Keywords
Last Name

Vidhya Kumaresan, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Building A
Boston MA 02118
Phone(617) 638-4345
ORCID ORCID Icon0000-0002-3374-5741
 Research Expertise & Professional Interests
Dr. Kumaresan’s expertise is in behavioral neuropharmacology. Dr. Kumaresan studies the neurobiological underpinnings of addiction using cellular, molecular and behavioral methods. The overall research objective is to study neuronal activity-dependent plasticity and its relevance for brain disorders. The current focus is to understand the neurobiological bases of addiction to psychostimulants. Recidivism to drug abuse is a major hurdle in the successful treatment of addiction. Illicit drug use usurps neural circuits involved in survival enhancing behaviors. The goal is to elucidate the cellular and molecular underpinnings of drug-induced enduring neural plasticity in these circuits using a combination of behavioral, cellular and molecular approaches. In particular, Dr. Kumaresan employs a novel approach of using cell-permeable peptides that disrupt protein-protein interactions in vivo in order to study ongoing behavior. These approaches are expected to lead to successful treatment of relapse precipitated by drug re-exposure, drug-associated cues and stress. Knowledge gained from these studies will also be applicable to the treatment of other brain dysfunctions involving persistent memories such as PTSD. Research techniques used include: immunocytochemistry, western blots, operant conditioning methods and site-specific intracranial microinjections of pharmacological reagents, viral vectors encoding specific constructs designed to interfere with protein-protein interactions and cell permeable peptides.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2012 Mechanisms of cue-induced reinstatement of cocaine seeking. 1R03DA030441-01A1
1997 DEVELOPMENT OF AUDITORY FUNCTION 5F32DC000192-03
1996 DEVELOPMENT OF AUDITORY FUNCTION 5F32DC000192-02
1995 DEVELOPMENT OF AUDITORY FUNCTION 1F32DC000192-01


 Self-Described Keywords
  • addiction
  • Behavioral Neuroscience
  • cellular
  • drug abuse
  • glutamate transmission
  • Homer
  • metabotropic glutamate receptors
  • molecular
  • Neuropharmacology
  • PDZ-domains
  • PICK-1
  • protein-protein interactions
  • PSD-95
  • psychostimulants
  • scaffolding proteins
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF, Pierce RC, Cha JH. Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. J Neurosci. 2010 Sep 1; 30(35):11735-44. PMID: 20810894.
    View in: PubMed
  2. Kumaresan V, Yuan M, Yee J, Famous KR, Anderson SM, Schmidt HD, Pierce RC. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res. 2009 Sep 14; 202(2):238-44. PMID: 19463707.
    View in: PubMed
  3. Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha JH, Pierce RC. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci. 2008 Oct 22; 28(43):11061-70. PMID: 18945913.
    View in: PubMed
  4. Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nat Neurosci. 2008 Mar; 11(3):344-53. PMID: 18278040.
    View in: PubMed
  5. Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC. Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. Eur J Pharmacol. 2005 Dec 5; 526(1-3):65-76. PMID: 16321382.
    View in: PubMed
  6. Pierce RC, Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev. 2006; 30(2):215-38. PMID: 16099045.
    View in: PubMed
  7. Kumaresan V, Kang C, Simmons AM. Development and differentiation of the anuran auditory brainstem during metamorphosis: an acetylcholinesterase histochemical study. Brain Behav Evol. 1998; 52(3):111-25. PMID: 9693158.
    View in: PubMed
Vidhya's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Similar BU People
_
Same Department