Nancy L Heard-Costa, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

PhD, University of Alabama at Birmingham
MPH, Boston University School of Public Health
BA, Ripon College



Expertise includes: Data management - both phenotype and genetic in nature, including storage , maintenance, quality control; Genetic data cleaning - both in unrelated and related individuals; Pedigree creation, verification and maintenance; Forensic analysis of genetic samples - identification of incorrect, cryptic duplicate, and related subject; Statistical analysis -from univariate to multivariate and more complex models, including design, implementation and interpretation/conclusion; Genetic statistical analysis - linkage, association and meta-analysis, including design, implementation and interpretation/conclusion; and Human Medical Genetics theory and practice.

Center Faculty Member
Framingham Heart Study
Framingham Heart Study




Return of Genomic Results and Estimating Penetrance in Population-Based Cohorts
08/01/2019 - 06/30/2024 (Subcontract PI)
Broad Institute, Inc., The NIH NHLBI
1R01HL143295-04



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR. GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study. Pharmacol Res. 2025 Jan 09; 212:107575.View Related Profiles. PMID: 39798939
     
  2. Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Cumhur DY, Heard-Costa NL, Orchard P, Carson AP, Raffield LM, Reiner A, Li Y, O'Connor G, Murabito JM, Munson P, Levy D. Integrating Whole Genome and Transcriptome Sequencing to Characterize the Genetic Architecture of Isoform Variation and its Implications for Health and Disease. medRxiv. 2024 Dec 06.View Related Profiles. PMID: 39677465; PMCID: PMC11643148; DOI: 10.1101/2024.12.04.24318434;
     
  3. Carbonneau M, Li Y, Qu Y, Zheng Y, Wood AC, Wang M, Liu C, Huan T, Joehanes R, Guo X, Yao J, Taylor KD, Tracy RP, Peter D, Liu Y, Johnson WC, Post WS, Blackwell T, Rotter JI, Rich SS, Redline S, Fornage M, Wang J, Ning H, Hou L, Lloyd-Jones D, Ferrier K, Min YI, Carson AP, Raffield LM, Teumer A, Grabe HJ, Völzke H, Nauck M, Dörr M, Domingo-Relloso A, Fretts A, Tellez-Plaza M, Cole S, Navas-Acien A, Wang M, Murabito JM, Heard-Costa NL, Prescott B, Xanthakis V, Mozaffarian D, Levy D, Ma J. DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases. medRxiv. 2024 Nov 20.View Related Profiles. PMID: 39606375; PMCID: PMC11601778; DOI: 10.1101/2024.11.19.24317587;
     
  4. Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483.View Related Profiles. PMID: 39428839; PMCID: PMC11667527; DOI: 10.1002/alz.14283;
     
  5. Rocheleau G, Clarke SL, Auguste G, Hasbani NR, Morrison AC, Heath AS, Bielak LF, Iyer KR, Young EP, Stitziel NO, Jun G, Laurie C, Broome JG, Khan AT, Arnett DK, Becker LC, Bis JC, Boerwinkle E, Bowden DW, Carson AP, Ellinor PT, Fornage M, Franceschini N, Freedman BI, Heard-Costa NL, Hou L, Chen YI, Kenny EE, Kooperberg C, Kral BG, Loos RJF, Lutz SM, Manson JE, Martin LW, Mitchell BD, Nassir R, Palmer ND, Post WS, Preuss MH, Psaty BM, Raffield LM, Regan EA, Rich SS, Smith JA, Taylor KD, Yanek LR, Young KA, Hilliard AT, Tcheandjieu C, Peyser PA, Vasan RS, Rotter JI, Miller CL, Assimes TL, de Vries PS, Do R. Rare variant contribution to the heritability of coronary artery disease. Nat Commun. 2024 Oct 09; 15(1):8741. PMID: 39384761; PMCID: PMC11464707; DOI: 10.1038/s41467-024-52939-6;
     
  6. Levy D, Kirmani S, Huan T, Van Amburg J, Joehanes R, Uddin MM, Nguyen NQ, Yu B, Brody J, Fornage M, Bressler J, Sotoodehnia N, Ong D, Puddu F, Floyd J, Ballantyne C, Psaty B, Raffield L, Natarajan P, Conneely K, Carson A, Lange L, Ferrier K, Heard-Costa N, Murabito J, Bick A. Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation. Res Sq. 2024 Jul 16.View Related Profiles. PMID: 39070619; PMCID: PMC11276001; DOI: 10.21203/rs.3.rs-4656898/v1;
     
  7. Xu H, Gupta S, Dinsmore I, Kollu A, Cawley AM, Anwar MY, Chen HH, Petty LE, Seshadri S, Graff M, Below P, Brody JA, Chittoor G, Fisher-Hoch SP, Heard-Costa NL, Levy D, Lin H, Loos RJ, Mccormick JB, Rotter JI, Mirshahi T, Still CD, Destefano A, Cupples LA, Mohlke KL, North KE, Justice AE, Liu CT. Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci. medRxiv. 2024 Jun 12.View Related Profiles. PMID: 38903089; PMCID: PMC11188121; DOI: 10.1101/2024.06.11.24308730;
     
  8. Carbonneau M, Li Y, Prescott B, Liu C, Huan T, Joehanes R, Murabito JM, Heard-Costa NL, Xanthakis V, Levy D, Ma J. Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality. J Am Heart Assoc. 2024 Jun 04; 13(11):e032743.View Related Profiles. PMID: 38808571; PMCID: PMC11255626; DOI: 10.1161/JAHA.123.032743;
     
  9. Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett D, Barnes K, Bis JC, Blackwell T, Becker LC, Boerwinkle E, Bowler RP, Budoff MJ, Carson AP, Chen J, Cho MH, Coresh J, Cox N, de Vries PS, DeMeo DL, Fardo DW, Fornage M, Guo X, Hall ME, Heard-Costa N, Hidalgo B, Irvin MR, Johnson AD, Kenny EE, Levy D, Li Y, Lima JA, Liu Y, Loos RJF, Machiela MJ, Mathias RA, Mitchell BD, Murabito J, Mychaleckyj JC, North K, Orchard P, Parker SC, Pershad Y, Peyser PA, Pratte KA, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Shah SJ, Smith JA, Smith AP, Smith A, Taub M, Tiwari HK, Tracy R, Tuftin B, Bick AG, Sankaran VG, Reiner AP, Scheet P, Auer PL. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood. medRxiv. 2024 Apr 19.View Related Profiles. PMID: 38699360; PMCID: PMC11065036; DOI: 10.1101/2024.04.16.24305851;
     
  10. Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE, Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL. Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data. Alzheimers Dement. 2024 May; 20(5):3290-3304.View Related Profiles. PMID: 38511601; PMCID: PMC11095439; DOI: 10.1002/alz.13705;
     
Showing 10 of 112 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 112 publications over 24 distinct years, with a maximum of 17 publications in 2023

YearPublications
20013
20021
20036
20042
20052
20061
20074
20093
20103
20111
20123
20134
20145
20155
20164
20176
20184
20195
20202
20219
202211
202317
202410
20251

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

genetic analysis
genetic forensic analysis
pedigree analysis
statistical analysis
Contact for Mentoring:

72 E. Concord St Robinson (B)
Boston MA 02118
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