George T. O'Connor, MD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health




My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

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Boston Medical Center
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Framingham Heart Study




Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2019 (PI)
University of Wisconsin, Madison NIH OD
4UH3OD023282-03

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2019 (PI)
The Brigham and Women's Hospital, Inc. NIH OD
4UH3OD023268-03

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2019 (PI)
University of Wisconsin System NIH OD
4UH3OD023282-03

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2019 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-02

Inner City Asthma Consortium 3 (ICAC3)
08/01/2016 - 07/31/2019 (PI)
University of Wisconsin System NIH NIAID
5UM1AI114271-05

Randomized Controlled Trial: VDAART CONTINUATION STUDY - DCC - LEAD
05/15/2014 - 04/30/2019 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL091528-10

Children's Respiratory and Environmental Workgroup (CREW), CREW Year 2
09/01/2017 - 08/31/2018 (PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Children's Respiratory and Environmental Workgroup (CREW) CREW Year 2
09/01/2017 - 08/31/2018 (PI)
University of Wisconsin, Madison NIH OD
5UG3OD023282-02

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/21/2016 - 08/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH OD
5UG3OD023268-02

Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
07/01/2016 - 06/30/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL111024-05

Showing 10 of 31 results. Show All Results

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2018 - 02/28/2019 (PI)
Mass General Hosp NIH-OD

A New England Enrollment Center for the PMI Cohort Program
04/01/2017 - 02/28/2019 (PI)
Mass General Hosp NIH-OD

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.



Yr Title Project-Sub Proj Pubs
2019 The New England Precision Medicine Consortium of the All of Us Research Program 3OT2OD026553-01S1
2018 The New England Precision Medicine Consortium of the All of Us Research Program 1OT2OD026553-01
2017 A New England Enrollment Center for PMI Cohort Program 3OT2OD024612-01S1
2016 A New England Enrollment Center for PMI Cohort Program 1OT2OD024612-01
2013 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-04 2
2012 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-03 2
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 2
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 2
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 2
2011 Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype 5R01HL101390-02 2
Showing 10 of 76 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gern JE, Jackson DJ, Lemanske RF, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB. The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population. Respir Res. 2019 Jun 10; 20(1):115. PMID: 31182091.
     
  2. Synn AJ, Zhang C, Washko GR, Estépar RSJ, O'Connor GT, Li W, Mittleman MA, Rice MB. Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study. Ann Am Thorac Soc. 2019 Jun; 16(6):698-706. PMID: 30714821.
     
  3. Mirzakhani H, Carey VJ, McElrath TF, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Maternal Asthma, Preeclampsia and Risk of Childhood Asthma at Age Six. Am J Respir Crit Care Med. 2019 May 06. PMID: 31059286.
     
  4. Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 May 06; 9(1):6978.View Related Profiles. PMID: 31061400.
     
  5. Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O'Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A. The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age. Clin Exp Allergy. 2019 May 02.View Related Profiles. PMID: 31046157.
     
  6. Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019 05; 20(5):637-651. PMID: 30962590.
     
  7. Miller ER, Putman RK, Diaz AA, Xu H, San José Estépar R, Araki T, Nishino M, Poli de Frías S, Hida T, Ross J, Coxson H, Dupuis J, O'Connor GT, Silverman EK, Rosas IO, Hatabu H, Washko G, Hunninghake GM. Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 Apr; 16(4):447-454.View Related Profiles. PMID: 30543456.
     
  8. Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Weiss ST, Litonjua AA. Integrative analysis of the intestinal metabolome of childhood asthma. J Allergy Clin Immunol. 2019 Mar 23.View Related Profiles. PMID: 30914378.
     
  9. Sordillo JE, Korrick S, Laranjo N, Carey V, Weinstock GM, Gold DR, O'Connor G, Sandel M, Bacharier LB, Beigelman A, Zeiger R, Litonjua AA, Weiss ST. Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial. JAMA Netw Open. 2019 Mar 01; 2(3):e190905.View Related Profiles. PMID: 30901046.
     
  10. Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR, Launer LJ, Lemaitre RN, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Rohde RR, Rich SS, Rotter JI, Seshadri S, Smith LJ, Tiemeier H, Tsai MY, Uitterlinden AG, Voruganti VS, Xu H, Zilhão NR, Fornage M, Zillikens MC, London SJ, Barr RG, Dupuis J, Gharib SA, Gudnason V, Lahousse L, North KE, Steffen LM, Cassano PA, Hancock DB. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019 Mar 01; 199(5):631-642.View Related Profiles. PMID: 30199657.
     
Showing 10 of 238 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 237 publications over 33 distinct years, with a maximum of 21 publications in 2017

YearPublications
19874
19882
19895
19901
19913
19922
19936
19943
19954
19964
19973
19982
19994
20003
20016
20023
20037
20044
20055
20064
20076
20084
200913
20108
20116
201210
201315
201411
201516
201620
201721
201815
201917
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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