Keywords
Last Name

Jennifer J. Schlezinger, PhD

TitleAssociate Professor
InstitutionBoston University School of Public Health
DepartmentEnvironmental Health
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6497
ORCID ORCID Icon0000-0001-6834-4369
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Dr. Schlezinger received her B.S. from Boston College in 1992 and her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program in Biological Oceanography in 1998. Her PhD research involved the study of the molecular mechanisms of PCB toxicity in a marine fish model. Since coming to Boston University School of Public Health as a post-doctoral researcher in 1998, she has worked closely with Dr. David Sherr on immunotoxicology studies. Dr. Schlezinger is an active member of the Society of Toxiology. Her studies focus on the mechanisms by which environmental contaminants impair bone marrow physiology, both mesenchymal stem cell differentiation and B lymphocyte development. Dr. Schlezinger has invesitagted the role of two receptors, the aryl hydrocarbon receptor (an intracellular protein which is activated by dioxins, polycyclic aromatic hydrocarbons/PAH, and polychlorinated biphenyls/PCBs) and the peroxisome proliferators activated receptor-g (a protein which is activated by endogenous prostaglandins, anti-diabetic drugs, and phthalates), in the death of immature B lymphocytes. Currently, her laboratory is testing the hypotheses that 1) environmental obesogens (e.g. phthalates, organotins, organophophates) induce adipogenesis and suppress osteogenesis through activation of PPARg and RXR, accelerating the development of osteoporosis and 2) that environmental PPAR/RXR ligands suppress B lymphopoiesis by two mechanisms, directly by inducing apoptosis in early B cells and indirectly by altering the bone marrow microenvironment that supports lymphopoiesis, resulting in aging-like suppression of immune responses.

 Self-Described Keywords
  • bone marrow, osteogenesis, adipogenesis, environmental obesogen, AhR, PPARg, RXR, tributyltin, phthalate, triphenyl phosphate, mixture toxiciology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ. Tributyltin alters the bone marrow microenvironment and suppresses B cell development. Toxicol Sci. 2017 Apr 07. PMID: 28398592.
    View in: PubMed
  2. Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. Sci Rep. 2017 Feb 08; 7:42104. PMID: 28176856.
    View in: PubMed
  3. Watt J, Webster TF, Schlezinger JJ. Generalized Concentration Addition Modeling Predicts Mixture Effects of Environmental PPAR? Agonists. Toxicol Sci. 2016 Sep; 153(1):18-27. PMID: 27255385.
    View in: PubMed
  4. Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCastâ„¢ High-Throughput Data. Environ Health Perspect. 2016 Aug; 124(8):1141-54. PMID: 26978842.
    View in: PubMed
  5. Bolt AM, Grant MP, Wu TH, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK. Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells. Toxicol Sci. 2016 Apr; 150(2):333-46. PMID: 26865663.
    View in: PubMed
  6. Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol. 2015 Jun 15; 28(6):1156-66. PMID: 25932594.
    View in: PubMed
  7. Watt J, Schlezinger JJ. Structurally-diverse, PPAR?-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology. 2015 May 4; 331:66-77. PMID: 25777084.
    View in: PubMed
  8. Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307. PMID: 24962433.
    View in: PubMed
  9. Parks AJ, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov; 86(5):593-608. PMID: 25159092.
    View in: PubMed
  10. Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect. 2014 Nov; 122(11):1225-32. PMID: 25062436.
    View in: PubMed
  11. Simmons AL, Schlezinger JJ, Corkey BE. What Are We Putting in Our Food That Is Making Us Fat? Food Additives, Contaminants, and Other Putative Contributors to Obesity. Curr Obes Rep. 2014 Jun 1; 3(2):273-85. PMID: 25045594.
    View in: PubMed
  12. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One. 2014; 9(2):e87877. PMID: 24498387.
    View in: PubMed
  13. Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K. Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust. Environ Health Perspect. 2012 Dec; 120(12):1711-9. PMID: 23014847.
    View in: PubMed
  14. Goldstone HM, Tokunaga S, Schlezinger JJ, Goldstone JV, Stegeman JJ. EZR1: a novel family of highly expressed retroelements induced by TCDD and regulated by a NF-?B-like factor in embryos of zebrafish (Danio rerio). Zebrafish. 2012 Mar; 9(1):15-25. PMID: 22356696.
    View in: PubMed
  15. Yanik SC, Baker AH, Mann KK, Schlezinger JJ. Organotins are potent activators of PPAR? and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells. Toxicol Sci. 2011 Aug; 122(2):476-88. PMID: 21622945.
    View in: PubMed
  16. Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci. 2010 Nov; 118(1):108-18. PMID: 20810541.
    View in: PubMed
  17. Teague JE, Ryu HY, Kirber M, Sherr DH, Schlezinger JJ. Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. J Immunol. 2010 Sep 15; 185(6):3369-78. PMID: 20720205.
    View in: PubMed
  18. Howard GJ, Schlezinger JJ, Hahn ME, Webster TF. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect. 2010 May; 118(5):666-72. PMID: 20435555.
    View in: PubMed
  19. Schlezinger JJ, Bernard PL, Haas A, Grandjean P, Weihe P, Sherr DH. Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans. Environ Health Perspect. 2010 May; 118(5):693-8. PMID: 20435556.
    View in: PubMed
  20. Bissonnette SL, Teague JE, Sherr DH, Schlezinger JJ. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. J Immunol. 2008 Aug 1; 181(3):1728-36. PMID: 18641309.
    View in: PubMed
  21. Schlezinger JJ, Emberley JK, Bissonnette SL, Sherr DH. An L-tyrosine derivative and PPARgamma agonist, GW7845, activates a multifaceted caspase cascade in bone marrow B cells. Toxicol Sci. 2007 Jul; 98(1):125-36. PMID: 17400580.
    View in: PubMed
  22. Schlezinger JJ, Liu D, Farago M, Seldin DC, Belguise K, Sonenshein GE, Sherr DH. A role for the aryl hydrocarbon receptor in mammary gland tumorigenesis. Biol Chem. 2006 Sep; 387(9):1175-87. PMID: 16972784.
    View in: PubMed
  23. Schlezinger JJ, Emberley JK, Sherr DH. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci. 2006 Aug; 92(2):433-44. PMID: 16672323.
    View in: PubMed
  24. Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol. 2006 May 25; 77(4):422-32. PMID: 16500718.
    View in: PubMed
  25. Allan LL, Schlezinger JJ, Shansab M, Sherr DH. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):227-35. PMID: 16472762.
    View in: PubMed
  26. Ryu HY, Emberley JK, Schlezinger JJ, Allan LL, Na S, Sherr DH. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol Pharmacol. 2005 Oct; 68(4):1087-96. PMID: 16014577.
    View in: PubMed
  27. Schaefer KL, Denevich S, Ma C, Cooley SR, Nakajima A, Wada K, Schlezinger J, Sherr D, Saubermann LJ. Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms. Inflamm Bowel Dis. 2005 Mar; 11(3):244-52. PMID: 15735430.
    View in: PubMed
  28. Schlezinger JJ, Howard GJ, Hurst CH, Emberley JK, Waxman DJ, Webster T, Sherr DH. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. J Immunol. 2004 Sep 1; 173(5):3165-77. PMID: 15322177.
    View in: PubMed
  29. Jensen BA, Leeman RJ, Schlezinger JJ, Sherr DH. Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study. Environ Health. 2003 Dec 16; 2(1):16. PMID: 14678569.
    View in: PubMed
  30. Allan LL, Mann KK, Matulka RA, Ryu HY, Schlezinger JJ, Sherr DH. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci. 2003 Dec; 76(2):357-65. PMID: 14514961.
    View in: PubMed
  31. Ryu HY, Mann KK, Schlezinger JJ, Jensen B, Sherr DH. Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27Kip1, and p21WAF1 reveals a death pathway distinct from clonal deletion. J Immunol. 2003 May 15; 170(10):4897-904. PMID: 12734332.
    View in: PubMed
  32. Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. 2003 Jan; 144(1):69-74. PMID: 12488331.
    View in: PubMed
  33. Schlezinger JJ, Jensen BA, Mann KK, Ryu HY, Sherr DH. Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells. J Immunol. 2002 Dec 15; 169(12):6831-41. PMID: 12471115.
    View in: PubMed
  34. Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu HY, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JL. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet. 2001 Aug; 28(4):355-60. PMID: 11455387.
    View in: PubMed
  35. Schlezinger JJ, Stegeman JJ. Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops). Aquat Toxicol. 2001 Apr; 52(2):101-15. PMID: 11164533.
    View in: PubMed
  36. Mann KK, Doerre S, Schlezinger JJ, Sherr DH, Quadri S. The role of NF-kappaB as a survival factor in environmental chemical-induced pre-B cell apoptosis. Mol Pharmacol. 2001 Feb; 59(2):302-9. PMID: 11160867.
    View in: PubMed
  37. Stegeman JJ, Schlezinger JJ, Craddock JE, Tillitt DE. Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones. Environ Sci Technol. 2001 Jan 1; 35(1):54-62. PMID: 11352026.
    View in: PubMed
  38. Schlezinger JJ, Stegeman JJ. Induction of cytochrome P450 1A in the American Eel by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquat Toxicol. 2000 Oct 01; 50(4):375-386. PMID: 10967399.
    View in: PubMed
  39. White RD, Shea D, Schlezinger JJ, Hahn ME, Stegeman JJ. In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jul; 126(3):267-84. PMID: 11048677.
    View in: PubMed
  40. Schlezinger JJ, Stegeman JJ. Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Drug Metab Dispos. 2000 Jun; 28(6):701-8. PMID: 10820144.
    View in: PubMed
  41. Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact. 2000 May 1; 126(2):137-57. PMID: 10862814.
    View in: PubMed
  42. Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Mar; 125(3):273-86. PMID: 11790349.
    View in: PubMed
  43. Schlezinger JJ, White RD, Stegeman JJ. Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol. 1999 Sep; 56(3):588-97. PMID: 10462547.
    View in: PubMed
  44. Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers. Arch Biochem Biophys. 1998 May 15; 353(2):265-75. PMID: 9606961.
    View in: PubMed
  45. Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE, Hannink M. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Toxicol Appl Pharmacol. 1998 Jan; 148(1):24-34. PMID: 9465260.
    View in: PubMed
  46. Stegeman JJ, Hahn ME, Weisbrod R, Woodin BR, Joy JS, Najibi S, Cohen RA. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol Pharmacol. 1995 Feb; 47(2):296-306. PMID: 7870038.
    View in: PubMed
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