Matthew Nayor | Profiles RNS

Matthew Nayor, MD, MPH

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Cardiovascular Medicine

MD, New York University School of Medicine
MPH, Harvard School of Public Health
BA, University of Michigan at Ann Arbor

Websites

	ResearchGate
	ORCID ID: 0000-0002-6993-9396

ORCID : 0000-0002-6993-9396

Dr. Nayor is a clinical-translational investigator and heart failure cardiologist. He received training in Internal Medicine at the Johns Hopkins Hospital Osler Medical Residency training program and Cardiology and Heart Failure and Transplantation training at Brigham and Women's Hospital. His research background includes basic science investigations, physiologic studies, and cardiovascular epidemiology focusing on the intersection of metabolic health and cardiovascular disease. His group and collaborators have studied: 1) the effect of exercise on metabolism via assaying >500 circulating metabolites; 2) physiologic determinants of fitness; 3) novel protein biomarkers of heart failure risk through broad proteomic profiling; 4) and lifestyle contributors to cardiometabolic disease and heart failure, among other topics.

Dr. Nayor has worked closely with the Framingham Heart Study for the last 8 years and currently leads community-based studies evaluating metabolic responses to discrete physiologic perturbations, such as exercise and a dietary intervention.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Preventive Medicine & Epidemiology

BU Research
NIH RePORTER Research

Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
04/05/2023 - 02/28/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL131029-05A1

Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance
08/20/2021 - 06/30/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL156975-03

NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT
03/01/2023 - 02/28/2026 (Subcontract PI)
Massachusetts General Hospital NIH NIAMS
5R01AR065944-07

Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS
02/01/2022 - 01/31/2026 (Subcontract PI)
Broad Institute, Inc., The NIH NHLBI
1R01HL157717-01A1

The San Antonio Heart and Mind Study
07/01/2023 - 03/31/2024 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1R01AG082360-01

Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training
08/05/2021 - 06/30/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
7K23HL138260-07

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum	5R01HL131029-06
2023	Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance	5R01HL156975-03
2023	Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum	2R01HL131029-05A1
2022	Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance	5R01HL156975-02
2021	Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance	1R01HL156975-01
2021	Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training	5K23HL138260-06	4
2021	Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training	7K23HL138260-07	4
2020	Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training	5K23HL138260-05	4
2019	Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training	5K23HL138260-04	4
2018	Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training	5K23HL138260-03	4

Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Shah RV, Zhong J, Massier L, Tanriverdi K, Hwang SJ, Haessler J, Nayor M, Zhao S, Perry AS, Wilkins JT, Shadyab AH, Manson JE, Martin L, Levy D, Kooperberg C, Freedman JE, Rydén M, Murthy VL. Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults. Circ Genom Precis Med. 2024 Feb; 17(1):e004192.View Related Profiles.

Nayor, Matthew
Hwang, Shih-Jen

PMID: 38323454; PMCID: PMC10940209; DOI: 10.1161/CIRCGEN.123.004192;

Perry AS, Hadad N, Chatterjee E, Ramos MJ, Farber-Eger E, Roshani R, Stolze LK, Zhao S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Freedman J, Tanriverdi K, Alsop E, Keuren-Jensen KV, Sauld JFK, Mahajan G, Khan S, Colangelo L, Nayor M, Fisher-Hoch S, McCormick J, North KE, Below J, Wells Q, Abel D, Kalhan R, Scott C, Guilliams M, Fallowfield JA, Banovich NE, Das S, Shah R. A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver. medRxiv. 2024 Jan 29. PMID: 38352394; PMCID: PMC10863022; DOI: 10.1101/2024.01.26.24301828;

Motiwala SR, Nayor M. Risk Stratification in Advanced Heart Failure: Can Simple Hemodynamic Indices Replace Comprehensive CPET? JACC Heart Fail. 2024 Feb; 12(2):272-274. PMID: 37999666

Lau ES, Roshandelpoor A, Zarbafian S, Wang D, Guseh JS, Allen N, Varadarajan V, Nayor M, Shah RV, Lima JAC, Shah SJ, Yu B, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction. Nat Commun. 2023 Nov 20; 14(1):7557. PMID: 37985769; PMCID: PMC10662264; DOI: 10.1038/s41467-023-43363-3;

Li Y, Wang M, Liu X, Rong J, Miller PE, Joehanes R, Huan T, Guo X, Rotter JI, Smith JA, Yu B, Nayor M, Levy D, Liu C, Ma J. Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease. BMC Med. 2023 Nov 16; 21(1):443.View Related Profiles.

Liu, Chunyu
Nayor, Matthew

PMID: 37968697; PMCID: PMC10652547; DOI: 10.1186/s12916-023-03149-2;

Shah RV, Hwang SJ, Murthy VL, Zhao S, Tanriverdi K, Gajjar P, Duarte K, Schoenike M, Farrell R, Brooks LC, Gopal DM, Ho JE, Girerd N, Vasan RS, Levy D, Freedman JE, Lewis GD, Nayor M. Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study. J Am Heart Assoc. 2023 Nov 07; 12(21):e029980.View Related Profiles.

Gopal, Deepa
Nayor, Matthew
Hwang, Shih-Jen

PMID: 37889181; PMCID: PMC10727424; DOI: 10.1161/JAHA.122.029980;

Nayor M, Gajjar P, Miller P, Murthy VL, Shah RV, Houstis NE, Velagaleti RS, Larson MG, Vasan RS, Lewis GD, Mitchell GF. Arterial Stiffness and Cardiorespiratory Fitness Impairment in the Community. J Am Heart Assoc. 2023 Nov 07; 12(21):e029619.View Related Profiles.

Larson, Martin
Nayor, Matthew
Velagaleti, Raghava

PMID: 37850464; PMCID: PMC10727403; DOI: 10.1161/JAHA.123.029619;

Mi MY, Gajjar P, Walker ME, Miller P, Xanthakis V, Murthy VL, Larson MG, Vasan RS, Shah RV, Lewis GD, Nayor M. Association of healthy dietary patterns and cardiorespiratory fitness in the community. Eur J Prev Cardiol. 2023 Oct 10; 30(14):1450-1461.View Related Profiles.

Larson, Martin
Nayor, Matthew
Walker, Maura
Xanthakis, Vanessa

PMID: 37164358; PMCID: PMC10562138; DOI: 10.1093/eurjpc/zwad113;

Perry AS, Zhao S, Gajjar P, Murthy VL, Lehallier B, Miller P, Nair S, Neill C, Carr JJ, Fearon W, Kapadia S, Kumbhani D, Gillam L, Lindenfeld J, Farrell L, Marron MM, Tian Q, Newman AB, Murabito J, Gerszten RE, Nayor M, Elmariah S, Lindman BR, Shah R. Proteomic architecture of frailty across the spectrum of cardiovascular disease. Aging Cell. 2023 Nov; 22(11):e13978.View Related Profiles.

Murabito, Joanne
Nayor, Matthew
Elmariah, Sammy

PMID: 37731195; PMCID: PMC10652351; DOI: 10.1111/acel.13978;

Ramirez MF, Lau ES, Parekh JK, Pan AS, Owunna N, Wang D, McNeill JN, Malhotra R, Nayor M, Lewis GD, Ho JE. Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF. Circ Heart Fail. 2023 Nov; 16(11):e010618. PMID: 37703087; PMCID: PMC10698557; DOI: 10.1161/CIRCHEARTFAILURE.123.010618;

Showing 10 of 72 results. Show More

Hardin KM, Giverts I, Campain J, Farrell R, Cunningham T, Brooks L, Christ A, Wooster L, Bailey CS, Schoenike M, Sbarbaro J, Baggish A, Nayor M, Ho JE, Malhotra R, Shah R, Lewis GD. Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion. J Card Fail. 2024 Jan; 30(1):39-47. PMID: 37467924

Nayor M, Lloyd-Jones DM, Shah RV. Introduction to the Compendium on Early Cardiovascular Disease. Circ Res. 2023 Jun 09; 132(12):1567-1569. PMID: 37289907

Li Y, Wang M, Liu X, Rong J, Miller PE, Joehanes R, Huan T, Guo X, Rotter J, Smith J, Yu B, Nayor M, Levy D, Liu C, Ma J. Circulating Metabolites May Illustrate Relationship of Alcohol Consumption with Cardiovascular Disease. medRxiv. 2023 May 29. PMID: 37398015; PMCID: PMC10312833; DOI: 10.1101/2023.05.24.23290487;

Perry AS, Annis JS, Master H, Nayor M, Hughes A, Kouame A, Natarajan K, Marginean K, Murthy V, Roden DM, Harris PA, Shah R, Brittain EL. Association of Longitudinal Activity Measures and Diabetes Risk: An Analysis From the National Institutes of Health All of Us Research Program. J Clin Endocrinol Metab. 2023 Apr 13; 108(5):1101-1109. PMID: 36458881; PMCID: PMC10306083; DOI: 10.1210/clinem/dgac695;

Petek BJ, Churchill TW, Gustus SK, Schoenike MW, Nayor M, Moulson N, Guseh JS, VanAtta C, Blodgett JB, Contursi M, Lewis GD, Baggish AL, Wasfy MM. Characterization of ventilatory efficiency during cardiopulmonary exercise testing in healthy athletes. Eur J Prev Cardiol. 2023 Mar 27; 30(5):e21-e24. PMID: 36321382; PMCID: PMC10290882; DOI: 10.1093/eurjpc/zwac255;

Shah RV, Steffen LM, Nayor M, Reis JP, Jacobs DR, Allen NB, Lloyd-Jones D, Meyer K, Cole J, Piaggi P, Vasan RS, Clish CB, Murthy VL. Dietary metabolic signatures and cardiometabolic risk. Eur Heart J. 2023 Feb 14; 44(7):557-569. PMID: 36424694; PMCID: PMC10169425; DOI: 10.1093/eurheartj/ehac446;

Mi MY, Gajjar P, Walker ME, Miller P, Xanthakis V, Murthy VL, Larson MG, Vasan RS, Shah RV, Lewis GD, Nayor M. Association of Healthy Dietary Patterns and Cardiorespiratory Fitness in the Community. medRxiv. 2023 Feb 10.View Related Profiles.

Larson, Martin
Nayor, Matthew
Xanthakis, Vanessa

PMID: 36798343; PMCID: PMC9934801; DOI: 10.1101/2023.02.09.23285714;

Nayor M, Gajjar P, Murthy VL, Miller PE, Velagaleti RS, Larson MG, Vasan RS, Lewis GD, Mitchell GF, Shah RV. Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications. Arterioscler Thromb Vasc Biol. 2023 Jan; 43(1):163-173.View Related Profiles.

Larson, Martin
Nayor, Matthew
Velagaleti, Raghava

PMID: 36384270; PMCID: PMC9780190; DOI: 10.1161/ATVBAHA.122.318512;

Perry AS, Tanriverdi K, Risitano A, Hwang SJ, Murthy VL, Nayor M, Zhao S, Levy D, Shah RV, Freedman JE. The inflammatory proteome, obesity, and medical weight loss and regain in humans. Obesity (Silver Spring). 2023 Jan; 31(1):150-158.View Related Profiles.

Risitano, Antonina
Nayor, Matthew
Hwang, Shih-Jen

PMID: 36334095; PMCID: PMC9923277; DOI: 10.1002/oby.23587;

Gonzalez Izundegui D, Miller PE, Shah RV, Clish CB, Walker ME, Mitchell GF, Gerszten RE, Larson MG, Vasan RS, Nayor M. Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community. Cardiovasc Diabetol. 2022 Oct 15; 21(1):213.View Related Profiles.

Izundegui, Daniel
Larson, Martin
Nayor, Matthew
Walker, Maura

PMID: 36243866; PMCID: PMC9568897; DOI: 10.1186/s12933-022-01647-w;

Shah RV, Miller P, Colangelo LA, Chernofsky A, Houstis NE, Malhotra R, Velagaleti RS, Jacobs DR, Gabriel KP, Reis JP, Lloyd-Jones DM, Clish CB, Larson MG, Vasan RS, Murthy VL, Lewis GD, Nayor M. Blood-Based Fingerprint of Cardiorespiratory Fitness and Long-Term Health Outcomes in Young Adulthood. J Am Heart Assoc. 2022 Sep 20; 11(18):e026670.View Related Profiles.

Larson, Martin
Nayor, Matthew
Velagaleti, Raghava

PMID: 36073631; PMCID: PMC9683648; DOI: 10.1161/JAHA.122.026670;

McNeill J, Chernofsky A, Nayor M, Rahaghi FN, San Jose Estepar R, Washko G, Synn A, Vasan RS, O'Connor G, Larson MG, Ho JE, Lewis GD. The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community. Eur Respir J. 2022 Aug; 60(2).View Related Profiles.

O'Connor, George
Larson, Martin
Nayor, Matthew

PMID: 34996832; PMCID: PMC9259762; DOI: 10.1183/13993003.01821-2021;

Nayor M, Chernofsky A, Miller PE, Spartano NL, Murthy VL, Malhotra R, Houstis NE, Murabito JM, Clish CB, Larson MG, Vasan RS, Shah RV, Lewis GD. Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness. Circ Genom Precis Med. 2022 Jun; 15(3):e003592.View Related Profiles.

Murabito, Joanne
Larson, Martin
Nayor, Matthew
Spartano, Nicole

PMID: 35536222; PMCID: PMC9233103; DOI: 10.1161/CIRCGEN.121.003592;

Namasivayam M, Lau ES, Zern EK, Schoenike MW, Hardin KM, Sbarbaro JA, Cunningham TF, Farrell RM, Rouvina J, Kowal A, Bhat RR, Brooks LC, Nayor M, Shah RV, Ho JE, Malhotra R, Lewis GD. Exercise Blood Pressure in Heart Failure With Preserved and Reduced Ejection Fraction. JACC Heart Fail. 2022 Apr; 10(4):278-286. PMID: 35361448; PMCID: PMC9730937; DOI: 10.1016/j.jchf.2022.01.012;

Izundegui DG, Nayor M. Metabolomics of Type 1 and Type 2 Diabetes: Insights into Risk Prediction and Mechanisms. Curr Diab Rep. 2022 02; 22(2):65-76.View Related Profiles.

Izundegui, Daniel
Nayor, Matthew

PMID: 35113332; PMCID: PMC8934149; DOI: 10.1007/s11892-022-01449-0;

Murthy VL, Nayor M, Carnethon M, Reis JP, Lloyd-Jones D, Allen NB, Kitchen R, Piaggi P, Steffen LM, Vasan RS, Freedman JE, Clish CB, Shah RV. Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Diabetologia. 2022 Apr; 65(4):657-674. PMID: 35041022; PMCID: PMC8969893; DOI: 10.1007/s00125-021-05641-x;

Lau ES, Panah LG, Zern EK, Liu EE, Farrell R, Schoenike MW, Namasivayam M, Churchill TW, Curreri L, Malhotra R, Nayor M, Lewis GD, Ho JE. Arterial Stiffness and Vascular Load in HFpEF: Differences Among Women and Men. J Card Fail. 2022 02; 28(2):202-211. PMID: 34955334; PMCID: PMC8840989; DOI: 10.1016/j.cardfail.2021.10.019;

Zlotoff DA, Nayor M. Can We Estimate Cardiorespiratory Fitness in Breast Cancer Survivors Without Exercise? JACC CardioOncol. 2021 Dec; 3(5):692-694. PMID: 34988477; PMCID: PMC8702789; DOI: 10.1016/j.jaccao.2021.10.001;

Nayor M, Chernofsky A, Spartano NL, Tanguay M, Blodgett JB, Murthy VL, Malhotra R, Houstis NE, Velagaleti RS, Murabito JM, Larson MG, Vasan RS, Shah RV, Lewis GD. Physical activity and fitness in the community: the Framingham Heart Study. Eur Heart J. 2021 11 21; 42(44):4565-4575.View Related Profiles.

Murabito, Joanne
Larson, Martin
Nayor, Matthew
Spartano, Nicole
Velagaleti, Raghava

PMID: 34436560; PMCID: PMC8633734; DOI: 10.1093/eurheartj/ehab580;

Nayor M, Shen L, Hunninghake GM, Kochunov P, Barr RG, Bluemke DA, Broeckel U, Caravan P, Cheng S, de Vries PS, Hoffmann U, Kolossváry M, Li H, Luo J, McNally EM, Thanassoulis G, Arnett DK, Vasan RS. Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop. Circ Cardiovasc Imaging. 2021 08; 14(8):e012943. PMID: 34387095; PMCID: PMC8486340; DOI: 10.1161/CIRCIMAGING.121.012943;

Nayor M, Shah RV, Tanguay M, Blodgett JB, Chernofsky A, Miller PE, Xanthakis V, Malhotra R, Houstis NE, Velagaleti RS, Larson MG, Vasan RS, Lewis GD. Feasibility, Methodology, and Interpretation of Broad-Scale Assessment of Cardiorespiratory Fitness in a Large Community-Based Sample. Am J Cardiol. 2021 10 15; 157:56-63.View Related Profiles.

Larson, Martin
Nayor, Matthew
Velagaleti, Raghava
Xanthakis, Vanessa

PMID: 34391575; PMCID: PMC9252421; DOI: 10.1016/j.amjcard.2021.07.020;

Nayor M, Shah SH, Murthy V, Shah RV. Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes: JACC Focus Seminar. J Am Coll Cardiol. 2021 08 03; 78(5):481-495. PMID: 34325838

Elezaby A, Parikh VN, Nayor M. Iron Deficiency as a Potential Modulator of Subclinical Deficiencies in Cardiac Performance and Exercise Capacity. J Card Fail. 2021 07; 27(7):822-824.View Related Profiles.

Elezaby, Aly
Nayor, Matthew

PMID: 34246431

Andersson C, Nayor M, Tsao CW, Levy D, Vasan RS. Framingham Heart Study: JACC Focus Seminar, 1/8. J Am Coll Cardiol. 2021 06 01; 77(21):2680-2692.View Related Profiles.

Levy, Daniel
Nayor, Matthew

PMID: 34045026

Shah RV, Schoenike MW, Armengol de la Hoz MÁ, Cunningham TF, Blodgett JB, Tanguay M, Sbarbaro JA, Nayor M, Rouvina J, Kowal A, Houstis N, Baggish AL, Ho JE, Hardin C, Malhotra R, Larson MG, Vasan RS, Lewis GD. Metabolic Cost of Exercise Initiation in Patients With Heart Failure With Preserved Ejection Fraction vs Community-Dwelling Adults. JAMA Cardiol. 2021 06 01; 6(6):653-660.View Related Profiles.

Larson, Martin
Nayor, Matthew

PMID: 33729454; PMCID: PMC7970388; DOI: 10.1001/jamacardio.2021.0292;

Katz DH, Tahir UA, Ngo D, Benson MD, Gao Y, Shi X, Nayor M, Keyes MJ, Larson MG, Hall ME, Correa A, Sinha S, Shen D, Herzig M, Yang Q, Robbins JM, Chen ZZ, Cruz DE, Peterson B, Vasan RS, Wang TJ, Wilson JG, Gerszten RE. Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults. Circ Genom Precis Med. 2021 06; 14(3):e003191.View Related Profiles.

Larson, Martin
Nayor, Matthew
Yang, Qiong

PMID: 34019435; PMCID: PMC8497179; DOI: 10.1161/CIRCGEN.120.003191;

McNeill JN, Lau ES, Zern EK, Nayor M, Malhotra R, Liu EE, Bhat RR, Brooks LC, Farrell R, Sbarbaro JA, Schoenike MW, Medoff BD, Lewis GD, Ho JE. Association of obesity-related inflammatory pathways with lung function and exercise capacity. Respir Med. 2021 07; 183:106434. PMID: 33964816; PMCID: PMC8144063; DOI: 10.1016/j.rmed.2021.106434;

Zern EK, Ho JE, Panah LG, Lau ES, Liu E, Farrell R, Sbarbaro JA, Schoenike MW, Pappagianopoulos PP, Namasivayam M, Malhotra R, Nayor M, Lewis GD. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Arterial Stiffness and Aabnormal Left Ventricular Hemodynamic Responses During Exercise. J Card Fail. 2021 06; 27(6):625-634. PMID: 33647476; PMCID: PMC8180488; DOI: 10.1016/j.cardfail.2021.02.011;

Nayor M, Brown KJ, Vasan RS. The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk. Circ Res. 2021 01 22; 128(2):287-303. PMID: 33476202; PMCID: PMC7839236; DOI: 10.1161/CIRCRESAHA.120.315890;

Churchill TW, Li SX, Curreri L, Zern EK, Lau ES, Liu EE, Farrell R, Shoenike MW, Sbarbaro J, Malhotra R, Nayor M, Tschöpe C, de Boer RA, Lewis GD, Ho JE. Evaluation of 2 Existing Diagnostic Scores for Heart Failure With Preserved Ejection Fraction Against a Comprehensively Phenotyped Cohort. Circulation. 2021 01 19; 143(3):289-291. PMID: 33464963; PMCID: PMC8059354; DOI: 10.1161/CIRCULATIONAHA.120.050757;

Murthy VL, Reis JP, Pico AR, Kitchen R, Lima JAC, Lloyd-Jones D, Allen NB, Carnethon M, Lewis GD, Nayor M, Vasan RS, Freedman JE, Clish CB, Shah RV. Comprehensive Metabolic Phenotyping Refines Cardiovascular Risk in Young Adults. Circulation. 2020 12; 142(22):2110-2127. PMID: 33073606; PMCID: PMC7880553; DOI: 10.1161/CIRCULATIONAHA.120.047689;

Suthahar N, Lau ES, Blaha MJ, Paniagua SM, Larson MG, Psaty BM, Benjamin EJ, Allison MA, Bartz TM, Januzzi JL, Levy D, Meems LMG, Bakker SJL, Lima JAC, Cushman M, Lee DS, Wang TJ, deFilippi CR, Herrington DM, Nayor M, Vasan RS, Gardin JM, Kizer JR, Bertoni AG, Allen NB, Gansevoort RT, Shah SJ, Gottdiener JS, Ho JE, de Boer RA. Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure. J Am Coll Cardiol. 2020 09 22; 76(12):1455-1465.View Related Profiles.

Benjamin, Emelia
Larson, Martin
Nayor, Matthew

PMID: 32943164; PMCID: PMC7493711; DOI: 10.1016/j.jacc.2020.07.044;

Nayor M, Shah RV, Miller PE, Blodgett JB, Tanguay M, Pico AR, Murthy VL, Malhotra R, Houstis NE, Deik A, Pierce KA, Bullock K, Dailey L, Velagaleti RS, Moore SA, Ho JE, Baggish AL, Clish CB, Larson MG, Vasan RS, Lewis GD. Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community. Circulation. 2020 11 17; 142(20):1905-1924.View Related Profiles.

Larson, Martin
Nayor, Matthew
Velagaleti, Raghava

PMID: 32927962; PMCID: PMC8049528; DOI: 10.1161/CIRCULATIONAHA.120.050281;

Snipelisky D, Fudim M, Perez A, Nayor M, Lever NM, Raymer DS, Rosenbaum AN, AbouEzzeddine O, Hernandez AF, Stevenson LW, Gilstrap LG. Expected vs Actual Outcomes of Elective Initiation of Inotropic Therapy During Heart Failure Hospitalization. Mayo Clin Proc Innov Qual Outcomes. 2020 Oct; 4(5):529-536. PMID: 33083701; PMCID: PMC7557209; DOI: 10.1016/j.mayocpiqo.2020.05.007;

Nayor M, Houstis NE, Namasivayam M, Rouvina J, Hardin C, Shah RV, Ho JE, Malhotra R, Lewis GD. Impaired Exercise Tolerance in Heart Failure With Preserved Ejection Fraction: Quantification of Multiorgan System Reserve Capacity. JACC Heart Fail. 2020 08; 8(8):605-617. PMID: 32535122; PMCID: PMC7395858; DOI: 10.1016/j.jchf.2020.03.008;

Nayor M, Short MI, Rasheed H, Lin H, Jonasson C, Yang Q, Hveem K, Felix JF, Morrison AC, Wild PS, Morley MP, Cappola TP, Benson MD, Ngo D, Sinha S, Keyes MJ, Shen D, Wang TJ, Larson MG, Brumpton BM, Gerszten RE, Omland T, Vasan RS. Aptamer-Based Proteomic Platform Identifies Novel Protein Predictors of Incident Heart Failure and Echocardiographic Traits. Circ Heart Fail. 2020 05; 13(5):e006749.View Related Profiles.

Lin, Honghuang
Larson, Martin
Nayor, Matthew
Yang, Qiong

PMID: 32408813; PMCID: PMC7236427; DOI: 10.1161/CIRCHEARTFAILURE.119.006749;

Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O'Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020 05; 13(5):e006729.View Related Profiles.

O'Connor, George
Larson, Martin
Nayor, Matthew
Velagaleti, Raghava
Xanthakis, Vanessa

PMID: 32362167; PMCID: PMC7224335; DOI: 10.1161/CIRCHEARTFAILURE.119.006729;

Nayor M, Murthy VL, Shah RV. For Non-HDL Cholesterol, "Lower Is Better" but "Lower for Longer" May Be Best. Circ Res. 2020 03 27; 126(7):836-838. PMID: 32213138; PMCID: PMC7147968; DOI: 10.1161/CIRCRESAHA.120.316697;

Ho JE, Zern EK, Lau ES, Wooster L, Bailey CS, Cunningham T, Eisman AS, Hardin KM, Farrell R, Sbarbaro JA, Schoenike MW, Houstis NE, Baggish AL, Shah RV, Nayor M, Malhotra R, Lewis GD. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. J Am Coll Cardiol. 2020 01 07; 75(1):17-26. PMID: 31918830; PMCID: PMC7043927; DOI: 10.1016/j.jacc.2019.10.048;

Lau ES, Cunningham T, Hardin KM, Liu E, Malhotra R, Nayor M, Lewis GD, Ho JE. Sex Differences in Cardiometabolic Traits and Determinants of Exercise Capacity in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2020 01 01; 5(1):30-37. PMID: 31664435; PMCID: PMC6822160; DOI: 10.1001/jamacardio.2019.4150;

Bethea ED, Gaj K, Gustafson JL, Axtell A, Lebeis T, Schoenike M, Turvey K, Coglianese E, Thomas S, Newton-Cheh C, Ibrahim N, Carlson W, Ho JE, Shah R, Nayor M, Gift T, Shao S, Dugal A, Markmann J, Elias N, Yeh H, Andersson K, Pratt D, Bhan I, Safa K, Fishman J, Kotton C, Myoung P, Villavicencio MA, D'Alessandro D, Chung RT, Lewis GD. Pre-emptive pangenotypic direct acting antiviral therapy in donor HCV-positive to recipient HCV-negative heart transplantation: an open-label study. Lancet Gastroenterol Hepatol. 2019 10; 4(10):771-780. PMID: 31353243

Ho JE, Zern EK, Wooster L, Bailey CS, Cunningham T, Eisman AS, Hardin KM, Zampierollo GA, Jarolim P, Pappagianopoulos PP, Malhotra R, Nayor M, Lewis GD. Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions. Circulation. 2019 07 30; 140(5):353-365. PMID: 31132875; PMCID: PMC6684250; DOI: 10.1161/CIRCULATIONAHA.118.039136;

de Boer RA, Nayor M, Ho JE. High-Sensitivity Troponin and Heart Failure With Preserved Ejection Fraction-Balancing P Values With Prior Knowledge and Common Sense-Reply. JAMA Cardiol. 2018 09 01; 3(9):892-893. PMID: 29926109

Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, Kizer JR, Sarma A, Blaha MJ, Gansevoort RT, Gardin JM, Hillege HL, Ji F, Kop WJ, Lau ES, Lee DS, Sadreyev R, van Gilst WH, Wang TJ, Zanni MV, Vasan RS, Allen NB, Psaty BM, van der Harst P, Levy D, Larson M, Shah SJ, de Boer RA, Gottdiener JS, Ho JE. The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF. JACC Heart Fail. 2018 08; 6(8):701-709.View Related Profiles.

Larson, Martin
Nayor, Matthew

PMID: 30007554; PMCID: PMC6076337; DOI: 10.1016/j.jchf.2018.05.018;

Nayor M, Cooper LL, Enserro DM, Xanthakis V, Larson MG, Benjamin EJ, Aragam J, Mitchell GF, Vasan RS. Left Ventricular Diastolic Dysfunction in the Community: Impact of Diagnostic Criteria on the Burden, Correlates, and Prognosis. J Am Heart Assoc. 2018 06 01; 7(11).View Related Profiles.

Benjamin, Emelia
Larson, Martin
Nayor, Matthew
Xanthakis, Vanessa

PMID: 29858363; PMCID: PMC6015390; DOI: 10.1161/JAHA.117.008291;

Nayor M, Enserro DM, Xanthakis V, Larson MG, Benjamin EJ, Aragam J, Mitchell GF, Vasan RS. Comorbidities and Cardiometabolic Disease: Relationship With Longitudinal Changes in Diastolic Function. JACC Heart Fail. 2018 04; 6(4):317-325.View Related Profiles.

Benjamin, Emelia
Aragam, Jayashri
Larson, Martin
Nayor, Matthew
Xanthakis, Vanessa

PMID: 29525334; PMCID: PMC5878123; DOI: 10.1016/j.jchf.2017.12.018;

de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL, Shah SJ, Levy D, Herrington DM, Larson MG, van Gilst WH, Gottdiener JS, Bertoni AG, Ho JE. Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction. JAMA Cardiol. 2018 03 01; 3(3):215-224.View Related Profiles.

Benjamin, Emelia
Larson, Martin
Nayor, Matthew
Ramachandran, Vasan

PMID: 29322198; PMCID: PMC5862778; DOI: 10.1001/jamacardio.2017.4987;

Nayor M, Duncan MS, Musani SK, Xanthakis V, LaValley MP, Larson MG, Fox ER, Vasan RS. Incidence of cardiovascular disease in individuals affected by recent changes to US blood pressure treatment guidelines. J Hypertens. 2018 02; 36(2):436-443.View Related Profiles.

Larson, Martin
Nayor, Matthew
LaValley, Michael
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 29084083; PMCID: PMC6062206; DOI: 10.1097/HJH.0000000000001570;

Addison D, Lawler PR, Emami H, Janjua SA, Staziaki PV, Hallett TR, Hennessy O, Lee H, Szilveszter B, Lu M, Mousavi N, Nayor MG, Delling FN, Romero JM, Wirth LJ, Chan AW, Hoffmann U, Neilan TG. Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer. J Stroke. 2018 Jan; 20(1):71-79. PMID: 29402065; PMCID: PMC5836583; DOI: 10.5853/jos.2017.01802;

Bhambhani V, Kizer JR, Lima JAC, van der Harst P, Bahrami H, Nayor M, de Filippi CR, Enserro D, Blaha MJ, Cushman M, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Brouwers FP, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL, Levy D, Herrington DM, van Gilst WH, Bertoni AG, Larson MG, de Boer RA, Gottdiener JS, Shah SJ, Ho JE. Predictors and outcomes of heart failure with mid-range ejection fraction. Eur J Heart Fail. 2018 04; 20(4):651-659.View Related Profiles.

Benjamin, Emelia
Larson, Martin
Nayor, Matthew
Ramachandran, Vasan

PMID: 29226491; PMCID: PMC5899688; DOI: 10.1002/ejhf.1091;

DeFilippis EM, Nayor M, Lewis EF. Chest Pain and Shortness of Breath After a Heart Transplant. JAMA Cardiol. 2017 11 01; 2(11):1271-1272. PMID: 28975203

Nayor M, Larson MG, Wang N, Santhanakrishnan R, Lee DS, Tsao CW, Cheng S, Benjamin EJ, Vasan RS, Levy D, Fox CS, Ho JE. The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction. Eur J Heart Fail. 2017 May; 19(5):615-623.View Related Profiles.

Benjamin, Emelia
Larson, Martin
Nayor, Matthew
Ramachandran, Vasan

PMID: 28217978; PMCID: PMC5423843; DOI: 10.1002/ejhf.778;

Nayor M, Vasan RS. Recent Update to the US Cholesterol Treatment Guidelines: A Comparison With International Guidelines. Circulation. 2016 May 03; 133(18):1795-806.View Related Profiles.

Nayor, Matthew
Ramachandran, Vasan

PMID: 27143546; PMCID: PMC4857879; DOI: 10.1161/CIRCULATIONAHA.116.021407;

Nayor M, Wang N, Larson MG, Vasan RS, Levy D, Ho JE. Circulating Galectin-3 Is Associated With Cardiometabolic Disease in the Community. J Am Heart Assoc. 2015 Dec 31; 5(1).View Related Profiles.

Larson, Martin
Nayor, Matthew
Ramachandran, Vasan

PMID: 26722123; PMCID: PMC4859357; DOI: 10.1161/JAHA.115.002347;

Nayor M, Enserro DM, Vasan RS, Xanthakis V. Cardiovascular Health Status and Incidence of Heart Failure in the Framingham Offspring Study. Circ Heart Fail. 2016 Jan; 9(1):e002416.View Related Profiles.

Nayor, Matthew
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 26699391; PMCID: PMC4692176; DOI: 10.1161/CIRCHEARTFAILURE.115.002416;

Nayor M, Enserro DM, Beiser AS, Cheng S, DeCarli C, Vasan RS, Seshadri S. Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study. Stroke. 2016 Feb; 47(2):383-9.View Related Profiles.

Beiser, Alexa
Nayor, Matthew
Seshadri, Sudha
Ramachandran, Vasan

PMID: 26696648; PMCID: PMC4729607; DOI: 10.1161/STROKEAHA.115.010405;

Nayor M, Vasan RS. Preventing heart failure: the role of physical activity. Curr Opin Cardiol. 2015 Sep; 30(5):543-50.View Related Profiles.

Nayor, Matthew
Ramachandran, Vasan

PMID: 26154074; PMCID: PMC4615715; DOI: 10.1097/HCO.0000000000000206;

Nayor M, Vasan RS. Endogenous carbon monoxide and cardiometabolic risk: can measuring exhaled carbon monoxide be used to refine cardiometabolic risk assessment? Future Cardiol. 2015; 11(1):9-12.View Related Profiles.

Nayor, Matthew
Ramachandran, Vasan

PMID: 25606696; DOI: 10.2217/fca.14.78;

Nayor M, Maron BA. Contemporary approach to paradoxical embolism. Circulation. 2014 May 06; 129(18):1892-7.View Related Profiles.

Maron, Bradley
Nayor, Matthew

PMID: 24799505; PMCID: PMC4053687; DOI: 10.1161/CIRCULATIONAHA.113.005462;

Nayor M, Berliner AJ, Chow GV, Spragg DD. An Unusual Case of Asystole following Penetrating Neck Trauma and Anoxic Brain Injury. Case Rep Cardiol. 2011; 2011:579805. PMID: 24826224; PMCID: PMC4008474; DOI: 10.1155/2011/579805;

Konno T, Chen D, Wang L, Wakimoto H, Teekakirikul P, Nayor M, Kawana M, Eminaga S, Gorham JM, Pandya K, Smithies O, Naya FJ, Olson EN, Seidman JG, Seidman CE. Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18097-102. PMID: 20923879; PMCID: PMC2964244; DOI: 10.1073/pnas.1012826107;

Teekakirikul P, Eminaga S, Toka O, Alcalai R, Wang L, Wakimoto H, Nayor M, Konno T, Gorham JM, Wolf CM, Kim JB, Schmitt JP, Molkentin JD, Norris RA, Tager AM, Hoffman SR, Markwald RR, Seidman CE, Seidman JG. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-ß. J Clin Invest. 2010 Oct; 120(10):3520-9. PMID: 20811150; PMCID: PMC2947222; DOI: 10.1172/JCI42028;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 72 publications over 13 distinct years, with a maximum of 15 publications in 2023

Bar chart showing 72 publications over 13 distinct years, with a maximum of 15 publications in 2023

Year	Publications
2010	2
2011	1
2014	1
2015	5
2016	1
2017	3
2018	7
2019	2
2020	10
2021	14
2022	9
2023	15
2024	2

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New Study Reveals the Best Type of Exercise for Getting Fit and Healthy

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2021 Boston University School of Medicine: Aram Chobanian Assistant Professor of Medicine

2021 Boston University Medical Center: Boston University School of Medicine Department of Medicine Career Development Award

2018-2020 National Institutes of Health: Loan Repayment Program

2016 Brigham and Women's Hospital, Cardiovascular Medicine Division: Richard Gorlin Fellowship in Cardiovascular Medicine

2012 Johns Hopkins Hospital Osler Medical Residency: Frank L. Coulson, Jr. Award for Clinical Excellence

2009 NYU School of Medicine: Clerkship Award for Outstanding Essay in the Philosophy of Medicine

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Epidemiology, Molecular
Exercise, Physical
Metabolomics
Proteomics
Heart Failure, Diastolic
Heart Failure, Systolic
Metabolic Cardiovascular Syndrome

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Career Mentor
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Education Mentor
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Research / Scholarly Mentor

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