Jennifer J. Schlezinger, PhD
Associate Professor
Boston University School of Public Health
Dept of Environmental Health

PhD, Massachusetts Institute of Technology



Dr. Schlezinger received her B.S. from Boston College in 1992 and her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program in Biological Oceanography in 1998. Her PhD research involved the study of the molecular mechanisms of PCB toxicity in a marine fish model. Since coming to Boston University School of Public Health as a post-doctoral researcher in 1998, she has worked closely with Dr. David Sherr on immunotoxicology studies. Dr. Schlezinger is an active member of the Society of Toxiology. Her studies focus on the mechanisms by which environmental contaminants impair bone marrow physiology, both mesenchymal stem cell differentiation and B lymphocyte development. Dr. Schlezinger has invesitagted the role of two receptors, the aryl hydrocarbon receptor (an intracellular protein which is activated by dioxins, polycyclic aromatic hydrocarbons/PAH, and polychlorinated biphenyls/PCBs) and the peroxisome proliferators activated receptor-g (a protein which is activated by endogenous prostaglandins, anti-diabetic drugs, and phthalates), in the death of immature B lymphocytes. Currently, her laboratory is testing the hypotheses that 1) environmental obesogens (e.g. phthalates, organotins, organophophates) induce adipogenesis and suppress osteogenesis through activation of PPARg and RXR, accelerating the development of osteoporosis and 2) that environmental PPAR/RXR ligands suppress B lymphopoiesis by two mechanisms, directly by inducing apoptosis in early B cells and indirectly by altering the bone marrow microenvironment that supports lymphopoiesis, resulting in aging-like suppression of immune responses.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Testing of Adipogenic ToxPi Compounds
07/20/2016 - 12/31/2017 (PI)
NIH/National Institute of Environmental

Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (Co-PI)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental
5P42ES007381-19

Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
09/01/2012 - 08/31/2014 (PI)
NIH/National Institute of Environmental
5R21ES021136-02

Testing of Adipogenic ToxPi Compunds
04/01/2012 - 12/31/2012 (PI)
Professional & Scientific Associates NIH NIEHS

Molecular Mechanisms of Aryl Hydrocarbon Receptor - Mediated Breast Cancer
01/03/2000 - 12/31/2001 (PI)
Comm. of Mass./Department of Public Health

Aryl Hydrocarbon Receptor and NF-kappaB Interactions
08/24/2000 - 08/23/2001 (PI)
NIH/National Institute of Environmental Health Sciences
1 F32 ES05911 01



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. Sci Rep. 2017 Feb 08; 7:42104.View Related Profiles. PMID: 28176856; DOI: 10.1038/srep42104;.
  2. Watt J, Webster TF, Schlezinger JJ. Generalized Concentration Addition Modeling Predicts Mixture Effects of Environmental PPAR? Agonists. Toxicol Sci. 2016 Sep; 153(1):18-27.View Related Profiles. PMID: 27255385; PMCID: PMC5013877; DOI: 10.1093/toxsci/kfw100;.
  3. Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data. Environ Health Perspect. 2016 Aug; 124(8):1141-54. PMID: 26978842; PMCID: PMC4977057; DOI: 10.1289/ehp.1510456;.
  4. Bolt AM, Grant MP, Wu TH, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK. Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells. Toxicol Sci. 2016 Apr; 150(2):333-46. PMID: 26865663; PMCID: PMC4900133; DOI: 10.1093/toxsci/kfw008;.
  5. Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol. 2015 Jun 15; 28(6):1156-66.View Related Profiles. PMID: 25932594; PMCID: PMC4737589; DOI: 10.1021/tx500433r;.
  6. Watt J, Schlezinger JJ. Structurally-diverse, PPAR?-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology. 2015 May 4; 331:66-77. PMID: 25777084; PMCID: PMC4406869; DOI: 10.1016/j.tox.2015.03.006;.
  7. Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307.View Related Profiles. PMID: 24962433; PMCID: PMC4317374; DOI: 10.1002/jcp.24705;.
  8. Parks AJ, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov; 86(5):593-608.View Related Profiles. PMID: 25159092; PMCID: PMC4201140; DOI: 10.1124/mol.114.093369;.
  9. Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. Ligand binding and activation of PPAR? by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect. 2014 Nov; 122(11):1225-32.View Related Profiles. PMID: 25062436; PMCID: PMC4216168; DOI: 10.1289/ehp.1408111;.
  10. Simmons AL, Schlezinger JJ, Corkey BE. What Are We Putting in Our Food That Is Making Us Fat? Food Additives, Contaminants, and Other Putative Contributors to Obesity. Curr Obes Rep. 2014 Jun 1; 3(2):273-85.View Related Profiles. PMID: 25045594; PMCID: PMC4101898; DOI: 10.1007/s13679-014-0094-y;.
Showing 10 of 45 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 19 distinct years, with a maximum of 5 publications in 2000

YearPublications
19951
19982
19991
20005
20014
20021
20034
20041
20052
20064
20071
20081
20104
20111
20122
20144
20153
20163
20171
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72 E. Concord St Housman (R)
Boston MA 02118
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