Jennifer J. Schlezinger, PhD
|Institution||Boston University School of Public Health|
|Address||72 E. Concord St Housman (R)|
Boston MA 02118
|Title||Graduate Faculty (Primary Mentor of Grad Students)|
|Institution||Boston University School of Medicine, Division of Graduate Medical Sciences|
Dr. Schlezinger received her B.S. from Boston College in 1992 and her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program in Biological Oceanography in 1998. Her PhD research involved the study of the molecular mechanisms of PCB toxicity in a marine fish model. Since coming to Boston University School of Public Health as a post-doctoral researcher in 1998, she has worked closely with Dr. David Sherr on immunotoxicology studies. Dr. Schlezinger is an active member of the Society of Toxiology. Her studies focus on the mechanisms by which environmental contaminants impair bone marrow physiology, both mesenchymal stem cell differentiation and B lymphocyte development. Dr. Schlezinger has invesitagted the role of two receptors, the aryl hydrocarbon receptor (an intracellular protein which is activated by dioxins, polycyclic aromatic hydrocarbons/PAH, and polychlorinated biphenyls/PCBs) and the peroxisome proliferators activated receptor-g (a protein which is activated by endogenous prostaglandins, anti-diabetic drugs, and phthalates), in the death of immature B lymphocytes. Currently, her laboratory is testing the hypotheses that 1) environmental obesogens (e.g. phthalates, organotins, organophophates) induce adipogenesis and suppress osteogenesis through activation of PPARg and RXR, accelerating the development of osteoporosis and 2) that environmental PPAR/RXR ligands suppress B lymphopoiesis by two mechanisms, directly by inducing apoptosis in early B cells and indirectly by altering the bone marrow microenvironment that supports lymphopoiesis, resulting in aging-like suppression of immune responses.
- bone marrow, osteogenesis, adipogenesis, environmental obesogen, AhR, PPARg, RXR, tributyltin, phthalate, triphenyl phosphate, mixture toxiciology
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