Marcia H. Ratner, PhD
|Institution||Boston University School of Medicine|
|Department||Pharmacology & Experimental Therapeutics|
|Address||72 East Concord Street, L-601|
Boston MA 02118
|2016||BU-CTSI National Center for Advancing Translational Sciences, NIH through Grant Number 1UL1TR001430:
BU-CTSI Funding Opportunity Award|
|2004||-||2007||Boston University School of Medicine (PI: Peter Polgar; Mentor: David Farb), NRSA T32 AG 00115 :
Post-Doctoral Fellowship in the Biochemistry of Aging|
|1995||International Honor Society in Psychology:
Dr. Marcia H. Ratner earned her doctoral degree in Behavioral Neuroscience from the Boston University School of Medicine where she trained in the Department of Neurology under Drs. Robert G. Feldman and Raymon Durso. She subsequently completed a post-doctoral fellowship in the Biochemistry of Aging in the Department of Pharmacology and Experimental Therapeutics under the supervision of Dr. David H. Farb.
Dr. Ratner's training at the BUSM has provided her with genuine translational research experience in clinical as well as basic neuroscience and neurotoxicology. This unique training experience has enabled her to evaluate how chemicals can modify neurological function and the progression of neurodegenerative disease.
Dr. Ratner works with her colleague Dr. David Farb in the Laboratory of Molecular Neurobiology where her research focuses on investigating how chemicals alter learning and memory function in healthy subjects and those with neurodegenerative diseases. She currently employs basic behavioral and in vivo electrophysiological techniques in her studies of how chemicals modify hippocampal neural network activity and disease progression in animal models of age-related amnestic mild cognitive impairment and Alzheimer's disease. The major advantage of in vivo electrophysiology over noninvasive measures such as surface electroencephalogram and functional imaging studies of regional cerebral blood flow is found in the ability of this technology to differentiate the activity of inhibitory interneurons from that of excitatory pyramidal cells both across brain regions and within subregions. This highly translational approach is well suited for target-based as well as repurposing studies of drug-induced changes in both single unit activity and local field potentials. A recent paper on which Dr. Ratner shares first authorship has shown that co-administration of low doses of the FDA approved anti epileptic drugs levetiracetam and valproic acid improves aspects of place cell firing dynamics including increasing spatial information content in aged rats (Robitsek et al, Hippocampus, 2015). Dr. Ratner recently authored an invited editorial on the future role of in vivo electrophysiology in preclinical drug discovery. The observations of Dr. Ratner and her colleagues suggest that the specificity with which, not just the rate at which, a neuron fires plays an important role in learning and memory function and, that interventions designed to increase the specificity with which hippocampal pyramidal cells fire may improve memory function in subjects with age-related amnestic mild cognitive impairment and Alzheimer’s disease.
Dr. Ratner serves as an ad hoc reviewer for several peer reviewed journals including: Neurology, Toxicology, Clinical Toxicology, Food and Chemical Toxicology, and BMC Pharmacology and Toxicology.
Dr. Ratner is a member of the Society of Toxicology and the American Academy of Clinical Toxicology.
Dr. Ratner also serves as an ad hoc neurotoxicology consultant to industry, government agencies and law firms.
Dr. Ratner has expertise and training in the following methods used in preclinical and clinical behavioral neuroscience and neurotoxicology:
Rodent stereotactic brain surgery
In vivo electrophysiology
Animal behavioral models
Human neuropsychological assessment
- Neurodegenerative disease
- In vivo electrophysiology
- Behavioral Neuroscience
- Toxic encephalopathy
- Learning and memory disorders
- Preclinical Drug Discovery
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