Jingzhou Zhang, MD MPH
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Peking Union Medical College
MPH, Columbia University School of Public Health

Pronouns: he/him/his



Dr. Zhang is a clinician-investigator specializing in pulmonary and critical care medicine, with a research focus on integrating traditional epidemiologic methods with bioinformatics and multi-omics approaches to improve risk prediction and elucidate the pathobiology of COPD and other chronic lung diseases. He conducts epidemiologic research through the Framingham Heart Study and the COPDGene Study and collaborates with other cohorts within the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. His current research interests include: 1) Identifying obesity- and body composition-related determinants of COPD risk and heterogeneity, including cardiovascular outcomes; and 2) Defining lung disease risk and improving disease risk stratification in individuals with alpha-1 antitrypsin deficiency, including genetic carriers.


Obesity-Related Determinants of COPD Heterogeneity: A Multiomics Investigation
07/01/2025 - 06/30/2028 (PI)
Parker B. Francis Fellowship Program


Genetic and Proteomic Prediction and Pathways of COPD Risk in Alpha-1 Antitrypsin MZ
07/01/2025 - 06/30/2028 (PI)
Alpha-1 Foundation




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Zhang C, Konigsberg IR, He Y, Zhang J, Chikowore T, Feldman WB, Hu X, Ding Y, Pasaniuc B, Chang D, Chen Q, Lasky-Su JA, Hecker J, Tobin MD, Chen J, Kalra S, Pratte KA, Im HK, Wan ES, Manichaikul A, Silverman EK, Bowler RP, Lange LA, Ortega VE, Martin AR, Cho MH, Moll MR. Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins. medRxiv. 2025 Aug 26.View Related Profiles. PMID: 40909810; PMCID: PMC12407601; DOI: 10.1101/2025.08.22.25334001;
     
  2. Zhang J, Hobbs BD, Silverman EK, Sparrow D, Ortega VE, Xu H, Zhang C, Dupuis J, Walkey AJ, O'Connor GT, Cho MH, Moll M. Polygenic Risk Score Added to Conventional Case Finding to Identify Undiagnosed Chronic Obstructive Pulmonary Disease. JAMA. 2025 Mar 04; 333(9):784-792.View Related Profiles. PMID: 39841442; PMCID: PMC11880956; DOI: 10.1001/jama.2024.24212;
     
  3. Moll M, Hecker J, Platig J, Zhang J, Ghosh AJ, Pratte KA, Wang RS, Hill D, Konigsberg IR, Chiles JW, Hersh CP, Castaldi PJ, Glass K, Dy JG, Sin DD, Tal-Singer R, Mouded M, Rennard SI, Anderson GP, Kinney GL, Bowler RP, Curtis JL, McDonald ML, Silverman EK, Hobbs BD, Cho MH. Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies. EBioMedicine. 2024 Dec; 110:105429. PMID: 39509750; PMCID: PMC11570824; DOI: 10.1016/j.ebiom.2024.105429;
     
  4. Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW, McDonald MN, Divo MJ, Silverman EK, Celli BR, O'Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 Oct 01; 210(7):890-899.View Related Profiles. PMID: 38471013; PMCID: PMC11506912; DOI: 10.1164/rccm.202308-1384OC;
     
  5. Shen BH, Dobie AC, Shusterman SL, Duzgol M, Homer-Bouthiette C, Kearney LE, Newman J, Pang B, Shankar DA, Zhang J, Gillmeyer KR, Bosch NA, Law AC. Variation in Triage to Pediatric vs Adult ICUs Among Adolescents and Young Adults With Asthma Exacerbations. CHEST Crit Care. 2024 Sep; 2(3).View Related Profiles. PMID: 39364391; PMCID: PMC11449464; DOI: 10.1016/j.chstcc.2024.100088;
     
  6. Pang B, Kearney L, Maccarone J, Zhang J, Kearney C, Sangani R, Shankar DA, Gillmeyer KR, Law AC, Bosch NA. Association between Early Venous Thromboembolism Prophylaxis, Bleeding Risk, and Venous Thromboembolism among Critically Ill Patients with Thrombocytopenia. Ann Am Thorac Soc. 2023 Jun; 20(6):917-920.View Related Profiles. PMID: 36867519; PMCID: PMC10257036; DOI: 10.1513/AnnalsATS.202210-847RL;
     
  7. Pang B, Kearney L, Maccarone J, Zhang J, Kearney C, Sangani R, Shankar DA, Gillmeyer KR, Law AC, Bosch NA. Association between Early Venous Thromboembolism Prophylaxis, Bleeding Risk, and Venous Thromboembolism among Critically Ill Patients with Thrombocytopenia. Ann Am Thorac Soc. 2023; 20(6):917-920.
  8. Zhang J, Xu H, Qiao D, DeMeo DL, Silverman EK, O'Connor GT, Hobbs BD, Dupuis J, Cho MH, Moll M. A polygenic risk score and age of diagnosis of COPD. Eur Respir J. 2022 Sep; 60(3).View Related Profiles. PMID: 35115341; PMCID: PMC9969342; DOI: 10.1183/13993003.01954-2021;
     
  9. Hu X, Zhang J, Cao Y. Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study. BMC Cancer. 2022 May 14; 22(1):544. PMID: 35568827; PMCID: PMC9107191; DOI: 10.1186/s12885-022-09637-7;
     
  10. Zhang J, DeMeo DL, Silverman EK, Make BJ, Wade RC, Wells JM, Cho MH, Hobbs BD. Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors. BMC Pulm Med. 2021 Jul 14; 21(1):235. PMID: 34261472; PMCID: PMC8278596; DOI: 10.1186/s12890-021-01585-5;
     
Showing 10 of 14 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 14 publications over 8 distinct years, with a maximum of 3 publications in 2024

YearPublications
20161
20171
20182
20211
20222
20232
20243
20252


2025 Francis Family Foundation: Parker B. Francis Fellowship Award
2025 Alpha-1 Foundation: John W. Walsh Career Development Award
2025 Boston University: Department of Medicine Career Investment Award
2023 American Thoracic Society: Abstract Scholarship Award
2023 Respiratory Disease Young Investigators' Forum: Young Investigator
2022 American Thoracic Society: Clinical Year In Review, COPD section (PMID: 35115341)
2018 American College of Physicians Massachusetts Chapter: First Runner Up in Research Poster
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

COPD
Epidemiology
Asthma
Genetics
Multiple Omics
Alpha-1 Antitrypsin Deficiency

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