Keywords
Last Name

Barbara E. Slack, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
DivisionOther Pathology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-5487
ORCID ORCID Icon0000-0002-7619-410X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(3):e0174875. PMID: 28334015.
    View in: PubMed
  2. Mellott TJ, Huleatt OM, Shade BN, Pender SM, Liu YB, Slack BE, Blusztajn JK. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One. 2017; 12(1):e0170450. PMID: 28103298.
    View in: PubMed
  3. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72. PMID: 24218590.
    View in: PubMed
  4. Akle V, Guelin E, Yu L, Brassard-Giordano H, Slack BE, Zhdanova IV. F-spondin/spon1b expression patterns in developing and adult zebrafish. PLoS One. 2012; 7(6):e37593. PMID: 22768035.
    View in: PubMed
  5. Cissé M, Duplan E, Guillot-Sestier MV, Rumigny J, Bauer C, Pagès G, Orzechowski HD, Slack BE, Checler F, Vincent B. The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein. J Biol Chem. 2011 Aug 19; 286(33):29192-206. PMID: 21586567.
    View in: PubMed
  6. Carey RM, Blusztajn JK, Slack BE. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC Cell Biol. 2011; 12:20. PMID: 21586144.
    View in: PubMed
  7. Kishi S, Slack BE, Uchiyama J, Zhdanova IV. Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology. 2009; 55(4):430-41. PMID: 19654474.
    View in: PubMed
  8. Slack BE, Blusztajn JK. Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. J Cell Biochem. 2008 Aug 1; 104(5):1818-31. PMID: 18348264.
    View in: PubMed
  9. Alfa Cissé M, Louis K, Braun U, Mari B, Leitges M, Slack BE, Fisher A, Auberger P, Checler F, Vincent B. Isoform-specific contribution of protein kinase C to prion processing. Mol Cell Neurosci. 2008 Nov; 39(3):400-10. PMID: 18722532.
    View in: PubMed
  10. Alfa Cissé M, Sunyach C, Slack BE, Fisher A, Vincent B, Checler F. M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity. J Neurosci. 2007 Apr 11; 27(15):4083-92. PMID: 17428986.
    View in: PubMed
  11. Slack BE, Siniaia MS, Blusztajn JK. Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor 1: involvement of Src tyrosine kinase. J Cell Biochem. 2006 Jun 1; 98(3):672-84. PMID: 16440311.
    View in: PubMed
  12. Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res. 2006 May 9; 1088(1):49-56. PMID: 16626664.
    View in: PubMed
  13. Carey RM, Balcz BA, Lopez-Coviella I, Slack BE. Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 2005; 6:30. PMID: 16095541.
    View in: PubMed
  14. Slack BE, Siniaia MS. Adhesion-dependent redistribution of MAP kinase and MEK promotes muscarinic receptor-mediated signaling to the nucleus. J Cell Biochem. 2005 May 15; 95(2):366-78. PMID: 15779001.
    View in: PubMed
  15. Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6984-9. PMID: 15870197.
    View in: PubMed
  16. Slack BE, Ma LK, Seah CC. Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme. Biochem J. 2001 Aug 1; 357(Pt 3):787-94. PMID: 11463349.
    View in: PubMed
  17. Farber SA, Slack BE, Blusztajn JK. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J. 2000 Nov; 14(14):2198-206. PMID: 11053240.
    View in: PubMed
  18. Slack BE. The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase. Biochem J. 2000 Jun 1; 348 Pt 2:381-7. PMID: 10816433.
    View in: PubMed
  19. Slack BE. Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7281-6. PMID: 9636140.
    View in: PubMed
  20. Slack BE, Breu J, Muchnicki L, Wurtman RJ. Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C. Biochem J. 1997 Oct 1; 327 ( Pt 1):245-9. PMID: 9355759.
    View in: PubMed
  21. Li H, Leeman SE, Slack BE, Hauser G, Saltsman WS, Krause JE, Blusztajn JK, Boyd ND. A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9475-80. PMID: 9256507.
    View in: PubMed
  22. Petryniak MA, Wurtman RJ, Slack BE. Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism. Biochem J. 1996 Dec 15; 320 ( Pt 3):957-63. PMID: 9003386.
    View in: PubMed
  23. Farber SA, Savci V, Wei A, Slack BE, Wurtman RJ. Choline's phosphorylation in rat striatal slices is regulated by the activity of cholinergic neurons. Brain Res. 1996 Jun 3; 723(1-2):90-9. PMID: 8813385.
    View in: PubMed
  24. Slack BE, Breu J, Petryniak MA, Srivastava K, Wurtman RJ. Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J Biol Chem. 1995 Apr 7; 270(14):8337-44. PMID: 7713942.
    View in: PubMed
  25. Slack BE, Breu J, Livneh E, Eldar H, Wurtman RJ. Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha. Biochem J. 1995 Jan 15; 305 ( Pt 2):621-6. PMID: 7832781.
    View in: PubMed
  26. Nitsch RM, Slack BE, Farber SA, Schulz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. J Neural Transm Suppl. 1994; 44:21-7. PMID: 7897393.
    View in: PubMed
  27. Slack BE, Nitsch RM, Livneh E, Kunz GM, Breu J, Eldar H, Wurtman RJ. Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. J Biol Chem. 1993 Oct 5; 268(28):21097-101. PMID: 8407946.
    View in: PubMed
  28. Slack BE, Nitsch RM, Livneh E, Kunz GM, Eldar H, Wurtman RJ. Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Ann N Y Acad Sci. 1993 Sep 24; 695:128-31. PMID: 8239270.
    View in: PubMed
  29. Nitsch RM, Slack BE, Farber SA, Borghesani PR, Schulz JG, Kim C, Felder CC, Growdon JH, Wurtman RJ. Receptor-coupled amyloid precursor protein processing. Ann N Y Acad Sci. 1993 Sep 24; 695:122-7. PMID: 8239269.
    View in: PubMed
  30. Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science. 1992 Oct 9; 258(5080):304-7. PMID: 1411529.
    View in: PubMed
  31. Slack BE, Richardson UI, Nitsch RM, Wurtman RJ. Dioctanoylglycerol stimulates accumulation of [methyl-14C]choline and its incorporation into acetylcholine and phosphatidylcholine in a human cholinergic neuroblastoma cell line. Brain Res. 1992 Jul 10; 585(1-2):169-76. PMID: 1511298.
    View in: PubMed
  32. Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1671-5. PMID: 1311847.
    View in: PubMed
  33. Slack BE, Breu J, Wurtman RJ. Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells. J Biol Chem. 1991 Dec 25; 266(36):24503-8. PMID: 1662212.
    View in: PubMed
  34. Nitsch R, Pittas A, Blusztajn JK, Slack BE, Growdon JH, Wurtman RJ. Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:110-3. PMID: 1663712.
    View in: PubMed
  35. Wurtman RJ, Blusztajn JK, Ulus IH, Coviella IL, Buyukuysal RL, Growdon JH, Slack BE. Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. Adv Neurol. 1990; 51:117-25. PMID: 2403709.
    View in: PubMed
  36. Slack BE, Liscovitch M, Blusztajn JK, Wurtman RJ. Uptake of exogenous phosphatidylserine by human neuroblastoma cells stimulates the incorporation of [methyl-14C]choline into phosphatidylcholine. J Neurochem. 1989 Aug; 53(2):472-81. PMID: 2746233.
    View in: PubMed
  37. Liscovitch M, Slack B, Blusztajn JK, Wurtman RJ. Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells. J Biol Chem. 1987 Dec 25; 262(36):17487-91. PMID: 3693364.
    View in: PubMed
  38. Slack BE. Pre- and postsynaptic actions of noradrenaline and clonidine on myenteric neurons. Neuroscience. 1986 Dec; 19(4):1303-9. PMID: 2434878.
    View in: PubMed
  39. Slack BE, Bell JE, Benos DJ. Inositol-1,4,5-trisphosphate injection mimics fertilization potentials in sea urchin eggs. Am J Physiol. 1986 Feb; 250(2 Pt 1):C340-4. PMID: 3485384.
    View in: PubMed
  40. North RA, Slack BE, Surprenant A. Muscarinic M1 and M2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system. J Physiol. 1985 Nov; 368:435-52. PMID: 4078746.
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  41. Downie JW, Slack BE. Sensitivity to indomethacin of tetrodotoxin-resistant contractions of smooth muscle from the base of rabbit bladder. Br J Pharmacol. 1983 Jun; 79(2):334-6. PMID: 6652332.
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  42. Slack BE, Downie JW. Pharmacological analysis of the responses of the feline urethra to autonomic nerve stimulation. J Auton Nerv Syst. 1983 Jun; 8(2):141-60. PMID: 6619512.
    View in: PubMed
  43. Slack BE, Downie JW, Elbadawi A. Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of rabbit. J Pharmacol Exp Ther. 1982 Jan; 220(1):216-22. PMID: 7053418.
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  44. Slack BE, Boegman RJ, Downie JW, Jasmin G. Cardiac membrane cholesterol in dystrophic and verapamil-treated hamsters. J Mol Cell Cardiol. 1980 Feb; 12(2):179-85. PMID: 7365803.
    View in: PubMed
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