George T. O'Connor, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health




My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute




Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
05/01/2019 - 04/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
2R01HL111024-06

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH OD
4UH3OD023268-03

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2020 (Subcontract PI)
University of Wisconsin System NIH OD
5UH3OD023282-04

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-03

Inner City Asthma Consortium 3 (ICAC3)
08/01/2016 - 07/31/2020 (Subcontract PI)
University of Wisconsin System NIH NIAID
5UM1AI114271-06

The New England Precision Medicine Consortium of the All of Us Research Program
01/01/2020 - 02/29/2020 (Subcontract PI)
Massachusetts General Hospital NIH OD
3OT2OD026553-01S1

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2019 (Subcontract PI)
University of Wisconsin, Madison NIH OD
4UH3OD023282-03

Randomized Controlled Trial: VDAART CONTINUATION STUDY - DCC - LEAD
05/15/2014 - 04/30/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL091528-10

Children's Respiratory and Environmental Workgroup (CREW), CREW Year 2
09/01/2017 - 08/31/2018 (Subcontract PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Children's Respiratory and Environmental Workgroup (CREW) CREW Year 2
09/01/2017 - 08/31/2018 (Subcontract PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Showing 10 of 33 results. Show All Results

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2018 - 02/28/2020 (PI)
Mass General Hosp NIH-OD
3OT2OD026553-01S1

A New England Enrollment Center for the PMI Cohort Program
04/01/2017 - 02/28/2018 (PI)
Mass General Hosp NIH-OD

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.


Title


Yr Title Project-Sub Proj Pubs
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2019 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S1 3
2018 The New England Precision Medicine Consortium of the All of Us Research Program 1OT2OD026553-01 3
2017 A New England Enrollment Center for PMI Cohort Program 3OT2OD024612-01S1
2016 A New England Enrollment Center for PMI Cohort Program 1OT2OD024612-01
2013 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-04 3
2012 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-03 3
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 3
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 3
Showing 10 of 78 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Synn AJ, Li W, San José Estépar R, Washko GR, O'Connor GT, Tsao CW, Mittleman MA, Rice MB. Pulmonary Vascular Pruning on Computed Tomography and Risk of Death in the Framingham Heart Study. Am J Respir Crit Care Med. 2020 Sep 14. PMID: 32926788
     
  2. Lu M, Litonjua AA, O'Connor GT, Zeiger RS, Bacharier L, Schatz M, Carey VJ, Weiss ST, Mirzakhani H. Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze. J Allergy Clin Immunol. 2020 Aug 19. PMID: 32822692
     
  3. Kim JS, Steffen BT, Podolanczuk AJ, Kawut SM, Noth I, Raghu G, Michos ED, Hoffman EA, Axelsson GT, Gudmundsson G, Gudnason V, Gudmundsson EF, Murphy RA, Dupuis J, Xu H, Vasan RS, O'Connor GT, Harris WS, Hunninghake GM, Barr RG, Tsai MY, Lederer DJ. Associations of Omega-3 Fatty acids with Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults. Am J Epidemiol. 2020 Aug 17.View Related Profiles. PMID: 32803215
     
  4. Synn AJ, Li W, Hunninghake GM, Washko GR, San José Estépar R, O'Connor GT, Kholdani CA, Hallowell RW, Bankier AA, Mittleman MA, Rice MB. Vascular Pruning on Computed Tomography and Interstitial Lung Abnormalities in the Framingham Heart Study. Chest. 2020 Aug 13. PMID: 32798523
     
  5. Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O'Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020 May; 13(5):e006729.View Related Profiles. PMID: 32362167
     
  6. Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020 05; 8(5):482-492. PMID: 32380068
     
  7. Balte PP, Chaves PHM, Couper DJ, Enright P, Jacobs DR, Kalhan R, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith BM, Smith LJ, White WB, Yende S, Oelsner EC. Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults. JAMA Intern Med. 2020 May 01; 180(5):676-686. PMID: 32119036
     
  8. Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020 Jul; 146(1):203-206.e3. PMID: 32333915
     
  9. Bou Jawde S, Walkey AJ, Majumdar A, O'Connor GT, Smith BJ, Bates JHT, Lutchen KR, Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Sci Rep. 2020 04 21; 10(1):6722.View Related Profiles. PMID: 32317734
     
  10. Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. A Dyadic Growth Modeling Approach to Examine Associations Between Weight Gain and Lung Function Decline: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2020 Apr 14. PMID: 32286615
     
Showing 10 of 259 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 259 publications over 34 distinct years, with a maximum of 25 publications in 2019

YearPublications
19874
19882
19895
19901
19913
19922
19936
19943
19954
19964
19973
19982
19994
20003
20016
20023
20037
20044
20055
20064
20076
20084
200913
20108
20116
201210
201315
201411
201516
201620
201721
201815
201925
202014
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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