Keywords
Last Name

David H. Farb, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4300
ORCID ORCID Icon0000-0002-9050-6480
Other Positions
TitleChair of Pharmacology & Experimental Therapeutics
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Awards and Honors

Start-EndDescription
2014-PresNIH/NIGMS Institutional Predoctoral Training, CSR: Special Emphasis Panel and Site Visitor
2013-PresNIH, CSR: Emerging Technologies and Training in Neuroscience, Special Emphasis Panel
2013-2013NIH/NIGMS, CSR: NIGMS Institutional Predoctoral Training, BRT-A Subcommittee
2013US-India Chamber of Commerce: BioPharma Summit, Panel Member on Industry Academia Collaborations
2009-PresThe NorthEast Under/graduate Research Organization for Neuroscience (N.E.U.R.O.N.): Steering Committee
2006-2007Boston University Office of Technology Transfer: Ignition Award for Research Leading to the Development of Novel Analgesics
2005-2007American Society for Pharmacology and Experimental Therapeutics (ASPET): President, New England Pharmacologists Chapter
2005NTRC: Study Section
2005IUPHAR (International Union of Basic and Clinical Pharmacology) : GABAB Committee
2004NIAAA: Brain Resiliency and Repair Workshop, Future Directions Panel
1999Wellcome Trust Infrastructure Fund: Chair, Review Committee
1998NIGMS ZGM1 PS-5 (1) Site Visit, Ad Hoc Committee: Chair
1997NIMH Future Directions Conference: Panel Member
1997-2003Tufts University School of Medicine, Department of Pharmacology and Experimental Therapeutics: External Advisory Board
1989-1990MRC Molecular Genetics Unit at Cambridge University: Fogarty Senior International Fellow with Dr. Sydney Brenner
 Research Expertise & Professional Interests
David H. Farb was appointed Professor and Chairman of the Department of Pharmacology & Experimental Therapeutics at Boston University School of Medicine in 1990. Dr. Farb is also Director of the university-wide NIGMS training program in Biomolecular Pharmacology. He has also served as a member of the Drug Development Work Group of Mass Insight, co-author of the Massachusetts Technology Road Map for Drug Discovery, and a consultant for a number of small to large pharmaceutical, biotechnology, and patent litigation companies. He is regularly interviewed by local, national and international media.

As head of the Laboratory of Molecular Neurobiology, he focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man. Deficits in aspects of episodic memory dependent on hippocampal function are evident in a variety of mental disorders, including schizophrenia, autism, Alzheimer’s Disease, and normal aging. Existing pharmacotherapies are limited and carry substantial risk of adverse effects. In search of new approaches for discovery, high-density electrophysiological recordings in awake behaving rats are being used to identify deficits in hippocampal function that underlie cognitive deficits exhibited by aged animals and animals reared in social isolation, the latter being a model for environmental stress during development. Drug delivery via nanoparticles encapsulating hydrophilic or hydrophobic molecules are being engineered for delivery across the blood brain barrier. Nanoparticle composition is being tailored to better deliver drug to specific target sites. Neuroactive drugs and proteins, biomarkers for novel diagnostics, sensitive dyes for neural mapping, and many other applications are envisioned. The major advantage of this technique is the noninvasive delivery of molecules to the CNS via a peripheral injection.

A multidisciplinary approach that includes the techniques of neurophysiology, molecular biology, patch-clamp electrophysiology, cell biology, and molecular neuroanatomy are combined to elucidate the mechanisms and modalities of cognitive enhancers and the discovery of therapeutic treatments for disorders or diseases of the nervous system.

 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Farb DH, Ratner MH. Targeting the modulation of neural circuitry for the treatment of anxiety disorders. Pharmacol Rev. 2014 Oct; 66(4):1002-32.
    View in: PubMed
  2. Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH. A Role for Picomolar Concentrations of Pregnenolone Sulfate in Synaptic Activity-Dependent Ca2+ Signaling and CREB Activation. Mol Pharmacol. 2014 Oct; 86(4):390-8.
    View in: PubMed
  3. Smith CC, Gibbs TT, Farb DH. Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl). 2014 Sep; 231(17):3537-56.
    View in: PubMed
  4. Gutiérrez ML, Ferreri MC, Farb DH, Gravielle MC. GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor. J Neurosci Res. 2014 Aug; 92(8):1054-61.
    View in: PubMed
  5. Farb DH. An interview with David H Farb, Section Editor for Basic Pharmacology. BMC Pharmacol Toxicol. 2013; 14:42.
    View in: PubMed
  6. Saha S, Hu Y, Martin SC, Bandyopadhyay S, Russek SJ, Farb DH. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol. 2013; 14:37.
    View in: PubMed
  7. Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug; 84(2):261-74.
    View in: PubMed
  8. Desbiens S, Farb DH. Development of Therapeutic Agents, Shayne Gad, Editor. Chapter 1: Medicine and Pathology – Current Needs for New Therapeutic Agents and Discovery Strategies – A Systems Pharmacology Approach. Hardcopy version of Desbiens and Farb, 2010. John Wiley & Sons. 2012.
    View in: External Website
  9. Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. J Neurochem. 2012 Jan; 120(2):210-9.
    View in: PubMed
  10. Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH. A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons. J Neurochem. 2011 Nov; 119(3):486-96.
    View in: PubMed
  11. Desbiens S, Farb DH. Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing, Shayne Gad, Editor. Current Needs for New Therapeutic Agents and Discovery Strategies – A Systems Pharmacology Approach. John Wiley & Sons. 2010.
    View in: External Website
  12. Eagleson KL, Gravielle MC, Schlueter McFadyen-Ketchum LJ, Russek SJ, Farb DH, Levitt P. Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes. Neuroscience. 2010 Jul 14; 168(3):797-810.
    View in: PubMed
  13. Berezhnoy D, Gibbs TT, Farb DH. Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site. Mol Pharmacol. 2009 Aug; 76(2):440-50.
    View in: PubMed
  14. Kim JH, Farb DH, Russek SJ. Encyclopedia of Neuroscience, MD Binder, N Hirokawa, U Windhorst, and MC Hirsch, Editors. Promoter Structure. Spring Publishing. 2009.
  15. Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH. Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. J Pharmacol Exp Ther. 2008 Dec; 327(3):840-5.
    View in: PubMed
  16. Whittaker MT, Gibbs TT, Farb DH. Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. J Neurochem. 2008 Oct; 107(2):510-21.
    View in: PubMed
  17. Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol. 2008; 8:11.
    View in: PubMed
  18. Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. J Biol Chem. 2008 Apr 4; 283(14):9328-40.
    View in: PubMed
  19. Farb DH, Steiger JL, Martin SC, Gravielle MC, Gibbs TT, Russek SJ. The GABA Receptors, S Enna and H Mohler, Editors. Mechanisms of GABAA and GABAB Receptor Gene Expression. Humana Press. 2007.
  20. Berezhnoy D, Gravielle MC, Farb DH. Handbook of Contemporary Neuropharmacology, D Sibley, M Kuhar, I Hanin, P Skolnick, Editors. Pharmacology of the GABA-A Receptor. John Wiley & Sons. 2007.
  21. Gibbs TT, Russek SJ, Farb DH. Sulfated steroids as endogenous neuromodulators. Pharmacol Biochem Behav. 2006 Aug; 84(4):555-67.
    View in: PubMed
  22. Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 2006 Dec; 319(3):1244-52.
    View in: PubMed
  23. Downing SS, Lee YT, Farb DH, Gibbs TT. Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation. Br J Pharmacol. 2005 Aug; 145(7):894-906.
    View in: PubMed
  24. Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7380-5.
    View in: PubMed
  25. Gravielle MC, Faris R, Russek SJ, Farb DH. GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons. J Biol Chem. 2005 Jun 3; 280(22):20954-60.
    View in: PubMed
  26. Steiger JL, Bandyopadhyay S, Farb DH, Russek SJ. cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters. J Neurosci. 2004 Jul 7; 24(27):6115-26.
    View in: PubMed
  27. Jang MK, Mierke DF, Russek SJ, Farb DH. A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8198-203.
    View in: PubMed
  28. Martin SC, Steiger JL, Gravielle MC, Lyons HR, Russek SJ, Farb DH. Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons. J Comp Neurol. 2004 May 17; 473(1):16-29.
    View in: PubMed
  29. Steiger JL, Alexander MJ, Galler JR, Farb DH, Russek SJ. Effects of prenatal malnutrition on GABAA receptor alpha1, alpha3 and beta2 mRNA levels. Neuroreport. 2003 Sep 15; 14(13):1731-5.
    View in: PubMed
  30. Sadri-Vakili G, Johnson DW, Janis GC, Gibbs TT, Pierce RC, Farb DH. Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate. J Neurochem. 2003 Jul; 86(1):92-101.
    View in: PubMed
  31. Gibbs TT, Farb DH. . Neurosteroid Effects in the Central Nervous System, Sheryl S. Smith, Editor. Direct Modulation of Amino Acid Recptors by Neuroactive Steroids: Physiological and Pharmacological Implications. CRC Press. 2003.
  32. Steiger JL, Galler JR, Farb DH, Russek SJ. Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum. Eur J Pharmacol. 2002 Jun 20; 446(1-3):201-2.
    View in: PubMed
  33. Malayev A, Gibbs TT, Farb DH. Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. Br J Pharmacol. 2002 Feb; 135(4):901-9.
    View in: PubMed
  34. Martin SC, Russek SJ, Farb DH. Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2. Gene. 2001 Oct 31; 278(1-2):63-79.
    View in: PubMed
  35. Lyons HR, Land MB, Gibbs TT, Farb DH. Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. J Neurochem. 2001 Sep; 78(5):1114-26.
    View in: PubMed
  36. Gibbs TT, Farb DH. Dueling enigmas: neurosteroids and sigma receptors in the limelight. Sci STKE. 2000 Nov 28; 2000(60):pe1.
    View in: PubMed
  37. Russek SJ, Bandyopadhyay S, Farb DH. An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8600-5.
    View in: PubMed
  38. Weaver CE, Land MB, Purdy RH, Richards KG, Gibbs TT, Farb DH. Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death. J Pharmacol Exp Ther. 2000 Jun; 293(3):747-54.
    View in: PubMed
  39. McLean PJ, Shpektor D, Bandyopadhyay S, Russek SJ, Farb DH. A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity. J Neurochem. 2000 May; 74(5):1858-69.
    View in: PubMed
  40. Lyons HR, Gibbs TT, Farb DH. Turnover and down-regulation of GABA(A) receptor alpha1, beta2S, and gamma1 subunit mRNAs by neurons in culture. J Neurochem. 2000 Mar; 74(3):1041-8.
    View in: PubMed
  41. Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH. Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res. 1999 May 29; 830(1):72-87.
    View in: PubMed
  42. Martin SC, Russek SJ, Farb DH. Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol Cell Neurosci. 1999 Mar; 13(3):180-91.
    View in: PubMed
  43. Gibbs TT, Yaghoubi N, Weaver Jr CE, Park-Chung M, Russek SJ, Farb DH. Contemporary Endocrinology: Neurosteroids: A New Regulatory Function in the Nervous System. Modulation of Ionotropic Glutamate Receptors by Neuroactive Steroids. Humana Press. 1999.
  44. Weaver CE, Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. Brain Res. 1998 Aug 24; 803(1-2):129-36.
    View in: PubMed
  45. Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH. Neurosteroid modulation of recombinant ionotropic glutamate receptors. Brain Res. 1998 Aug 24; 803(1-2):153-60.
    View in: PubMed
  46. Park-Chung M, Wu FS, Purdy RH, Malayev AA, Gibbs TT, Farb DH. Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol Pharmacol. 1997 Dec; 52(6):1113-23.
    View in: PubMed
  47. Weaver CE, Marek P, Park-Chung M, Tam SW, Farb DH. Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10450-4.
    View in: PubMed
  48. Weaver CE, Park-Chung M, Gibbs TT, Farb DH. 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 1997 Jul 4; 761(2):338-41.
    View in: PubMed
  49. Friedman LK, Gibbs TT, Farb DH. gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res. 1996 Jan 22; 707(1):100-9.
    View in: PubMed
  50. Rabow LE, Russek SJ, Farb DH. From ion currents to genomic analysis: recent advances in GABAA receptor research. Synapse. 1995 Nov; 21(3):189-274.
    View in: PubMed
  51. McLean PJ, Farb DH, Russek SJ. Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster. Genomics. 1995 Apr 10; 26(3):580-6.
    View in: PubMed
  52. Russek SJ, Farb DH. Mapping of the beta 2 subunit gene of the GABAA receptor (GABRB2) to human chromosome 5q34 using fluorescence in situ hybridization. Cell Mol Biol Res. 1995; 41(6):511-3.
    View in: PubMed
  53. Russek SJ, Farb DH. Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. Genomics. 1994 Oct; 23(3):528-33.
    View in: PubMed
  54. Gyenes M, Wang Q, Gibbs TT, Farb DH. Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1994 Sep; 46(3):542-9.
    View in: PubMed
  55. Park-Chung M, Wu FS, Farb DH. 3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons. Mol Pharmacol. 1994 Jul; 46(1):146-50.
    View in: PubMed
  56. Wu FS, Gibbs TT, Farb DH. Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol. 1993 Aug 15; 246(3):239-46.
    View in: PubMed
  57. Friedman L, Gibbs TT, Farb DH. Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol. 1993 Jul; 44(1):191-7.
    View in: PubMed
  58. Russek SJ, Quirk JC, Farb DH. Restriction selection cloning: a simple general method for the selection of recombinant DNA. Cell Mol Biol Res. 1993; 39(2):177-82.
    View in: PubMed
  59. Irwin RP, Maragakis NJ, Rogawski MA, Purdy RH, Farb DH, Paul SM. Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons. Neurosci Lett. 1992 Jul 6; 141(1):30-4.
    View in: PubMed
  60. Farb DH, Gibbs TT, Wu FS, Gyenes M, Friedman L, Russek SJ. Steroid modulation of amino acid neurotransmitter receptors. Adv Biochem Psychopharmacol. 1992; 47:119-31.
    View in: PubMed
  61. Farb DH, Gibbs TT, Wu F-S, Gyenes M, Friedman L, Russek SJ. Advances in Biochemical Psychopharmacology, G Biggio and E Costa, Editors. Steroid Modulation of Amino Acid Neurotransmitter Receptors. 1992.
  62. Celentano JJ, Gyenes M, Gibbs TT, Farb DH. Negative modulation of the gamma-aminobutyric acid response by extracellular zinc. Mol Pharmacol. 1991 Nov; 40(5):766-73.
    View in: PubMed
  63. Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991 Sep; 40(3):333-6.
    View in: PubMed
  64. Montpied P, Ginns EI, Martin BM, Roca D, Farb DH, Paul SM. gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture. J Biol Chem. 1991 Apr 5; 266(10):6011-4.
    View in: PubMed
  65. Roca DJ, Schiller GD, Friedman L, Rozenberg I, Gibbs TT, Farb DH. gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol Pharmacol. 1990 May; 37(5):710-9.
    View in: PubMed
  66. Wu FS, Gibbs TT, Farb DH. Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone. Mol Pharmacol. 1990 May; 37(5):597-602.
    View in: PubMed
  67. Farrant M, Gibbs TT, Farb DH. Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies. Neurochem Res. 1990 Feb; 15(2):175-91.
    View in: PubMed
  68. Roca DJ, Rozenberg I, Farrant M, Farb DH. Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex. Mol Pharmacol. 1990 Jan; 37(1):37-43.
    View in: PubMed
  69. Czajkowski C, Farb DH. Identification of an intracellular pool of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell surface of brain neurons in culture. Mol Pharmacol. 1989 Feb; 35(2):183-8.
    View in: PubMed
  70. Czajkowski C, Gibbs TT, Farb DH. Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ. Mol Pharmacol. 1989 Jan; 35(1):75-84.
    View in: PubMed
  71. Gibbs TT, Mierlak D, Gyenes M, Celentano JJ, Farb DH. Advances in Biochemical Psychopharmacology (G. Biggio and E. Costa) Chloride Channels and their Modulation by Neurotransmitters and Drugs. [Functional and Structural Correlates of GABA Receptor Modulation] Control of the GABA Gated Cl- Channel by Benzodiazepines and Divalent Cations. Raven Press. 1989.
  72. Gyenes M, Farrant M, Farb DH. "Run-down" of gamma-aminobutyric acidA receptor function during whole-cell recording: a possible role for phosphorylation. Mol Pharmacol. 1988 Dec; 34(6):719-23.
    View in: PubMed
  73. Borden LA, Farb DH. Mechanism of gamma-aminobutyric acid/benzodiazepine receptor turnover in neuronal cells: evidence for nonlysosomal degradation. Mol Pharmacol. 1988 Sep; 34(3):354-62.
    View in: PubMed
  74. Celentano JJ, Gibbs TT, Farb DH. Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons. Brain Res. 1988 Jul 12; 455(2):377-80.
    View in: PubMed
  75. Roca DJ, Schiller GD, Farb DH. Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions. Mol Pharmacol. 1988 May; 33(5):481-5.
    View in: PubMed
  76. Mierlak D, Farb DH. Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response. J Neurosci. 1988 Mar; 8(3):814-20.
    View in: PubMed
  77. Gibbs TT, Mierlak D, Gyenes M, Celentano JJ, Farb DH. Functional and structural correlates of GABA receptor modulation. Adv Biochem Psychopharmacol. 1988; 45:95-107.
    View in: PubMed
  78. Mierlak D, Farb DH. Ann. N.Y. Academy of Science. Benzodiazepine Stimulation of Gamma-Aminobutyric Acid Receptor Desensitization in Chick Spinal Cord Cell Cultures. 1988; (529):304-306.
  79. Borden LA, Gibbs TT, Farb DH. Identification, characterization, and developmental regulation of embryonic benzodiazepine binding sites. J Neurosci. 1987 Jun; 7(6):1902-10.
    View in: PubMed
  80. Czajkowski C, Farb DH. Transmembrane topology and subcellular distribution of the benzodiazepine receptor. J Neurosci. 1986 Oct; 6(10):2857-63.
    View in: PubMed
  81. Farb DH, Czajkowski CM, Borden LA, Schiller GD, Gibbs TT. Turnover of the benzodiazepine/gamma-aminobutyric acid receptor complex determined in situ. Adv Biochem Psychopharmacol. 1986; 41:51-66.
    View in: PubMed
  82. Gibbs TT, Chan CY, Farb DH. Ann. N.Y. Academy of Science. Enhancement of Benzodiazepine Binding by GABA is Reduced Rapidly During Chronic Exposure to Flurazepam. 1986; (463):183-185.
  83. Schiller GD, Farb DH. Ann. N.Y. Academy of Science. Enhancement of Benzodiazepine Binding by GABA is Reduced Rapidly During Chronic Exposure to Flurazepam. 1986; (463):221-223.
  84. Farb DH, Czajkowski CM, Borden LA, Schiller GD, Gibbs TT. Advances in Biochemical Psychopharmacology (G. Biggio and E. Costa). Turnover of the Benzodiazepine/Gamma-Aminobutyric Acid Receptor Complex Determined In Situ. Raven Press. 1986.
  85. Chan CY, Farb DH. Modulation of neurotransmitter action: control of the gamma-aminobutyric acid response through the benzodiazepine receptor. J Neurosci. 1985 Sep; 5(9):2365-73.
    View in: PubMed
  86. Gibbs TT, Chan CY, Czajkowski CM, Farb DH. Benzodiazepine receptor photoaffinity labeling: correlation of function with binding. Eur J Pharmacol. 1985 Apr 2; 110(2):171-80.
    View in: PubMed
  87. Borden LA, Czajkowski C, Chan CY, Farb DH. Benzodiazepine receptor synthesis and degradation by neurons in culture. Science. 1984 Nov 16; 226(4676):857-60.
    View in: PubMed
  88. Farb DH, Borden LA, Chan CY, Czajkowski CM, Gibbs TT, Schiller GD. Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture. Ann N Y Acad Sci. 1984; 435:1-31.
    View in: PubMed
  89. Farb DH, Borden LA, Chan CY, Czajkowski C, Gibbs TT, Schiller GD. First Colloquium in Biological Sciences. Ann. N.Y. Academy of Science. Modulation of Neuronal Function Through Benzodiazepine Receptors: Biochemical and Electrophysiological Studies of Neurons in Primary Monolayer Cell Culture. 1984; (435):1-31.
  90. Chan CY, Gibbs TT, Borden LA, Farb DH. Multiple embryonic benzodiazepine binding sites: evidence for functionality. Life Sci. 1983 Nov 21; 33(21):2061-9.
    View in: PubMed
  91. Choi DW, Farb DH, Fischbach GD. GABA-mediated synaptic potentials in chick spinal cord and sensory neurons. J Neurophysiol. 1981 Apr; 45(4):632-43.
    View in: PubMed
  92. Choi DW, Farb DH, Fischbach GD. Chlordiazepoxide selectively potentiates GABA conductance of spinal cord and sensory neurons in cell culture. J Neurophysiol. 1981 Apr; 45(4):621-31.
    View in: PubMed
  93. Rando RR, Bangerter FW, Farb DH. The inactivation of gamma-aminobutyric acid transaminase in dissociated neuronal cultures from spinal cord. J Neurochem. 1981 Mar; 36(3):985-90.
    View in: PubMed
  94. Farbs DH, Jencks WP. Dependence on pH of Activity of Pig Liver Esterase. Arch. Biochem. Biophys. 1980; (203):227-235.
  95. Yaksh TL, Farb DH, Leeman SE, Jessell TM. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science. 1979 Oct 26; 206(4417):481-3.
    View in: PubMed
  96. Farb DH, Berg DK, Fischbach GD. Uptake and release of [3H]gamma-aminobutyric acid by embryonic spinal cord neurons in dissociated cell culture. J Cell Biol. 1979 Mar; 80(3):651-61.
    View in: PubMed
  97. Choi DW, Farb DH, Fischbach GD. Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures. Nature. 1977 Sep 22; 269(5626):342-4.
    View in: PubMed
David's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department