Beth Bragdon | Profiles RNS

Beth Bragdon, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Orthopaedic Surgery

PhD, University of Maine
BS, University of Maine

Websites

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ORCID : 0000-0002-3270-127X

I am interested in the effects of trauma and repair as it pertains to the musculoskeletal system with an emphasis on stem/progenitor cell recruitment, differentiation, and formation of bone tissue and the signaling pathways involved with these processes. Currently, the stem cell population(s) that drives heterotopic ossification (HO) due to trauma or even fracture repair is unknown. My work focuses on 1) the identification and isolation of the stem/progenitor cell populations that contribute to post-natal bone formation (HO and fracture) and 2) compare the transcriptome of these different populations for similarities and identify key signaling pathways that could be used as targets for future therapy.

BU Research
NIH RePORTER Research

The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair
08/01/2018 - 07/31/2022 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R00AR068582-05

The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair
06/06/2016 - 05/31/2018 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5K99AR068582-02

Defining the Tissue Origin of DBM Responsive Sketelogenic Stem Cells
02/01/2015 - 03/31/2018 (PI)
Musculoskeletal Transplant Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2020	The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair	5R00AR068582-05
2019	The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair	5R00AR068582-04
2018	The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair	4R00AR068582-03
2017	The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair	5K99AR068582-02	1
2016	The Characterization of the Skeletogenic Stem Cells that Contribute to Post Natal Axial Skeletal Tissue Repair	1K99AR068582-01A1	1

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Liu Y, Ilinski A, Gerstenfeld LC, Bragdon B. Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Front Physiol. 2023; 14:1106474.View Related Profiles.

Bragdon, Beth
Gerstenfeld, Louis

PMID: 36793419; PMCID: PMC9922707; DOI: 10.3389/fphys.2023.1106474;

Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep. 2023 Jun; 18:101657.View Related Profiles.

Hussein, Amira
Bragdon, Beth
Morgan, Elise
Gerstenfeld, Louis
Demissie, Serkalem

PMID: 37425193; PMCID: PMC10323218; DOI: 10.1016/j.bonr.2023.101657;

Bragdon BC, Bennie A, Molinelli A, Liu Y, Gerstenfeld LC. Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. J Cell Physiol. 2022 May; 237(5):2550-2560.View Related Profiles.

Molinelli, Amanda
Bragdon, Beth
Gerstenfeld, Louis

PMID: 35338481; PMCID: PMC9133217; DOI: 10.1002/jcp.30728;

Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles.

Gower, Adam
Hussein, Amira
Bragdon, Beth
Morgan, Elise
Schlezinger, Jennifer
Gerstenfeld, Louis
Lenburg, Marc
Demissie, Serkalem
Alekseyev, Yuriy

PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;

Montagna G, Cristofaro F, Fassina L, Bruni G, Cucca L, Kochen A, Divieti Pajevic P, Bragdon B, Visai L, Gerstenfeld L. An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2. Front Bioeng Biotechnol. 2020; 8:499.View Related Profiles.

Bragdon, Beth
Gerstenfeld, Louis
Divieti Pajevic, Paola

PMID: 32612980; PMCID: PMC7308719; DOI: 10.3389/fbioe.2020.00499;

Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 08; 16(4):490-503. PMID: 29959723; PMCID: PMC6041151; DOI: 10.1007/s11914-018-0458-4;

Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61.View Related Profiles.

Hussein, Amira
Bragdon, Beth
Morgan, Elise
Gerstenfeld, Louis
Aly, Sherif

PMID: 28412469; PMCID: PMC5500242; DOI: 10.1016/j.bone.2017.04.002;

Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214.View Related Profiles.

Hussein, Amira
Bragdon, Beth
Gerstenfeld, Louis

PMID: 27324177; DOI: 10.1002/jbmr.2891;

Bragdon B, Lybrand K, Gerstenfeld L. Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming. Curr Protoc Mouse Biol. 2015; 5(1):21-34.View Related Profiles.

Bragdon, Beth
Gerstenfeld, Louis

PMID: 25727198; PMCID: PMC4358754; DOI: 10.1002/9780470942390.mo140166;

Lybrand K, Bragdon B, Gerstenfeld L. Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis. Curr Protoc Mouse Biol. 2015; 5(1):35-49.View Related Profiles.

Bragdon, Beth
Gerstenfeld, Louis

PMID: 25727199; PMCID: PMC4380295; DOI: 10.1002/9780470942390.mo140161;

Showing 10 of 24 results. Show More

Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307.View Related Profiles.

Belkina, Anna
Bragdon, Beth
Morgan, Elise
Denis, Gerald
Schlezinger, Jennifer
Gerstenfeld, Louis

PMID: 24962433; PMCID: PMC4317374; DOI: 10.1002/jcp.24705;

Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic injection of CK2.3, a novel peptide acting downstream of bone morphogenetic protein receptor BMPRIa, leads to increased trabecular bone mass. J Orthop Res. 2015 Feb; 33(2):208-15. PMID: 25331517; PMCID: PMC4304894; DOI: 10.1002/jor.22752;

Saldanha S, Bragdon B, Moseychuk O, Bonor J, Dhurjati P, Nohe A. Caveolae regulate Smad signaling as verified by novel imaging and system biology approaches. J Cell Physiol. 2013 May; 228(5):1060-9. PMID: 23041979; DOI: 10.1002/jcp.24253;

Moseychuk O, Akkiraju H, Dutta J, D'Angelo A, Bragdon B, Duncan RL, Nohe A. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes. J Cell Commun Signal. 2013 Dec; 7(4):265-78. PMID: 23637019; PMCID: PMC3889251; DOI: 10.1007/s12079-013-0199-1;

Bragdon B, Bonor J, Shultz KL, Beamer WG, Rosen CJ, Nohe A. Bone morphogenetic protein receptor type Ia localization causes increased BMP2 signaling in mice exhibiting increased peak bone mass phenotype. J Cell Physiol. 2012 Jul; 227(7):2870-9. PMID: 22170575; PMCID: PMC3309108; DOI: 10.1002/jcp.23028;

Bonor J, Adams EL, Bragdon B, Moseychuk O, Czymmek KJ, Nohe A. Initiation of BMP2 signaling in domains on the plasma membrane. J Cell Physiol. 2012 Jul; 227(7):2880-8. PMID: 21938723; PMCID: PMC3310286; DOI: 10.1002/jcp.23032;

Bragdon B, D'Angelo A, Gurski L, Bonor J, Schultz KL, Beamer WG, Rosen CJ, Nohe A. Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model. Bone. 2012 Jan; 50(1):189-99. PMID: 22036911; PMCID: PMC3651650; DOI: 10.1016/j.bone.2011.10.016;

Bragdon B, Thinakaran S, Moseychuk O, Gurski L, Bonor J, Price C, Wang L, Beamer WG, Nohe A. Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia. Bone. 2011 Nov; 49(5):944-54. PMID: 21763800; DOI: 10.1016/j.bone.2011.06.037;

Jiang Y, Nohe A, Bragdon B, Tian C, Rudarakanchana N, Morrell NW, Petersen NO. Trapping of BMP receptors in distinct membrane domains inhibits their function in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2011 Aug; 301(2):L218-27. PMID: 21622843; DOI: 10.1152/ajplung.00300.2010;

Bragdon B, Nohe A. Bone Morphogenetic Protein Treatments for Bone Healing and Regeneration. Bone Morphogenetic Proteins: New Research. 2011.

Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A. Bone morphogenetic proteins: a critical review. Cell Signal. 2011 Apr; 23(4):609-20. PMID: 20959140; DOI: 10.1016/j.cellsig.2010.10.003;

Bragdon B, Thinakaran S, Moseychuk O, King D, Young K, Litchfield DW, Petersen NO, Nohe A. Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Biophys J. 2010 Aug 4; 99(3):897-904. PMID: 20682268; PMCID: PMC2913199; DOI: 10.1016/j.bpj.2010.04.070;

Bragdon B, Thinakaran S, Bonor J, Underhill TM, Petersen NO, Nohe A. FRET reveals novel protein-receptor interaction of bone morphogenetic proteins receptors and adaptor protein 2 at the cell surface. Biophys J. 2009 Sep 2; 97(5):1428-35. PMID: 19720031; PMCID: PMC2749760; DOI: 10.1016/j.bpj.2009.05.061;

Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008 Jan; 24(1):139-49. PMID: 18034918; DOI: 10.1185/030079908X253519;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 15 distinct years, with a maximum of 4 publications in 2011

Bar chart showing 24 publications over 15 distinct years, with a maximum of 4 publications in 2011

Year	Publications
2008	1
2009	1
2010	2
2011	4
2012	2
2013	2
2014	1
2015	3
2016	1
2017	1
2018	1
2020	1
2021	1
2022	1
2023	2

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2017 Orthopaedic Research Society: Alice L. Jee Award

2017 ORS 47th International Musculoskeletal Biology Workshop : Blue Ribbon Poster Presentation

2017 Orthopaedic Research Society Regional Meeting / University of Rochester NY: Center for Musculoskeletal Research Poster Award

2015 American Society for Bone and Mineral Research: John Haddad Young Investigator Award

2007 University of Maine: Dysart Travel Award

2007 University of Maine: Chemical BioPhysics Symposium Graduate Student Travel Award

Contact for Mentoring:

72 E. Concord St Evans Building
Boston MA 02118
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617.358.3655

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