George T. O'Connor, MD
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health
BA, Boston University



My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I am currently a multiple PI and Co-director of the NHLBI's Framingham Heart Study, and I am a co-investigator in the Risk Underlying Rural Areas Longitudinal (RURAL) Cohort Study. I am the Boston University-Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, including the All of Us Research Program, the Childhood Asthma in Urban Settings (CAUSE) consortium, and the Vitamin D Antenatal Asthma Reduction Trial (VDAART. I have led the BU-BMC site of clinical trials in children and adolescents with asthma and the Urban Environment and Childhood Asthma (URECA) birth-cohort study examining the risk factors for asthma and allergy in urban settings. l conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. My research spans disciplines including adult medicine, pediatrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Ad-interim Director; Co-Principle Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute




Genetic and Genomic Characterization of the Occurence and Progression of Interstitial Lung Abnormalities
02/01/2024 - 11/30/2027 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
2R01HL135142-05A1

Clinical Center for NIH's Nurtrition for Precision Health: The All of Us NEw England Research Collaborative
12/10/2021 - 11/30/2026 (Subcontract PI)
Trustees of Tufts College, Inc NIH NICHD
5UG1HD107691-03

Framingham Heart Study
04/01/2019 - 06/30/2025 (Multi-PI)
PI: George T. O'Connor, MD
NIH/National Heart, Lung, and Blood Institute


The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2019 - 05/31/2025 (Multi-PI)
PI: George T. O'Connor, MD
Massachusetts General Hospital NIH OD
3OT2OD026553-01S4

Childhood Asthma in Urban Settings (CAUSE)- Leadership Center
08/01/2021 - 03/31/2025 (Subcontract PI)
University of Wisconsin, Madison NIH NIAID
5UM1AI160040-04

The Boston University Clinical and Transitional Science Institute
04/15/2020 - 03/31/2025 (Key Person)
PI: Megan H. Bair-Merritt, MD, MSCE
NIH/National Center for Advancing Translational Sciences
5UL1TR001430-09

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH OD
5UH3OD023268-07

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2023 (Subcontract PI)
University of Wisconsin System NIH OD
5UH3OD023282-07

Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
05/01/2019 - 04/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL111024-09

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-04

Showing 10 of 39 results. Show All Results

PRE-NOTIFICATION ACCOUNT The New England Precision Medicine Consortium of the All of Us Research Program
06/01/2024 - 05/31/2025 (Subcontract PI)
PI: George T. O'Connor, MD
The General Hospital Corporation / MGH NIH

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2018 - 05/31/2024 (Subcontract PI)
PI: George T. O'Connor, MD
The General Hospital Corporation / MGH NIH

A New England Enrollment Center for PMI Cohort Program (All of Us Research Program AURP)
04/01/2017 - 07/31/2017 (Subcontract PI)
PI: George T. O'Connor, MD
The General Hospital Corporation / MGH NIH

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.


Title


Yr Title Project-Sub Proj Pubs
2024 The All of Us New England Consortium Geographical Expansion 1OT2OD037638-01
2023 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S5
2022 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S4
2021 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S3 3
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2019 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S1 3
2018 The New England Precision Medicine Consortium of the All of Us Research Program 1OT2OD026553-01 3
2017 A New England Enrollment Center for PMI Cohort Program 3OT2OD024612-01S1
2016 A New England Enrollment Center for PMI Cohort Program 1OT2OD024612-01
2013 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-04 3
Showing 10 of 76 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW, McDonald MN, Divo MJ, Silverman EK, Celli BR, O'Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 Oct 01; 210(7):890-899.View Related Profiles. PMID: 38471013
     
  2. Ramratnam SK, Johnson M, Visness CM, Calatroni A, Altman MC, Janczyk T, McCauley KE, Schachtschneider C, Fujimura KE, Fadrosh DW, Lynch SV, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Gergen PJ, Jackson DJ, Togias A, Gern JE. Clinical and Molecular Analysis of Longitudinal Rhinitis Phenotypes in an Urban Birth Cohort. J Allergy Clin Immunol. 2024 Sep 20.View Related Profiles. PMID: 39307288
     
  3. Havens TN, LeBeau P, Calatroni A, Gern JE, O'Connor GT, Wood RA, Lamm C, Krouse RZ, Visness CM, Gergen PJ, Jackson DJ, Bacharier LB. Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children. Pediatr Allergy Immunol. 2024 Jul; 35(7):e14197. PMID: 39016335; PMCID: PMC11360514; DOI: 10.1111/pai.14197;
     
  4. Kearney CM, Sangani R, Shankar D, O'Connor GT, Law AC, Walkey AJ, Bosch NA. Comparative Effectiveness of Mepolizumab, Benralizumab, and Dupilumab among Patients with Difficult-to-Control Asthma: A Multicenter Retrospective Propensity-matched Analysis. Ann Am Thorac Soc. 2024 Jun; 21(6):866-874.View Related Profiles. PMID: 38241013; PMCID: PMC11160126; DOI: 10.1513/AnnalsATS.202306-566OC;
     
  5. Fulkerson PC, Lussier SJ, Bendixsen CG, Castina SM, Gebretsadik T, Marlin JS, Russell PB, Seibold MA, Everman JL, Moore CM, Snyder BM, Thompson K, Tregoning GS, Wellford S, Arbes SJ, Bacharier LB, Calatroni A, Camargo CA, Dupont WD, Furuta GT, Gruchalla RS, Gupta RS, Hershey GK, Jackson DJ, Johnson CC, Kattan M, Liu AH, Murrison L, O'Connor GT, Phipatanakul W, Rivera-Spoljaric K, Rothenberg ME, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Hartert TV, Heros Study Team OBOT. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods. Am J Epidemiol. 2024 May 21. PMID: 38775275
     
  6. Abdalla M, Elalami R, Cho MH, O'Connor GT, Rice M, Horowitz M, Akhoundi N, Yen A, Kalhan R, Diaz AA. Airway Mucus Plugs in Community-Living Adults: A Study Protocol. medRxiv. 2024 May 16. PMID: 38798504; PMCID: PMC11118634; DOI: 10.1101/2024.05.15.24307439;
     
  7. Sangani R, Lee MM, Xu H, Dupuis J, O'Connor GT. The Upper Limit of Normal Rate of Lung Function Decline in Healthy Adults in the Framingham Heart Study. CHEST Pulm. 2024 Sep; 2(3).View Related Profiles. PMID: 39421758; PMCID: PMC11484874; DOI: 10.1016/j.chpulm.2024.100058;
     
  8. Konno-Yamamoto A, Goswamy V, Calatroni A, Gergen PJ, Johnson M, Sorkness RL, Bacharier LB, O'Connor GT, Kattan M, Wood RA, Gagalis L, Visness CM, Gern JE. Relationships between lung function, allergy, and wheezing in urban children. J Allergy Clin Immunol. 2024 Aug; 154(2):316-324.e3. PMID: 38574825; PMCID: PMC11305952; DOI: 10.1016/j.jaci.2024.02.025;
     
  9. Seo J, Gaddis NC, Patchen BK, Xu J, Barr RG, O'Connor G, Manichaikul AW, Gharib SA, Dupuis J, North KE, Cassano PA, Hancock DB. Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. Am J Clin Nutr. 2024 May; 119(5):1227-1237.View Related Profiles. PMID: 38484975; PMCID: PMC11130669; DOI: 10.1016/j.ajcnut.2024.03.007;
     
  10. McCauley KE, Durack J, Lynch KV, Fadrosh DW, Fujimura KE, Vundla F, Özçam M, LeBeau P, Caltroni A, Burns P, Tran HT, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Togias A, Boushey HA, Jackson DJ, Gern JE, Lynch SV. Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children. J Allergy Clin Immunol. 2024 Jun; 153(6):1563-1573. PMID: 38423369; PMCID: PMC11162315; DOI: 10.1016/j.jaci.2023.12.032;
     
Showing 10 of 348 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 348 publications over 38 distinct years, with a maximum of 26 publications in 2021 and 2022

YearPublications
19874
19882
19895
19901
19913
19922
19936
19943
19954
19964
19973
19982
19994
20003
20016
20023
20037
20044
20055
20064
20076
20084
200913
20108
20116
201210
201315
201411
201516
201620
201721
201815
201925
202017
202126
202226
202322
202412
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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