Helen Hollingsworth | Profiles RNS

Helen M. Hollingsworth, MD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, University of Rochester School of Medicine & Dentistry
BA, Brown University

Websites

	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	Boston Medical Center Provider Profile
	UpToDate Authors and Editors in Pulmonary and Critical Care Medicine

ORCID : 0000-0001-9007-9012

For almost fifteen years, I served as a Physician Editor for pulmonary medicine at UpToDate, an online clinical resource for physicians. In my work as a Physician Editor, I collaborated with outside authors and editors to research and evaluate the medical literature for pulmonary medicine to provide evidence-based, point-of-care guidance for the practicing physician. While the main goal of UpToDate is to guide clinical decision-making, UpToDate also serves as a major resource for Continuing Medical Education, Maintenance-of-Certification, and Patient Education. Previously, I developed the curriculum for the Allergy & Immunology fellowship program at Boston Medical Center and served as the training program director for many years. In addition, I participated in a number of multicenter trials of medications for asthma, COPD, and idiopathic pulmonary fibrosis.

Member
Boston University
Pulmonary Center

BU Research

An Open-Label Study of the Safety of Subcutaneous Recombinant Interferon gamma-1b (IFN-y 1b) in Patients with Idiopathic Pulmonary Fibrosis
01/01/2004 - 12/31/2009 (PI)
InterMune, Inc.

A Randomized, Double-Blind, Placebo-Controlled, Phase 3, Three-Arm Study of the Safety and Efficacy of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis PIPF-004.
08/21/2006 - 10/31/2008 (PI)
InterMune, Inc.

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Safety and Efficacy of ug Subcutaneous Interferon gamma-1b in Patients with Idiopathic Pulmonary Fibrosis GIPF-007
10/21/2003 - 12/31/2007 (PI)
InterMune, Inc.

A Randomized, Double-Blind, Parallel Group, 52 Week Study to Compare the Effect of Fluticasone Propionate/Salmeterol DISKUS Combination Product 250/50mcg BID with Salmeterol DISKUS 50mcg BID on t
09/30/2004 - 03/28/2007 (PI)
GlaxoSmithKline LLC

Protocol SB 207499/180
09/01/2003 - 09/01/2005 (PI)
GlaxoSmithKline, Inc.

Inspire 01-312 A Double Blind, Placebo Controlled, Parallel Group Study of Uridine 5’-Triphosphate (UTP)
07/15/2003 - 12/31/2004 (PI)
Inspire Pharmaceuticals Inc

An Open Label Study of the Safety and Efficacy of Subcutaneous Recombinant Interferon Gamma-ibin Patients with Idiopathic Pulmonary Fibrosis
10/01/2002 - 12/31/2003 (PI)
InterMune, Inc.

A Randomized, Double-Blind, Placebo Controlled, Phase 2/3 Study of the Safety and Efficacy of Subcutaneous Recombinant ACTIMMUNE in Patients with Idiopathic Pulmonary Fibrosis
07/01/2000 - 12/31/2003 (PI)
InterMune, Inc.

Start-Inhaled Steroid Treatment as Regular Therapy in Early Asthma
04/01/1997 - 12/31/2003 (PI)
ASTRA USA Inc

A 3-Month, Multi-center, Multinational, Double-blind, Group Comparative Study to Investigate the Effects of AR C68397AA via MDI Compared with Placebo in Adult Patients with Chronic Obstructive Pulmonary Disease (COPD)
05/30/2000 - 06/30/2001 (PI)
AstraZeneca

Showing 10 of 12 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Kathuria H, Hollingsworth HM, Vilvendhan R, Reardon C. Management of life-threatening hemoptysis. J Intensive Care. 2020; 8:23.View Related Profiles.

Reardon, Christine
Kathuria, Hasmeena
Hollingsworth, Helen
Vilvendhan, Rajendran

PMID: 32280479; PMCID: PMC7132983; DOI: 10.1186/s40560-020-00441-8;

Hollingsworth HM, O'Connor GT. Asthma-Here Today, Gone Tomorrow? JAMA. 2017 01 17; 317(3):262-263.View Related Profiles.

O'Connor, George
Hollingsworth, Helen

PMID: 28114530; DOI: 10.1001/jama.2016.19676;

Saketkoo LA, Mittoo S, Frankel S, LeSage D, Sarver C, Phillips K, Strand V, Matteson EL. Reconciling healthcare professional and patient perspectives in the development of disease activity and response criteria in connective tissue disease-related interstitial lung diseases. J Rheumatol. 2014 Apr; 41(4):792-8. PMID: 24488412; PMCID: PMC4369780; DOI: 10.3899/jrheum.131251;

Hollingsworth HM, Parada, NA. Manual of Intensive Care Medicine. Anaphylaxis. Lippincott Williams & Wilkins. 2014; 1119-1126.

Saketkoo LA, Mittoo S, Huscher D, Khanna D, Dellaripa PF, Distler O, Flaherty KR, Frankel S, Oddis CV, Denton CP, Fischer A, Kowal-Bielecka OM, LeSage D, Merkel PA, Phillips K, Pittrow D, Swigris J, Antoniou K, Baughman RP, Castelino FV, Christmann RB, Christopher-Stine L, Collard HR, Cottin V, Danoff S, Highland KB, Hummers L, Shah AA, Kim DS, Lynch DA, Miller FW, Proudman SM, Richeldi L, Ryu JH, Sandorfi N, Sarver C, Wells AU, Strand V, Matteson EL, Brown KK, Seibold JR. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials. Thorax. 2014 May; 69(5):428-36.View Related Profiles.

Hollingsworth, Helen
Christmann de Souza, Romy

PMID: 24368713; PMCID: PMC3995282; DOI: 10.1136/thoraxjnl-2013-204202;

Hollingsworth HM, Pratter MR, Irvin RS. Extrapulmonary Causes of Respiratory Failure. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2012.
Little FF, Hollingsworth HM. Anaphylaxis. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2012.
Reardon CC, Hollingsworth HM. Acute Respiratory Failure in Pregnancy. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2012.

Noble PW, Albera C, Bradford WZ, Costabel U, Glassberg MK, Kardatzke D, King TE, Lancaster L, Sahn SA, Szwarcberg J, Valeyre D, du Bois RM. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. Lancet. 2011 May 21; 377(9779):1760-9. PMID: 21571362; DOI: 10.1016/S0140-6736(11)60405-4;

King TE, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet. 2009 Jul 18; 374(9685):222-8. PMID: 19570573; DOI: 10.1016/S0140-6736(09)60551-1;

Showing 10 of 66 results. Show More

Hollingsworth HM, Parada N. Anaphylaxis. Manual of Intensive Care Medicine, RS Irwin, JM Rippe, eds. Lippincott Wilkins & Williams. 2009.
Wexler P, Hollingsworth H. Chronic rhinosinusitis. Challenging Cases in Allergy and Immunology, M Mahmoudi, ed. Springer. 2009.

O'Byrne PM, Pedersen S, Lamm CJ, Tan WC, Busse WW. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med. 2009 Jan 1; 179(1):19-24. PMID: 18990678; DOI: 10.1164/rccm.200807-1126OC;

Chen TH, Hollingsworth H. Images in clinical medicine. Allergic bronchopulmonary aspergillosis. N Engl J Med. 2008 Aug 7; 359(6):e7.View Related Profiles.

Hollingsworth, Helen
Chen, Ting-hsu

PMID: 18687635; DOI: 10.1056/NEJMicm055764;

Busse WW, Pedersen S, Pauwels RA, Tan WC, Chen YZ, Lamm CJ, O'Byrne PM. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol. 2008 May; 121(5):1167-74. PMID: 18405951; DOI: 10.1016/j.jaci.2008.02.029;

Little FF, Hollingsworth HM. Anaphylaxis. In: Intensive Care Medicine, 6th ed. Irwin R, Rippe J, eds. Lippincott Wilkins & Williams 2008. Anaphylaxis. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2008.
Reardon CC, Hollingsworth HM. Acute Respiratory Failure in Pregnancy. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2008.
Hollingsworth HM, Pratter MR, Irvin RS. Extrapulmonary Causes of Respiratory Failure. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2008.

O'Byrne PM, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, Ullman A, Lamm CJ, Pauwels RA. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest. 2006 Jun; 129(6):1478-85. PMID: 16778264; DOI: 10.1378/chest.129.6.1478;

Hollingsworth H. Observations from TENOR: opportunities to improve asthma care. Ann Allergy Asthma Immunol. 2006 Mar; 96(3):383-4. PMID: 16597069

Hollingsworth HM, Parada N. Anaphylaxis. Manual of Intensive Care Medicine, RS Irwin, JM Rippe, eds. 2005.

Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, Ullman A, Lamm CJ, O'Byrne PM. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet. 2003 Mar 29; 361(9363):1071-6. PMID: 12672309; DOI: 10.1016/S0140-6736(03)12891-7;

Hollingsworth HM, Pratter MR, Irvin RS. Extrapulmonary Causes of Respiratory Failure. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2003.
Reardon CC, Hollingsworth HM. Acute Respiratory Failure in Pregnancy. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2003.
Hollingsworth HM. Case records of the Massachusetts General Hospital. (Case 32-2001). NEJM. 2001; 345:1193-1200.
Parada N, HM Hollingsworth. Anaphylaxis. Manual of Intensive Care Medicine, eds: RS Irwin, JM Rippe. Lippincott Williams and Wilkins. Philadelphia PA. 2000; pp.853-858.
Wilson MM, HM Hollingsworth. Extrapulmonary causes of respiratory failure. Manual of Intensive Care Medicine, RS Irwin, JM Rippe, eds. Lippincott Williams and Wilkins. Philadelphia PA. 2000; pp. 274-277.
Wilson MM, HM Hollingsworth. Acute respiratory failure in pregnancy. Manual of Intensive Care Medicine eds: RS Irwin, JM Rippe. Lippincott Williams and Wilkins. Philadelphia PA. 2000; pp. 2278-282.
Hollingsworth HM, Giansiracusa DS, Parada N:. Anaphylaxis. Intensive Care Medicine Eds. JM Rippe, RS Irwin, FB Cerra. Little, Brown and Company. Boston, MA. 1999.
Hollingsworth HM, Irwin RS. Extrapulmonary causes of respiratory failure. Intensive Care Medicine Eds. JM Rippe, RS Irwin, FB Cerra. Little, Brown and Company. Boston, MA. 1999.
Hollingsworth HM, Reardon CC. Acute respiratory failure in pregnancy. Intensive Care Medicine Eds. JM Rippe, RS Irwin, FB Cerra. Little, Brown and Company. Boston, MA. 1999.

Hollingsworth H. Preventing insect sting anaphylaxis. JAMA. 1997 Apr 16; 277(15):1196-7. PMID: 9103334

Hollingsworth HM. Theophylline/Corticosteroids. Textbook on Pulmonary Diseases Eds. G Baum, J Crappo, B Celli, J Karlinsky. Little, Brown and Company. Boston, MA. 1997.
Hollingsworth HM. Pulmonary Therapeutics. A Practical Approach to Pulmonary Diseases Eds. RH Goldstein, JB Karlinsky. Little, Brown and Company. Boston, MA. 1997.
Hollingsworth, HM, Irwin RS. The upper respiratory tract. Management of Symptoms of the Respiratory Tract Eds. RS Irwin, FJ Curley, RF Grossman. Futura Publishing Company, Inc. Armonk, NY. 1997.

Hollingsworth HM. Allergic rhinoconjunctivitis: current therapy. Hosp Pract (1995). 1996 Jun 15; 31(6):61-2, 65-7, 71-3. PMID: 8675546

Hollingsworth HM. Acute respiratory failure in pregnancy. Intensive Care Medicine Eds. JM Rippe, RS Irwin, MP Fink, FB Cerra. Little, Brown and Company. Boston, MA. 1996.
Hollingsworth HM, Irwin RS. Extrapulmonary causes of respiratory failure. Intensive Care Medicine Eds. JM Rippe, RS Irwin, MP Fink, FB Cerra. Little, Brown and Company. Boston, MA. 1996.
Hollingsworth HM, Giansiracusa DS, Upchurch KS. Anaphylaxis. Intensive Care Medicine Eds. JM Rippe, RS Irwin, MP Fink, FB Cerra. Little, Brown and Company. Boston, MA. 1996.
Shaker KG, Hollingsworth HM, Irwin RS, Umali CB. Tracheobronchial injuries caused by blunt trauma. J Intensive Care Med. 1995; 10:226-233.

Hollingsworth HM, Silver KH, Irwin RS, Aurigemma GP. Lethargy, confusion, and a mediastinal abnormality in a 68-year-old woman. Chest. 1994 Sep; 106(3):939-41. PMID: 8082383

Tsimikas S, Hollingsworth HM, Nash G. Aspergillus brain abscess complicating allergic Aspergillus sinusitis. J Allergy Clin Immunol. 1994 Aug; 94(2 Pt 1):264-7. PMID: 8064081

Jacobs TE, Hollingsworth HM, Nash G. Persistent bilateral effusions and fever in a 48-year-old man. Chest. 1993 Nov; 104(5):1597-9. PMID: 8222830

Jacobs TE, Hollingsworth HM, Nash G. Persistent bilateral pleural effusions and fever in a 48-year-old man. Chest. 1993; 104:1597-9.
Hollingsworth HM. Drug-induced bronchiolitis obliterans organizing pneumonia. Bronchiolitis Obliterans and Bronchiolitis Obliterans Organizing Pneumonia Ed. GR Epler. 1993.
Irwin RS, Hollingsworth, HM. The upper respiratory tract. Comprehensive Textbook of Pulmonary Medicine Eds RC Bone, D Dantzker, R George, R Matthay, H Reynolds. Mosby-Year book Inc. 1993.

Hollingsworth HM, Irwin RS. Acute respiratory failure in pregnancy. Clin Chest Med. 1992 Dec; 13(4):723-40. PMID: 1362144

Smyrnios NA, Forster R, Hollingsworth HM. A 47-year-old woman with hypotension and recurrent pulmonary infiltrates. J Intensive Care Med. 1992; 7:261-273.
Hollingsworth HM, Giansiracusa DS. Anaphylaxis. Emer Med. 1992; 24:142-154.

Hollingsworth HM, Pratter MR, Dubois JM, Braverman LE, Irwin RS. Effect of triiodothyronine-induced thyrotoxicosis on airway hyperresponsiveness. J Appl Physiol (1985). 1991 Aug; 71(2):438-44.View Related Profiles.

Hollingsworth, Helen
Braverman, Lewis

PMID: 1938715

Hollingsworth HM, Giansiracusa DS, Upchurch KS. Anaphylaxis. J Intensive Care Med. 1991; 6:55-70.
Hollingsworth HM, Giansiracusa DS, Upchurch KS. Anaphylaxis. Intensive Care Medicine Eds. JM Rippe, RS Irwin, JS Alpert, MP Fink. Little, Brown and Company. Boston, MA,. 1991.
Hollingsworth HM. Acute respiratory failure in pregnancy. Intensive Care Medicine Eds. JM Rippe, RS Irwin, JS Alpert, MP Fink. Little, Brown and Company. Boston, MA. 1991.
Hollingsworth HM, Irwin RS: Extrapulmonary causes of respiratory failure. In: Intensive Care Medicine Eds. JM Rippe, RS Irwin, JS Alpert, MP Fink. Little, Brown and Company, Boston, MA, 1991. Extrapulmonary causes of respiratory failure. Intensive Care Medicine Eds. JM Rippe, RS Irwin, JS Alpert, MP Fink. Little, Brown and Company. Boston, MA. 1991.
Hollingsworth HM, Irwin RS. Immunologic lung disease. Intensive Care Medicine Eds. JM Rippe, RS Irwin, JS Alpert, MP Fink. Little, Brown and Company. Boston, MA. 1991.
Hollingsworth HM, Pratter MP, Irwin RS. Acute respiratory failure in pregnancy. J Intensive Care Med. 1989; 4:11-34.
Bartter T, Irwin RS, Nash G, Balikian JP, Hollingsworth HM. Idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) with peripheral infiltrates on chest roentgenogram. Arch Intern Med. 1989; 149:273-279.

Hollingsworth HM. Wheezing and stridor. Clin Chest Med. 1987 Jun; 8(2):231-40. PMID: 3304813

Bartter T, Hollingsworth HM, Irwin RS, Bianco JA, Frid DJ, Dalen JE. Pulmonary embolism from a venous thrombus located below the knee. Arch Intern Med. 1987 Feb; 147(2):373-5. PMID: 3813758

Hollingsworth HM, and Center DM. Neutrophil chemotactic factor in aspirin-induced bronchospasm. Chest. 1985; 87S:167S-168S.
Hollingsworth HM, Beer D. Clinical variants of asthma. Current Topics in the Management of Respiratory Disease, Vol.II. Eds. J.S. Brody and G.L. Snider. Churchill Livingston. New York. 1985.
Hollingsworth HM, Bernardo J. Asthma. Textbook of General Medicine Ed. John Noble. Little, Brown and Company. Boston, MA. 1985; 875:1675-1685.

Hollingsworth HM, Downing ET, Braman SS, Glassroth J, Binder R, Center DM. Identification and characterization of neutrophil chemotactic activity in aspirin-induced asthma. Am Rev Respir Dis. 1984 Sep; 130(3):373-9.View Related Profiles.

Center, David
Hollingsworth, Helen

PMID: 6433757

Bruenn J, Hollingsworth H. A mutant of Escherichia coli with a new, highly efficient promoter for the lactose operon. Proc Natl Acad Sci U S A. 1973 Dec; 70(12):3693-7. PMID: 4590169; PMCID: PMC427308

Little FF, Hollingsworth HM. Anaphylaxis. Intensive Care Medicine, Irwin R, Rippe J, eds. Lippincott Wilkins & Williams. 2003.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 25 distinct years, with a maximum of 6 publications in 1991 and 2008

Bar chart showing 63 publications over 25 distinct years, with a maximum of 6 publications in 1991 and 2008

Year	Publications
1984	1
1985	3
1987	2
1989	2
1991	6
1992	3
1993	4
1994	2
1995	1
1996	4
1997	4
1999	3
2000	3
2001	1
2003	3
2005	1
2006	2
2008	6
2009	3
2011	1
2012	3
2013	1
2014	2
2017	1
2020	1

2018-2019 Massachusetts Pulmonary Society: Henry D. Chadwick Medal

2007-2017 Castle Connolly: Top Doctors

2004 Boston Medical Center: Robert Dawson Evans Department of Medicine Teaching Award

2004-2017 Boston Magazine: Best Doctors

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Asthma
Idiopathic pulmonary fibrosis
Interstitial lung disease

As a training program director for Allergy & Immunology and a faculty member in Pulmonary, Allergy, Critical Care, and Sleep Medicine, I have mentored over 35 Allergy-Immunology and Pulmonary-Critical Care trainees as well as other residents and students, in areas of career development, publications, thesis preparation, and career-life balance. I received the Robert Dawson Evans Department of Medicine Teaching Award in 2004, and throughout my career I have enjoyed teaching and mentoring junior faculty, fellows, residents, and medical students and helping them to clarify and achieve their aspirations.

Available to Mentor as: (Review Mentor Role Definitions):