Haralambos Gavras | Profiles RNS

Haralambos P. Gavras, MD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Hypertension

MD, University of Athens
BS, University of Athens

Websites

	LinkedIn
	ResearchGate
	Scinapse.io

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Mouse Models of Heart, Lung and Blood Disease
09/30/2000 - 07/31/2008 (PI)
Jackson Laboratory NIH NHLBI

Effects of Telmisartan on Cardiac Function and Expression of the LACS and Cmya 3 genes in Mice with Ischemic Cardiomyopathy
03/30/2005 - 03/31/2008 (PI)
Boehringer Ingelheim Pharmaceuticals, Inc. (Germany)

Bradykinin in Cardiovascular Disease
05/01/1998 - 11/30/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL58807 08

Identifying Genes in Abnormal Blood Pressure
02/05/2001 - 07/31/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
5 P50 HL55001 10

SCOR: Identifying Genes in Abnormal Blood Pressure
02/01/1996 - 01/31/2006 (PI)
NIH/National Heart, Lung, and Blood Institute
5 P50 HL55001 08

Hypertension and Alpha 2 Adrenergic Receptors
04/01/2002 - 03/31/2005 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL65311 03

Microarray Expression Profiling of Rodent Models of Human Disease
09/30/2000 - 07/31/2004 (PI)
NIH/National Heart, Lung, and Blood Institute
5 U01 HL66617 04

Contribution of Mitochondrial Genes to Hypertension
01/01/2001 - 12/02/2003 (Dept Sponsor)
American Heart Association

Title

Yr	Title	Project-Sub Proj	Pubs
2008	BRADYKININ IN CARDIOVASCULAR DISEASE	5P41RR010888-12-5304	259
2007	BRADYKININ IN CARDIOVASCULAR DISEASE	2P41RR010888-11-8125	259
2006	Bradykinin in Cardiovascular Disease	5R01HL058807-08	10
2005	Bradykinin in Cardiovascular Disease	5R01HL058807-07	10
2005	IDENTIFYING GENES IN ABNORMAL BLOOD PRESSURE	5P50HL055001-10	38
2005	CORE B--ANIMAL	5P50HL055001-10-9001	38
2005	IDENTIFYING GENES INVOLVED IN ABNORMAL BLOOD PRESSURE	5P50HL055001-10-1	38
2004	IDENTIFYING GENES INVOLVED IN ABNORMAL BLOOD PRESSURE	5P50HL055001-09-1	38
2004	CORE A-- ADMINISTRATIVE CORE	5P50HL055001-09-5974	38
2004	CORE B--ANIMAL	5P50HL055001-09-9001	38

Showing 10 of 58 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Rassias G, Leonardi S, Rigopoulou D, Vachlioti E, Afratis K, Piperigkou Z, Koutsakis C, Karamanos NK, Gavras H, Papaioannou D. Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved? Eur J Med Chem. 2021 Jan 15; 210:112948. PMID: 33139111

Kouremenos N, Zacharopoulou IV, Triantafyllidi H, Zacharopoulos GV, Mornos C, Filippatos G, Lekakis J, Kremastinos D, Manolis AI, Gavras H. Genes and genetic variations involved in the development of hypertension: focusing on a Greek patient cohort. Hellenic J Cardiol. 2014 Jan-Feb; 55(1):9-16. PMID: 24491930

Marketou ME, Kintsurashvili E, Androulakis NE, Kontaraki J, Alexandrakis MG, Gavras I, Vardas PE, Gavras H. Blockade of platelet alpha2B-adrenergic receptors: a novel antiaggregant mechanism. Int J Cardiol. 2013 Oct 3; 168(3):2561-6.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 23582690; DOI: 10.1016/j.ijcard.2013.03.051;

Gavras I, Gavras H. 'Volume-expanded' hypertension: the effect of fluid overload and the role of the sympathetic nervous system in salt-dependent hypertension. J Hypertens. 2012 Apr; 30(4):655-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 22227820; DOI: 10.1097/HJH.0b013e32834f6de1;

Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation. 2012 Jan 17; 125(2):354-63.View Related Profiles.

Gavras, Haralambos
Johnston-Cox, Hillary
Ravid, Katya
Koupenova-Zamor, Milka
Zannis, Vassilis

PMID: 22144568; PMCID: PMC3265935; DOI: 10.1161/CIRCULATIONAHA.111.057596;

Manolis AJ, Marketou ME, Gavras I, Gavras H. Cardioprotective properties of bradykinin: role of the B(2) receptor. Hypertens Res. 2010 Aug; 33(8):772-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 20505673; DOI: 10.1038/hr.2010.82;

Marketou M, Kintsurashvili E, Papanicolaou KN, Lucero HA, Gavras I, Gavras H. Cardioprotective effects of a selective B(2) receptor agonist of bradykinin post-acute myocardial infarct. Am J Hypertens. 2010 May; 23(5):562-8.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 20186129; DOI: 10.1038/ajh.2010.20;

McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ. Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res. 2010 Mar 19; 106(5):952-60.View Related Profiles.

Gavras, Haralambos
Ohashi, Koji

PMID: 20093629; PMCID: PMC2858324; DOI: 10.1161/CIRCRESAHA.109.209007;

Lucero HA, Kintsurashvili E, Marketou ME, Gavras H. Cell signaling, internalization, and nuclear localization of the angiotensin converting enzyme in smooth muscle and endothelial cells. J Biol Chem. 2010 Feb 19; 285(8):5555-68.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos

PMID: 20022959; PMCID: PMC2820783; DOI: 10.1074/jbc.M109.074740;

Ahmad S, Cesana F, Lamperti E, Gavras H, Yu J. Attenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant. Am J Hypertens. 2009 Dec; 22(12):1320-5.View Related Profiles.

Gavras, Haralambos
Yu, Jun

PMID: 19779471; PMCID: PMC2848119; DOI: 10.1038/ajh.2009.181;

Showing 10 of 493 results. Show More

Kintsurashvili E, Shenouda S, Ona D, Ona L, Ahmad S, Ravid K, Gavras I, Gavras H. Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor. Am J Hypertens. 2009 Jan; 22(1):41-5.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene
Ravid, Katya

PMID: 18989257; DOI: 10.1038/ajh.2008.314;

Silva VS, Martin LC, Franco RJ, Carvalho FC, Bregagnollo EA, Castro JH, Gavras I, Gavras H. Pleiotropic effects of statins may improve outcomes in atherosclerotic renovascular disease. Am J Hypertens. 2008 Oct; 21(10):1163-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 18670414; DOI: 10.1038/ajh.2008.249;

Duka A, Kintsurashvili E, Duka I, Ona D, Hopkins TA, Bader M, Gavras I, Gavras H. Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptors. Hypertension. 2008 May; 51(5):1352-7.View Related Profiles.

Duka, Arvi
Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 18347228; DOI: 10.1161/HYPERTENSIONAHA.107.108506;

Gavras H, Brunner HR. Evolution and hypertension: is the Renin system necessary? Hypertension. 2007 Jun; 49(6):e36; author reply e37. PMID: 17389253

Sun B, Kintsurashvili E, Ona D, Ignjacev-Lazich I, Gavras I, Gavras H. Inhibition of the alpha(1D)-adrenergic receptor gene by RNA interference (RNAi) in rat vascular smooth muscle cells and its effects on other adrenergic receptors. Vascul Pharmacol. 2007 May; 46(5):367-72.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 17307398; PMCID: PMC1868522; DOI: 10.1016/j.vph.2007.01.002;

Cardoso de Carvalho F, Bregagnollo E, Santos Silva V, Brunie A, da Silva Franco RJ, Martin LC, Gavras I, Gavras H. Frequency of coronary artery disease in patients with renal artery stenosis without clinical manifestations of coronary insufficiency. Am J Hypertens. 2006 Nov; 19(11):1125-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 17070422

Shenouda SM, Johns C, Kintsurashvili E, Gavras I, Gavras H. Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats. Am J Hypertens. 2006 Nov; 19(11):1135-43.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 17070424

Martin LC, Franco RJ, Gavras I, Matsubara BB, Okoshi K, Zanati SG, Caramori JT, Barretti P, Balbi AL, Gavras H. Is 44-hour better than 24-hour ambulatory blood pressure monitoring in hemodialysis? Kidney Blood Press Res. 2006; 29(5):273-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 17035712

Brunner HR, Gavras H. Validation of in-vitro data by in-vivo evidence: the example of angiotensin (1-7). J Hypertens. 2006 Oct; 24(10):1919-20. PMID: 16957547

Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23.View Related Profiles.

Schreiber, Barbara
Seldin, David
Nguyen, Hao
Gavras, Haralambos
Ravid, Katya
Jones, Matthew
Koupenova-Zamor, Milka
Toselli, Paul

PMID: 16823489; PMCID: PMC1483170; DOI: 10.1172/JCI27933;

Ribeiro AB, Gavras H. Angiotensin II antagonists: clinical experience in the treatment of hypertension, prevention of cardiovascular outcomes and renal protection in diabetic nephropathy and proteinuria. Arq Bras Endocrinol Metabol. 2006 Apr; 50(2):327-33. PMID: 16767299

Triantafyllidi H, Kintsurashvili E, Johns C, Gavras I, Gavras H. Central plasmid antisense administration reduces blood pressure inhibiting alpha2B adrenoceptor gene expression in spontaneously hypertensive rats in vivo. Hellenic J Cardiol. 2006 May-Jun; 47(3):144-9.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 16862820

Duka A, Schwartz F, Duka I, Johns C, Melista E, Gavras I, Gavras H. A novel gene (Cmya3) induced in the heart by angiotensin II-dependent but not salt-dependent hypertension in mice. Am J Hypertens. 2006 Mar; 19(3):275-81.View Related Profiles.

Duka, Arvi
Schwartz, Faina
Gavras, Haralambos
Gavras, Irene

PMID: 16500513

Duka A, Duka I, Gao G, Shenouda S, Gavras I, Gavras H. Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E268-74.View Related Profiles.

Duka, Arvi
Gavras, Haralambos
Gavras, Irene

PMID: 16507603

Nguyen GH, Nguyen NC, Storm N, Gange C, Gavras H, Smith CL. Targeted cDNA differential display (TcDD). Biomol Eng. 2006 Mar; 23(1):41-54. PMID: 16466965

Ignjacev-Lazich I, Kintsurashvili E, Johns C, Vitseva O, Duka A, Shenouda S, Gavras I, Gavras H. Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1814-20.View Related Profiles.

Duka, Arvi
Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene
Vitseva, Olga

PMID: 16219810

Russo CJ, Melista E, Cui J, DeStefano AL, Bakris GL, Manolis AJ, Gavras H, Baldwin CT. Association of NEDD4L ubiquitin ligase with essential hypertension. Hypertension. 2005 Sep; 46(3):488-91.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos

PMID: 16103266

Larkin JE, Frank BC, Gavras H, Sultana R, Quackenbush J. Independence and reproducibility across microarray platforms. Nat Methods. 2005 May; 2(5):337-44. PMID: 15846360

Standridge JB, Sealey JE, Laragh JH, Houston MC, Gavras H, Johnson RJ, Blumenfeld JD, Brown M, Egan BM, Meltzer JI, Shimosawa T, Fujita T. A free-ranging roundtable discussion on hypertension. J Hum Hypertens. 2005 Apr; 19(4):259-66. PMID: 15716983

Kintsurashvili E, Duka A, Ignjacev I, Pattakos G, Gavras I, Gavras H. Age-related changes of bradykinin B1 and B2 receptors in rat heart. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H202-5.View Related Profiles.

Duka, Arvi
Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 15708952

Zhou XF, Cui J, DeStefano AL, Chazaro I, Farrer LA, Manolis AJ, Gavras H, Baldwin CT. Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Markers. 2005; 21(1):3-7.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Farrer, Lindsay

PMID: 15735318; PMCID: PMC3851957; DOI: 10.1155/2005/487014;

Manolis AJ, Iraklianou S, Pittaras A, Zaris M, Tsioufis K, Psaltiras G, Psomali D, Foussas S, Gavras I, Gavras H. Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy. Am J Hypertens. 2005 Jan; 18(1):18-22.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 15691612

Handy DE, Gavras H . Hypertension and atherogenesis. In: Molecular Mechanisms of Atherosclerosis. Joseph Loscalzo, editor. Taylor & Francis. Abingdon, Oxon, UK. 2005; 195-207.

Gavras I, Gavras H. The debate goes on--what is your choice? Am J Cardiol. 2005 Jan 1; 95(1):53-4.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 15619394

Gavras I, Gavras H. ACE Inhibitor Trials: Effects in Hypertension. In: Hypertension: A companion to Brenner and Rectors the kidney, second edition. Editors: Suzanne Oparil, Michael A. Weber. Elsevier Saunders. Philadelphia, PA. 2005; 388-390.

Cui J, Melista E, Chazaro I, Zhang Y, Zhou X, Manolis AJ, Baldwin CT, Destefano AL, Gavras H. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens. 2005 Jan; 23(1):55-62.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos

PMID: 15643125

Gavras H. Report on the fifth annual Laragh conference: Interaction of the angiotensin converting enzyme (ACE) with the renin-angiotensin system, the kinin system and beyond. Am J Hypertens. 2005 Jan; 18(1):1-2. PMID: 15691609

Martin LC, Franco RJ, Gavras I, Matsubara BB, Garcia S, Caramori JT, Barretti BB, Balbi AL, Barsanti R, Padovani C, Gavras H. Association between hypervolemia and ventricular hypertrophy in hemodialysis patients. Am J Hypertens. 2004 Dec; 17(12 Pt 1):1163-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 15607624

Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL. Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. 1981. Br J Clin Pharmacol. 2004 Dec; 58(7):S778-84; discussion S785-7. PMID: 15595971; PMCID: PMC1884670

Larkin JE, Frank BC, Gaspard RM, Duka I, Gavras H, Quackenbush J. Cardiac transcriptional response to acute and chronic angiotensin II treatments. Physiol Genomics. 2004 Jul 8; 18(2):152-66. PMID: 15126644

Schwartz F, Duka A, Duka I, Cui J, Gavras H. Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1957-66.View Related Profiles.

Duka, Arvi
Schwartz, Faina
Gavras, Haralambos

PMID: 15242839

Schwartz F, Duka A, Sun F, Cui J, Manolis A, Gavras H. Mitochondrial genome mutations in hypertensive individuals. Am J Hypertens. 2004 Jul; 17(7):629-35.View Related Profiles.

Duka, Arvi
Schwartz, Faina
Gavras, Haralambos

PMID: 15233983

Gavras I, Gavras H. Hypertension, vasoactive peptides and coagulation factors. J Hypertens. 2004 Jun; 22(6):1091-2.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 15167441

DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill GA, Paigen B. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics. 2004 Apr 13; 17(2):215-20. PMID: 14996992

Elijovich F, Laffer CL, Schiffrin EL, Gavras H, Amador E. Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. J Hypertens. 2004 Mar; 22(3):573-82. PMID: 15076164

Gavras H. The discovery of captopril: reply. FASEB J. 2004 Feb; 18(2):225. PMID: 14769815

Schwartz F, Gavras H. Genetics of Human Essential Hypertension – Review. Rev Bras Hipertens. 2004; 11:88-93.
Gavras I, Gavras H . Progress in stroke prevention: Lessons from the lastest trials. Cardiovasc Rev & Reports. 2004; 25:229-231.
Triantafyllidi E, Baldwin C, Schwartz F, Gavras H. Study of hypertension in spantaneous hypertensive rats by sequecing the genomic DNA of alpha2B receptors. Hellenic J Cardiol. 2004; 45:65-70.

Gavras H. Adrenergic receptors in hypertension and heart failure. Am J Hypertens. 2004 Jan; 17(1):98-9. PMID: 14700521

Schwartz F, Duka A, Triantafyllidi E, Johns C, Duka I, Cui J, Gavras H. Serial analysis of gene expression in mouse kidney following angiotensin II administration. Physiol Genomics. 2003 Dec 16; 16(1):90-8.View Related Profiles.

Duka, Arvi
Gavras, Haralambos

PMID: 14570981

Voudris V, Avramides D, Gatzov P, Malakos J, Skoularigis J, Manolis A, Gavras H, Gavras I, Cokkinos DV. The effect of rapid decreases of blood pressure by different mechanisms on coronary flow and flow reserve in normal coronary arteries. Am J Hypertens. 2003 Dec; 16(12):1000-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 14643572

Duka I, Duka A, Kintsurashvili E, Johns C, Gavras I, Gavras H. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension. 2003 Nov; 42(5):1021-5.View Related Profiles.

Duka, Arvi
Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 14557281

Cui J, Zhou X, Chazaro I, DeStefano AL, Manolis AJ, Baldwin CT, Gavras H. Association of polymorphisms in the promoter region of the PNMT gene with essential hypertension in African Americans but not in whites. Am J Hypertens. 2003 Oct; 16(10):859-63.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos

PMID: 14553966

Kintsurashvili E, Johns C, Ignjacev I, Gavras I, Gavras H. Central alpha2B-adrenergic receptor antisense in plasmid vector prolongs reversal of salt-dependent hypertension. J Hypertens. 2003 May; 21(5):961-7.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 12714871

Sun F, Cui J, Gavras H, Schwartz F. A novel class of tests for the detection of mitochondrial DNA-mutation involvement in diseases. Am J Hum Genet. 2003 Jun; 72(6):1515-26. PMID: 12730827; PMCID: PMC1180311

Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension. 2003 Jun; 41(6):1191-5.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Farrer, Lindsay

PMID: 12719438

Gavras I, Gavras H. Are patients who develop angioedema with ACE inhibition at risk of the same problem with AT1 receptor blockers? Arch Intern Med. 2003 Jan 27; 163(2):240-1.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 12546617

Gavras H. Inappropriate attribution: the "Lazy Author Syndrome". Am J Hypertens. 2002 Sep; 15(9):831. PMID: 12722775

Gavras I, Gavras H. Angiotensin II as a cardiovascular risk factor. J Hum Hypertens. 2002 May; 16 Suppl 2:S2-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11967726

Brunner HR, Gavras H. Angiotensin blockade for hypertension: a promise fulfilled. Lancet. 2002 Mar 23; 359(9311):990-2. PMID: 11937175

Gavras I, Gavras H. Metabolic effects of angiotensin-converting enzyme inhibition: the role of bradykinin. Current Opinion in Endocrinology & Diabetes. 2002; 9:323-328.
Gavras, Gavras H. . Angiotensin-converting enzyme/kininase II: hemodynamic and metabolic effects. Greek Nephrology. 2002; 14:445-448.
Gavras I, Gavras H . Angiotensin blockers in the treatment of hypertension. In: Harrison's Advances in Cardiology. Eugene Braunwald, ed. McGraw-Hill. 2002; 75-79.

Monteagudo PT, Gavras H, Gavras I, Kohlmann O, Ribeiro AB, Zanella MT. Role of vasopressin in 24-hour blood pressure regulation in diabetic patients with autonomic neuropathy. Am J Hypertens. 2002 Jan; 15(1 Pt 1):42-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11824859

Gavras I, Manolis AJ, Gavras H. The alpha2 -adrenergic receptors in hypertension and heart failure: experimental and clinical studies. J Hypertens. 2001 Dec; 19(12):2115-24.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11725152

Duka I, Shenouda S, Johns C, Kintsurashvili E, Gavras I, Gavras H. Role of the B(2) receptor of bradykinin in insulin sensitivity. Hypertension. 2001 Dec 1; 38(6):1355-60.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 11751717

Kintsurashvili E, Gavras I, Johns C, Gavras H. Effects of antisense oligodeoxynucleotide targeting of the alpha(2B)-adrenergic receptor messenger RNA in the central nervous system. Hypertension. 2001 Nov; 38(5):1075-80.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 11711500

Kintsurashvili E, Duka I, Gavras I, Johns C, Farmakiotis D, Gavras H. Effects of ANG II on bradykinin receptor gene expression in cardiomyocytes and vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1778-83.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 11557571

Stefanadis C, Manolis A, Dernellis J, Tsioufis C, Tsiamis E, Gavras I, Gavras H, Toutouzas P. Acute effect of clonidine on left ventricular pressure-volume relation in hypertensive patients with diastolic heart dysfunction. J Hum Hypertens. 2001 Sep; 15(9):635-42.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11550110

Gavras HP. Issues in hypertension: drug tolerability and special populations. Am J Hypertens. 2001 Jul; 14(7 Pt 2):231S-236S. PMID: 11459211

DeStefano AL, Gavras H, Heard-Costa N, Bursztyn M, Manolis A, Farrer LA, Baldwin CT, Gavras I, Schwartz F. Maternal component in the familial aggregation of hypertension. Clin Genet. 2001 Jul; 60(1):13-21.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Gavras, Irene
Farrer, Lindsay
Heard-Costa, Nancy

PMID: 11531965

Gavras I, Gavras H. Role of alpha2-adrenergic receptors in hypertension. Am J Hypertens. 2001 Jun; 14(6 Pt 2):171S-177S.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11411753

Duka I, Kintsurashvili E, Gavras I, Johns C, Bresnahan M, Gavras H. Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension. Circ Res. 2001 Feb 16; 88(3):275-81.View Related Profiles.

Kintsurashvili, Ekaterina
Gavras, Haralambos
Gavras, Irene

PMID: 11179194

Gavras H, Brunner HR. Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure. Hypertension. 2001 Feb; 37(2 Pt 2):342-5. PMID: 11230297

Elijovich F, Laffer CL, Amador E, Gavras H, Bresnahan MR, Schiffrin EL. Regulation of plasma endothelin by salt in salt-sensitive hypertension. Circulation. 2001 Jan 16; 103(2):263-8. PMID: 11208687

Gavras I, Gavras H. Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT? Curr Control Trials Cardiovasc Med. 2001; 2(6):257-259.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11806808; PMCID: PMC64825

Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1; 71(1):70-7. PMID: 11161799

Gavras I, Gavras H . Role of angiotensin-converting enzyme (ACE) in the pathophysiology of hypertension. In: Angiotensin-Converting Enzyme (ACE): Clinical and Experimental Insights. Editor: Thomas D. Giles. Health Care Communications, Inc. Fort Lee, NJ. 2001; 123-126.
Gavras I, Gavras H. The role of ACE inhibition in heart failure. In: ACE Inhibitors, editors: Pedro D'Orleans-Juste, Gerard E. Plante. Birkhauser Verlag. Basel, Switzerland. 2001; 71-79.

Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension. 2000 Oct; 36(4):477-83.View Related Profiles.

DeStefano, Anita
O'Donnell, Christopher
Gavras, Haralambos
Larson, Martin
Myers, Richard

PMID: 11040222

Gavras H. Effect of ramipril on cardiovascular events in high-risk patients. N Engl J Med. 2000 Jul 6; 343(1):65-6. PMID: 10896546

Gavras I, Gavras H. The antiarrhythmic potential of angiotensin II antagonism: experience with losartan. Am J Hypertens. 2000 May; 13(5 Pt 1):512-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10826402

Zhao Z, Makaritsis K, Francis CE, Gavras H, Ravid K. A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice. Biochim Biophys Acta. 2000 Mar 17; 1500(3):280-90.View Related Profiles.

Gavras, Haralambos
Ravid, Katya

PMID: 10699369

Nicolaou M, DeStefano AL, Gavras I, Cupples LA, Manolis AJ, Baldwin CT, Gavras H, Farrer LA. Genetic predisposition to stroke in relatives of hypertensives. Stroke. 2000 Feb; 31(2):487-92.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Gavras, Irene
Cupples, L
Farrer, Lindsay

PMID: 10657427

Duka I, Gavras I, Johns C, Handy DE, Gavras H. Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction. Gen Pharmacol. 2000 Feb; 34(2):101-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10974417

Makaritsis KP, Johns C, Gavras I, Gavras H. Role of alpha(2)-adrenergic receptor subtypes in the acute hypertensive response to hypertonic saline infusion in anephric mice. Hypertension. 2000 Feb; 35(2):609-13.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10679505

Brunner HR, Gavras H. Early experience with angiotensin II recepor antagonists and angiotensin-converting enzyme inhibitors. In: Angiotensin II Receptor Antagonists. Eds.: Epstein M, Brunner HR. Hanley & Belfus, Inc. Philadephia, PA. 2000; 79-87.
Gavras H, Gavras I. Commentary: Implications for the pathophysiology of hypertension and heart failure derived from clinical experience with drugs modifying the renin-angiotensin system. In Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery. Eds: Husain A, Graham RM. Harwood Academic Publishers. Amsterdam,The Netherlands. 2000; 187-190.

Gavras H. Update on the clinical pharmacology of candesartan cilexetil. Am J Hypertens. 2000 Jan; 13(1 Pt 2):25S-30S. PMID: 10678285

Gavras H, Gavras I . Cardiac effects of angiotensin II and AT1 receptor blockade. In: Angiotensin II Receptor Antagonists. Eds.: Epstein M, Brunner HR. Hanley & Belfus, Inc. Philadelphia, PA. 2000; 215-222.
Gavras I, Gavras H . The role of AII antagonists in hypertension: Focus on telmisartan. Cardiovascular Reviews and Reports. 2000; 21:76-80.

Gavras I, Manolis AJ, Gavras H. The economics of therapeutic advances: the paradigm of sympathetic suppression in chronic heart failure. Arch Intern Med. 1999 Dec 13-27; 159(22):2634-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10597753

Schwartz F, Baldwin CT, Baima J, Gavras H. Mitochondrial DNA mutations in patients with orthostatic hypotension. Am J Med Genet. 1999 Sep 10; 86(2):145-50.View Related Profiles.

Baldwin, Clinton
Gavras, Haralambos

PMID: 10449650

Baldwin CT, Schwartz F, Baima J, Burzstyn M, DeStefano AL, Gavras I, Handy DE, Joost O, Martel T, Manolis A, Nicolaou M, Bresnahan M, Farrer L, Gavras H. Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension. Am J Hypertens. 1999 Sep; 12(9 Pt 1):853-7.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Gavras, Irene
Farrer, Lindsay

PMID: 10509541

Makaritsis KP, Johns C, Gavras I, Altman JD, Handy DE, Bresnahan MR, Gavras H. Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtype. Hypertension. 1999 Sep; 34(3):403-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10489385

Baima J, Nicolaou M, Schwartz F, DeStefano AL, Manolis A, Gavras I, Laffer C, Elijovich F, Farrer L, Baldwin CT, Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul; 34(1):4-7.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Gavras, Irene
Farrer, Lindsay

PMID: 10406815

Gavras H. Historical evolution of angiotensin II receptor blockers: therapeutic advantages. J Am Soc Nephrol. 1999 Apr; 10 Suppl 12:S255-7. PMID: 10201879

Gavras I, Gavras H. Safety and tolerability of eprosartan. Pharmacotherapy. 1999 Apr; 19(4 Pt 2):102S-107S.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10213529

Gavras I, Manolis A, Gavras H. Genetic epidemiology of essential hypertension. J Hum Hypertens. 1999 Apr; 13(4):225-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10333339

Makaritsis KP, Handy DE, Johns C, Kobilka B, Gavras I, Gavras H. Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension. Hypertension. 1999 Jan; 33(1):14-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9931075

Manolis AJ, Tsalopoulos E, Ramos C, Katsaros K, Dalabiras P, Hatzissavas J, Foussas S, Gavras I, Bresnahan M, Gavras H. Benefits of central sympathetic suppression with clonidine after acute myocardial infarction. Advances in Therapy. 1999; 16:272-282.
Gavras H, Gavras I. Bioactive peptides in the treatment of hypertension and heart failure. In: Bioactive Peptides in Drug Discovery and Design: Medical Aspects. Eds.: Matsoukas J, Mavromoustakos T. IOS Press. Amsterdam, Netherlands. 1999; 41-50.
Gavras H, Gavras I . The renin-angiotensin system and the heart. In: Contemporary Endocrinology: Hormones and the Heart in Health and Disease. Ed.: Share L. Humana Press Inc. Totowa, NJ. 1999; 63-67.

Gavras I, Gavras H. Effects of eprosartan versus enalapril in hypertensive patients on the renin-angiotensin-aldosterone system and safety parameters: results from a 26-week, double-blind, multicentre study. Eprosartan Multinational Study Group. Curr Med Res Opin. 1999; 15(1):15-24.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 10216807

Makaritsis KP, Gavras H, Du Y, Chobanian AV, Brecher P. Alpha1-adrenergic plus angiotensin receptor blockade reduces atherosclerosis in apolipoprotein E-deficient mice. Hypertension. 1998 Dec; 32(6):1044-8.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Brecher, Peter

PMID: 9856971

DeStefano AL, Baldwin CT, Burzstyn M, Gavras I, Handy DE, Joost O, Martel T, Nicolaou M, Schwartz F, Streeten DH, Farrer LA, Gavras H. Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q. Am J Hum Genet. 1998 Nov; 63(5):1425-30.View Related Profiles.

DeStefano, Anita
Baldwin, Clinton
Gavras, Haralambos
Gavras, Irene
Farrer, Lindsay

PMID: 9792870; PMCID: PMC1377553

Manolis AJ, Olympios C, Sifaki M, Smirnioudis N, Handanis S, Argirakis S, Katsaros C, Gavras I, Gavras H. Chronic sympathetic suppression in the treatment of chronic congestive heart failure. Clin Exp Hypertens. 1998 Oct; 20(7):717-31.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9764717

Balbi AL, Franco RJ, Barretti P, Gavras I, Gavras H. Renal artery clipping attenuates the progression of adriamycin nephropathy. Am J Hypertens. 1998 Sep; 11(9):1124-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9752899

Handy DE, Johns C, Bresnahan MR, Tavares A, Bursztyn M, Gavras H. Expression of alpha2-adrenergic receptors in normal and atherosclerotic rabbit aorta. Hypertension. 1998 Aug; 32(2):311-7. PMID: 9719060

Manolis AJ, Beldekos D, Handanis S, Haralabidis G, Hatzissavas J, Foussas S, Cokkinos DV, Bresnahan M, Gavras I, Gavras H. Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity. Am J Hypertens. 1998 Jun; 11(6 Pt 1):640-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9657622

Gavras I, Gavras H. The calcium channel antagonist controversy. Am Fam Physician. 1998 Apr 1; 57(7):1484, 1492.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9556636

Gavras H, Chrysant SG, Niederman AL, Marbury TC, Goldstein R, Conradi E. Evaluation of enalapril combined with diltiazem ER in patients with stage 3-4 essential hypertension. Clin Exp Hypertens. 1998 Jan; 20(1):41-52. PMID: 9507787

Gavras I, Gavras H. The renin-angiotensin system in hypertensive cardiac disease. In: Renin Angiotensin. Editors: Ulfendahl HR, Aurell M. Portland Press. London. 1998; 74:265-272.
Gavras H . Genetic Profiling in Hypertension. In: Hypertension Primer, Second Edition. Senior Editors: Joseph L. Izzo, Jr. and Henry R. Black. Lippincott Williams & Wilkins. Baltimore, MD. 1998; 306-307.

Gavras I, Gavras H. Salt in hypertension: physiological and molecular aspects. Recent Prog Horm Res. 1998; 53:1-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9769699

Gavras H. Historical overview: blocking the renin-angiotensin system in heart failure. In: 100 years of the renin—angiotensin system. Eds.: Nicholls MG, Brunner HR, Ikram H, Charles S. Sweet and J. Findlay Walker. Hughes Associates. Hooper House, Oxford, UK. 1998; 43-45.
Gavras H, Gavras I. Hypertension in the Elderly. Hormonal and Therapeutic Aspects. In: Recent Advances in Geriatrics, editors: Mario Barbagallo, Giuseppe Licata, James R. Sowers. Plenum Press. New York,NY. 1998; 69-74.

Bakris GL, Kusmirek SL, Smith AC, Gavras I, Gavras H. Calcium antagonism abolishes the antipressor action of vasopressin (V1) receptor antagonism. Am J Hypertens. 1997 Oct; 10(10 Pt 1):1153-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9370387

Manolis AJ, Beldekos D, Hatzissavas J, Foussas S, Cokkinos D, Bresnahan M, Gavras I, Gavras H. Hemodynamic and humoral correlates in essential hypertension: relationship between patterns of LVH and myocardial ischemia. Hypertension. 1997 Sep; 30(3 Pt 2):730-4.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9323014

Chrysant SG, Gavras H, Niederman AL, Marbury TC, Goldstein R. Clinical utility of long-term enalapril/diltiazem ER in stage 3-4 essential hypertension. Long-term Use of Enalapril/Diltiazem ER in Stage 3-4 Hypertension Group. J Clin Pharmacol. 1997 Sep; 37(9):810-5. PMID: 9549634

Bakris G, Bursztyn M, Gavras I, Bresnahan M, Gavras H. Role of vasopressin in essential hypertension: racial differences. J Hypertens. 1997 May; 15(5):545-50.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9170008

Gavras I, Manolis A, Gavras H. Drug therapy for hypertension. Am Fam Physician. 1997 Apr; 55(5):1823-6, 1829-34.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9105208

Gavras H. Angiotensin II antagonism: a new avenue of hypertension management. Blood Press Suppl. 1997; 1:42-6. PMID: 9285108

Gavras I, Gavras H . Potencial cardioprotector de los inhibidores del enzima conversor de la angiotensina. Anales De Cirugia Cardiaca Y Cirugia Vascular. 1997; 3:185-189.

Kohlmann O, Cesaretti ML, Ginoza M, Tavares A, Zanella MT, Ribeiro AB, Ramos OL, Leeman SE, Gavras I, Gavras H. Role of substance P in blood pressure regulation in salt-dependent experimental hypertension. Hypertension. 1997 Jan; 29(1 Pt 2):506-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene
Leeman, Susan

PMID: 9039150

Manolis AJ, Olympios C, Sifaki M, Handanis S, Cokkinos D, Bresnahan M, Gavras I, Gavras H. Combined sympathetic suppression and angiotensin-converting enzyme inhibition in congestive heart failure. Hypertension. 1997 Jan; 29(1 Pt 2):525-30.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9039154

Gavras H . Commentary: A hypertension report card. In: Postgraduate Medicine, A special Report on Clinical Experience with Losartan, the first A-II blocker, in diverse hypertensive populations. Healthcare Information Programs, McGraw-Hill Healthcare Information Group. Minneapolis, MN. 1997; 7-12.
Gavras H. Introduction. In: Postgraduate Medicine, A Special Report on Clinical Experience with Losartan, the first A-II blocker, in diverse hypertensive populations. Healthcare Information Programs, McGraw-Hill Healthcare Information Group. Minneapolis, MN. 1997; 5&6.

Johns C, Gavras I, Handy DE, Salomao A, Gavras H. Models of experimental hypertension in mice. Hypertension. 1996 Dec; 28(6):1064-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8952597

Gavras HP, Salerno CM. The angiotensin II type 1 receptor blocker losartan in clinical practice: a review. Clin Ther. 1996 Nov-Dec; 18(6):1058-67; discussion 1057. PMID: 9001823

Gavras I, Gavras H. What Data Are Required to Adopt New Antihypertensive Agents? Am J Ther. 1996 Aug; 3(8):604-607.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 11862298

Gavras I, Gavras H. Cardioprotective potential of angiotensin converting enzyme inhibitors. Braz J Med Biol Res. 1996 Jun; 29(6):701-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 9070382

Gavras I, Gavras H. Commentary on Kostis' report from SOLVD. Am J Hypertens. 1996 Jun; 9(6):615, 616-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8783788

Handy DE, Gavras H. Evidence for cell-specific regulation of transcription of the rat alpha2A-adrenergic receptor gene. Hypertension. 1996 Apr; 27(4):1018-24. PMID: 8613257

Tavares A, Handy DE, Bogdanova NN, Rosene DL, Gavras H. Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain. Hypertension. 1996 Mar; 27(3 Pt 1):449-55.View Related Profiles.

Rosene, Douglas
Gavras, Haralambos

PMID: 8698452

Wall BM, Huch KM, Runyan KR, Williams HH, Gavras H, Cooke CR. Effects of vasopressin V1-receptor blockade during acute and sustained hypovolemic hypotension. Am J Physiol. 1996 Feb; 270(2 Pt 2):R356-64. PMID: 8779866

Gavras H, Gavras I . Initiating antihypertensive therapy in the 1990s. In: ACE Inhibition & Your Practice. Ikram H, ed., English Thornton Communications, Inc. 1996; 1-6.
Manolis A, Gavras I, Gavras H . Clonidine and heart failure. Hypertension (Letter to Editor). 1996; 27:1187-1188.
Gavras H. Contemporary choices for the treatment of hypertension. Hellenic J Cardiol (Editorial). 1996; 37:493-499.
Gavras H, Gavras I. Endothelial function in cardiovascular disease: the role of bradykinin. In: Bradykinin. Sara Black, ed. Science Press Limited. London, UK. 1996; 1-58.

Kohlmann O, Ginoza M, Cezaretti ML, Zanella MT, Ribeiro AB, Tavares A, Ramos OL, Leeman SE, Gavras I, Gavras H. Cardiovascular effects of a specific nonpeptide antagonist of substance P (NK-1) receptor in DOCA-salt hypertension. Hypertension. 1995 Dec; 26(6 Pt 2):1186-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene
Leeman, Susan

PMID: 7498993

Haefliger JA, Bergonzelli G, Waeber G, Aubert JF, Nussberger J, Gavras H, Nicod P, Waeber B. Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive rats. Hypertension. 1995 Nov; 26(5):733-7. PMID: 7591011

Manolis AJ, Olympios C, Sifaki M, Handanis S, Bresnahan M, Gavras I, Gavras H. Suppressing sympathetic activation in congestive heart failure. A new therapeutic strategy. Hypertension. 1995 Nov; 26(5):719-24.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7591009

Gavras H, Gavras I. Modern approaches to initiating antihypertensive therapy. Cardiol Clin. 1995 Nov; 13(4):593-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8565022

Handy DE, Zanella MT, Kanemaru A, Tavares A, Flordellis C, Gavras H. A negative regulatory element in the promoter region of the rat alpha 2A-adrenergic receptor gene overlaps an SP1 consensus binding site. Biochem J. 1995 Oct 15; 311 ( Pt 2):541-7. PMID: 7487893; PMCID: PMC1136033

Ruocco NA, Bergelson BA, Yu TK, Gavras I, Gavras H. Augmentation of coronary blood flow by ACE inhibition: role of angiotensin and bradykinin. Clin Exp Hypertens. 1995 Oct; 17(7):1059-72.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8556004

Manolis AJ, Gavras I, Pieprzak M, Gavras H. Isradipine versus captopril in patients with essential hypertension. Clin Ther. 1995 Jul-Aug; 17(4):648-55.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8565028

Gavras I, Manolis A, Gavras H. Effects of ACE inhibition on the heart. J Hum Hypertens. 1995 Jun; 9(6):455-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7473527

Kohlman O, Neves Fde A, Ginoza M, Tavares A, Cezaretti ML, Zanella MT, Ribeiro AB, Gavras I, Gavras H. Role of bradykinin in insulin sensitivity and blood pressure regulation during hyperinsulinemia. Hypertension. 1995 May; 25(5):1003-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7737706

Flordellis CS, Berguerand M, Gouache P, Barbu V, Gavras H, Handy DE, Béréziat G, Masliah J. Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway. J Biol Chem. 1995 Feb 24; 270(8):3491-4. PMID: 7876081

Huch KM, Runyan KR, Wall BM, Gavras H, Cooke CR. Hemodynamic response to vasopressin during V1-receptor antagonism in baroreflex-deficient subjects. Am J Physiol. 1995 Jan; 268(1 Pt 2):R156-63. PMID: 7840317

Gavras I, Gavras H. Role of Vasopressin in Hypertensive Disorders. In: Hypertension: Pathophysiology, Diagnosis, and Management, Second Edition. Laragh JH, Brenner BM, eds. Raven Press, Ltd. New York,NY. 1995; 789-800.
Gavras H, Handy D, Gavras I. Alpha-adrenergic receptors in hypertension. In: Hypertension: Pathophysiology, Diagnosis, and Management, Second Edition. Laragh JH, Brenner BM, eds. Raven Press, Ltd. New York,NY. 1995; 853-861.
Gavras H . What to anticipate from Ang II antagonists in the treatment of hypertension and chronic heart failure. High Blood Pressure Research Council Newsletter. 1995; 3:20-21.
Gavras I, Gavras H . Bradykinin in hypertension and heart disease: effects of ACE inhibition. In: ACE Report 116. Nicholls MG, ed. Current Science, Ltd. 1995; 1-5.

Tobian L, Brunner HR, Cohn JN, Gavras H, Laragh JH, Materson BJ, Weber MA. Modern strategies to prevent coronary sequelae and stroke in hypertensive patients differ from the JNC V Consensus Guidelines. Am J Hypertens. 1994 Oct; 7(10 Pt 1):859-72. PMID: 7826548

Gavras H. Corcoran Lecture. Angiotensin-converting enzyme inhibition and the heart. Hypertension. 1994 Jun; 23(6 Pt 2):813-8. PMID: 8206609

Bursztyn M, Gavras I, Gourley L, DeSilva J, Whalen J, Gavras H. Effect of combination therapy with atenolol and the angiotensin-converting enzyme inhibitor benazepril. Clin Ther. 1994 May-Jun; 16(3):429-36.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7923309

Gavras H, Gavras I. On the JNC V report. A different point of view. Am J Hypertens. 1994 Mar; 7(3):288-93.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8003283

Franco R, Gut A, Ferrari-Spadotto A, Georgette J, Gavras I, Gavras H. Pressor mechanisms in adriamycin-induced nephropathy with hypertension in rats. Hypertension. 1994 Jan; 23(1 Suppl):I246-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8282368

de Paula RB, Plavnik FL, Rodrigues CI, Neves Fde A, Kohlmann O, Ribeiro AB, Gavras I, Gavras H. Contribution of vasopressin to orthostatic blood pressure maintenance in essential hypertension. Am J Hypertens. 1993 Sep; 6(9):794-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8110434

De Paula RB, Plavnik FL, Rodrigues CI, Neves Fde A, Kohlmann Júnior O, Ribeiro AB, Gavras I, Gavras H. Age and race determine vasopressin participation in upright blood pressure control in essential hypertension. Ann N Y Acad Sci. 1993 Jul 22; 689:534-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8373040

Gavras I, Gavras H. ACE inhibitors: a decade of clinical experience. Hosp Pract (Off Ed). 1993 Jul 15; 28(7):117-20, 123, 126-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8325908

Handy DE, Flordellis CS, Bogdanova NN, Bresnahan MR, Gavras H. Diverse tissue expression of rat alpha 2-adrenergic receptor genes. Hypertension. 1993 Jun; 21(6 Pt 1):861-5. PMID: 7684725

Manolis A, Athanasopoulos G, Karatasakis G, Gavras I, Bresnahan M, Cokkinos DV, Gavras H. Pressor hormone profile during stress in hypertension: does vasopressin interfere with left ventricular hypertrophy? Clin Exp Hypertens. 1993 May; 15(3):539-55.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 8490595

Sambhi MP, Gavras H, Robertson JI, Smith WM. Long-range safety and protective benefits of angiotensin-converting enzyme inhibitors for hypertension. Do we need more clinical trials? West J Med. 1993 Mar; 158(3):286-94. PMID: 8460511; PMCID: PMC1311755

Gavras H. ACE inhibitors and myocardial infarction. Lancet. 1993 Feb 20; 341(8843):493-4. PMID: 8094511

Gavras I, Gavras H. Does bradykinin contribute to the actions of angiotensin converting enzyme inhibitors?. In: Ace Report 95, Nicholls MG, ed. Current Science Ltd. 1993; 1-8.
Bakris GL, Gavras H. Renin in acute and chronic renal failure: implications for treatment. In: The Renin-Angiotensin System, Pathophysiology Therapeutics, Robertson JIS, Nicholls MG, eds. Gower Medical Publishing. London,UK. 1993; 2:56.1-56.14.
Gavras I, Gavras H. Angiotensin II -- Possible adverse effects on arteries, heart, brain, and kidney: Experimental, clinical, and epidemiological evidence. In: The Renin-Angiotensin System, Biochemistry Physiology Vol 1, Robertson JIS, Nicholls MG, eds. Gower Medical Publishing. London,UK. 1993; 1:40.1-40.11.
Gavras H, Gavras I. Hypertension in the elderly: Pathophysiology of aging of the cardiovascular system. In: Nephrology and Urology in the Aged patient. Oreopoulos DG, Michelis MF, Herschorn S, eds. Kluwer Academic Publishers. 1993; 141-145.

Handy DE, Gavras H. Promoter region of the human alpha 2A adrenergic receptor gene. J Biol Chem. 1992 Nov 25; 267(33):24017-22. PMID: 1385431

Gavras H. Oral milrinone in severe chronic heart failure. N Engl J Med. 1992 Jun 4; 326(23):1566; author reply 1567. PMID: 1579143

Lammek B, Konieczna E, Wierzba T, Wang YX, Gavras H. Synthesis and some pharmacological properties of new V1/V2 antagonists of arginine-vasopressin with structural changes at their N-terminals. Pol J Pharmacol Pharm. 1992 Mar-Apr; 44(2):179-86. PMID: 1409118

Wang YX, Gavras I, Wierzba T, Gavras H. Comparison of systemic and regional hemodynamic effects of a diuretic, an angiotensin II receptor antagonist, and an angiotensin-converting enzyme inhibitor in conscious renovascular hypertensive rats. J Lab Clin Med. 1992 Mar; 119(3):267-72.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1541876

Wang YX, Gavras I, Wierzba T, Lammek B, Gavras H. Inhibition of nitric oxide, bradykinin, and prostaglandins in normal rats. Hypertension. 1992 Feb; 19(2 Suppl):II255-61.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1735588

Gavras H. Early experience with quinapril in the management of hypertension. Cardiovasc Rev & Rep. 1992; 13:55-57.
Gavras H, Gavras I. How ACE inhibition lowers blood pressure. Choices in Cardiol 6 (suppl 1). 1992; 15-17.
Gavras H. The role of angiotensin converting enzyme inhibitors in the management of urgent hypertensive situations: A review. Cardiovas Drug Rev. 1992; 10:117-124.
Gavras H, Gavras I. Hypertension in the elderly: Choosing the right therapy. J Crit Illness. 1992; 7:1862-1874.
Lammek B, Ito Y, Gavras I, Gavras H . Acylation of the N-terminus of B2 bradykinin antagonists with bulky substituents dramatically increases potency. Collect Czech Chem Commun. 1992; 57:1960-1966.

Lammek B, Wang YX, Gavras I, Gavras H. A novel bradykinin antagonist with improved properties. J Pharm Pharmacol. 1991 Dec; 43(12):887-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1687595

Castellano M, Handy DE, Beschi M, Wang YX, Agabiti-Rosei E, Gavras H. Gene expression of catecholaminergic receptors in the central nervous system of hypertensive rats. J Hypertens Suppl. 1991 Dec; 9(6):S54-5. PMID: 1819011

Gavras H, Gavras I. Angiotensin converting enzyme inhibitors. J Hypertens. 1991 Nov; 9(11):1075-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1661767

Gavras H. Role of vasopressin in clinical hypertension and congestive cardiac failure: interaction with the sympathetic nervous system. Clin Chem. 1991 Oct; 37(10 Pt 2):1828-30. PMID: 1914197

Wang YX, Gavras I, Lammek B, Bresnahan M, Gavras H. Effects of bradykinin and prostaglandin inhibition on systemic and regional hemodynamics in conscious normotensive rats. J Hypertens. 1991 Sep; 9(9):805-12.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1663981

Gavras I, Gavras H. Cardioprotective potential of angiotensin-converting enzyme inhibitors. Clin Cardiol. 1991 Aug; 14(8 Suppl 4):IV68-71; discussion IV83-90.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1893645

Gavras H, Gavras I. Cardioprotective potential of angiotensin converting enzyme inhibitors. J Hypertens. 1991 May; 9(5):385-92.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1649858

Wang YX, Franco R, Gavras I, Gavras H. Effects of chronic administration of a vasopressin antagonist with combined antivasopressor and antiantidiuretic activities in rats with left ventricular dysfunction. J Lab Clin Med. 1991 Apr; 117(4):313-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1826304

Flordellis CS, Handy DE, Bresnahan MR, Zannis VI, Gavras H. Cloning and expression of a rat brain alpha 2B-adrenergic receptor. Proc Natl Acad Sci U S A. 1991 Feb 1; 88(3):1019-23.View Related Profiles.

Gavras, Haralambos
Zannis, Vassilis

PMID: 1704126; PMCID: PMC50946

Lammek B, Wang Y-X, Gavras H . Synthesis and some pharmacologic properties of three new bradykinin antagonists. Coll Czech Chem Comm. 1991; 56:1539-1544.
Gavras H. Angiotensin-converting enzyme inhibitors in hypertension and congestive heart failure. J KAU: Med Sci (1411 A.H./1991 A.D.). 1991; 1:3-8.
Gavras H, Gavras I . Effects of bradykinin antagonists on the cardiovascular system. In: Bradykinin Antagonists Basic & Clinical Research. Burch RM, ed. Marcel Dekker. New York,NY. 1991; 171-189.
Bursztyn M, Gavras H. Clinical aspects of oral angiotensin converting enzyme inhibitors. In: Progress in Hypertension. Saito H, Minami M, Parvez SH, eds. VSP BV. The Netherlands. 1991; 2:107-129.
Bakris GL, Gavras H . Treatment of hypertension in the elderly: a review: Geriatr Nephrol & Urol. 1991; 1:121-127.

Lammek B, Wang YX, Franco R, Gavras I, Gavras H. Two highly effective V1/V2 antagonists of vasopressin containing novel thioacids at position 1. J Pharm Pharmacol. 1991 Jan; 43(1):40-2.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1676057

Lammek B, Wang YX, Gavras I, Gavras H. A new highly potent antagonist of bradykinin. Peptides. 1990 Nov-Dec; 11(6):1319.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2087444

Gavras H. Pressor systems in hypertension and congestive heart failure. Role of vasopressin. Hypertension. 1990 Nov; 16(5):587-93. PMID: 2228158

Lammek B, Wang YX, Gavras I, Gavras H. A new highly potent antagonist of bradykinin. Peptides. 1990 Sep-Oct; 11(5):1041-3.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2284196

Gavras H. [International experience with the use of lisinopril in arterial hypertension]. Arq Bras Cardiol. 1990 Aug; 55 Suppl A:A20-2. PMID: 1965523

Flordellis CS, Castellano M, Franco R, Zannis VI, Gavras H. Expression of multiple alpha 2-adrenergic receptor messenger RNA species in rat tissues. Hypertension. 1990 Jun; 15(6 Pt 2):881-7.View Related Profiles.

Gavras, Haralambos
Zannis, Vassilis

PMID: 2161794

Bursztyn M, Bresnahan M, Gavras I, Gavras H. Effect of aging on vasopressin, catecholamines, and alpha 2-adrenergic receptors. J Am Geriatr Soc. 1990 Jun; 38(6):628-32.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2162869

Bresnahan MR, Flordellis CS, Vassilatis DK, Makrides SC, Zannis VI, Gavras H. High level of expression of functional human platelet alpha 2-adrenergic receptors in a stable mouse C127 cell line. Biochim Biophys Acta. 1990 May 22; 1052(3):439-45.View Related Profiles.

Gavras, Haralambos
Zannis, Vassilis

PMID: 1972337

Bursztyn M, Gavras I, Tifft CP, Luther R, Boger R, Gavras H. Effects of a novel renin inhibitor in patients with essential hypertension. J Cardiovasc Pharmacol. 1990 Mar; 15(3):493-500.View Related Profiles.

Tifft, Charles
Gavras, Haralambos
Gavras, Irene

PMID: 1691375

Bursztyn M, Bresnahan M, Gavras I, Gavras H. Pressor hormones in elderly hypertensive persons. Racial differences. Hypertension. 1990 Feb; 15(2 Suppl):I88-92.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2153631

Gavras H. Angiotensin converting enzyme inhibition and its impact on cardiovascular disease. Circulation. 1990 Jan; 81(1):381-8. PMID: 2404627

Gavras H . Angiotensin-Converting Enzyme Inhibitors or Calcium Channel Blockers? An Overview. Drugs 39 (Suppl 2). 1990; 73-75.
Gavras I, Gavras H. The future of converting enzyme inhibitors as cardioprotective agents. Curr Opin in Cardiol. 1990; 5:626-629.
Wierzba T, Manolis A, Gavras I, Bursztyn M, Gavras H. Enalapril in mild to moderate hypertension. Curr Ther Res. 1990; 48(6):1101-1110.
Gavras I, Gavras H. Angiotensin-converting enzyme inhibitors in hypertension and congestive heart failure. In: Adv Intern Med. Year Book Medical Publishers, Inc. 1990; 35:249-267.

Waeber B, Niederberger M, Gavras H, Nussberger J, Brunner HR. Hemodynamic effects of a kinin antagonist. J Cardiovasc Pharmacol. 1990; 15 Suppl 6:S78-82. PMID: 1697367

Gavras I, Gavras H. Enalapril. In: Drugs for the Heart and Circulation. Messerli FH, ed. WB Saunders Co. 1990; 792-799.
Wang YX, Franco R, Gavras I, Gavras H . Effects of chronic administration of a vasopressin antagonist with combined antivasopressor and anti-antidiuretic activities in rats with left ventricular dysfunction. Clin Res. 1990; 38:583A.

Chobanian AV, Gavras H. Hypertension. Clin Symp. 1990; 42(5):1-32.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos

PMID: 2276260

Gavras I, Gavras H . Enalapril. In: Cardiovascular Drug Therapy. Messerli F, ed. WB Saunders Co. Philadelphia, PA. 1990; 792-799.

Gavras I, Gavras H. Angiotensin-converting enzyme inhibitors in hypertension and congestive heart failure. Adv Intern Med. 1990; 35:249-67.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2405595

Mulinari RA, Gavras I, Wang YX, Franco R, Gavras H. Effects of a vasopressin antagonist with combined antipressor and antiantidiuretic activities in rats with left ventricular dysfunction. Circulation. 1990 Jan; 81(1):308-11.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2404626

Bursztyn M, Gavras I, Tifft CP, Bauer JH, Melby JC, Gavras H. Renin inhibition with A-64662: effect on blood pressure and hormonal response in man. J Hypertens Suppl. 1989 Dec; 7(6):S306-7.View Related Profiles.

Tifft, Charles
Gavras, Haralambos
Gavras, Irene

PMID: 2698944

Wallin JD, Cook ME, Fletcher E, Holtzman JL, Winer N, Gavras H, Grim CE, Ramanathan KB, Vidt DG, Johnson BF, et al. Dilevalol in severe hypertension. A multicenter trial of bolus intravenous dosing. Arch Intern Med. 1989 Dec; 149(12):2655-61. PMID: 2688585

Lammek B, Wang YX, Derdowska I, Franco R, Gavras H. Synthesis and some pharmacologic properties of five novel V1 or V1/V2 antagonists of AVP. Peptides. 1989 Sep-Oct; 10(5):1109-12. PMID: 2608555

Gavras H, Gavras I. Salt-induced hypertension: the interactive role of vasopressin and of the sympathetic nervous system. J Hypertens. 1989 Aug; 7(8):601-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2681406

Bursztyn M, Gavras I, Gavras H. Hypertension in the aging patient. Implications for the selection of drug therapy. J Am Geriatr Soc. 1989 Aug; 37(8):814-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2754162

Glazier JJ, Faxon DP, Mills RM, Bresnahan MR, Ryan TJ, Gavras H. Effect of arginine vasopressin on coronary and systemic hemodynamics in man. Int J Cardiol. 1989 Jul; 24(1):95-103. PMID: 2759761

Mulinari R, Gavras I, Franco R, Gavras H. Bradykinin antagonism and prostaglandins in blood pressure regulation. Hypertension. 1989 Jun; 13(6 Pt 2):960-3.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2567708

Bursztyn M, Gavras I, Blasucci DJ, Gavras H. Intravenous dilevalol in the treatment of severe hypertension. J Cardiovasc Pharmacol. 1989 May; 13(5):799-802.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2472530

Mulinari R, Gavras I, Gavras H. The role of vasopressin in blood pressure regulation. In: Perspectives in Hypertension: II Endocrine mechanisms of Hypertension. Brenner BM, Kaplan N, Laragh JH, eds. Raven Press. New York,NY. 1989; 201-218.
Gavras I, Gavras H. Role of vasopressin in hypertensive disorders. In: Hypertension: Pathophysiology, Diagnosis and Management. Laragh JH and Brenner BM, eds. Raven Press. New York,NY. 1989; 779-789.
Flordellis C, Castellano M, Zannis V, Gavras H. Tissue-specific expression of alpha2-adrenoceptor mRNA isoforms in rat. Hypertension. 1989; 14:353.
Glazier JJ, Gavras H, Mills RM, Bresnahan M, Ryan TJ, Faxon DP. What is the effect of arginine vasopressin on coronary and systemic vascular tone in man?. Clin Sci. 1989; 77(Suppl 21):34P.
Gavras H . Cardioprotective effects of angiotensin-converting-enzyme inhibitors in hypertension. Practical Cardiology. 1989; 15:25-31.
Bursztyn M, Gavras I, Gavras H. Quinapril: Mechanism of action, safety, and effectiveness. Inter Med. 1989; 10:79-85.

Gavras H. The place of angiotensin-converting enzyme inhibition in the treatment of cardiovascular diseases. N Engl J Med. 1988 Dec 8; 319(23):1541-3. PMID: 3185679

Gavras I, Mulinari R, Gavras H. Renin-angiotensin and vasopressin in the development of salt-induced hypertension. J Hypertens. 1988 Dec; 6(12):999-1002.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2975694

Gavras H. Effect of sodium on central alpha 2-adrenergic receptors. Hypertension. 1988 Nov; 12(5):525-6. PMID: 2847984

Vlahakos D, Gavras H. Central sympathetic stimulation produced by saline application into the nucleus tractus solitarii area of conscious rats. Neurosci Lett. 1988 Oct 17; 92(3):335-40. PMID: 3200489

Makrides SC, Mulinari R, Zannis VI, Gavras H. Regulation of renin gene expression in hypertensive rats. Hypertension. 1988 Oct; 12(4):405-10.View Related Profiles.

Gavras, Haralambos
Zannis, Vassilis

PMID: 3049341

Gavras I, Gavras H. Anti-hormones and blood pressure: bradykinin antagonists in blood pressure regulation. Kidney Int Suppl. 1988 Oct; 26:S60-2.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3059034

Paglin S, Takuwa Y, Kamm KE, Stull JT, Gavras H, Rasmussen H. Atrial natriuretic peptide inhibits the agonist-induced increase in extent of myosin light chain phosphorylation in aortic smooth muscle. J Biol Chem. 1988 Sep 15; 263(26):13117-20. PMID: 2971037

Mulinari RA, Gouni I, Gavras I, Gavras H. Acute effects of the new angiotensin-converting enzyme inhibitor cilazapril: a pilot study. J Clin Pharmacol. 1988 Jul; 28(7):660-3.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2975290

Mulinari R, Benetos A, Gavras I, Gavras H. Vascular and sympathoadrenal responses to bradykinin and a bradykinin analogue. Hypertension. 1988 Jun; 11(6 Pt 2):754-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2899059

Gavras I, Gavras H. Role of bradykinin in hypertension and the antihypertensive effect of angiotensin-converting enzyme inhibitors. Am J Med Sci. 1988 Apr; 295(4):305-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2834950

Gavras H, Gavras I. Angiotensin converting enzyme inhibitors. Properties and side effects. Hypertension. 1988 Mar; 11(3 Pt 2):II37-41.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3280490

Saad CI, Ribeiro AB, Zanella MT, Mulinari RA, Gavras I, Gavras H. The role of vasopressin in blood pressure maintenance in diabetic orthostatic hypotension. Hypertension. 1988 Feb; 11(2 Pt 2):I217-21.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3346060

Gavras I, Bursztyn M, Gavras H . Changing trends in hypertension therapy: ACE inhibitors and calcium blockers. Mod Medicine. 1988; 56:106-117.
Gavras I, Mulinari R, Ribeiro A, Gavras H . Role of vasopressin in hypertension and heart failure: Clinical Studies. In: Vasopressin : Cellular and Integrative Functions. Cowley AW, ed. Raven Press. New York,NY. 1988; 467-479.

Gavras I, Mulinari R, Gavras H, Higgins JT, Reeves RL, Zawada ET, Crook J, Halperin AK, Garrett B. Antihypertensive effectiveness of the nifedipine gastrointestinal therapeutic system. Am J Med. 1987 Dec 21; 83(6B):20-3.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3332575

Schneider SH, Khachadurian AK, Amorosa LF, Gavras H, Fineberg SE, Ruderman NB. Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism. 1987 Dec; 36(12):1161-6.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil

PMID: 3316925

Benetos A, Bresnahan M, Gavras I, Gavras H. Central catecholamines and alpha-adrenoceptors in acute hypertension induced by intracerebroventricular hypertonic saline. J Hypertens. 1987 Dec; 5(6):699-704.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2828469

Gavras H, Benetos A, Gavras I. Contribution of bradykinin to maintenance of normal blood pressure. Hypertension. 1987 Jun; 9(6 Pt 2):III147-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3596781

Benetos A, Gavras I, Gavras H. Stimulation of vasopressin by calcium microinjections in the area of the paraventricular nucleus of the hypothalamus. Brain Res. 1987 May 26; 412(1):182-4.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3607454

Gavras I, Gavras H. [Clinical management of hypertension in the elderly]. Rev Clin Esp. 1987 Mar; 180(5):229-31.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3602521

Papadoliopoulou-Diamandopoulou N, Papagalanis N, Gavras I, Gavras H. Vasopressin in end-stage renal disease: relationship to salt, catecholamines and renin activity. Clin Exp Hypertens A. 1987; 9(7):1197-208.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3304733

Benetos A, Gavras H, Stewart JM, Vavrek R, Hatinoglou S, Gavras I. The antihypertensive contribution of bradykinin as assessed by a specific bradykinin antagonist. Agents Actions Suppl. 1987; 22:355-64.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2829598

Mulinari R, Gavras I, Gavras H. Efficacy and tolerability of enalapril monotherapy in mild-to-moderate hypertension in older patients compared to younger patients. Clin Ther. 1987; 9(6):678-89.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2830974

Gavras I, Gavras H. The role of angiotensin converting enzyme inhibitors in hypertension. In: The pharmacological treatment of cardiovascular diseases. Kostis JB, DeFelice EA, eds. MEPC. Alan Liss Inc. New York,NY. 1987; 93-122.
Gavras I, Gavras H. Clinical management of hypertension in the elderly. In: Hypertension in the Community, Eds Rosenthal T, Silderberg D. Karger Publ. 1987; 62-67.

Bresnahan MR, Gavras I, Hatinoglou S, Muller RE, Gavras H. Central alpha-adrenoceptors during the development of hypertension in rats on high and low salt intake. J Hypertens. 1986 Dec; 4(6):719-26.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3029217

Benetos A, Gavras H, Stewart JM, Vavrek RJ, Hatinoglou S, Gavras I. Vasodepressor role of endogenous bradykinin assessed by a bradykinin antagonist. Hypertension. 1986 Nov; 8(11):971-4.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3021624

Benetos A, Gavras I, Gavras H. Hypertensive effect of a bradykinin antagonist in normotensive rats. Hypertension. 1986 Nov; 8(11):1089-92.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3770870

Young JC, Treadway JL, Balon TW, Gavras HP, Ruderman NB. Prior exercise potentiates the thermic effect of a carbohydrate load. Metabolism. 1986 Nov; 35(11):1048-53.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil
Balon, Thomas

PMID: 3534517

Gavras I, Gavras H. Clinical utility of angiotensin converting enzyme inhibitors in hypertension. Am J Med. 1986 Oct 31; 81(4C):28-31.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3022582

Benetos A, Gavras I, Gavras H. Norepinephrine applied in the paraventricular hypothalamic nucleus stimulates vasopressin release. Brain Res. 1986 Sep 3; 381(2):322-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3827993

Gavras I, Hatinoglou S, Benetos A, Gavras H. Calcium stimulates vasopressin release. J Hypertens. 1986 Aug; 4(4):451-4.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3772099

Gavras I, Hatinoglou S, Gavras H. The adrenergic system and the release and pressor action of vasopressin. Hypertension. 1986 Jun; 8(6 Pt 2):II163-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2873100

Creager MA, Faxon DP, Cutler SS, Kohlmann O, Ryan TJ, Gavras H. Contribution of vasopressin to vasoconstriction in patients with congestive heart failure: comparison with the renin-angiotensin system and the sympathetic nervous system. J Am Coll Cardiol. 1986 Apr; 7(4):758-65. PMID: 3514728

Gavras H. How does salt raise blood pressure? A hypothesis. Hypertension. 1986 Jan; 8(1):83-8. PMID: 3002978

Strauss R, Gavras I, Vlahakos D, Gavras H. Enalaprilat in hypertensive emergencies. J Clin Pharmacol. 1986 Jan; 26(1):39-43.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3005376

Ribeiro A, Mulinari R, Gavras I, Kohlmann O Jr, RAMOS O, Gavras H: . Sequential elimination of pressor mechanisms in severe hypertension in humans. Hypertension. 1986; 8(Suppl I):I-169-I-173.

Gavras H. A multicenter trial of enalapril in the treatment of essential hypertension. Clin Ther. 1986; 9(1):24-38. PMID: 3028633

Gavras H, Gavras I. Inhibitors of the renin-angiotensin system. In: Tratado Sobre Hipertension Arterial. Rodicio JL, et Madrid. 1986.

Vlahakos D, Gavras I, Gavras H. alpha-Adrenoceptor agonists applied in the area of the nucleus tractus solitarii in the rat: effect of anesthesia on cardiovascular responses. Brain Res. 1985 Nov 18; 347(2):372-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2866015

Gavras H, Bain GT, Bland L, Vlahakos D, Gavras I. Hypertensive response to saline microinjection in the area of the nucleus tractus solitarii of the rat. Brain Res. 1985 Sep 16; 343(1):113-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2994826

Gavras I, Gavras H. Nifedipine in the treatment of essential hypertension. J Clin Pharmacol. 1985 Sep; 25(6):429-32.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 3902911

Fahmy NR, Gavras HP. Impact of captopril on hemodynamic and hormonal effects of nitroprusside. J Cardiovasc Pharmacol. 1985 Sep-Oct; 7(5):869-74. PMID: 2413294

Chatterjee K, Parmley WW, Cohn JN, Levine TB, Awan NA, Mason DT, Faxon DP, Creager M, Gavras HP, Fouad FM, et al. A cooperative multicenter study of captopril in congestive heart failure: hemodynamic effects and long-term response. Am Heart J. 1985 Aug; 110(2):439-47. PMID: 3895877

Kohlmann O, Gavras I, Biollaz J, Biollaz B, Gavras H. Sodium chloride-induced partial inhibition in vivo of alpha 2-adrenoceptor agonist function. J Hypertens. 1985 Jun; 3(3):269-74.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 2862207

Creager MA, Faxon DP, Rockwell SM, Gavras H, Coffman JD. The contribution of the renin-angiotensin system to limb vasoregulation in patients with heart failure: observations during orthostasis and alpha-adrenergic blockade. Clin Sci (Lond). 1985 Jun; 68(6):659-67. PMID: 2485267

Gavras H, Gavras I. Interaction of vasopressin with the sympathetic nervous system and arterial pressure and control. In: Vasopressin, Robert W Schrier, ed. Raven Press. New York,NY. 1985.

Charocopos F, Gavras H. Cardiovascular effects of dobutamine and converting enzyme inhibition in rats with diabetic ketoacidosis. Pharmacology. 1985; 30(2):65-70. PMID: 2983358

Gavras H, Gavras I. Risk of stroke in the hypertensive elderly patient. Geriatric Med Today. 1985; 4(11):72-75.
Gavras H, Gavras I. Managing hypertensives with parenchymal renal disease. Cardiovasc Med. 1985; 10(2):43-54.

Madias JE, Madias NE, Gavras HP. Nonarrhythmogenicity of diuretic-induced hypokalemia. Its evidence in patients with uncomplicated hypertension. Arch Intern Med. 1984 Nov; 144(11):2171-6. PMID: 6497518

Ying CY, Tifft CP, Gavras H, Chobanian AV. Renal revascularization in the azotemic hypertensive patient resistant to therapy. N Engl J Med. 1984 Oct 25; 311(17):1070-5.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos

PMID: 6237260

Gavras I, Vlahakos D, Melby JC, Gavras H. Pilot study of the effects of the angiotensin-converting enzyme inhibitor CI-906 on patients with essential hypertension. J Clin Pharmacol. 1984 Aug-Sep; 24(8-9):343-50.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6090509

Biollaz B, Biollaz J, Kohlman O, Bresnahan M, Gavras I, Gavras H. Acute cardiovascular effects of two central phenylethanolamine-N-methyl-transferase inhibitors in unanesthetized desoxycorticosterone-salt hypertensive rats. Eur J Pharmacol. 1984 Jul 20; 102(3-4):515-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6489438

Charocopos F, Gavras H. Cardiovascular responses in the diabetic rat. Q J Exp Physiol. 1984 Jul; 69(3):463-8. PMID: 6236471

Hatzinikolaou P, Gavras H, North WG, Kohlmann O, Gavras I. Evidence for dopaminergic regulation of vasopressin release in the anephric rat. J Hypertens. 1984 Jun; 2(3):311-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6442313

Kohlmann O, Bresnahan M, Gavras H. Central and peripheral indices of sympathetic activity after blood pressure lowering with enalapril (MK-421) or hydralazine in normotensive rats. Hypertension. 1984 Mar-Apr; 6(2 Pt 2):I1-6. PMID: 6327520

Gavras H, Ribeiro AB, Kohlmann O, Saragoça M, Mulinari RA, Ramos O, Gavras I. Effects of a specific inhibitor of the vascular action of vasopressin in humans. Hypertension. 1984 Mar-Apr; 6(2 Pt 2):I156-60.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6547112

Creager MA, Faxon DP, Rockwell SM, Melby JC, Gavras H, Coffman JD. Effect of renin-angiotensin system on limb circulation in normal subjects. Am J Physiol. 1984 Feb; 246(2 Pt 2):H239-44. PMID: 6364845

Bussien JP, Waeber B, Nussberger J, Schaller MD, Gavras H, Hofbauer K, Brunner HR. Does vasopressin sustain blood pressure of normally hydrated healthy volunteers? Am J Physiol. 1984 Jan; 246(1 Pt 2):H143-7. PMID: 6364837

Charocopos F, Hatzinikolaou P, Gavras I, Gavras H. Regional blood flows and cardiac hemodynamics in renovascular and mineralocorticoid hypertensive rats. J Physiol (Paris). 1984; 79(3):162-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6381695

DiPette D, Gavras I, North W, DiPette P, Gavras H. Vasopressin response to hyperosmotic stimulus: blood pressure effect in normal subjects and patients with impaired sympathetic system. Clin Exp Hypertens A. 1984; 6(4):851-61.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6723091

Waeber B, Gavras H, Bresnahan MR, Gavras I, Brunner HR. Role of vasoconstrictor systems in experimental glucocorticoid-hypertension in rats. Clin Sci (Lond). 1983 Sep; 65(3):255-61.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6872460

Gavras I, Gavras H. Captopril and enalapril. Ann Intern Med. 1983 Apr; 98(4):556-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6301322

DiPette D, Waeber B, Volicer L, Chao P, Gavras I, Gavras H, Brunner H. Salt-induced hypertension in chronic renal failure: evidence for a neurogenic mechanism. Life Sci. 1983 Feb 14; 32(7):733-40.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6827908

Gavras H. Hypertension and congestive heart failure: benefits of converting enzyme inhibition (captopril). J Am Coll Cardiol. 1983 Feb; 1(2 Pt 1):518-20. PMID: 6338084

Gavras H, Gavras I. Hypertension in the elderly. John Wright PS Inc. Boston,MA. 1983.
Chobanian AV, Gavras H . Hypertensive emergencies. In: Medical emergencies diagnostic and management procedures from the Boston City Hospital, Cohen AS, Combes JR, Koh HK, eds. 2nd edition. Little Brown and Company. Boston,MA. 1983; 105-114.

Hatzinikolaou P, Charocopos F, Gavras I, Gavras H. Systemic and regional hemodynamic effects of propranolol in intact and anephric rats. Clin Exp Hypertens A. 1983; 5(5):729-39.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6883742

Gavras H, Biollaz J, Waeber B, Brunner HR, Gavras I. Clinical application of orally active angiotensin converting enzyme inhibitors. Adv Exp Med Biol. 1983; 156 (Pt B):1127-31.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6305164

Burnier M, Biollaz J, Brunner DB, Gavras H, Brunner HR. Alpha and beta adrenoceptor blockade in normotensive and deoxycorticosterone (DOC)-hypertensive rats; plasma vasopressin and vasopressin pressor effect. J Pharmacol Exp Ther. 1983 Jan; 224(1):222-7. PMID: 6129318

Gavras I, Gavras H . Captopril and enalapril. Ann Int Med (Reply to letter). 1983; 99:281.

Liang CS, Gavras H, Black J, Sherman LG, Hood WB. Renin-angiotensin system inhibition in acute myocardial infarction in dogs. Effects on systemic hemodynamics, myocardial blood flow, segmental myocardial function and infarct size. Circulation. 1982 Dec; 66(6):1249-55.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 6183019

Waeber B, Gavras H, Gavras I, Chao P, Kohlman O, Bresnahan MR, Brunner HR, Vaughan D. Evidence for a sodium-induced activation of central neurogenic mechanisms in one-kidney, one-clip renal hypertensive rats. J Pharmacol Exp Ther. 1982 Nov; 223(2):510-5.View Related Profiles.

Vaughan, Deborah
Gavras, Haralambos
Gavras, Irene

PMID: 6752375

Biollaz J, Brunner HR, Gavras I, Waeber B, Gavras H. Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade. J Cardiovasc Pharmacol. 1982 Nov-Dec; 4(6):966-72.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6185790

Halperin JL, Faxon DP, Creager MA, Bass TA, Melidossian CD, Gavras H, Ryan TJ. Coronary hemodynamic effects of angiotensin inhibition by captopril and teprotide in patients with congestive heart failure. Am J Cardiol. 1982 Nov; 50(5):967-72. PMID: 6182786

Charocopos F, Hatzinikolaou P, North WG, Gavras H. Systemic and regional hemodynamic effects of endogenous vasopressin stimulation in rats. Am J Physiol. 1982 Oct; 243(4):H560-5. PMID: 7124963

Waeber B, Brunner HR, Haeusler G, Gavras H. Pre- and postsynaptic effects of SKF64139, a phenylethanolamine N-methyltransferase inhibitor, in conscious normotensive rats. J Cardiovasc Pharmacol. 1982 Sep-Oct; 4(5):759-64. PMID: 6182406

Use of saralasin as a diagnostic test in hypertension. Report of a Consensus Committee. Arch Intern Med. 1982 Aug; 142(8):1437-40. PMID: 7049102

Andrews P, Papadakis N, Gavras H. Reversal of experimental acute cerebral vasospasm by angiotensin converting enzyme inhibition. Stroke. 1982 Jul-Aug; 13(4):480-3. PMID: 6179264

Liang C, Doherty JU, Faillace R, Maekawa K, Arnold S, Gavras H, Hood WB. Insulin infusion in conscious dogs. Effects on systemic and coronary hemodynamics, regional blood flows, and plasma catecholamines. J Clin Invest. 1982 Jun; 69(6):1321-36.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 6123523; PMCID: PMC370205

Biollaz J, Dürr J, Brunner HR, Porchet M, Gavras H. Escape from mineralocorticoid excess: the role of angiotensin II. J Clin Endocrinol Metab. 1982 Jun; 54(6):1187-93. PMID: 6281293

DiPette DJ, Gavras I, North WG, Brunner HR, Gavras H. Vasopressin in salt-induced hypertension of experimental renal insufficiency. Hypertension. 1982 May-Jun; 4(3 Pt 2):125-30.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7068202

Gavras H, Hatzinikolaou P, North WG, Bresnahan M, Gavras I. Interaction of the sympathetic nervous system with vasopressin and renin in the maintenance of blood pressure. Hypertension. 1982 May-Jun; 4(3):400-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7040232

Burnier M, Biollaz J, Brunner HR, Turini GA, Gavras H. Comparison in normal volunteers of three converting enzyme inhibitors: RHC 3659, MK 421 and captopril. Am J Cardiol. 1982 Apr 21; 49(6):1550-1. PMID: 6280484

Waeber B, Gavras I, Brunner HR, Cook CA, Charocopos F, Gavras HP. Prediction of sustained antihypertensive efficacy of chronic captopril therapy: relationships to immediate blood pressure response and control plasma renin activity. Am Heart J. 1982 Mar; 103(3):384-90.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6278905

Gavras I, Gavras H. Leukopenia: idiopathic or drug-induced? N Engl J Med. 1982 Feb 25; 306(8):484.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7057850

Waeber B, Brunner HR, Gavras H . The renin-angiotensin system and its inhibition in the treatment of hypertension. In: Hypertension, Sleight P, Freis ED, eds. Butterworth Scientific. London,UK. 1982; 293-305.
Gavras H. Essential hypertension. In: Clinical Hypertension and Hypotension. Brunner HR, Gavras H, eds. Marcel Dekker. New York,NY. 1982.
Gavras H, Biollaz J, Waeber B, Brunner HR, Gavras I . Clinical application of orally active angiotensin converting enzyme inhibitors. In: Mechanisms of action of antihypertensive drugs. Dollery CT, Frohlich ED, eds. Guadalajara, Mexico. 1982.

Waeber B, Brunner HR, Burckhardt P, Gavras H. Hypertension in a patient with hypercalcemia: captopril and verapamil. Arch Intern Med. 1982 Jan; 142(1):143-5. PMID: 7032443

Clinical Hypertension and Hypotension. Brunner HR, Gavras H: eds. Marcel Dekker Inc. New York,NY. 1982.
Brunner HR, Waeber B, Biollaz J, Gavras H. Acute and long-term inhibition of the renin-angiotensin system. In: Mechanisms of action of antihypertensive drugs. Dollery CT, Frohlich ED, eds. Guadalajara, Mexico. 1982.
Burnier M, Biollaz J, Brunner HR, Gavras H. Vasopressin blood pressure dependency following beta-adrenoceptor blockade in normotensive and mineralocorticoid-salt hypertensive rats. Ninth Scientific Meeting of the Int Soc Hypertens. 1982; 61.

Gavras H. Possible mechanisms of sodium-dependent hypertension: volume expansion or vasoconstriction? Clin Exp Hypertens A. 1982; 4(4-5):737-49. PMID: 7105437

Faxon DP, Creager MA, Halperin JL, Sussman HA, Gavras H, Ryan TJ. The effect of angiotensin converting enzyme inhibition of coronary blood flow and hemodynamics in patients without coronary artery disease. Int J Cardiol. 1982; 2(2):251-62. PMID: 6185446

Burnier M, Biollaz J, Brunner HR, Gavras H . Vasopressin blood pressure dependency after alpha-adrenoceptor blockade in normotensive and mineralocorticoid salt hypertensive rats. Clin Sci. 1982; 101s-103s.

Gavras H, Biollaz J, Waeber B, Brunner HR, Gavras I, Davies RO. Effects of the new oral angiotensin converting enzyme inhibitor MK-421 in human hypertension. Clin Exp Hypertens A. 1982; 4(1-2):303-14.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6280900

Richter EA, Ruderman NB, Gavras H, Belur ER, Galbo H. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol. 1982 Jan; 242(1):E25-32.View Related Profiles.

Gavras, Haralambos
Ruderman, Neil

PMID: 7058885

Dipette D, Dipette P, North WG, Gavras I, Brunner HR, Gavras H . Plasma vasopressin response to hyperosmotic solution (renograffin) and its effect on blood pressure in quadriplegic patients. Clin Res. 1982; 30:510.
Brunner HR, Gavras H. Renin and angiotensin II, aldosterone, salt and the kidney. In: Clinical Hypertension and Hypotension. Brunner HR, Gavras H, eds. Marcel Dekker Inc. New York,NY. 1982.

Gavras I, Gavras H, Chobanian AV, Tifft CP, Melby JC, Jick H. Hypertension and age: clinical and biochemical correlates. Clin Exp Hypertens A. 1982; 4(7):1097-106.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Jick, Hershel
Gavras, Irene

PMID: 6749343

Hatzinikolaou P, Gavras I, North WG, Brunner HR, Gavras H. Interaction of the sympathetic nervous system with vasopressin and renin in the maintenance of blood pressure in rats. Clin Sci. 1982; 63:313s-317s.

Burnier M, Turini GA, Brunner HR, Porchet M, Kruithof D, Vukovich RA, Gavras H. RHC 3659: a new orally active angiotensin converting enzyme inhibitor in normal volunteers. Br J Clin Pharmacol. 1981 Dec; 12(6):893-9. PMID: 6280740; PMCID: PMC1401926

Gavras H, Andrews P, Papadakis N. Reversal of experimental delayed cerebral vasospasm by angiotensin-converting enzyme inhibition. J Neurosurg. 1981 Dec; 55(6):884-8. PMID: 6170740

Gavras H, Biollaz J, Waeber B, Brunner HR, Gavras I, Sackel H, Charocopos F, Davies RO. Effects of the oral angiotensin-converting enzyme inhibitor MK-421 in human hypertension. Clin Sci (Lond). 1981 Dec; 61 Suppl 7:281s-283s.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6274572

Waeber B, Gavras I, Brunner HR, Gavras H. Safety and efficacy of chronic therapy with captopril in hypertensive patients: an update. J Clin Pharmacol. 1981 Nov-Dec; 21(11-12 Pt 1):508-16.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6460791

Hatzinikolaou P, Brecher P, Gavras H. Chronic hypertension increases tyrosine transport across the blood-brain barrier in the rat. Life Sci. 1981 Oct 19; 29(16):1657-60. PMID: 7311712

Gavras H, Brunner HR, Gavras I. Captopril in the treatment of hypertension. Ann Intern Med. 1981 Oct; 95(4):505-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7025722

Gavras H, Biollaz J, Waeber B, Brunner HR, Gavras I, Davies RO. Antihypertensive effect of the new oral angiotensin converting enzyme inhibitor "MK-421". Lancet. 1981 Sep 12; 2(8246):543-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6116000

Creager MA, Halperin JL, Bernard DB, Faxon DP, Melidossian CD, Gavras H, Ryan TJ. Acute regional circulatory and renal hemodynamic effects of converting-enzyme inhibition in patients with congestive heart failure. Circulation. 1981 Sep; 64(3):483-9. PMID: 6266691

Black J, Waeber B, Bresnahan MR, Gavras I, Gavras H. Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats. Circ Res. 1981 Aug; 49(2):518-24.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7249286

Wauters JP, Waeber B, Brunner HR, Guignard JP, Turini GA, Gavras H. Uncontrollable hypertension in patients on hemodialysis: long-term treatment with captopril and salt subtraction. Clin Nephrol. 1981 Aug; 16(2):86-92. PMID: 6266727

Gavras H, Waeber B, Kershaw GR, Liang CS, Textor SC, Brunner HR, Tifft CP, Gavras I. Role of reactive hyperreninemia in blood pressure changes induced by sodium depletion in patients with refractory hypertension. Hypertension. 1981 Jul-Aug; 3(4):441-7.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos
Gavras, Irene

PMID: 7030951

Hatzinikolaou P, Gavras H, Waeber B, Fisher GH, Ryan JW. Comparative study of three parenteral inhibitors of the angiotensin converting enzyme. Biochem Pharmacol. 1981 Jul 1; 30(13):1869-72. PMID: 6168270

Liang CS, Yi JM, Sherman LG, Black J, Gavras H, Hood WB. Dobutamine infusion in conscious dogs with and without acute myocardial infarction. Effects on systemic hemodynamics, myocardial blood flow, and infarct size. Circ Res. 1981 Jul; 49(1):170-80.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 7237692

Hatzinikolaou P, Gavras H, Brunner HR, Gavras I. Role of vasopressin, catecholamines, and plasma volume in hypertonic saline-induced hypertension. Am J Physiol. 1981 Jun; 240(6):H827-31.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7246746

Biollaz J, Burnier M, Turini GA, Brunner DB, Porchet M, Gomez HJ, Jones KH, Ferber F, Abrams WB, Gavras H, Brunner HR. Three new long-acting converting-enzyme inhibitors: relationship between plasma converting-enzyme activity and response to angiotensin I. Clin Pharmacol Ther. 1981 May; 29(5):665-70. PMID: 6260419

Textor SC, Gavras H, Tifft CP, Bernard DB, Idelson B, Brunner HR. Norepinephrine and renin activity in chronic renal failure. Evidence for interacting roles in hemodialysis hypertension. Hypertension. 1981 May-Jun; 3(3):294-9. PMID: 7019067

Gavras H, Charocopos F, Brunner H, Gavras I. Angiotensin converting enzyme inhibition: a new therapeutic modality. Bull N Y Acad Med. 1981 May; 57(4):304-10.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6164426; PMCID: PMC1805226

Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL. Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. Br J Clin Pharmacol. 1981 May; 11(5):461-7. PMID: 6268131; PMCID: PMC1401601

Faxon DP, Halperin JL, Creager MA, Gavras H, Schick EC, Ryan TJ. Angiotensin inhibition in severe heart failure: acute central and limb hemodynamic effects of captopril with observations on sustained oral therapy. Am Heart J. 1981 May; 101(5):548-56. PMID: 7013458

Spertini F, Brunner HR, Waeber B, Gavras H. The opposing effects of chronic angiotensin-converting enzyme blockade by captopril on the responses to exogenous angiotensin II and vasopressin vs. norepinephrine in rats. Circ Res. 1981 May; 48(5):612-8. PMID: 6260396

Textor SC, Brunner HR, Gavras H. Converting enzyme inhibition during chronic angiotensin II infusion in rats. Evidence against a nonangiotensin mechanism. Hypertension. 1981 Mar-Apr; 3(2):269-76. PMID: 6260647

Textor SC, Brunner H, Gavras H. Evidence for bradykinin potentiation by angiotensin congeners in conscious rats. Am J Physiol. 1981 Feb; 240(2):H255-61. PMID: 6258451

Gavras I, Gavras H, Tifft CP, Kershaw GR, Bresnahan M. Effect of pindolol on blood pressure, plasma renin activity, and catecholamines in hypertensive patients. J Clin Pharmacol. 1981 Feb-Mar; 21(2):79-83.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7014658

Brunner HR, Turini GA, Waeber B, Gavras H . Clinical pharmacological studies with captopril. In: Angiotensin Converting Enzyme Inhibitors: Mechanisms of Action and Clinical Implications, Horowitz ZP, ed. Urt and Schwarzenberg. Baltimore. 1981.
Gavras H, Gavras I . The renin angiotensin system in hypertension. In: Contemporary Issues in Nephrology, Hypertension, Brenner BM, Stein JH, eds. Churchill, Livingston. New York,NY. 1981; 8:65-99.

Gavras I, Graff LG, Rose BD, McKenna JM, Brunner HR, Gavras H. Fatal pancytopenia associated with the use of captopril. Ann Intern Med. 1981 Jan; 94(1):58-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7004300

Brunner HR, Waeber B, Turini GA, Wauters JP, Brunner DB, Gavras H. Position paper: angiotensin-converting enzyme blockade as a therapeutic modality. In: Frontiers in Hypertension Research, Laragh JH, F Buhler, Seldin DW, eds. Springer-Verlag. New York,NY. 1981; 503-516.
Gavras H, Gavras I, Brunner HR . Clinical relevance of reactive hyperreninemia. Res and Staff Phys. 1981; 27:65-72.
Gavras H, Hatzinikolaou P, Brunner HR, Gavras I. Clinical applications of angiotensin blockade. Eighth International Congress of Nephrology, Athens. Zurukzollu W, Pyrpasopoulos M, Sion M, Zamboulis C, eds. S Karger. Basel. 1981; 1060-1066.
Gavras H, Gavras I, Brunner HR . Hypertension, vasopressors and the susceptibility to vascular injury: experimental and clinical studies. In: Frontiers in Hypertension Research, Laragh JH, Buhler F, Seldin DW, eds. Springer-Verlag. New York,NY. 1981.
Brunner HR, Gavras H . Medical therapy of renovascular hypertension. Eighth International Congress of Nephrology, Athens, Zurukzoglu W, Papadimitriou M, Pyrpasopoulos M, Sion M, Zamboulis C, eds. S Karger. Basel. 1981; 1139-1145.

Waeber B, Brunner HR, Wauters JP, Gavras H. Angiotensin-converting enzyme inhibitors: pathogenic and therapeutic implications for arterial hypertension. Adv Nephrol Necker Hosp. 1981; 10:111-33. PMID: 6267906

Doherty JU, Liang C, Faillace RT, Yi M, Arnold S, Gavras H, Hood WB Jr. Inotropic and chronotropic effects of insulin in the conscious dog: contributions of catecholamines and hypoglycemia. Am J Cardiol. 1981; 47:460.
Gavras H, Gavras I, Brunner HR . Vasoconstriction and sodium volume factors in renovascular hypertension. In: Frontiers in Hypertension Research, Laragh JH, Buhler F, Seldin DW, eds. Springer-Verlag. New York,NY. 1981; 159-164.

Textor SC, Brunner HR, Gavras H. Converting enzyme inhibition during chronic angiotensin II infusion in rats: evidence against a non-angiotensin mechanism. Clin Sci (Lond). 1980 Dec; 59 Suppl 6:71s-74s. PMID: 6256120

Brunner HR, Gavras H. Is the renin system necessary? Am J Med. 1980 Nov; 69(5):739-45. PMID: 6254360

Gavras H, Liang C. Acute renovascular hypertension in conscious dogs. Interaction of the renin-angiotensin system and sympathetic nervous system in systemic hemodynamics and regional blood flow responses. Circ Res. 1980 Sep; 47(3):356-65.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 6157500

Hatzinikolaou P, Gavras H, Brunner HR, Gavras I. Sodium-induced elevation of blood pressure in the anephric state. Science. 1980 Aug 22; 209(4459):935-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7403861

Bresnahan MR, Hatzinikolaou P, Brunner HR, Gavras H. Effects of tyrosine infusion in normotensive and hypertensive rats. Am J Physiol. 1980 Aug; 239(2):H206-11. PMID: 7406057

Gavras I, Gavras H. Special considerations in treating hypertension in the elderly. Geriatrics. 1980 Jul; 35(7):34-40.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 7380255

Brunner HR, Gavras H, Waeber B, Textor SC, Turini GA, Wauters JP. Clinical use of an orally acting converting enzyme inhibitor: captopril. Hypertension. 1980 Jul-Aug; 2(4):558-66. PMID: 6995296

Gavras H, Gavras I, Brunner HR. Angiotensin inhibitors for hypertension. Compr Ther. 1980 May; 6(5):14-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 6155240

Faxon DP, Creager MA, Halperin JL, Gavras H, Coffman JD, Ryan TJ. Central and peripheral hemodynamic effects of angiotensin inhibition in patients with refractory congestive heart failure. Circulation. 1980 May; 61(5):925-30. PMID: 6153939

Kowaloff H, Gavras H, Brecher P. Reninlike enzymatic activity in the cerebral microvessels of the rat. Am J Physiol. 1980 Mar; 238(3):H384-8. PMID: 6989271

Waeber B, Brunner HR, Brunner DB, Curtet AL, Turini GA, Gavras H. Discrepancy between antihypertensive effect and angiotensin converting enzyme inhibition by captopril. Hypertension. 1980 Mar-Apr; 2(2):236-42. PMID: 6247269

Brunner HR, Gavras H, Waeber B, Turini GA, Wauters JP. Captopril: an oral angiotension converting enzyme inhibitor active in man. Arch Int Pharmacodyn Ther. 1980; Suppl:188-212. PMID: 6251762

Gavras H. Angiotensin inhibition for he characterization and treatment of arterial hypertension. Proceedings of the First Panhellenic Congress of Nephrology, Thessaloniki, March. 1980.
Volicer L, Volicer BJ, Gavras H . The effect of alcohol intake on compliance with antihypertensive treatment. In: Alcoholism: A Perspective. Messiha FS, Tyner GS, eds. PJD Publications Ltd. Westbury, New York. 1980; 88-99.
Waeber B, Brunner HR, Gavras H . Les inhibiteurs de l'enzyme de conversion de l'angiotensine: implications pathogeniques et therapeutiques dans l'hypertension arterielle. In: Actualites Nephrologiques de l`Hopital Necker. Flammarion. Belgium. 1980.
Gavras H. B158Congestive heart failure: treatment by angiotensin blockade. Primary Cardiol. 1980; 6:103-113.
Brunner HR, Waeber B, Gavras H, Brunner DB . Zwechmassige Anwendung von Diuretika in der Behandlung der Arteriellen Hypertonie. In: Diuretika, Rosenthal J, Knauf H, eds. Edition Medizin. Weinheim, Germany. 1980; 307-318.

Brunner HR, Gavras H, Waeber B. Enhancement by diuretics of the antihypertensive action of long-term angiotensin converting enzyme blockade. Clin Exp Hypertens. 1980; 2(3-4):639-57. PMID: 6253243

Gavras H, Gavras I, Hadzinikolaou P, Brunner HR. Inhibition of angiotensin conversion: its role in treatment of hypertension and congestive heart failure. J Cardiovasc Med. 1980; 5:327-335.
Gavras H, Gavras I, Textor S, Tifft CP, Kershaw GR, Brunner HR . The use of SQ 20881 converting enzyme inhibitor (teprotide) for diagnostic purposes in hypertension. In: Captopril and Hypertension. Case D, Sonnenblick E, Laragh JH, eds. Plenum Medical Book Company. New York,NY. 1980; 210-214.

Liang C, Tuttle RR, Hood WB, Gavras H. Conditioning effects of chronic infusions of dobutamine. Comparison with exercise training. J Clin Invest. 1979 Aug; 64(2):613-9.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 457872; PMCID: PMC372158

Chobanian AV, Volicer L, Tifft CP, Gavras H, Liang CS, Faxon D. Mineralocorticoid-induced hypertension in patients with orthostatic hypotension. N Engl J Med. 1979 Jul 12; 301(2):68-73.View Related Profiles.

Chobanian, Aram
Liang, Chang-seng
Gavras, Haralambos

PMID: 449947

Turini GA, Brunner HR, Gribic M, Waeber B, Gavras H. Improvement of chronic congestive heart-failure by oral captopril. Lancet. 1979 Jun 9; 1(8128):1213-5. PMID: 87679

Brunner HR, Waeber B, Gavras H. Rational use of captopril. Lancet. 1979 Apr 14; 1(8120):832. PMID: 86084

Gavras H, Gavras I, Brunner HR, Liang CS. Physiologic studies with saralasin in animals. Kidney Int Suppl. 1979 Mar; (9):S20-8.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos
Gavras, Irene

PMID: 384069

Volicer L, Liang CS, Gavras H, Tifft CP, Kershaw GR, Gavras I, Griffith DL, Vukovitch R, Brunner HR. Effect of nadolol in treatment of hypertension. J Clin Pharmacol. 1979 Feb-Mar; 19(2-3):137-47.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos
Gavras, Irene

PMID: 33998

Volicer L, O'Donnell A, Chase A, Gavras H. Cyclic nucleotide levels in brains of control and hypertensive rats. Life Sci. 1979 Jan 8; 24(2):131-5. PMID: 216871

Brunner HR, Gavras H, Waeber B, Turini GA, McKinstry DN, Vukovich RA, Gavras I. Orally active angiotensin-converting enzyme inhibitor (SO 14,225) as a treatment for essential hypertension. Br J Clin Pharmacol. 1979; 7 Suppl 2:205S-211S.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 223614; PMCID: PMC1429327

Wauters JP, Waeber B, Brunner HR, Turini GA, Guignard JP, Gavras H. Captopril and salt subtraction to treat "uncontrollable" hypertension in haemodialysis patients. Proc Eur Dial Transplant Assoc. 1979; 16:610-7. PMID: 232915

Gavras H, Gavras I, Brunner HR . Converting enzyme inhibition in the diagnosis and treatment of hypertension. In: Controversies in Nephrology - Schreiner GE, Winchester JF, Mattern W, Mendelson BF, eds. Washington DC. 1979; 1:260-268.

Gavras I, Gavras H, Sullivan PC, Tifft CP, Chobanian AV, Brunner HR. A comparative study of the effects of oxprenolol versus propranolol in essential hypertension. J Clin Pharmacol. 1979 Jan; 19(1):8-14.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Gavras, Irene

PMID: 368088

Tifft CP, Gavras H, Kershaw GR, Gavras I, Brunner HR, Liang CS, Chobanian AV. Converting enzyme inhibition in hypertensive emergencies. Ann Intern Med. 1979 Jan; 90(1):43-7.View Related Profiles.

Chobanian, Aram
Liang, Chang-seng
Gavras, Haralambos
Gavras, Irene

PMID: 420460

Brunner HR, Gavras H, Waeber B, Kershaw GR, Turini GA, Vukovich RA, McKinstry DN, Gavras I. Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. Ann Intern Med. 1979 Jan; 90(1):19-23.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 217289

Brunner HR, Waeber B, Ferguson RK, Turini GA, Gavras H. The position of beta-blockers in antihypertensive therapy. Comparison with other antihypertensive agents. Cardiology. 1979; 64 Suppl 1:88-95. PMID: 42489

Brunner HR, Waiters JP, Waeber B, Gavras H. The renin angiotensin system in hypertensive patients with chronic renal failure. In mitteilungen der Arbeitsgemeinschaft fur Klin. Nephrologie. 1979; 8:4-14.

Gavras I, Gavras H, Brunner HR, Liang CS. Antihypertensive action of beta-adrenoceptor blockade and the renin-angiotensin system. Br J Clin Pharmacol. 1979; 7 Suppl 2:213S-217S.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos
Gavras, Irene

PMID: 37876; PMCID: PMC1429320

Waeber B, Brunner HR, Turini GA, Curtet N, Keller I, Gavras H. [Potentiation of the antihypertensive effect of captopril by diuretics (author's transl)]. Ann Cardiol Angeiol (Paris). 1979 Jan-Feb; 28(1):9-11. PMID: 219758

Waeber B, Gavras H, Brunner HR, Chappuis P, Turini GA. [Chronic treatment of hypertension by an inhibitor of angiotensin converting enzyme]. Schweiz Med Wochenschr. 1978 Dec 9; 108(49):1981-3.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 219469

Liang CS, Gavras H, Brunner HR. Redistribution of regional blood flow after administration of saralasin in salt-depleted dogs. Clin Sci Mol Med Suppl. 1978 Dec; 4:243s-246s.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 282061

Chobanian AV, Gavras H, Melby JC, Gavras I, Jick H. Relationship of basal plasma noradrenaline to blood pressure, age, sex, plasma renin activity and plasma volume in essential hypertension. Clin Sci Mol Med Suppl. 1978 Dec; 4:93s-96s.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Jick, Hershel
Gavras, Irene

PMID: 282107

Brunner HR, Gavras H, Turini GA, Waeber B, Cappuis P, McKinstry DN. Long-term treatment of hypertension in man by an orally active angiotensin-converting enzyme inhibitor. Clin Sci Mol Med Suppl. 1978 Dec; 4:293s-295s. PMID: 215374

Jaeger P, Brunner HR, Turini GA, Jéquier E, Ferguson RK, Gavras H. [Long-term minoxidil therapy: renin, aldosterone, noradrenaline and the need for beta blockers]. Schweiz Med Wochenschr. 1978 Nov 4; 108(44):1707-9. PMID: 715407

Liang CS, Gavras H. Renin-angiotensin system inhibition in conscious dogs during acute hypoxemia. Effects on systemic hemodynamics, regional blood flows, and tissue metabolism. J Clin Invest. 1978 Nov; 62(5):961-70.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 711860; PMCID: PMC371854

Gavras H, Faxon DP, Berkoben J, Brunner HR, Ryan TJ. Angiotensin converting enzyme inhibition in patients with congestive heart failure. Circulation. 1978 Nov; 58(5):770-6. PMID: 699246

Brecher P, Tercyak A, Gavras H, Chobanian AV. Peptidyl dipeptidase in rabbit brain microvessels. Biochim Biophys Acta. 1978 Oct 12; 526(2):537-46.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos

PMID: 214128

Turini GA, Brunner HR, Ferguson RK, Rivier JL, Gavras H. Congestive heart failure in normotensive man. Haemodynamics, renin, and angiotensin II blockade. Br Heart J. 1978 Oct; 40(10):1134-42. PMID: 708515; PMCID: PMC483539

Brunner HR, Waeber B, Wauters JP, Turin G, McKinstry D, Gavras H. Innappropriate renin secretion unmasked by captopril (SQ 14 225) in hypertension of chronic renal failure. Lancet. 1978 Sep 30; 2(8092 Pt 1):704-7. PMID: 80634

Chobanian AV, Garvras H, Gavras I, Bresnahan M, Sullivan P, Melby JC. Studies on the activity of the sympathetic nervous system in essential hypertension. J Human Stress. 1978 Sep; 4(3):22-8.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Gavras, Irene

PMID: 690418

Koch-Weser J. Angiotensin converting-enzyme inhibitor in refractory hypertension. N Engl J Med. 1978 Aug 17; 299(7):363-4. PMID: 210382

Brunner HR, Jaeger P, Ferguson RK, Jequier E, Turini G, Gavras H. Need for beta-blockade in hypertension reduced with long-term minoxidil. Br Med J. 1978 Aug 5; 2(6134):385-8. PMID: 28811; PMCID: PMC1609020

Jaeger P, Ferguson RK, Brunner HR, Turini GA, Gavras H. Relationships of renin and aldosterone to antihypertensive effects of spironolactone and propranolol. J Clin Pharmacol. 1978 Jul; 18(7):311-8. PMID: 353088

Gavras H, Brunner HR, Turini GA, Kershaw GR, Tifft CP, Cuttelod S, Gavras I, Vukovich RA, McKinstry DN. Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man. N Engl J Med. 1978 May 4; 298(18):991-5.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 205788

Turini GA, Brunner HR, Ferguson RK, Rivier JL, Gavras H. Angiotensin II blockade in congestive heart failure. Arch Int Pharmacodyn Ther. 1978 May; 233(1):166-76. PMID: 686905

Jaeger P, Ferguson RK, Brunner HR, Kirchertz EJ, Gavras H. Mechanism of blood pressure reduction by teprotide (SQ 20881) in rats. Kidney Int. 1978 Apr; 13(4):289-96. PMID: 651128

Liang CS, Gavras H, Hood WB. Renin-angiotensin system inhibition in conscious sodium-depleted dogs. Effects on systemic and coronary hemodynamics. J Clin Invest. 1978 Apr; 61(4):874-83.View Related Profiles.

Liang, Chang-seng
Gavras, Haralambos

PMID: 659580; PMCID: PMC372606

Gavras H, Gavras I, Textor S, Volicer L, Brunner HR, Rucinska EJ. Effect of angiotensin converting enzyme inhibition on blood pressure, plasma renin activity and plasma aldosterone in essential hypertension. J Clin Endocrinol Metab. 1978 Feb; 46(2):220-6.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 220274

Jaeger P, Ferguson RK, Brunner GR, Turini GA, Gavras H, Brunner HR . La tension arterielle, la renine et l'aldosterone au cours d'un essay controle avec la spironolactone et le propranolol, seuls et en association. La Revue de Medicine. 1978; 19:45-51.

Chobanian AV, Gavras H, Melby JC, Gavras I, Jick H. Relationship of basal plasma norepinephrine to blood pressure, plasma renin activity, mineralocorticoids, and plasma volume in essential hypertension. Trans Assoc Am Physicians. 1978; 91:368-80.View Related Profiles.

Chobanian, Aram
Gavras, Haralambos
Jick, Hershel
Gavras, Irene

PMID: 754399

Liang C, Gavras H, Hood W. Systemic and coronary hemodynamic effect of renin-angiotensin system inhibition in sodium depleted dogs. Amer J Cardiol. 1978; 41:394.
Gavras H, Gavras I. Angiotensin inhibition: a new approach to the treatment of hypertension. Iatriki. 1978; 34:521-525.

Gavras H, Gavras I, Cannon PJ, Brunner HR, Laragh JH. Is elevated plasma renin activity of prognostic importance in progressive systemic sclerosis? Arch Intern Med. 1977 Nov; 137(11):1554-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 921442

Gavras H, Flessas A, Ryan TJ, Brunner HR, Faxon DP, Gavras I. Angiotensin II inhibition. Treatment of congestive cardiac failure in a high-renin hypertension. JAMA. 1977 Aug 22; 238(8):880-2.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 577978

Gavras H, Gavras I, Brunner HR, Laragh JH. The antihypertensive action of methyldopa in relation to its effect on the renin-aldosterone system. J Clin Pharmacol. 1977 Jul; 17(7):372-8.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 881470

Gavras H, Gavras I, Brunner HR, Laragh JH. Effect of a new beta-adrenergic blocker, l-bunolol, on blood pressure and on the renin-aldosterone system. J Clin Pharmacol. 1977 May-Jun; 17(5-6):350-7.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 323300

Ferguson RK, Turini GA, Brunner HR, Gavras H, McKinstry DN. A specific orally active inhibitor of angiotensin-converting enzyme in man. Lancet. 1977 Apr 9; 1(8015):775-8. PMID: 66571

Posternak L, Brunner HR, Gavras H, Brunner DB. Angiotensin II blockade in normal man: interaction of renin and sodium in maintaining blood pressure. Kidney Int. 1977 Mar; 11(3):197-203. PMID: 846071

Brunner HR, Gavras H. Vascular damage in hypertension. In: Hypertension: Mechanisms, Diagnosis and Management, Davis JO, Laragh JH, Selwyn A, eds. HP Publishing Co. New York,NY. 1977; 169-180.
Jaeger P, Ferguson RK, Brunner HR, Gavras H . Comparison of SQ 20881 and saralasin in normotensive and hypertensive rats. Kidney Int. 1977; 12:75.

Brunner HR, Gavras H. [Angiotensin II inhibitors for the diagnosis and treatment of hypertension]. Schweiz Med Wochenschr. 1976 Dec 11; 106(50):1791-8. PMID: 1013701

Gavras H, Ribeiro AB, Gavras I, Brunner HR. Reciprocal relation between renin dependency and sodium dependency in essential hypertension. N Engl J Med. 1976 Dec 2; 295(23):1278-83.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 980059

Gavras H, Ribeiro A, Brunner HR, Gavras I. Determination of renin-dependency and sodium-dependency in the three renin sub-groups of essential hypertension. Clin Sci Mol Med Suppl. 1976 Dec; 3:197s-200s.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1071607

Gavras H, Brunner HR. Letter: Renin profiling in hypertension. N Engl J Med. 1976 Sep 23; 295(13):734. PMID: 958254

Brunner HR, Gavras H, Ribeiro AB, Posternak L. Angiotensin II blockade in normal man and patients with essential hypertension. Blood pressure effects depending on renin and sodium balance. Prog Biochem Pharmacol. 1976; 12:145-62.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1019161

Gavras H, Oliver JA, Cannon PJ. Interrelations of renin, angiotensin II, and sodium in hypertension and renal failure. Annu Rev Med. 1976; 27:485-521. PMID: 779610

Brunner HR, Gavras H. Les inhibiteurs de l"angiotensine II pour le diagnostic et le traitment de l'hypertension. Schweiz Med Wschr. 1976; 106:1791.

Brunner HR, Gavras H. Pathophysiological concepts of renovascular hypertension. Contrib Nephrol. 1976; 3:20-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1026366

Vaughan ED, Bühler FR, Laragh JH, Sealey JE, Gavras H, Baer L. Hypertension and unilateral parenchymal renal disease. Evidence for abnormal vasoconstriction-volume interaction. JAMA. 1975 Sep 15; 233(11):1177-83. PMID: 1174172

Brunner HR, Gavras H. Clinical implications of renin in the hypertensive patient. JAMA. 1975 Sep 8; 233(10):1091-3. PMID: 1174160

Gavras H, Oliver N, Aitchison J, Begg C, Briggs JD, Brown JJ, Horton PW, Lee F, Lever AF, Prentice C, Robertson JI. Abnormalities of coagulation and the development of malignant phase hypertension. Kidney Int Suppl. 1975 Sep; S252-61. PMID: 1059805

Gavras H, Brunner HR, Thurston H, Laragh JH. Reciprocation of renin dependency with sodium volume dependency in renal hypertension. Science. 1975 Jun 27; 188(4195):1316-7. PMID: 1145199

Gavras H, Brunner HR, Laragh JH, Gavras I, Vukovich RA. The use of angiotensin-converting enzyme inhibitor in the diagnosis and treatment of hypertension. Clin Sci Mol Med Suppl. 1975 Jun; 2:57s-60s.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 1077792

Gavras H, Kremer D, Brown JJ, Gray B, Lever AF, MacAdam RF, medina A, Morton JJ, Robertson JI. Angiotensin- and norepinephrine-induced myocardial lesions: experimental and clinical studies in rabbits and man. Am Heart J. 1975 Mar; 89(3):321-32. PMID: 234666

Gavras H, Brunner HR, Laragh JH, Vaughan ED, Koss M, Cote LJ, Gavras I. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes. Circ Res. 1975 Feb; 36(2):300-9.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 234807

Brunner HR, Gavras H . Vascular damage in hypertension. Hospital Practice. 1975; 10:97-108.
Brunner HR, Gavras H. The role of renin and sodium in high blood pressure regulation. In: Pathophysiology and management of arterial hypertension. Berglund G, Hansson I, Werko L, eds. AB Hassle. Molndel, Sweden. 1975; 32-44.
Brunner HR, Gavras H. Sodium dependent hypertension. Medcom. 1975.

Paton AM, Lever AF, Oliver NW, Medina A, Briggs JD, Morton JJ, Brown JJ, Robertson JI, Fraser R, Tree M, Gavras H. Plasma angiotensin II, renin, renin-substrate and aldosterone concentrations in acute renal failure in man. Clin Nephrol. 1975 Jan; 3(1):18-23. PMID: 1126059

Gavras H, Oliver N, Brown JJ, Aitchison J, Briggs JD, Lee F, Lever AF, Robertson JIS . Microangiopathic hemolytic anemia and the pathogenesis of malignant hypertension. Kidney Int. 1975; 8:S-252.

Laragh JH, Sealey JE, Bühler FR, Vaughan ED, Brunner HR, Gavras H, Baer L. The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. Am J Med. 1975 Jan; 58(1):4-13. PMID: 234677

Gavras H, Brunner HR, Laragh JH, Sealey JE, Gavras I, Vukovich RA. An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients. N Engl J Med. 1974 Oct 17; 291(16):817-21.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 4371298

Brunner HR, Gavras H. [Renin and sodium in blood pressure regulation]. Schweiz Med Wochenschr. 1974 Oct 5; 104(40):1401-11. PMID: 4376263

Gavras H, Brunner HR. [Renin and sodium and the formation of vascular lesions in hypertension]. Schweiz Med Wochenschr. 1974 Sep 21; 104(38):1301-10. PMID: 4371116

Brunner HR, Gavras H, Laragh JH. Specific inhibition of the renin-angiotensin system: A key to understanding blood pressure regulation. Prog Cardiovasc Dis. 1974 Sep-Oct; 17(2):87-98. PMID: 4369198

Gavras H, Brunner HR, Gavras I, Laragh JH. Letter: Hypotensive effect of angiotensin-converting-enzyme inhibitor SQ 20,881. Lancet. 1974 Aug 10; 2(7876):353.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 4136088

Gavras H, Brunner HR, Laragh JH. Renin and aldosterone and the pathogenesis of hypertensive vascular damage. Prog Cardiovasc Dis. 1974 Jul-Aug; 17(1):39-49. PMID: 4365952

Vaughan ED Jr, Laragh JH, Gavras I, Buhler FR, Gavras H, Brunner HR, Baer L . The volume factor in low and normal renin essential hypertension. Its treatment with either spironolactone or chlorothalidone. In Hypertension Manual, Laragh JH, ed. Dunn-Donnelly Publ Co. New York,NY. 1974; 851-871.
Buhler FR, Laragh JH, Vaughan ED Jr, Brunner HR, Gavras H, Baer L. The antihypertensive action of propranolol: specific anti-renin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension. In: Hypertension Manual, Laragh JH, ed. Dunn-Donnelly Publ Co. New York,NY. 1974; 873-989.

Brunner HR, Gavras H, Laragh JH. Angiotensin-II blockade in man by sar1-ala8-angiotensin II for understanding and treatment of high blood-pressure. Lancet. 1973 Nov 10; 2(7837):1045-8. PMID: 4127309

Vaughan ED, Laragh JH, Gavras I, Bühler FR, Gavras H, Brunner HR, Baer L. Volume factor in low and normal renin essential hypertension. Treatment with either spironolactone or chlorthalidone. Am J Cardiol. 1973 Sep 20; 32(4):523-32.View Related Profiles.

Gavras, Haralambos
Gavras, Irene

PMID: 4729722

Bühler FR, Laragh JH, Vaughan ED, Brunner HR, Gavras H, Baer L. Antihypertensive action of propranolol. Specific antirenin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension. Am J Cardiol. 1973 Sep 20; 32(4):511-22. PMID: 4729721

Oliver N, Gavras H, Aitchison J, Begg C, Briggs JD, Brown JJ, Horton PW, Lee F, Lever AF, Prentice C, Robertson JI. Microangiopathic haemolytic anaemia in malignant phase hypertension. Br Heart J. 1973 Aug; 35(8):863. PMID: 4729850

Gavras H, Brunner HB, Vaughan ED, Laragh JH. Angiotensin-sodium interaction in blood pressure maintenance of renal hypertensive and normotensive rats. Science. 1973 Jun 29; 180(4093):1369-71. PMID: 4350930

Vaughan ED, Gavras H, Laragh JH, Koss MN. Vascular permeability factor: dissociation from the angiotensin II induced pressor and drinking responses. Nature. 1973 Mar 30; 242(5396):334-5. PMID: 4349236

Brown JJ, Gavras H, Kremer D, Lever AF, MacGregor J, Powell-Jackson JD, Robertson JIS. Renin and acute renal failure. Proceedings of Conference on Acute Renal Failure, State University of New York, Downstate Medical Center. Washington, D.C.: U.S. Government Printing Office. 1973; 57.

Lawson DH, Macadam RF, Singh MH, Gavras H, Hartz S, Turnbull D, Linton AL. Effect of furosemide on antibiotic-induced renal damage in rats. J Infect Dis. 1972 Dec; 126(6):593-600. PMID: 4664116

Leckie B, Gavras H, McGregor J, McElwee G. The conversion of angiotensin I to angiotensin II by rabbit glomeruli. J Endocrinol. 1972 Oct; 55(1):229-30. PMID: 4350083

Papapetrou PD, Marchant B, Gavras H, Alexander WD. Biliary excretion of 35 S-labelled propylthiouracil, methimazole and carbimazole in untreated and pentobarbitone pretreated rats. Biochem Pharmacol. 1972 Feb 1; 21(3):363-77. PMID: 4111354

MacGregor J, Briggs JD, Brown JJ, Chinn RC, Gavras H, Lever AF, MacAdam RF, Medina A, Morton JJ, Oliver NWJ, Paton A, Powell-Jackson JD, Robertson JIS Waite MA. Renin and renal function. International Congress Series #268. Modern Diuretic Therapy in the Treatment of Cardiovascular and Renal Disease. Amsterdam: Excerpta Medica. 1972; 71.

Brown WC, Brown JJ, Gavras H, Jackson A, Lever AF, McGregor J, MacAdam RF, Robertson JI. Renin and acute circulatory renal failure in the rabbit. Circ Res. 1972 Jan; 30(1):114-22. PMID: 5007522

Brown JJ, Chinn RH, Gavras H, Leckie B, Lever AF, MacGregor J, Morton J, Robertson JIS . Renin and renal function. In: Hypertension 1972, Genest J, Koiw E, eds. Springer-Verlag. Berlin. 1972.

Gavras H, Lawson DH, Linton AL. Extended therapy with a trimethoprim-sulphonamide for the treatment of established urinary tract infection. Scott Med J. 1971 Dec; 16(12):506-8. PMID: 4944205

Gavras H, Lever AF, Brown JJ, Macadam RF, Robertson JI. Acute renal failure, tubular necrosis, and myocardial infarction induced in the rabbit by intravenous angiotensin II. Lancet. 1971 Jul 3; 2(7714):19-22. PMID: 4103665

Gavras H, Brown WC, Brown JJ, Lever AF, Linton AL, MacAdam RF, McNicol GP, Robertson JI, Wardrop C. Microangipathic hemolytic anemia and the development of the malignant phase of hypertension. Circ Res. 1971 May; 28(5):Suppl 2:127-42. PMID: 5568228

Brown JJ, Gavras H, Leckie B, Lever AF, MacAdam RF, Morton JJ, Robertson JIS. Acute renal circulatory failure: a probable manifestation of excess renin release. In: Control of Renin Secretion, Assaykeen TA, ed. Plenum Publishing Co. New York,NY. 1971.
Gavras H, Brown JJ, Lever AF, MacAdam RF, Robertson JIS . Angiotensin II and renal failure. Lancet II: (Letter). 1971; 764-765.

Lawson DH, Macadam RF, Singh H, Gavras H, Linton AL. The nephrotoxicity of cephaloridine. Postgrad Med J. 1970 Oct; Suppl:36-9. PMID: 5488206

Gavras H, Brown JJ, Lever AF, Robertson JI. Changes of renin in individual glomeruli in response to variations of sodium intake in the rabbit. Clin Sci. 1970 Apr; 38(4):409-14. PMID: 5428805

Brown JJ, Brown WCB, Dusterdieck G, Gavras H, Gleadle RI, Jackson AM, Lawson DH, Lever AF, Linton AL, MacGregor M, MacAdam RF, Prentice E, Robertson JIS, Tree M. Renin and acute renal failure. Eur J Clin Invest. 1970; 1:127.

Linton AL, Gavras H, Gleadle RI, Hutchison HE, Lawson DH, Lever AF, Macadam RF, McNicol GP, Robertson JI. Microangiopathic haemolytic anaemia and the pathogenesis of malignant hypertension. Lancet. 1969 Jun 28; 1(7609):1277-82. PMID: 4182177

Melleissinos K, Gavras H, Danopoulos E . Thrombocytopenia in the liver cirrhosis resembling idiopathic-thrombocytopenic purpura (Werlhof's disease). Nosokomiaka Chron. 1969; 31:379.
Yatzidis H, Gavras H. The diagnostic value of the different tests in hypertension renal vascular disease. Nosokomiaka Chron. 1968; 30:33-45.
Gavras H. The value of different tests in the diagnosis of occlusive renal artery hypertension (clinical and laboratory studies of 29 cases). Thesis, Athens University. 1967.

YATZIDIS H, OREOPOULOS D, TRIANTAPHYLLIDIS D, VOUDICLARI S, TSAPARAS N, GAVRAS C, STAVROULAKI A. TREATMENT OF SEVERE BARBITURATE POISONING. Lancet. 1965 Jul 31; 1(7405):216-7. PMID: 14315232

Gavras H. Result of the U.S. Hypertension Report Card.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 389 publications over 36 distinct years, with a maximum of 34 publications in 1981

Bar chart showing 389 publications over 36 distinct years, with a maximum of 34 publications in 1981

Year	Publications
1980	20
1981	34
1982	31
1983	10
1984	12
1985	11
1986	14
1987	11
1988	14
1989	14
1990	21
1991	15
1992	10
1993	11
1994	5
1995	15
1996	12
1997	11
1998	13
1999	13
2000	12
2001	15
2002	7
2003	8
2004	13
2005	12
2006	10
2007	2
2008	3
2009	2
2010	3
2011	1
2012	1
2013	1
2014	1
2020	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

basic research
clinical research
hypertension
lectures

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