Keywords
Last Name

Jeffrey S. Berman, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
ORCID ORCID Icon0000-0001-8523-4778
 Research Expertise & Professional Interests
I have had an interest in Pulmonary Immunology for over 20 years. I began by looking at basic mechanisms of lymphocyte accumulation in response to cytokine signals, and I have gradually turned my interest to clinical and translational research. In the past ten years I have divided my time between basic and translational investigations involving the novel cytokine, osteopontin, and clinical research involving patients with Sarcoidosis.

My interest in osteopontin (Opn) began upon hearing a report that OPN was the most prevalent message upregulated in macrophages upon exposure to mycobacterium. It is an odd duck amongst cytokines, in that it is prominently expressed in bone and is involved in disparate processes such as bone remodeling, wound healing, inflammation, and tumor metastasis. I have been interested in the immunologic and inflammatory aspects of Opn, and my laboratory has been involved in research linking Opn to T cell function, granuloma formation and interstitial pulmonary fibrosis.

My interest in Sarcoidosis rose out of my 20-year involvement in the Tuberculosis Clinic at the Boston City Hospital and an affiliated homeless shelter. Viewing Sarcoidosis as a “companion” disease to TB, I was intrigued by the mysteries behind this granulomatous disease. I gradually built a Sarcoid population within the TB clinic and 10 years ago spun off my current Sarcoid Clinic. My colleague, David Serlin, and I see approximately 150 new patients each year, some referred for second opinions and other referred for ongoing diagnosis or management. We have a number of clinical research projects ongoing, including the examination of the impact of atopy and nasal disease on Sarcoid clinical course, the use of nasal lavage and brushing for biopsy and prognostication in Sarcoidosis, diagnosis of cardiac disease, and management of calcium and bone metabolism in Sarcoidosis. We share clinic space and collaborate with Dr. Hap Farber and the Pulmonary Hypertension Center in the diagnosis and care of patients with Sarcoidosis who develop pulmonary arterial hypertension. We hope to soon be involved in a large national study of Sarcoidosis in African American women with Sarcoidosis.

 Self-Described Keywords
  • sarcoidosis
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Govender P, Berman JS. The Diagnosis of Sarcoidosis. Clin Chest Med. 2015 Dec; 36(4):585-602. PMID: 26593135.
    View in: PubMed
  2. Grayson PC, Steiling K, Platt M, Berman JS, Zhang X, Xiao J, Alekseyev YO, Liu G, Monach PA, Kaplan MJ, Spira A, Merkel PA. Defining the nasal transcriptome in granulomatosis with polyangiitis (Wegener's). Arthritis Rheumatol. 2015 May; 67(8):2233-9. PMID: 25939343.
    View in: PubMed
  3. Cozier YC, Coogan PF, Govender P, Berman JS, Palmer JR, Rosenberg L. Obesity and weight gain in relation to incidence of sarcoidosis in US black women: data from the Black Women's Health Study. Chest. 2015 Apr; 147(4):1086-93. PMID: 25411869.
    View in: PubMed
  4. Ahmadian A, Brogan A, Berman J, Sverdlov AL, Mercier G, Mazzini M, Govender P, Ruberg FL, Miller EJ. Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis. J Nucl Cardiol. 2014 Oct; 21(5):925-39. PMID: 24879453.
    View in: PubMed
  5. Berman JS, Govender P, Ruberg FL, Mazzini M, Miller EJ. Scadding revisited: a proposed staging system for cardiac sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2014; 31(1):2-5. PMID: 24751447.
    View in: PubMed
  6. Tukey MH, Berman JS, Boggs DA, White LF, Rosenberg L, Cozier YC. ??Mortality among African American women with sarcoidosis: data from the Black Women's Health Study. Sarcoidosis Vasc Diffuse Lung Dis. 2013 Jul; 30(2):128-33. PMID: 24071884.
    View in: PubMed
  7. Cozier Y, Ruiz-Narvaez E, McKinnon C, Berman J, Rosenberg L, Palmer J. Replication of genetic loci for sarcoidosis in US black women: data from the Black Women's Health Study. Hum Genet. 2013 Jul; 132(7):803-10. PMID: 23543185.
    View in: PubMed
  8. Cozier YC, Ruiz-Narvaez EA, McKinnon CJ, Berman JS, Rosenberg L, Palmer JR. Fine-mapping in African-American women confirms the importance of the 10p12 locus to sarcoidosis. Genes Immun. 2012 Oct; 13(7):573-8. PMID: 22972473.
    View in: PubMed
  9. Cozier YC, Berman JS, Palmer JR, Boggs DA, Wise LA, Rosenberg L. Reproductive and hormonal factors in relation to incidence of sarcoidosis in US Black women: The Black Women's Health Study. Am J Epidemiol. 2012 Oct 1; 176(7):635-41. PMID: 22967742.
    View in: PubMed
  10. O'Regan A, Berman JS. Sarcoidosis. Ann Intern Med. 2012 May 1; 156(9):ITC5-1, ITC5-2, ITC5-3, ITC5-4, ITC5-5, ITC5-6, ITC5-7, ITC5-8, ITC5-9, ITC5-10, ITC5-11, ITC5-12, ITC5-13, ITC5-14, ITC5-15; quiz ITC5-16. PMID: 22547486.
    View in: PubMed
  11. Donagh C, Bruzzi J, MacNeill B, DaCosta M, Berman JS, O'Regan AW. Clinical problem-solving. Looking at the whole picture. N Engl J Med. 2011 Aug 4; 365(5):448-53. PMID: 21812675.
    View in: PubMed
  12. Cozier YC, Berman JS, Palmer JR, Boggs DA, Serlin DM, Rosenberg L. Sarcoidosis in black women in the United States: data from the Black Women's Health Study. Chest. 2011 Jan; 139(1):144-50. PMID: 20595459.
    View in: PubMed
  13. Morgan RK, Berman JS. Anchors away. N Engl J Med. 2007 May 3; 356(18):1892-3; author reply 1892-3. PMID: 17476022.
    View in: PubMed
  14. Little F, Wilson KW, Berman JS, Center DM. Lymphocyte and macrophage-mediated inflammation in the lung. In Fishman A, “Pulmonary Diseases and Disorders”. 2007.
  15. Fisher KA, Serlin DM, Wilson KC, Walter RE, Berman JS, Farber HW. Sarcoidosis-associated pulmonary hypertension: outcome with long-term epoprostenol treatment. Chest. 2006 Nov; 130(5):1481-8. PMID: 17099027.
    View in: PubMed
  16. Konno S, Eckman JA, Plunkett B, Li X, Berman JS, Schroeder J, Huang SK. Interleukin-10 and Th2 cytokines differentially regulate osteopontin expression in human monocytes and dendritic cells. J Interferon Cytokine Res. 2006 Aug; 26(8):562-7. PMID: 16881866.
    View in: PubMed
  17. Serlin DM, Kuang PP, Subramanian M, O'Regan A, Li X, Berman JS, Goldstein RH. Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts. J Cell Biochem. 2006 Feb 15; 97(3):519-29. PMID: 16211580.
    View in: PubMed
  18. O'Regan AW, Serlin D, Berman JS. Asbestos exposure and serum osteopontin. N Engl J Med. 2006 Jan 19; 354(3):304-5; author reply 304-5. PMID: 16421377.
    View in: PubMed
  19. Berman JS, Serlin D, Li X, Whitley G, Hayes J, Rishikof DC, Ricupero DA, Liaw L, Goetschkes M, O'Regan AW. Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1311-8. PMID: 14977630.
    View in: PubMed
  20. O’Regan AW, Berman JS. Bronchiectasis. In Baum’s Textbook of Pulmonary Diseases, 7th edition; Crapo, Glassroth, Karlinsky, King, eds. Lippincott, William and Wilkins. 2004.
  21. O'Regan AW, Berman JS. The gene for acute sarcoidosis? Am J Respir Crit Care Med. 2003 Nov 15; 168(10):1142-3. PMID: 14607818.
    View in: PubMed
  22. Li X, O'Regan AW, Berman JS. IFN-gamma induction of osteopontin expression in human monocytoid cells. J Interferon Cytokine Res. 2003 May; 23(5):259-65. PMID: 12804068.
    View in: PubMed
  23. O'Regan AW, Sadeh J, Berman JS. The effect of unfractionated heparin on circulating lymphocyte counts and subsets in humans. Thromb Res. 2002 Apr 1; 106(1):31-3. PMID: 12165286.
    View in: PubMed
  24. Rittling SR, O’Regan AW, Berman JS . Osteopontin, a surprisingly flexible cytokine: functions revealed from osteopontin knockout mice. In, Contemporary Immunology: Cytokine Knockouts, Familia G, ed. Humana Press. Totowa, NJ. 2002.
  25. O'Regan AW, Hayden JM, Body S, Liaw L, Mulligan N, Goetschkes M, Berman JS. Abnormal pulmonary granuloma formation in osteopontin-deficient mice. Am J Respir Crit Care Med. 2001 Dec 15; 164(12):2243-7. PMID: 11751194.
    View in: PubMed
  26. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001 May; 107(9):1055-61. PMID: 11342566.
    View in: PubMed
  27. O'Regan A, Berman JS. Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int J Exp Pathol. 2000 Dec; 81(6):373-90. PMID: 11298186.
    View in: PubMed
  28. O'Regan AW, Hayden JM, Berman JS. Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells. J Leukoc Biol. 2000 Oct; 68(4):495-502. PMID: 11037970.
    View in: PubMed
  29. O'Regan AW, Nau GJ, Chupp GL, Berman JS. Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Immunol Today. 2000 Oct; 21(10):475-8. PMID: 11071524.
    View in: PubMed
  30. Nau GJ, Chupp GL, Emile JF, Jouanguy E, Berman JS, Casanova JL, Young RA. Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection. Am J Pathol. 2000 Jul; 157(1):37-42. PMID: 10880373.
    View in: PubMed
  31. Nau GJ, Liaw L, Chupp GL, Berman JS, Hogan BL, Young RA. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. Infect Immun. 1999 Aug; 67(8):4223-30. PMID: 10417195.
    View in: PubMed
  32. O'Regan AW, Chupp GL, Lowry JA, Goetschkes M, Mulligan N, Berman JS. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro. J Immunol. 1999 Jan 15; 162(2):1024-31. PMID: 9916729.
    View in: PubMed
  33. Chupp GL, Wright EA, Wu D, Vallen-Mashikian M, Cruikshank WW, Center DM, Kornfeld H, Berman JS. Tissue and T cell distribution of precursor and mature IL-16. J Immunol. 1998 Sep 15; 161(6):3114-9. PMID: 9743378.
    View in: PubMed
  34. Chupp GL, Berman JS. “Drug induced lung disease.”. In Problems in Management of Pulmonary Disease. Goldstein R, Karlkinsky J, eds. Little, Brown. Boston,MA. 1998.
  35. Saukkonen JJ, Furfaro S, Mahoney KM, Strieter RM, Burdick M, Wright EA, Kornfeld H, Berman JS. In vitro transendothelial migration of blood T lymphocytes from HIV-infected individuals. AIDS. 1997 Nov; 11(13):1595-601. PMID: 9365764.
    View in: PubMed
  36. Nau GJ, Guilfoile P, Chupp GL, Berman JS, Kim SJ, Kornfeld H, Young RA. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6414-9. PMID: 9177232.
    View in: PubMed
  37. Berman JS, Center DM. Lymphocyte and macrophage-mediated inflammation in the lung. In Fishman A, “Pulmonary Diseases and Disorders”. 1997.
  38. Berman JS, Blumenthal RL, Kornfeld H, Cook JA, Cruikshank WW, Vermeulen MW, Chatterjee D, Belisle JT, Fenton MJ. Chemotactic activity of mycobacterial lipoarabinomannans for human blood T lymphocytes in vitro. J Immunol. 1996 May 15; 156(10):3828-35. PMID: 8621920.
    View in: PubMed
  39. Furfaro S, Berman J, Center DM. Determinants of T cell Migration to the Lung. In, "Immunopathology of Lung Disease," Kradin R ed. 1996.
  40. Berman JS, Mahoney K, Saukkonen JJ, Masuyama J. Migration of distinct subsets of CD8+ blood T cells through endothelial cell monolayers in vitro. J Leukoc Biol. 1995 Sep; 58(3):317-24. PMID: 7665987.
    View in: PubMed
  41. Center DM, Berman JS, Kornfeld H, Theodore AC, Cruikshank WW. The lymphocyte chemoattractant factor. J Lab Clin Med. 1995 Feb; 125(2):167-72. PMID: 7844466.
    View in: PubMed
  42. Parada N, Center DM, Berman JS. "Sarcoidosis". In, Clinical Immunology, Rich B, ed. Mosby. New York,NY. 1995.
  43. Center DM, Kornfeld H, Wu MJ, Falvo M, Theodore AC, Bernardo J, Berman JS, Cruikshank WW, Djukanovic R, Teran L, et al. Cytokine binding to CD4+ inflammatory cells: implications for asthma. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 2):S59-62. PMID: 7952594.
    View in: PubMed
  44. Houts AC, Berman JS, Abramson H. Effectiveness of psychological and pharmacological treatments for nocturnal enuresis. J Consult Clin Psychol. 1994 Aug; 62(4):737-45. PMID: 7962877.
    View in: PubMed
  45. Kim KC, Zheng QX, Wilson AK, Lee BC, Berman JS. Binding kinetics of ATP gamma S35 on cultured primary tracheal surface epithelial cells. Am J Respir Cell Mol Biol. 1994 Feb; 10(2):154-9. PMID: 8110471.
    View in: PubMed
  46. Saukkonen JJ, Kornfeld H, Berman JS. Expansion of a CD8+CD28- cell population in the blood and lung of HIV-positive patients. J Acquir Immune Defic Syndr. 1993 Nov; 6(11):1194-204. PMID: 8229654.
    View in: PubMed
  47. Center DM, Berman JS, Kornfeld H, Theodore AC, Cruikshank WW. Mechanisms of lymphocyte accumulation in pulmonary disease. Chest. 1993 Feb; 103(2 Suppl):88S-91S. PMID: 8094048.
    View in: PubMed
  48. Furfaro S, Berman JS. The relation between cell migration and activation in inflammation: beyond adherence. Am J Respir Cell Mol Biol. 1992 Sep; 7(3):248-50. PMID: 1520489.
    View in: PubMed
  49. Berman JS, Weller PF. Airway eosinophils and lymphocytes in asthma. Birds of a feather? Am Rev Respir Dis. 1992 Jun; 145(6):1246-8. PMID: 1375819.
    View in: PubMed
  50. Masuyama J, Berman JS, Cruikshank WW, Morimoto C, Center DM. Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol. 1992 Mar 1; 148(5):1367-74. PMID: 1371526.
    View in: PubMed
  51. Berman JS. Lymphocytes in the lung: should we continue to exalt only BALT? Am J Respir Cell Mol Biol. 1990 Aug; 3(2):101-2. PMID: 2198894.
    View in: PubMed
  52. Berman JS, Beer DJ, Theodore AC, Kornfeld H, Bernardo J, Center DM. Lymphocyte recruitment to the lung. Am Rev Respir Dis. 1990 Jul; 142(1):238-57. PMID: 2195933.
    View in: PubMed
  53. Robinson LA, Berman JS, Neimeyer RA. Psychotherapy for the treatment of depression: a comprehensive review of controlled outcome research. Psychol Bull. 1990 Jul; 108(1):30-49. PMID: 2200072.
    View in: PubMed
  54. Couser JI, Berman JS. Respiratory muscle fatigue from functional upper airway obstruction. Chest. 1989 Sep; 96(3):689-90. PMID: 2766836.
    View in: PubMed
  55. Berman JS, Cruikshank WW, Beer DJ, Kornfeld H, Bernardo J, Theodore AC, Center DM. Lymphocyte motility and lymphocyte chemoattractant factors. Immunol Invest. 1988 Nov-Dec; 17(8-9):625-77. PMID: 3068125.
    View in: PubMed
  56. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. 1988 Sep 29; 335(6189):445-8. PMID: 2843775.
    View in: PubMed
  57. Tapson VF, Boni-Schnetzler M, Pilch PF, Center DM, Berman JS. Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro. J Clin Invest. 1988 Sep; 82(3):950-7. PMID: 3262126.
    View in: PubMed
  58. Beer DJ, Cruikshank WW, Berman JS, Bernardo J, AC Theodore, Center DM. Histamine_induced human lymphocyte chemoattractant lymphokines: Mechanisms for the amplification of cell_mediated immune responses. In "The effect of histamine and histamine-type 2 antagonists in inflammation and immunodeficiency." Rocklin R, ed. Marcel Dekker. New York,NY. 1988.
  59. Cruikshank WW, Berman JS, Theodore AC, Bernardo J, Center DM. Lymphokine activation of T4+ T lymphocytes and monocytes. J Immunol. 1987 Jun 1; 138(11):3817-23. PMID: 3108375.
    View in: PubMed
  60. Berman JS, Center DM. Chemotactic activity of porcine insulin for human T lymphocytes in vitro. J Immunol. 1987 Apr 1; 138(7):2100-3. PMID: 3549897.
    View in: PubMed
  61. Berman JS, Beer DJ, Bernardo J, Kornfeld H, Center DM. A proposed model for the accumulation of helper/inducer lymphocytes in sarcoidosis. The role of lymphocyte subset-specific chemoattractant lymphokines. Ann N Y Acad Sci. 1986; 465:98-109. PMID: 2942081.
    View in: PubMed
  62. Berman JS, Cruikshank WW, Center DM, Theodore AC, Beer DJ. Chemoattractant lymphokines specific for the helper/inducer T-lymphocyte subset. Cell Immunol. 1985 Oct 1; 95(1):105-12. PMID: 3161625.
    View in: PubMed
  63. Berman JS, Norton NC. Does professional training make a therapist more effective? Psychol Bull. 1985 Sep; 98(2):401-7. PMID: 3901068.
    View in: PubMed
  64. Casey RJ, Berman JS. The outcome of psychotherapy with children. Psychol Bull. 1985 Sep; 98(2):388-400. PMID: 3901067.
    View in: PubMed
  65. Kornfeld H, Berman JS, Beer DJ, Center DM. Induction of human T lymphocyte motility by interleukin 2. J Immunol. 1985 Jun; 134(6):3887-90. PMID: 3157752.
    View in: PubMed
  66. Berman JS, Miller RC, Massman PJ. Cognitive therapy versus systematic desensitization: is one treatment superior? Psychol Bull. 1985 May; 97(3):451-61. PMID: 2860682.
    View in: PubMed
  67. Berman JS, Beer DJ, Cruikshank WW, DM Center DM . Selective production of lymphocyte chemoattractant lymphokines with histamine used as a ligand: a strategy for the purification of lymphokines. In: Cellular and Molecular Biology of Lymphokines, Sorg C, Schimpl A, eds. Academic Press. 1985; 527-32.
  68. Beer DJ, Cruikshank WW, Berman JS, Center DM . Histamine-induced human lymphokines affecting T_lymphocyte motility. In Frontiers in Histamine Research. Ganellin CR, Schwartz JC, eds. Pergamon Press. 1985; 371-377.
  69. Kornfeld H, Berman JS, Beer DJ, Center DM . Interleukin_2 stimulated Lymphocyte migration. In: Cellular and Molecular Biology of Lymphokines, Sorg C, Schimpl A, eds. Academic Press. 1985; 533-37.
  70. Berman JS, Woodford DM. The Respiratory Muscles. In: Current Topics in the Management of Respiratory Diseases, Brody JS, Snider GL, eds. Churchill Livingstone. 1985; 2.
  71. Berman JS, McFadden RG, Cruikshank WW, Center DM, Beer DJ. Functional characteristics of histamine receptor-bearing mononuclear cells. II. Identification and characterization of two histamine-induced human lymphokines that inhibit lymphocyte migration. J Immunol. 1984 Sep; 133(3):1495-504. PMID: 6379050.
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  72. Center DM, Cruikshank WW, Berman JS, Beer DJ. Functional characteristics of histamine receptor-bearing mononuclear cells. I. Selective production of lymphocyte chemoattractant lymphokines with histamine used as a ligand. J Immunol. 1983 Oct; 131(4):1854-9. PMID: 6352807.
    View in: PubMed
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