David H. Sherr, PhD

Since 1993, David Sherr's laboratory has conducted research on how common environmental pollutants, such as dioxins, polycyclic aromatic hydrocarbons and PCBs, adversely affect the growth and behavior of several different types of normal and malignant cells. In previous work, the Sherr laboratory studied how environmental chemicals affect the development of the immune system. In specific, his laboratory demonstrated that aromatic hydrocarbons (generated by the combuston of any carbon source) compromise the function of bone marrow cells required for the development of antibody-forming cells. These cells are critical for immune protection against viruses and bacteria. This work had its orignis in Dr. Sherr's graduate studies on the ontogeny of lymphocyte development.

More recently, Dr. Sherr's laboratory has focused on the molecular mechanisms that initiate and maintain breast cancer and on the effects of environmental chemicals on these processes. The laboratory has shown that a cellular protein receptor, referred to as the aryl hydrocarbon receptor (AhR), plays an important role in the initiation and progression of human breast cancer. The results explain, in part, the association between environmental chemical exposure and breast cancer risk. Perhaps most importantly, these studies demonstrate that the AhR drives human breast cancer cells to invade and, presumably, metastasize even in the absence of environmental chemicals. These observations have led to the development of AhR inhibitors which block AhR activity and prevent tumor cells from invading. One immediate goal of the laboratory, therefore, is the development of potent AhR inhibitors as novel, targeted therapeutics to be used for treatment of all breast cancers but especially for treatment of "triple negative" or chemotherapy-resistant breast cancers. Interestingly, preliminary studies suggest that these AhR inhibitors could be useful for treatment of several other cancer cell types.

A new area of study in Dr. Sherr's laboratory is the analysis of the role of the AhR in blood cell development. These studies are important from both an environmental science and medical science point of view. Studies performed to date suggest that the AhR plays an important roll in the normal development of blood cells. The results suggest the intriguing possibility that common environmental pollutants can alter normal blood cell development by interfering with AhR signaling.

Dr. Sherr came to BUSPH from the faculty of Harvard Medical School, where he had earlier been a postdoctoral fellow in the department of Nobel Laureate Baruj Benacerraf. The Sherr Laboratory is funded by research grants from the National Institute of Environmental Health Sciences, the NIH Superfund Basic Research Program, and the Art BeCAUSE breast cancer foundation. Dr. Sherr is the Director of the Boston University Immunology Training Program, and a member of the Amyloid Treatment Research Program, the BU Cancer Center, the Hematology/Oncology Training Program, and the BU Hormone-dependent Cancer Center. He has trained 21 postdoctoral (M.D. or Ph.D.) and 11 predoctoral (M.D. and/or Ph.D.) fellows.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Director
Boston University
Superfund Research Program


Director
Boston University
Immunology Training Program



2014-2016 Avon Foundation: Research Award


The Role of the Aryl Hydrocarbon Receptor (AHR) in Autoimmunity and Tumor Immunity
01/25/2018 - 01/25/2021 (PI)
AnTolRx, Inc.


Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2020 (PI)
NIH/National Institute of Environmental Health Sciences
5R01ES025409-04

Superfund Research Program at Boston University
08/01/2017 - 03/31/2020 (PI)
NIH/National Institute of Environmental Health Sciences
5P42ES007381-22

Intercepting the AHR to Enhance Tumor Immunity and Prevent Lung Cancer
12/12/2018 - 12/31/2019 (PI)
Johnson & Johnson


Research Training in Immunology
09/01/2014 - 08/31/2019 (PI of Sub-Project / SP)
PI: Thomas Kepler, PhD
NIH/National Institute of Allergy & Infectious Diseases
5T32AI007309-30

Meriem Supplies Role of adipocytes and persistant organics pollutants in metastasis development and the chemoresistance acquisition in breast cancer
06/01/2018 - 12/31/2018 (PI)
Universite de Paris


Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
04/01/2016 - 07/31/2017 (PI)
NIH/National Institute of Environmental Health Sciences
4P42ES007381-20

The Role of an Environmental Chemical Receptor in Development and Popagation of Cancer Stem Cells in Triple Negative and Inflammatory Breast Cancer
03/01/2016 - 04/20/2017 (PI)
Avon Breast Cancer Crusade, LLC.


Epidemiology of Immunotoxicant Exposure in Children
07/01/2011 - 02/28/2017 (PI)
President and Fellows of Harvard College NIH NIEHS
5R01ES012199-10

Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (PI)
NIH/National Institute of Environmental Health Sciences
5P42ES007381-19

Showing 10 of 31 results. Show All Results



Yr Title Project-Sub Proj Pubs
2019 Endogenous and Environmental AHR Ligands in Head and Neck Cancer Aggression and Immunosuppression 1R21ES029624-01A1
2019 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-04 4
2019 Superfund Research Program at Boston University 5P42ES007381-23 398
2019 Core A: Administrative Core 5P42ES007381-23-8619 398
2019 Core-005: Training Core 5P42ES007381-23-6458 398
2018 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-03 4
2018 Superfund Research Program at Boston University 5P42ES007381-22 398
2018 Core A: Administrative Core 5P42ES007381-22-8619 398
2018 Core-005: Training Core 5P42ES007381-22-6458 398
2017 Core-005: Training Core 2P42ES007381-21-6458 398
Showing 10 of 68 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Pratt A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 05; 22(5):729-740.View Related Profiles. PMID: 30962630.
     
  2. Li A, Lu X, Natoli T, Bittker J, Sipes NS, Subramanian A, Auerbach S, Sherr DH, Monti S. The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity. Environ Health Perspect. 2019 Apr; 127(4):47002.View Related Profiles. PMID: 30964323.
     
  3. Ash PEA, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna LFA, Boomhower SR, Newland MC, Sherr DH, Wolozin B. Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology. Toxicol Sci. 2019 Jan 01; 167(1):105-115.View Related Profiles. PMID: 30371865.
     
  4. Mohamed HT, Gadalla R, El-Husseiny N, Hassan H, Wang Z, Ibrahim SA, El-Shinawi M, Sherr DH, Mohamed MM. Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-ß-catenin signalling, the stem cell phenotype and disease progression. J Adv Res. 2019 Mar; 16:75-86. PMID: 30899591.
     
  5. Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X. Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29?31 August 2018 in Paris, France. Int J Mol Sci. 2018 Nov 15; 19(11). PMID: 30445691.
     
  6. Narasimhan S, Stanford Zulick E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2018 May 07; 19(5).View Related Profiles. PMID: 29735912.
     
  7. Krishnan S, Ding Y, Saedi N, Choi M, Sridharan GV, Sherr DH, Yarmush ML, Alaniz RC, Jayaraman A, Lee K. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. Cell Rep. 2018 Apr 24; 23(4):1099-1111. PMID: 29694888.
     
  8. Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 07; 36(7):1004-1019.View Related Profiles. PMID: 29569827.
     
  9. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep. 2018 Mar 21; 8(1):4970.View Related Profiles. PMID: 29563571.
     
  10. Wang, Z, Novikov O, Stanford-Zulick EA, Kenison-White J., Sherr DH. National Academy of Sciences, The Promise of Genome Editing to Advance Environmental Health Research Workshop. Tracking an AHR Regulatory Circuit in Cancer with AHR Inhibitors and CRISPR/Cas9 Knockdown. Washington DC. 2018.
Showing 10 of 223 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 215 publications over 37 distinct years, with a maximum of 15 publications in 1996

YearPublications
19802
19816
19821
19831
19843
19853
19864
19872
19882
19903
19925
19941
19952
199615
19976
19984
19995
20008
20014
20025
20037
20049
200513
200610
20078
20088
20096
20106
20114
20124
20139
201411
20154
201614
201710
20187
20193
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Aryl hydrocarbon receptor
Breast cancer and the environment
Immunology
Toxicology
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72 E. Concord St Housman (R)
Boston MA 02118
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