Ivana Delalle, MD, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine
Anatomic Pathology

MD, University of Zagreb
PhD, University of Zagreb



Ivana Delalle is a Professor of Pathology and Laboratory Medicine and Professor of Neurology at Boston University (BU) Chobanian and Avedisian School of Medicine and a Neuropathologist at the Department of Pathology and Laboratory Medicine at Boston Medical Center. Dr. Delalle conducts research bridging basic and clinical science to advance the understanding of the pathogenesis of neurodegenerative diseases. Her present focus, supported by the by National Institutes of Health (NIH) / National Institute of Aging (NIA) is on novel, early, and reliable biomarkers of Alzheimer’s Disease.
Dr. Delalle attended the Zagreb University School of Medicine, Zagreb, Croatia, where she received her MD in 1988 and, in 1992, her PhD in the Developmental Neuroanatomy Laboratory headed by Professor Ivica Kostovic, a pioneer in the understanding of transient layers in the developing human cortex. Dr. Delalle subsequently joined Developmental Neurobiology Laboratory headed by Professor Verne Caviness at Massachusetts General Hospital (MGH) in Boston where she elucidated the expression of cell cycle regulators in relation to the cortical development. After completing her Research Fellowship in Neurology at Harvard Medical School in 1997, Dr. Delalle pursued further postgraduate training as a resident in Anatomic Pathology and Neuropathology in the Department of Pathology at MGH. She became board certified by the American Board of Pathology in Anatomic Pathology and Neuropathology in 2001. Dr. Delalle worked in the teaching hospitals of Harvard Medical School and BU Chobanian and Avedisian School of Medicine as a scientist investigating neurodegenerative and neuropsychiatric diseases, as a neuropathologist with expertise in neurooncology in the clinical arena, and as a teacher and mentor committed to the education of medical students, residents, and neuropathology fellows. Dr. Delalle was the Director of Neuropathology Service at Rhode Island Hospital (2019 -2023) and a Professor of Pathology at Warren Alpert Medical School of Brown University (2020-2023).

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias
09/01/2024 - 05/31/2029 (Multi-PI)
PI: Ivana Delalle, MD, PhD
NIH/National Institute on Aging
1R01AG084624-01

Investigation of impaired neural stem cell activation in Alzheimer's Disease
08/01/2023 - 03/31/2027 (Subcontract PI)
Buck Institute for Research on Aging NIH NIA
7R01AG076933-03

MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease
11/01/2023 - 08/31/2025 (PI)
NIH/National Institute on Aging
7RF1AG078299-02

Epigenetic of Alzheimer's Disease
09/27/2011 - 08/31/2014 (Subcontract PI)
Massachusetts Institute of Technology NIH NINDS
5R01NS078839-02

Analysis of Retinal Degeneration in Drosophila
08/03/2001 - 05/31/2007 (PI)
NIH/National Eye Institute
7 K08 EY13639 04



Title


Yr Title Project-Sub Proj Pubs
2024 Long Non-coding RNAs as Therapeutic Targets and Biomarkers of Alzheimer's Disease and Related Dementias 1R01AG084624-01
2022 MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease 7RF1AG078299-02
2011 Exosomal and cell-class specific miRNA profiles in bipolar disorder and schizophr 5R21MH086079-02 2
2010 Exosomal and cell-class specific miRNA profiles in bipolar disorder and schizophr 1R21MH086079-01A2 2
2005 ANALYSIS OF RETINAL DEGENERATION IN DROSOPHILA 7K08EY013639-05 2
2004 ANALYSIS OF RETINAL DEGENERATION IN DROSOPHILA 5K08EY013639-04 2
2003 ANALYSIS OF RETINAL DEGENERATION IN DROSOPHILA 5K08EY013639-03 2
2002 ANALYSIS OF RETINAL DEGENERATION IN DROSOPHILA 5K08EY013639-02 2
2001 ANALYSIS OF RETINAL DEGENERATION IN DROSOPHILA 1K08EY013639-01 2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Fischer A, Nho K, Saykin AJ, Delalle I. Response to the Letter, "Circulating small RNAs shed light on dementia risk," by Anthony S. Zannas. Alzheimers Dement. 2025 Feb; 21(2):e14404. PMID: 39868847; PMCID: PMC11848421; DOI: 10.1002/alz.14404;
      Article has an altmetric score of 7
  2. Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers. Alzheimers Dement. 2024 Nov; 20(11):7698-7714.View Related Profiles. PMID: 39291737; PMCID: PMC11567826; DOI: 10.1002/alz.14230;
      Article has an altmetric score of 92
  3. Krüger DM, Pena-Centeno T, Liu S, Park T, Kaurani L, Pradhan R, Huang YN, Risacher SL, Burkhardt S, Schütz AL, Wan Y, Shaw LM, Brodsky AS, DeStefano AL, Lin H, Schroeder R, Krunic A, Hempel N, Sananbenesi F, Blusztajn JK, Saykin AJ, Delalle I, Nho K, Fischer A. The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals. Alzheimers Dement. 2024 Nov; 20(11):7479-7494.View Related Profiles. PMID: 39291752; PMCID: PMC11567822; DOI: 10.1002/alz.14157;
      Article has an altmetric score of 175
  4. Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A. PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease. Acta Neuropathol. 2024 Aug 29; 148(1):32. PMID: 39207536; PMCID: PMC11362476; DOI: 10.1007/s00401-024-02787-x;
      Article has an altmetric score of 13
  5. Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A. PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer's Disease. bioRxiv. 2024 Jul 01. PMID: 39005272; PMCID: PMC11244882; DOI: 10.1101/2024.06.27.600964;
      Article has an altmetric score of 1
  6. Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel A, Schulze TG, Falkai P, Sananbenesi F, Fischer A. Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. EMBO J. 2024 Apr; 43(8):1420-1444. PMID: 38528182; PMCID: PMC11021462; DOI: 10.1038/s44318-024-00067-8;
      Article has an altmetric score of 4
  7. Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45.View Related Profiles. PMID: 38407651; PMCID: PMC11348287; DOI: 10.1007/s00401-024-02690-5;
      Article has an altmetric score of 24
  8. Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Richter J, Kaurani L, Pradhan R, Sakib MS, Burkhardt S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A. Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proc Natl Acad Sci U S A. 2023 Feb 28; 120(9):e2204933120. PMID: 36812208; PMCID: PMC9992849; DOI: 10.1073/pnas.2204933120;
      Article has an altmetric score of 20
  9. Tubre T, Hacking S, Alexander A, Brickman A, Delalle I, Elinzano H, Donahue JE. Prostate-Specific Membrane Antigen Expression in Meningioma: A Promising Theranostic Target. J Neuropathol Exp Neurol. 2022 Nov 16; 81(12):1008-1017. PMID: 36179256; PMCID: PMC9677239; DOI: 10.1093/jnen/nlac089;
      Article has an altmetric score of 2
  10. Oraki Kohshour M, Papiol S, Delalle I, Rossner MJ, Schulze TG. Extracellular vesicle approach to major psychiatric disorders. Eur Arch Psychiatry Clin Neurosci. 2023 Sep; 273(6):1279-1293. PMID: 36302978; PMCID: PMC10450008; DOI: 10.1007/s00406-022-01497-3;
      Article has an altmetric score of 1
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 27 distinct years, with a maximum of 6 publications in 2024

YearPublications
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MicroRNAs Show Potential for Dementia Screening

Inside Precision Medicine 9/19/2024

New biomarkers offer hope for early detection and prevention of Alzheimer's

News Medical 9/18/2024

The microRNA Blood Test That Might Outsmart Alzheimer’s

SciTech Daily 9/18/2024

Breakthrough blood test could detect early stages of Alzheimer’s YEARS before symptoms show

The Sun 9/18/2024
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

biomarkers
bipolar disorder
cytoskeleton
exosomal miRNAs
neurodegeneration
schizophrenia
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