Paul Pilch, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, Purdue University



Research Interests: Cell biology of fuel utilization in adipocytes and skeletal muscle.

The modern Western diet coupled with a sedentary lifestyle has led to an epidemic of obesity, a consequence of which is a dramatic rise in the incidence of type II diabetes mellitus, a malfunction in insulin-regulated metabolism. At the cellular level, type II diabetes is characterized by failure of insulin to act in liver, muscle and fat. We study aspects of insulin signaling and action in the latter two tissues. Insulin resistance in muscle (and fat) derives from the failure of insulin to activate the tissue-specific glucose transporter GLUT4. The activation mechanism for this process involves vesicle trafficking and protein targeting with regard to GLUT4 and the insulin receptor. We are characterizing the formation and protein content of GLUT4-containing vesicles; we are trying to identify the organelles through which they pass on their way to and from the cell surface and we are determining the communication mechanism(s) (signaling) from the insulin receptor to the GLUT4-containing vesicles. These studies involve both fat and muscle cells, and we are also studying the physiological role of cell surface (plasma membrane) micro-domains called caveolae that are particularly abundant in these tissues. We have evidence for the hypothesis that caveolae (for little caves that are small invaginations of the plasma membrane into the cytosol) are involved in lipid trafficking.

We continue to study other aspects of adipocyte and muscle cell biology to understand the interplay between glucose and fat metabolism as well as the interplay between adipocytes and muscle required for overall metabolic homeostasis. Indeed, we wish to uncover the mechanism(s) by exercise also regulates some of these same parameters independent of insulin. Understanding these pathways will help us to figure out how they are compromised in pathophysiological states such as diabetes.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Medicine
Molecular Medicine Section

Research Professor
Boston University School of Medicine
Physiology & Biophysics


Boston Medical Center




Caveolae and Adipocyte Lipid Metabolism
05/01/2016 - 04/30/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
4R01DK097708-04

Adiporedoxin, a Novel Player in Adipokine Secretion
04/16/2012 - 03/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK092942-04

Caveolae and Adipocyte Lipid Metabolism
07/05/2013 - 04/30/2016 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK097708-03

Activation of Hexose Transport by Insulin
04/01/2008 - 02/28/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK030425-30

Regulation of Glut4 Expression and Translocation in Skeletal Muscle
07/01/2007 - 06/30/2010 (PI)
American Diabetes Association

Metabolism, Endocrinology and Obesity Training Grant
05/15/1998 - 04/30/2008 (Co-PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2 T32 DK07201 27

Exercise, Denervation, and Insulin Resistance in Muscle
08/01/1996 - 03/31/2007 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R01 DK49147 09

Mentor-based Postdoctoral Fellowship Program Application
07/01/1997 - 12/31/2004 (PI)
American Diabetes Association

Postdoctoral Training
12/01/1999 - 11/30/2002 (PI)
Adipogenix Inc


Impact of smoking and its cessation on systemic and airway immune activation
08/15/2016 - 06/30/2021 (Activity-level PI)
PI: Nina Lin, MD
NIH-NIDA
1R01DA042685-01

Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity
09/25/2014 - 07/01/2016 (Activity-level PI)
PI: Susan Fried, PhD
NIH-NIDDK
1R56DK104369-02



Yr Title Project-Sub Proj Pubs
2017 Caveolae and adipocyte lipid metabolism 5R01DK097708-05 2
2016 Caveolae and adipocyte lipid metabolism 4R01DK097708-04 2
2015 Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity 5R56DK104369-02
2015 Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity 3R56DK104369-02S1
2015 Caveolae and adipocyte lipid metabolism 5R01DK097708-03 2
2015 Adiporedoxin, a Novel Player in Adipokine Secretion 5R01DK092942-04 3
2014 Adiporedoxin and the Regulation of Adipocyte Function in Human Obesity 1R56DK104369-01
2014 Caveolae and adipocyte lipid metabolism 5R01DK097708-02 2
2014 Adiporedoxin, a Novel Player in Adipokine Secretion 5R01DK092942-03 3
2013 Caveolae and adipocyte lipid metabolism 1R01DK097708-01A1 2
Showing 10 of 77 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Ding SY, Liu L, Pilch PF. Muscular dystrophy in PTFR/cavin-1 null mice. JCI Insight. 2017 Mar 09; 2(5):e91023.View Related Profiles. PMID: 28289716; DOI: 10.1172/jci.insight.91023;.
  2. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2016 Dec 08; 7:13775. PMID: 27929114; DOI: 10.1038/ncomms13775;.
  3. Liu L, Pilch PF. PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16; 5.View Related Profiles. PMID: 27528195; PMCID: PMC4987143; DOI: 10.7554/eLife.17508;.
  4. Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding SY, Wu Y, Lee MJ, Gygi SP, Fried SK, Pilch PF. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.View Related Profiles. PMID: 26629401; DOI: 10.1016/j.molmet.2015.09.002;.
  5. Lo HP, Nixon SJ, Hall TE, Cowling BS, Ferguson C, Morgan GP, Schieber NL, Fernandez-Rojo MA, Bastiani M, Floetenmeyer M, Martel N, Laporte J, Pilch PF, Parton RG. The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle. J Cell Biol. 2015 Aug 31; 210(5):833-49. PMID: 26323694; PMCID: PMC4555827; DOI: 10.1083/jcb.201501046;.
  6. Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015; 6:7808. PMID: 26245716; PMCID: PMC4530473; DOI: 10.1038/ncomms8808;.
  7. Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014; 9(7):e102935.View Related Profiles. PMID: 25036884; PMCID: PMC4103889; DOI: 10.1371/journal.pone.0102935;.
  8. Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83.View Related Profiles. PMID: 24509860; PMCID: PMC3961672; DOI: 10.1074/jbc.M113.546242;.
  9. Fernández-Rojo MA, Gongora M, Fitzsimmons RL, Martel N, Martin SD, Nixon SJ, Brooks AJ, Ikonomopoulou MP, Martin S, Lo HP, Myers SA, Restall C, Ferguson C, Pilch PF, McGee SL, Anderson RL, Waters MJ, Hancock JF, Grimmond SM, Muscat GE, Parton RG. Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Rep. 2013 Jul 25; 4(2):238-47. PMID: 23850288; DOI: 10.1016/j.celrep.2013.06.017;.
  10. Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045.View Related Profiles. PMID: 23634221; PMCID: PMC3636273; DOI: 10.1371/journal.pone.0062045;.
Showing 10 of 149 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 147 publications over 37 distinct years, with a maximum of 9 publications in 1980 and 1989

YearPublications
19809
19814
19821
19835
19842
19865
19874
19888
19899
19905
19914
19924
19934
19944
19957
19966
19974
19987
19995
20005
20011
20022
20033
20042
20053
20064
20075
20082
20093
20102
20114
20123
20133
20142
20153
20162
20171
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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