George T. O'Connor, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health




My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute




Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
05/01/2019 - 04/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL111024-07

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2019 - 02/28/2022 (Subcontract PI)
Massachusetts General Hospital NIH OD
3OT2OD026553-01S1

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH OD
5UH3OD023268-05

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2021 (Subcontract PI)
University of Wisconsin System NIH OD
5UH3OD023282-05

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-04

Inner City Asthma Consortium 3 (ICAC3)
08/01/2016 - 07/31/2021 (Subcontract PI)
University of Wisconsin System NIH NIAID
3UM1AI114271-07S1

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2019 (Subcontract PI)
University of Wisconsin, Madison NIH OD
4UH3OD023282-03

Randomized Controlled Trial: VDAART CONTINUATION STUDY - DCC - LEAD
05/15/2014 - 04/30/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL091528-10

Children's Respiratory and Environmental Workgroup (CREW), CREW Year 2
09/01/2017 - 08/31/2018 (Subcontract PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Children's Respiratory and Environmental Workgroup (CREW) CREW Year 2
09/01/2017 - 08/31/2018 (Subcontract PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Showing 10 of 33 results. Show All Results

The New England Precision Medicine Consortium of the All of_
03/01/2018 - 02/28/2022 (PI)
The General Hospital Corporation / MGH National Institutes

A New England Enrollment Center for the PMI Cohort Program
04/01/2017 - 02/28/2018 (PI)
Mass General Hosp NIH-OD

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.


Title


Yr Title Project-Sub Proj Pubs
2021 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S3 3
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2019 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S1 3
2018 The New England Precision Medicine Consortium of the All of Us Research Program 1OT2OD026553-01 3
2017 A New England Enrollment Center for PMI Cohort Program 3OT2OD024612-01S1
2016 A New England Enrollment Center for PMI Cohort Program 1OT2OD024612-01
2013 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-04 3
2012 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-03 3
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 3
Showing 10 of 79 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function. Chest. 2021 Jul 05.View Related Profiles. PMID: 34237330
     
  2. Lovinsky-Desir S, Lussier SJ, Calatroni A, Gergen PJ, Rivera-Spoljaric K, Bacharier LB, De A, O'Connor GT, Sandel MT, Wood RA, Arteaga-Solis E, Gern JE, Kattan M. Trajectories of adiposity indicators and association with asthma and lung function in urban minority children. J Allergy Clin Immunol. 2021 Jun 22.View Related Profiles. PMID: 34166677
     
  3. Chen YS, Mirzakhani H, Lu M, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Carey VJ, Harshfield BJ, Laranjo N, Litonjua AA, Weiss ST, Lee-Sarwar KA. The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood. J Allergy Clin Immunol Pract. 2021 Jun 21.View Related Profiles. PMID: 34166843
     
  4. Altman MC, Flynn K, Rosasco MG, Dapas M, Kattan M, Lovinsky-Desir S, O'Connor GT, Gill MA, Gruchalla RS, Liu AH, Pongracic JA, Khurana Hershey GK, Zoratti EM, Teach SJ, Rastrogi D, Wood RA, Bacharier LB, LeBeau P, Gergen PJ, Togias A, Busse WW, Presnell S, Gern JE, Ober C, Jackson DJ. Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children. J Allergy Clin Immunol. 2021 May 18. PMID: 34019912
     
  5. Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD. Thorax. 2021 May 10.View Related Profiles. PMID: 33972452
     
  6. Sanders JL, Putman RK, Dupuis J, Xu H, Murabito JM, Araki T, Nishino M, Benjamin EJ, Levy DL, Ramachandran VS, Washko GR, Curtis JL, Freeman CM, Bowler RP, Hatabu H, O'Connor GT, Hunninghake GM. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2021 05 01; 203(9):1149-1157.View Related Profiles. PMID: 33080140
     
  7. Moll M, Jackson VE, Yu B, Grove ML, London SJ, Gharib SA, Bartz TM, Sitlani CM, Dupuis J, O'Connor GT, Xu H, Cassano PA, Patchen BK, Kim WJ, Park J, Kim KH, Han B, Barr RG, Manichaikul A, Nguyen JN, Rich SS, Lahousse L, Terzikhan N, Brusselle G, Sakornsakolpat P, Liu J, Benway CJ, Hall IP, Tobin MD, Wain LV, Silverman EK, Cho MH, Hobbs BD. A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 01; 321(1):L130-L143.View Related Profiles. PMID: 33909500
     
  8. Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 04 01; 203(7):864-870. PMID: 33535024; PMCID: PMC8017591; DOI: 10.1164/rccm.202003-0820OC;
     
  9. Synn AJ, Byanova KL, Li W, Gold DR, Di Q, Kloog I, Schwartz J, San José Estépar R, Washko GR, O'Connor GT, Mittleman MA, Rice MB. Ambient air pollution exposure and radiographic pulmonary vascular volumes. Environ Epidemiol. 2021 Apr; 5(2):e143. PMID: 33870015; PMCID: PMC8043731; DOI: 10.1097/EE9.0000000000000143;
     
  10. Terzikhan N, Xu H, Edris A, Bracke KR, Verhamme FM, Stricker BHC, Dupuis J, Lahousse L, O'Connor GT, Brusselle GG. Epigenome-wide association study on diffusing capacity of the lung. ERJ Open Res. 2021 Jan; 7(1).View Related Profiles. PMID: 33748261; PMCID: PMC7957297; DOI: 10.1183/23120541.00567-2020;
     
Showing 10 of 278 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 278 publications over 35 distinct years, with a maximum of 25 publications in 2019

YearPublications
19874
19882
19895
19901
19913
19922
19936
19943
19954
19964
19973
19982
19994
20003
20016
20023
20037
20044
20055
20064
20076
20084
200913
20108
20116
201210
201315
201411
201516
201620
201721
201815
201925
202017
202116
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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