George T. O'Connor, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health




My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Investigator
Framingham Heart Study


Member
Boston University
Pulmonary Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute




Clinical Center for NIH's Nurtrition for Precision Health: The All of Us NEw England Research Collaborative
12/10/2021 - 11/30/2026 (Subcontract PI)
Trustees of Tufts College, Inc NIH NICHD
1UG1HD107691-01

Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
05/01/2019 - 04/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL111024-08

Childhood Asthma in Urban Settings (CAUSE)- Leadership Center
08/01/2021 - 03/31/2023 (Subcontract PI)
University of Wisconsin, Madison NIH NIAID
1UM1AI160040-01

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2019 - 02/28/2023 (Subcontract PI)
Massachusetts General Hospital NIH OD
3OT2OD026553-01S3

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2022 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH OD
5UH3OD023268-06

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2022 (Subcontract PI)
University of Wisconsin System NIH OD
5UH3OD023282-06

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-04

Inner City Asthma Consortium 3 (ICAC3)
08/01/2016 - 07/31/2021 (Subcontract PI)
University of Wisconsin System NIH NIAID
3UM1AI114271-07S1

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2019 (Subcontract PI)
University of Wisconsin, Madison NIH OD
4UH3OD023282-03

Randomized Controlled Trial: VDAART CONTINUATION STUDY - DCC - LEAD
05/15/2014 - 04/30/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL091528-10

Showing 10 of 36 results. Show All Results

The New England Precision Medicine Consortium of the All of_
03/01/2018 - 02/28/2023 (PI)
The General Hospital Corporation / MGH National Institutes

A New England Enrollment Center for the PMI Cohort Program
04/01/2017 - 02/28/2018 (PI)
Mass General Hosp NIH-OD

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.


Title


Yr Title Project-Sub Proj Pubs
2021 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S3 3
2020 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S2 3
2019 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S1 3
2018 The New England Precision Medicine Consortium of the All of Us Research Program 1OT2OD026553-01 3
2017 A New England Enrollment Center for PMI Cohort Program 3OT2OD024612-01S1
2016 A New England Enrollment Center for PMI Cohort Program 1OT2OD024612-01
2013 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-04 3
2012 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-03 3
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 3
2010 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 1R01HL101390-01 3
Showing 10 of 73 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Bhatt SP, O'Connor GT. Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities. JAMA. 2022 05 10; 327(18):1768-1770. PMID: 35536275
     
  2. Eckhardt CM, Balte PP, Barr RG, Bertoni AG, Bhatt SP, Cuttica M, Cassano PA, Chaves P, Couper D, Jacobs DR, Kalhan R, Kronmal R, Lange L, Loehr L, London SJ, O'Connor GT, Rosamond W, Sanders J, Schwartz JE, Shah A, Shah SJ, Smith L, White W, Yende S, Oelsner EC. Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study. Eur Heart J. 2022 Apr 25. PMID: 35467708
     
  3. McNeill JN, Lee DH, Hwang SJ, Courchesne P, Yao C, Huan T, Joehanes R, O'Connor GT, Ho JE, Levy D. Association of 71 cardiovascular disease-related plasma proteins with pulmonary function in the community. PLoS One. 2022; 17(4):e0266523.View Related Profiles. PMID: 35390066; PMCID: PMC8989231; DOI: 10.1371/journal.pone.0266523;
     
  4. Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B, Cade BE, Laurie CA, Sofer T, Ruczinski I, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Gabriel S, Gupta N, Dugan-Perez S, Cupples LA, Loehr LR, Jain D, Rotter JI, Wilson JG, Psaty BM, Fornage M, Morrison AC, Vasan RS, Washko G, Rich SS, O'Connor GT, Bleecker E, Kaplan RC, Kalhan R, Redline S, Gharib SA, Meyers D, Ortega V, Dupuis J, London SJ, Lappalainen T, Oelsner EC, Silverman EK, Barr RG, Thornton TA, Wheeler HE, Cho MH, Im HK, Manichaikul A. Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. Am J Hum Genet. 2022 May 05; 109(5):857-870.View Related Profiles. PMID: 35385699
     
  5. Lee-Sarwar K, Dedrick S, Momeni B, Kelly RS, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Lasky-Su J, Litonjua AA, Liu YY, Weiss ST. Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma. J Allergy Clin Immunol. 2022 Feb 20.View Related Profiles. PMID: 35196534
     
  6. Bhatt SP, Balte PP, Schwartz JE, Jaeger BC, Cassano PA, Chaves PH, Couper D, Jacobs DR, Kalhan R, Kaplan R, Lloyd-Jones D, Newman AB, O'Connor G, Sanders JL, Smith BM, Sun Y, Umans JG, White WB, Yende S, Oelsner EC. Pooled Cohort Probability Score for Subclinical Airflow Obstruction. Ann Am Thorac Soc. 2022 Feb 17. PMID: 35176216
     
  7. McCauley KE, Flynn K, Calatroni A, DiMassa V, LaMere B, Fadrosh DW, Lynch KV, Gill MA, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Liu AH, Johnson CC, Kim H, Kattan M, O'Connor GT, Bacharier LB, Teach SJ, Gergen PJ, Wheatley LM, Togias A, LeBeau P, Presnell S, Boushey HA, Busse WW, Gern JE, Jackson DJ, Altman MC, Lynch SV. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations. J Allergy Clin Immunol. 2022 Feb 08. PMID: 35149044
     
  8. Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Gudmundsson EF, Qiao D, San José Estépar R, Dupuis J, O'Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, DeVivo I, Cho MH, Gudmundsson G, Hunninghake GM. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 Feb 03.View Related Profiles. PMID: 35115336
     
  9. Zhang J, Xu H, Qiao D, DeMeo DL, Silverman EK, O'Connor GT, Hobbs BD, Dupuis J, Cho MH, Moll M. A Polygenic Risk Score and Age of Diagnosis of Chronic Obstructive Pulmonary Disease. Eur Respir J. 2022 Feb 03.View Related Profiles. PMID: 35115341
     
  10. Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL. Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Blood. 2022 01 20; 139(3):357-368.View Related Profiles. PMID: 34855941; PMCID: PMC8777202; DOI: 10.1182/blood.2021013531;
     
Showing 10 of 299 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 299 publications over 36 distinct years, with a maximum of 26 publications in 2021

YearPublications
19874
19882
19895
19901
19913
19922
19936
19943
19954
19964
19973
19982
19994
20003
20016
20023
20037
20044
20055
20064
20076
20084
200913
20108
20116
201210
201315
201411
201516
201620
201721
201815
201925
202017
202126
202211
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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