Beth Bragdon, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Orthopaedic Surgery

PhD, University of Maine
BS, University of Maine



I am interested in the effects of trauma and repair as it pertains to the musculoskeletal system with an emphasis on stem/progenitor cell recruitment, differentiation, and formation of bone tissue and the signaling pathways involved with these processes. Currently, the stem cell population(s) that drives heterotopic ossification (HO) due to trauma or even fracture repair is unknown. My work focuses on 1) the identification and isolation of the stem/progenitor cell populations that contribute to post-natal bone formation (HO and fracture) and 2) compare the transcriptome of these different populations for similarities and identify key signaling pathways that could be used as targets for future therapy.


Pilot Awards Subproject Fund
09/01/2022 - 05/31/2024 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NIAMS
5P30AR075042-04

The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair
08/01/2018 - 07/31/2022 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R00AR068582-05

The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair
06/06/2016 - 05/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5K99AR068582-02

Defining the Tissue Origin of DBM Responsive Sketelogenic Stem Cells
02/01/2015 - 03/31/2018 (PI)
Musculoskeletal Transplant Foundation




Title


Yr Title Project-Sub Proj Pubs
2020 The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair 5R00AR068582-05
2019 The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair 5R00AR068582-04
2018 The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair 4R00AR068582-03
2017 The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair 5K99AR068582-02 1
2016 The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair 1K99AR068582-01A1 1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Blank K, Ekanayake D, Cooke M, Bragdon B, Hussein A, Gerstenfeld L. Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation. J Cell Physiol. 2024 Aug; 239(8):e31285.View Related Profiles. PMID: 38860464; PMCID: PMC11324414; DOI: 10.1002/jcp.31285;
     
  2. Liu Y, Ilinski A, Gerstenfeld LC, Bragdon B. Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Front Physiol. 2023; 14:1106474.View Related Profiles. PMID: 36793419; PMCID: PMC9922707; DOI: 10.3389/fphys.2023.1106474;
     
  3. Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep. 2023 Jun; 18:101657.View Related Profiles. PMID: 37425193; PMCID: PMC10323218; DOI: 10.1016/j.bonr.2023.101657;
     
  4. Bragdon BC, Bennie A, Molinelli A, Liu Y, Gerstenfeld LC. Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. J Cell Physiol. 2022 May; 237(5):2550-2560.View Related Profiles. PMID: 35338481; PMCID: PMC9133217; DOI: 10.1002/jcp.30728;
     
  5. Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles. PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;
     
  6. Montagna G, Cristofaro F, Fassina L, Bruni G, Cucca L, Kochen A, Divieti Pajevic P, Bragdon B, Visai L, Gerstenfeld L. An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2. Front Bioeng Biotechnol. 2020; 8:499.View Related Profiles. PMID: 32612980; PMCID: PMC7308719; DOI: 10.3389/fbioe.2020.00499;
     
  7. Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 08; 16(4):490-503. PMID: 29959723; PMCID: PMC6041151; DOI: 10.1007/s11914-018-0458-4;
     
  8. Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61.View Related Profiles. PMID: 28412469; PMCID: PMC5500242; DOI: 10.1016/j.bone.2017.04.002;
     
  9. Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214.View Related Profiles. PMID: 27324177; DOI: 10.1002/jbmr.2891;
     
  10. Bragdon B, Lybrand K, Gerstenfeld L. Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming. Curr Protoc Mouse Biol. 2015; 5(1):21-34.View Related Profiles. PMID: 25727198; PMCID: PMC4358754; DOI: 10.1002/9780470942390.mo140166;
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 16 distinct years, with a maximum of 4 publications in 2011

YearPublications
20081
20091
20102
20114
20122
20132
20141
20153
20161
20171
20181
20201
20211
20221
20232
20241

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2017 Orthopaedic Research Society: Alice L. Jee Award
2017 ORS 47th International Musculoskeletal Biology Workshop : Blue Ribbon Poster Presentation
2017 Orthopaedic Research Society Regional Meeting / University of Rochester NY: Center for Musculoskeletal Research Poster Award
2015 American Society for Bone and Mineral Research: John Haddad Young Investigator Award
2007 University of Maine: Dysart Travel Award
2007 University of Maine: Chemical BioPhysics Symposium Graduate Student Travel Award
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72 E. Concord St Evans Building
Boston MA 02118
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