Jennifer J. Schlezinger, PhD
Associate Professor
Boston University School of Public Health
Dept of Environmental Health

PhD, Massachusetts Institute of Technology

Dr. Schlezinger received her B.S. from Boston College in 1992 and her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program in Biological Oceanography in 1998. Dr. Schlezinger is an active member of the Society of Toxicology. Her PhD research involved the study of the molecular mechanisms of PCB toxicity in a marine fish model. Coming to Boston University School of Public Health as a post-doctoral researcher in 1998, she worked closely with Dr. David Sherr on investigating the immuntoxicity of polycyclic aromatic hydrocarbons. Now, the overarching goal of her laboratory’s research is to determine how exposure to environmental toxicants impair bone and adipose homeostasis, which lays the foundation for osteoporosis and metabolic disease. Dr. Schlezinger's lab investigates nuclear receptor activation (e.g. PPARg, RXRs, LXRs) in bone forming cells and the physiological impact of environmental chemical-driven changes in the activities of these receptors. they also investigate the hypothesis that environmental obesogen-driven changes in the balance of adipocyte and osteoblast differentiation from multipotent mesenchymal stromal cells underlies susceptibility to loss of bone. Adipocyte differentiation in bone marrow is a feature of aging and a significant contributor to osteoporosis. The lab has expanded its focus to include examining the role of environmental toxicants in development of metabolic disease. They are testing the novel hypothesis that environmental ligands selectively activate PPARg’s activities, contributing to the development of pathological adipose tissue and metabolic dyshomeostasis. This work has been built upon their identification of a novel environmental PPARg ligand, triphenyl phosphate, which is a component of the obesity-inducing flame retardant mixture Firemaster 550. The newest aspect of Dr. Schlezinger's research is an investigation of the impact of early life exposure on life-long metabolic and bone health.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Testing of Adipogenic ToxPi Compounds
07/20/2016 - 12/31/2017 (PI)
NIH/National Institute of Environmental Health Sciences

Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (Co-PI)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental Health Sciences

Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
09/01/2012 - 08/31/2014 (PI)
NIH/National Institute of Environmental Health Sciences

Testing of Adipogenic ToxPi Compunds
04/01/2012 - 12/31/2012 (PI)
Professional & Scientific Associates NIH NIEHS

Molecular Mechanisms of Aryl Hydrocarbon Receptor - Mediated Breast Cancer
01/03/2000 - 12/31/2001 (PI)
Comm. of Mass./Department of Public Health

Aryl Hydrocarbon Receptor and NF-kappaB Interactions
08/24/2000 - 08/23/2001 (PI)
NIH/National Institute of Environmental Health Sciences
1 F32 ES05911 01

Yr Title Project-Sub Proj Pubs
2017 Project 3: Environmental PPAR? Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostatsis 2P42ES007381-21-8625 314
2013 Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis 5R21ES021136-02
2012 Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis 1R21ES021136-01
2010 Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion 5R21CA134882-02 1
2009 Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion 1R21CA134882-01A1 1
2009 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-15-20 314
2008 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-14-20 314
2007 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-13-20 314
2006 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-12-20 314
2005 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 2P42ES007381-11-20 314
Showing 10 of 11 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol. 2018 Jan 30.View Related Profiles. PMID: 29380368.
  2. Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development. Toxicol Sci. 2017 Jul 01; 158(1):63-75.View Related Profiles. PMID: 28398592; DOI: 10.1093/toxsci/kfx067;.
  3. Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. Sci Rep. 2017 Feb 08; 7:42104.View Related Profiles. PMID: 28176856; DOI: 10.1038/srep42104;.
  4. Watt J, Webster TF, Schlezinger JJ. Generalized Concentration Addition Modeling Predicts Mixture Effects of Environmental PPAR? Agonists. Toxicol Sci. 2016 Sep; 153(1):18-27.View Related Profiles. PMID: 27255385; DOI: 10.1093/toxsci/kfw100;.
  5. Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data. Environ Health Perspect. 2016 Aug; 124(8):1141-54. PMID: 26978842; PMCID: PMC4977057; DOI: 10.1289/ehp.1510456;.
  6. Bolt AM, Grant MP, Wu TH, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK. Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells. Toxicol Sci. 2016 Apr; 150(2):333-46. PMID: 26865663; PMCID: PMC4900133; DOI: 10.1093/toxsci/kfw008;.
  7. Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol. 2015 Jun 15; 28(6):1156-66.View Related Profiles. PMID: 25932594; PMCID: PMC4737589; DOI: 10.1021/tx500433r;.
  8. Watt J, Schlezinger JJ. Structurally-diverse, PPAR?-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology. 2015 May 4; 331:66-77. PMID: 25777084; PMCID: PMC4406869; DOI: 10.1016/j.tox.2015.03.006;.
  9. Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307.View Related Profiles. PMID: 24962433; PMCID: PMC4317374; DOI: 10.1002/jcp.24705;.
  10. Parks AJ, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov; 86(5):593-608.View Related Profiles. PMID: 25159092; PMCID: PMC4201140; DOI: 10.1124/mol.114.093369;.
Showing 10 of 48 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 48 publications over 21 distinct years, with a maximum of 5 publications in 2000

Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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