD, Leeman SE, Miller RJ. Multiple calcium channels mediate neurotransmitter release from peripheral neurons. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6656-9. PMID: 2428039.
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  112. Canick JA, Vaccaro DE, Livingston EM, Leeman SE, Ryan KJ, Fox TO. Localization of aromatase and 5 alpha-reductase to neuronal and non-neuronal cells in the fetal rat hypothalamus. Brain Res. 1986 May 7; 372(2):277-82. PMID: 2423195.
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  113. Aronin N, Coslovsky R, Leeman SE. Substance P and neurotensin: their roles in the regulation of anterior pituitary function. Annu Rev Physiol. 1986; 48:537-49. PMID: 2423025.
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  114. Ferris CF, Carraway RE, Brandt K, Leeman SE. Chromatographic and immunochemical characterization of neurotensin in cat adrenal gland and its release during splanchnic nerve stimulation. Neuroendocrinology. 1986; 43(3):352-8. PMID: 3736783.
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  115. Coslovsky R, Braverman LE, Leeman SE, Aronin N. The differential effects of thyroid and gonadal hormones on substance P content in the anterior pituitary of the prepubertal rat. Endocrinology. 1985 Nov; 117(5):2198-202. PMID: 2412805.
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  116. Ferris CF, Carraway RE, Hammer RA, Leeman SE. Release and degradation of neurotensin during perfusion of rat small intestine with lipid. Regul Pept. 1985 Oct; 12(2):101-11. PMID: 3840906.
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  117. Floor E, Leeman SE. Evidence that large synaptic vesicles containing substance P and small synaptic vesicles have a surface antigen in common in rat. Neurosci Lett. 1985 Sep 30; 60(2):231-7. PMID: 2414702.
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  118. Ferris CF, Parker MC, Armstrong MJ, Leeman SE. Inhibition of neurotensin release by a cyclic hexapeptide analog of somatostatin. Peptides. 1985 Sep-Oct; 6(5):945-8. PMID: 2867526.
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  119. Ferris CF, Pollock J, Albers HE, Leeman SE. Inhibition of flank-marking behavior in golden hamsters by microinjection of a vasopressin antagonist into the hypothalamus. Neurosci Lett. 1985 Apr 9; 55(2):239-43. PMID: 4039806.
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  120. Ferris CF, Armstrong MJ, George JK, Stevens CA, Carraway RE, Leeman SE. Alcohol and fatty acid stimulation of neurotensin release from rat small intestine. Endocrinology. 1985 Mar; 116(3):1133-8. PMID: 3971900.
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  121. Coslovsky R, Evans RW, Leeman SE, Braverman LE, Aronin N. The effects of gonadal steroids on the content of substance P in the rat anterior pituitary. Endocrinology. 1984 Dec; 115(6):2285-9. PMID: 6209122.
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  122. Aronin N, Morency K, Leeman SE, Braverman LE, Coslovsky R. Regulation by thyroid hormone of the concentration of substance P in the rat anterior pituitary. Endocrinology. 1984 Jun; 114(6):2138-42. PMID: 6202496.
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  123. Difiglia M, Aronin N, Leeman SE. Ultrastructural localization of immunoreactive neurotensin in the monkey superficial dorsal horn. J Comp Neurol. 1984 May 1; 225(1):1-12. PMID: 6373845.
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  124. Ferris CF, Pan JX, Singer EA, Boyd ND, Carraway RE, Leeman SE. Stimulation of luteinizing hormone release after stereotaxic microinjection of neurotensin into the medial preoptic area of rats. Neuroendocrinology. 1984 Feb; 38(2):145-51. PMID: 6717745.
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  125. Takano Y, Martin JE, Leeman SE, Loewy AD. Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure. Brain Res. 1984 Jan 16; 291(1):168-72. PMID: 6199081.
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  126. Elkind-Hirsch K, King JC, Gerall AA, Leeman SE. Neonatal estrogen affects preoptic/anterior hypothalamic LHRH differently in adult male and female rats. Neuroendocrinology. 1984 Jan; 38(1):68-74. PMID: 6420719.
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  127. Zeytinoglu FN, Gagel RF, DeLellis RA, Wolfe HJ, Tashjian AH, Hammer RA, Leeman SE. Clonal strains of rat medullary thyroid carcinoma cells that produce neurotensin and calcitonin. Functional and morphologic studies. Lab Invest. 1983 Oct; 49(4):453-9. PMID: 6353060.
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  128. Aronin N, Cooper PE, Lorenz LJ, Bird ED, Sagar SM, Leeman SE, Martin JB. Somatostatin is increased in the basal ganglia in Huntington disease. Ann Neurol. 1983 May; 13(5):519-26. PMID: 6191621.
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  129. Zeytinoglu FN, Gagel RF, Tashjian AH, Hammer RA, Leeman SE. Regulation of neurotensin release by a continuous line of mammalian C-cells: the role of biogenic amines. Endocrinology. 1983 Apr; 112(4):1240-6. PMID: 6832044.
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  130. Heckmatt JZ, Leeman S, Dubowitz V. Ultrasound imaging in the diagnosis of muscle disease. J Pediatr. 1982 Nov; 101(5):656-60. PMID: 7131136.
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  131. Aronin N, Carraway RE, Ferris CF, Hammer RA, Leeman SE. The stability and metabolism of intravenously administered neurotensin in the rat. Peptides. 1982 Jul-Aug; 3(4):637-42. PMID: 7134032.
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  132. Hammer RA, Carraway RE, Leeman SE. Elevation of plasma neurotensinlike immunoreactivity after a meal. Characterization of the elevated components. J Clin Invest. 1982 Jul; 70(1):74-81. PMID: 7085889.
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  133. Floor E, Grad O, Leeman SE. Synaptic vesicles containing substance P purified by chromatography on controlled pore glass. Neuroscience. 1982 Jul; 7(7):1647-55. PMID: 6181432.
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  134. Reinecke M, Weihe E, Carraway RE, Leeman SE, Forssmann WG. Localization of neurotensin immunoreactive nerve fibers in the guinea-pig heart: evidence derived by immunohistochemistry, radioimmunoassay and chromatography. Neuroscience. 1982 Jul; 7(7):1785-95. PMID: 6181434.
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  135. DiFiglia M, Aronin N, Leeman SE. Light microscopic and ultrastructural localization of immunoreactive substance P in the dorsal horn of monkey spinal cord. Neuroscience. 1982 May; 7(5):1127-39. PMID: 6180349.
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  136. DiFiglia M, Aronin N, Leeman SE. Immunoreactive substance P in the substantia nigra of the monkey: light and electron microscopic localization. Brain Res. 1982 Feb 11; 233(2):381-8. PMID: 6174178.
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  137. Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ. Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol. 1982 Feb; 323:403-14. PMID: 6178820.
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  138. Leeman SE, Aronin N, Ferris C. Substance P and neurotensin. Recent Prog Horm Res. 1982; 38:93-132. PMID: 6181544.
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  139. Leeman SE, Carraway RE. Neurotensin: discovery, isolation, characterization, synthesis and possible physiological roles. Ann N Y Acad Sci. 1982; 400:1-16. PMID: 6963107.
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  140. Fernstrom MH, Mirski MA, Carraway RE, Leeman SE. Immunoreactive neurotensin levels in pancreas: elevation in diabetic rats and mice. Metabolism. 1981 Sep; 30(9):853-5. PMID: 6455583.
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  141. Gamse R, Leeman SE, Holzer P, Lembeck F. Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat. Naunyn Schmiedebergs Arch Pharmacol. 1981 Sep; 317(2):140-8. PMID: 6170896.
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  142. Cooper PE, Fernstrom MH, Rorstad OP, Leeman SE, Martin JB. The regional distribution of somatostatin, substance P and neurotensin in human brain. Brain Res. 1981 Aug 10; 218(1-2):219-32. PMID: 6168327.
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  143. Gamse R, Lackner D, Gamse G, Leeman SE. Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons. Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb; 316(1):38-41. PMID: 6168921.
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  144. Ferris CF, Hammer RA, Leeman SE. Elevation of plasma neurotensin during lipid perfusion of rat small intestine. Peptides. 1981; 2 Suppl 2:263-6. PMID: 7343961.
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  145. Fischbach GD, Dunlap K, Mudge A, Leeman S. Peptide and amine transmitter effect on embryonic chick sensory neurons in vitro. Adv Biochem Psychopharmacol. 1981; 28:175-88. PMID: 6163332.
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  146. Gamse R, Wax A, Zigmond RE, Leeman SE. Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin. Neuroscience. 1981; 6(3):437-41. PMID: 6164015.
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  147. Role LW, Leeman SE, Perlman RL. Somatostatin and substance P inhibit catecholamine secretion from isolated cells of guinea-pig adrenal medulla. Neuroscience. 1981; 6(9):1813-21. PMID: 6170913.
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  148. Leeman SE. Substance P and neurotensin: discovery, isolation, chemical characterization and physiological studies. J Exp Biol. 1980 Dec; 89:193-200. PMID: 6162907.
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  149. Nutt JG, Mrox EA, Leeman SE, Williams AC, Engel WK, Chase TN. Substance P in human cerebrospinal fluid: reductions in peripheral neuropathy and autonomic dysfunction. Neurology. 1980 Dec; 30(12):1280-5. PMID: 6161319.
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  150. Pettibone DJ, Wurtman RJ, Leeman SE. Striatal substance P-like immunoreactivity: characterization of high-performance liquid chromatography and aspects of subcellular distribution and in vitro release by potassium. Life Sci. 1980 Oct 27; 27(17):1593-602. PMID: 6160368.
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  151. Gamse R, Vaccaro DE, Gamse G, DiPace M, Fox TO, Leeman SE. Release of immunoreactive somatostatin from hypothalamic cells in culture: inhibition by gamma-aminobutyric acid. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5552-6. PMID: 6107913.
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  152. Carraway R, Hammer RA, Leeman SE. Neurotensin in plasma: immunochemical and chromatographic character of acid/acetone-soluble material. Endocrinology. 1980 Aug; 107(2):400-6. PMID: 7389661.
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  153. Yaksh TL, Jessell TM, Gamse R, Mudge AW, Leeman SE. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature. 1980 Jul 10; 286(5769):155-7. PMID: 6157098.
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  154. Vaccaro DE, Leeman SE, Messer A, Dichter MA. Primary cultures of dispersed hypothalamic cells from fetal rats: morphology, electrical activity, and peptide content. J Neurobiol. 1980 Jul; 11(4):417-24. PMID: 6157000.
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  155. Kahn D, Abrams GM, Zimmerman EA, Carraway R, Leeman SE. Neurotensin neurons in the rat hypothalamus: an immunocytochemical study. Endocrinology. 1980 Jul; 107(1):47-54. PMID: 6991249.
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  156. Zeytinoglu FN, Gagel RF, Tashjian AH, Hammer RA, Leeman SE. Characterization of neurotensin production by a line of rat medullary thyroid carcinoma cells. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3741-5. PMID: 6932046.
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  157. Hammer RA, Leeman SE, Carraway R, Williams RH. Isolation of human intestinal neurotensin. J Biol Chem. 1980 Mar 25; 255(6):2476-80. PMID: 7358684.
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  158. Floor E, Leeman SE. Substance P sulfoxide: separation from substance P by high-pressure liquid chromatography, biological and immunological activities, and chemical reduction. Anal Biochem. 1980 Jan 15; 101(2):498-503. PMID: 6153871.
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  159. Fernstrom MH, Carraway RE, Leeman SE. Neurotensin. In: Frontiers in Neuroendocrinology (L Martini and WF Ganong., eds.). Raven Press. New York. 1980; 6:103-127.
  160. Nicoll RA, Schenker C, Leeman SE. Substance P as a transmitter candidate. Annu Rev Neurosci. 1980; 3:227-68. PMID: 6158283.
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  161. Yaksh TL, Farb DH, Leeman SE, Jessell TM. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science. 1979 Oct 26; 206(4417):481-3. PMID: 228392.
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  162. Singer E, Sperk G, Placheta P, Leeman SE. Reduction of substance P levels in the ventral cervical spinal cord of the rat after intracisternal 5,7-dihydroxytryptamine injection. Brain Res. 1979 Oct 5; 174(2):362-5. PMID: 487135.
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  163. Vaccaro DE, Leeman SE, Reif-Lehrer L. Glutamine synthetase activity in vivo and in primary cell cultures of rat hypothalamus. J Neurochem. 1979 Oct; 33(4):953-7. PMID: 39982.
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  164. Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Delayed iontophoretic ejection of substance P from glass micropipettes: correlation with time-course of neuronal excitation in vivo. Neuropharmacology. 1979 Jun; 18(6):553-8. PMID: 481708.
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  165. Carraway R, Leeman SE. The amino acid sequence of bovine hypothalamic substance P. Identity to substance P from colliculi and small intestine. J Biol Chem. 1979 Apr 25; 254(8):2944-5. PMID: 429329.
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  166. Barber RP, Vaughn JE, Slemmon JR, Salvaterra PM, Roberts E, Leeman SE. The origin, distribution and synaptic relationships of substance P axons in rat spinal cord. J Comp Neurol. 1979 Mar 15; 184(2):331-51. PMID: 368089.
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  167. Pickel VM, Joh TH, Reis DJ, Leeman SE, Miller RJ. Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons. Brain Res. 1979 Jan 19; 160(3):387-400. PMID: 33743.
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  168. Mroz EA, Leeman SE. Substance P. In: Methods of Hormone Radioimmunoassay (BM Jaffe and HR Behrman, eds.). Academic Press. New York. 1979; 2:121-137.
  169. Mudge AW, Leeman SE, Fischbach GD. Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):526-30. PMID: 218204.
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  170. Carraway R, Kitabgi P, Leeman SE. The amino acid sequence of radioimmunoassayable neurotensin from bovine intestine. J Biol Chem. 1978 Nov 25; 253(22):7996-8. PMID: 711731.
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  171. Palkovits M, Mroz EA, Brownstein MJ, Leeman SE. Descending substance P-containing pathway: a component of the ansa lenticularis. Brain Res. 1978 Nov 3; 156(1):124-8. PMID: 308833.
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  172. Pettibone DJ, Wurtman RJ, Leeman SE. D-amphetamine administration reduces substance P concentration in the rat striatum. Psychopharmacol Bull. 1978 Oct; 14(4):24-6. PMID: 704753.
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  173. Gamse R, Mroz E, Leeman S, Lembeck F. The intestine as source of immunoreactive substance P in plasma of the cat. Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct; 305(1):17-21. PMID: 723966.
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  174. Pettibone DJ, Wurtman RJ, Leeman SE. D-amphetamine administration reduces substance P concentration in the rat striatum. Biochem Pharmacol. 1978 Mar 1; 27(5):839-12. PMID: 656130.
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  175. Brownstein MJ, Mroz EA, Tappaz ML, Leeman SE. On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra. Brain Res. 1977 Oct 28; 135(2):315-23. PMID: 922480.
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  176. Sundler F, Alumets J, Håkanson R, Carraway R, Leeman SE. Ultrastructure of the gut neurotensin cell. Histochemistry. 1977 Jul 18; 53(1):25-34. PMID: 332670.
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  177. Kitabgi P, Carraway R, Van Rietschoten J, Granier C, Morgat JL, Menez A, Leeman S, Freychet P. Neurotensin: specific binding to synaptic membranes from rat brain. Proc Natl Acad Sci U S A. 1977 May; 74(5):1846-50. PMID: 266706.
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  178. Mroz EA, Brownstein MJ, Leeman SE. Evidence for substance P in the striato-nigral tract. Brain Res. 1977 Apr 15; 125(2):305-11. PMID: 856411.
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  179. Sundler F, Håkanson R, Hammer RA, Alumets J, Carraway R, Leeman SE, Zimmerman EA. Immunohistochemical localization of neurotensin in endocrine cells of the gut. Cell Tissue Res. 1977 Mar 16; 178(3):313-21. PMID: 321127.
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  180. Pickel VM, Reis DJ, Leeman SE. Ultrastructural localization of substance P in neurons of rat spinal cord. Brain Res. 1977 Feb 25; 122(3):534-40. PMID: 843902.
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  181. Leeman SE, Mroz EA, Carraway RE. Substance P and Neurotensin. In: Peptides in Neurobiology (H Gainer, ed.). Plenum Press. New York and London. 1977; 5:99-144.
  182. Mroz EA, Leeman SE. Substance P. In: Vitamins and Hormones (P.L. Munson, J Glover, E Diczfalusy, RE Olson, eds.). Academic Press. New York and San Francisco. 1977; 35:209-281.
  183. Losay J, Mroz EA, Tregear GW, Leeman SE, Gamble WJ. Action of substance P on the coronary blood flow in the isolated dog heart. In: Substance P (US von Euler and B Pernow, eds.). Raven Press. New York. 1977; 287-293.
  184. Mroz EA, Leeman SE. Substance P. Vitam Horm. 1977; 35:209-81. PMID: 343362.
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  185. Canick JA, Vaccaro DE, Ryan KJ, Leeman SE. The aromatization of androgens by primary monolayer cultures of fetal rat hypothalamus. Endocrinology. 1977 Jan; 100(1):250-3. PMID: 830543.
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  186. Mroz EA, Brownstein MJ, Leeman SE. Distribution of immunoassayable substance P in the rat brain: Evidence for the existence of substance P-containing tracts. In: Substance P (US von Euler and B Pernow, eds.). Raven Press. New York. 1977; 147-154.
  187. Leeman SE, Carraway RE. Discovery of a sialogogic peptide in bovine hypothalamic extracts: Its isolation, characterization as substance P, structure and synthesis. In: Substance P (US von Euler and B Pernow, eds.). Raven Press. New York. 1977; 5-13.
  188. Schenker C, Mroz EA, Leeman SE. Release of substance P from isolated nerve endings. Nature. 1976 Dec 23-30; 264(5588):790-2. PMID: 13307.
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  189. Carraway RE, Demers LM, Leeman SE. Hyperglycemic effect of neurotensin, a hypothalamic peptide. Endocrinology. 1976 Dec; 99(6):1452-62. PMID: 826391.
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  190. Carraway R, Leeman SE. Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach. J Biol Chem. 1976 Nov 25; 251(22):7045-52. PMID: 993203.
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  191. Kitabgi P, Carraway R, Leeman SE. Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin. J Biol Chem. 1976 Nov 25; 251(22):7053-8. PMID: 993204.
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  192. Carraway R, Leeman SE. Radioimmunoassay for neurotensin, a hypothalamic peptide. J Biol Chem. 1976 Nov 25; 251(22):7035-44. PMID: 993202.
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  193. Brownstein MJ, Mroz EA, Kizer JS, Palkovits M, Leeman SE. Regional distribution of substance P in the brain of the rat. Brain Res. 1976 Nov 5; 116(2):299-305. PMID: 974776.
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  194. Folkers K, Chang D, Humphries J, Carraway R, Leeman SE, Bowers CY. Synthesis and activities of neurotensin, and its acid and amide analogs: possible natural occurrence of [Gln4]-neurotensin. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):3833-7. PMID: 1069268.
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  195. Mroz ED, Brownstein MJ, Leeman SE. Evidence for substance P in the habenulo-interpeduncular tract. Brain Res. 1976 Sep 3; 113(3):597-9. PMID: 953755.
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  196. Carraway R, Leeman SE. The amino acid sequence of a hypothalamic peptide, neurotensin. J Biol Chem. 1975 Mar 10; 250(5):1907-11. PMID: 1167549.
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  197. Carraway R, Leeman SE. The synthesis of neurotensin. J Biol Chem. 1975 Mar 10; 250(5):1912-8. PMID: 1112838.
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  198. Carraway R, Leeman SE. Structural requirements for the biological activity of neurotensin, A new vasoactive peptide. In: Peptides: Chemistry, Structure and Biology (R Walter, and J Meienhofer, eds). Ann Arbor Science. Ann Arbor, Michigan. 1975; 679-685.
  199. Leeman SE, Mroz EA. Substance P. Life Sci. 1974 Dec 15; 15(12):2033-44. PMID: 4621245.
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