Jennifer J. Schlezinger, PhD
Associate Professor
Boston University School of Public Health
Dept of Environmental Health

PhD, Massachusetts Institute of Technology




Dr. Schlezinger received her B.S. from Boston College in 1992 and her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program in Biological Oceanography in 1998. Dr. Schlezinger is an active member of the Society of Toxicology. Her PhD research involved the study of the molecular mechanisms of PCB toxicity in a marine fish model. Coming to Boston University School of Public Health as a post-doctoral researcher in 1998, she worked closely with Dr. David Sherr on investigating the immuntoxicity of polycyclic aromatic hydrocarbons. Now, the overarching goal of her laboratory’s research is to determine how exposure to environmental toxicants impair bone and adipose homeostasis, which lays the foundation for osteoporosis and metabolic disease. Dr. Schlezinger's lab investigates nuclear receptor activation (e.g. PPARg, RXRs, LXRs) in bone forming cells and the physiological impact of environmental chemical-driven changes in the activities of these receptors. they also investigate the hypothesis that environmental obesogen-driven changes in the balance of adipocyte and osteoblast differentiation from multipotent mesenchymal stromal cells underlies susceptibility to loss of bone. Adipocyte differentiation in bone marrow is a feature of aging and a significant contributor to osteoporosis. The lab has expanded its focus to include examining the role of environmental toxicants in development of metabolic disease. They are testing the novel hypothesis that environmental ligands selectively activate PPARg’s activities, contributing to the development of pathological adipose tissue and metabolic dyshomeostasis. This work has been built upon their identification of a novel environmental PPARg ligand, triphenyl phosphate, which is a component of the obesity-inducing flame retardant mixture Firemaster 550. The newest aspect of Dr. Schlezinger's research is an investigation of the impact of early life exposure on life-long metabolic and bone health.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease
03/02/2021 - 02/28/2023 (Multi-PI)
PI: Jennifer J. Schlezinger, PhD
NIH/National Institute of Environmental Health Sciences
5R21ES032882-02

Development of PPARy Ligand Exposure Biomarker
07/01/2016 - 06/30/2019 (Key Person / Mentor)
Environmental Protection Agency


Testing of Adipogenic ToxPi Compounds
07/20/2016 - 12/31/2017 (PI)
NIH/National Institute of Environmental Health Sciences


Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (Co-Investigator)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental Health Sciences
5P42ES007381-19

Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
09/01/2012 - 08/31/2014 (PI)
NIH/National Institute of Environmental Health Sciences
5R21ES021136-02

Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
09/01/2010 - 08/31/2014 (Key Person)
PI: Amelia Baker, MD, PhD
NIH/National Institute of Environmental Health Sciences
5F30ES019394-04

Testing of Adipogenic ToxPi Compunds
04/01/2012 - 12/31/2012 (Subcontract PI)
Professional & Scientific Associates NIH NIEHS


Molecular Mechanisms of Aryl Hydrocarbon Receptor - Mediated Breast Cancer
01/03/2000 - 12/31/2001 (PI)
Comm. of Mass./Department of Public Health

Aryl Hydrocarbon Receptor and NF-kappaB Interactions
08/24/2000 - 08/23/2001 (PI)
NIH/National Institute of Environmental Health Sciences
1 F32 ES05911 01



Title


Yr Title Project-Sub Proj Pubs
2021 Defining the Impact of Per/Polyfluoroalkyl Substance Exposure on Susceptibility to SARS-CoV-2 Infection and Disease 1R21ES032882-01
2019 Project 3: Environmental PPAR? Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostatsis 5P42ES007381-23-8625 413
2018 Project 3: Environmental PPAR? Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostatsis 5P42ES007381-22-8625 413
2017 Project 3: Environmental PPAR? Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostatsis 2P42ES007381-21-8625 413
2013 Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis 5R21ES021136-02 3
2012 Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis 1R21ES021136-01 3
2010 Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion 5R21CA134882-02 2
2009 Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion 1R21CA134882-01A1 2
2009 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-15-20 413
2008 Research Project 4: PPARgamma and Environmental Phthalate-Mediated Toxicity in 5P42ES007381-14-20 413
Showing 10 of 14 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles. PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;
     
  2. Nielsen G, Heiger-Bernays WJ, Schlezinger JJ, Webster TF. Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro. Toxicology. 2022 01 15; 465:153024.View Related Profiles. PMID: 34743024; PMCID: PMC8692422; DOI: 10.1016/j.tox.2021.153024;
     
  3. Sen P, Qadri S, Luukkonen PK, Ragnarsdottir O, McGlinchey A, Jäntti S, Juuti A, Arola J, Schlezinger JJ, Webster TF, Orešic M, Yki-Järvinen H, Hyötyläinen T. Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. J Hepatol. 2022 02; 76(2):283-293.View Related Profiles. PMID: 34627976
     
  4. Freid R, Hussein AI, Schlezinger JJ. Tributyltin protects against ovariectomy-induced trabecular bone loss in C57BL/6J mice with an attenuated effect in high fat fed mice. Toxicol Appl Pharmacol. 2021 11 15; 431:115736.View Related Profiles. PMID: 34619157; PMCID: PMC8545923; DOI: 10.1016/j.taap.2021.115736;
     
  5. Kassotis CD, Hoffman K, Völker J, Pu Y, Veiga-Lopez A, Kim SM, Schlezinger JJ, Bovolin P, Cottone E, Saraceni A, Scandiffio R, Atlas E, Leingartner K, Krager S, Tischkau SA, Ermler S, Legler J, Chappell VA, Fenton SE, Mesmar F, Bondesson M, Fernández MF, Stapleton HM. Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study. Toxicology. 2021 09; 461:152900. PMID: 34411659; PMCID: PMC8453119; DOI: 10.1016/j.tox.2021.152900;
     
  6. Kim S, Reed E, Monti S, Schlezinger JJ. A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens. Environ Health Perspect. 2021 07; 129(7):77006.View Related Profiles. PMID: 34323617; PMCID: PMC8320370; DOI: 10.1289/EHP6886;
     
  7. Schlezinger JJ, Hyötyläinen T, Sinioja T, Boston C, Puckett H, Oliver J, Heiger-Bernays W, Webster TF. Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARa mice fed an American diet. Toxicol Appl Pharmacol. 2021 09 01; 426:115644.View Related Profiles. PMID: 34252412; PMCID: PMC8338894; DOI: 10.1016/j.taap.2021.115644;
     
  8. Schlezinger JJ, Heiger-Bernays W, Webster TF. Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition. Toxicol Sci. 2020 10 01; 177(2):466-475.View Related Profiles. PMID: 32726424; PMCID: PMC7548291; DOI: 10.1093/toxsci/kfaa108;
     
  9. de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicol In Vitro. 2020 Dec; 69:104975.View Related Profiles. PMID: 32858110; PMCID: PMC7594746; DOI: 10.1016/j.tiv.2020.104975;
     
  10. Schlezinger JJ, Puckett H, Oliver J, Nielsen G, Heiger-Bernays W, Webster TF. Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARa mice fed an American diet. Toxicol Appl Pharmacol. 2020 10 15; 405:115204.View Related Profiles. PMID: 32822737; PMCID: PMC7503133; DOI: 10.1016/j.taap.2020.115204;
     
Showing 10 of 66 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 24 distinct years, with a maximum of 7 publications in 2021

YearPublications
19951
19961
19982
19991
20005
20014
20021
20034
20041
20052
20064
20071
20081
20104
20111
20122
20144
20153
20163
20172
20183
20194
20205
20217

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

bone marrow, osteogenesis, adipogenesis, environmental obesogen, AhR, PPARg, RXR, tributyltin, phthalate, triphenyl phosphate, mixture toxiciology
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