Last Name

Edward J. Miller, MD, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DivisionCardiovascular Medicine
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8071
ORCID ORCID Icon0000-0002-2156-5962
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine

 Awards and Honors

1994University of Notre Dame: Cum Laude Graduate
1999Loyola Stritch School of Medicine: Alpha Omega Alpha
1999Loyola Stritch School of Medicine: President's Medallion
2001United States Navy: Navy Combat Action Ribbon
2001United States Navy: Navy and Marine Corps Commendation Medal
2008Yale University: PhD with Distinction
2014American Society of Nuclear Cardiology: Fellow
 Research Expertise & Professional Interests
My research interest is in the regulation of energy metabolism in the heart, focusing on signaling pathways that are disrupted in diabetic/metabolic heart disease. The aims of my research are both to understand the basic mechanisms that are responsible for altered cardiomyocyte metabolism in obesity-related metabolic heart disease, but also to investigate therapeutic options that can improve cardiac function in metabolic heart disease. One major focus of my work is to understand mitochondrial function in metabolic heart disease and to develop new methods to measure mitochondrial function

My clinical interests are in the evaluation and treatment of patients with infiltrative cardiomyopathies, such as amyloidosis and sarcoidosis. In particular, my research in these areas focuses on use of nuclear imaging techniques such as FDG PET/CT to diagnose and monitor patients with cardiac sarcoidosis.

 Self-Described Keywords
  • cardiac imaging
  • diabetes
  • metabolic heart disease
  • cardiac sarcoidosis
  • cardiac amyloidosis
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73.
    View in: PubMed
  2. Ayalon N, Gopal DM, Mooney DM, Simonetti JS, Grossman JR, Dwivedi A, Donohue C, Perez AJ, Downing J, Gokce N, Miller EJ, Liang CS, Apovian CM, Colucci WS, Ho JE. Preclinical left ventricular diastolic dysfunction in metabolic syndrome. Am J Cardiol. 2014 Sep 15; 114(6):838-42.
    View in: PubMed
  3. Ahmadian A, Brogan A, Berman J, Sverdlov AL, Mercier G, Mazzini M, Govender P, Ruberg FL, Miller EJ. Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis. J Nucl Cardiol. 2014 Oct; 21(5):925-39.
    View in: PubMed
  4. Li J, Qi D, Cheng H, Hu X, Miller EJ, Wu X, Russell KS, Mikush N, Zhang J, Xiao L, Sherwin RS, Young LH. Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart. Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40):16133-8.
    View in: PubMed
  5. Ruberg FL, Miller EJ. Nuclear tracers for transthyretin cardiac amyloidosis: time to bone up? Circ Cardiovasc Imaging. 2013 Mar 1; 6(2):162-4.
    View in: PubMed
  6. Depuey EG, Mahmarian JJ, Miller TD, Einstein AJ, Hansen CL, Holly TA, Miller EJ, Polk DM, Samuel Wann L. Patient-centered imaging. J Nucl Cardiol. 2012 Apr; 19(2):185-215.
    View in: PubMed
  7. Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation. 2012 Apr 10; 125(14):1757-64, S1-6.
    View in: PubMed
  8. Russell RR, Abbott BG, Arrighi JA, Blankstein R, Faber TL, Mahmarian JJ, Miller EJ, Miller TD, Shaw LJ, Soman P, Travin MI. Highlights of the 2011 Scientific Session of the American Society of Nuclear Cardiology: Denver, Colorado, September 8-11, 2011. J Nucl Cardiol. 2012 Feb; 19(1):158-64.
    View in: PubMed
  9. Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol. 2011 Jul; 51(1):24-32.
    View in: PubMed
  10. Amundson D, Dadekian G, Etienne M, Gleeson T, Hicks T, Killian D, Kratovil K, Lewis C, Monsour M, Pasiuk B, Rhodes D, Miller EJ. Practicing internal medicine onboard the USNS COMFORT in the aftermath of the Haitian earthquake. Ann Intern Med. 2010 Jun 1; 152(11):733-7.
    View in: PubMed
  11. Ozcan C, Miller EJ, Russell KS, Dewar ML, Rosenfeld LE. An unusual case of nonbacterial thrombotic (marantic) endocarditis. J Thorac Cardiovasc Surg. 2009 Jan; 137(1):239-41.
    View in: PubMed
  12. Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature. 2008 Jan 31; 451(7178):578-82.
    View in: PubMed
  13. Miller EJ, Li J, Sinusas KM, Holman GD, Young LH. Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1922-8.
    View in: PubMed
  14. Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1927-34.
    View in: PubMed
  15. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR, Young LH. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res. 2005 Oct 28; 97(9):872-9.
    View in: PubMed
  16. Baron SJ, Li J, Russell RR, Neumann D, Miller EJ, Tuerk R, Wallimann T, Hurley RL, Witters LA, Young LH. Dual mechanisms regulating AMPK kinase action in the ischemic heart. Circ Res. 2005 Feb 18; 96(3):337-45.
    View in: PubMed
  17. Miller EJ. Doctors and torture. N Engl J Med. 2004 Oct 7; 351(15):1571-4; author reply 1571-4.
    View in: PubMed
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